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  1. Article ; Online: Safety and immunogenicity of COVID-19 vaccination in immunocompromised patients

    Jin-Wen Song / Wei Hu / Lili Shen / Fu-Sheng Wang / Yanjie Yin

    Chinese Medical Journal, Vol 135, Iss 22, Pp 2656-

    2022  Volume 2666

    Abstract: Abstract. The coronavirus disease 2019 (COVID-19) pandemic poses a great threat to public health. Individuals who are immunocompromised because of the progression of the primary disease or receiving immunosuppressive medications are prone to severe COVID- ...

    Abstract Abstract. The coronavirus disease 2019 (COVID-19) pandemic poses a great threat to public health. Individuals who are immunocompromised because of the progression of the primary disease or receiving immunosuppressive medications are prone to severe COVID-19 complications and poor outcomes. Abundant data have shown that many COVID-19 vaccines are safe and effective in large-scale populations; however, these clinical trials have excluded immunocompromised populations. Available evidence indicates that immunocompromised populations have a blunted immune response to other vaccines, raising concerns regarding the efficacy of COVID-19 vaccination in these populations. Thus, there is an urgent need to delineate the efficacy of COVID-19 vaccines in these vulnerable populations. Here, we review the characteristics of specific humoral and cellular responses to COVID-19 vaccination in immunocompromised populations, including HIV-infected patients and those receiving immunosuppressive treatment, especially solid organ transplant recipients and those undergoing anti-CD20 treatment. We also addressed the challenges that immunocompromised populations will face in the future pandemic and the need for basic and clinical translational studies to highlight the best vaccination strategies for these populations.
    Keywords Medicine ; R
    Subject code 610
    Language English
    Publishing date 2022-11-01T00:00:00Z
    Publisher Wolters Kluwer
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Severe intestinal barrier damage in HIV-infected immunological non-responders

    Xiao-Yan Guo / Yun-Tian Guo / Ze-Rui Wang / Yan-Mei Jiao / Yue Hu / Li-Na Fan / Rui-Qin Cheng / Meng-Meng Qu / Chao Zhang / Jin-Wen Song / Ruo-Nan Xu / Xing Fan / Wen Xu / Ji-Yuan Zhang / Bing-Ke Bai / En-Qiang Linghu / Yao-Kai Chen / Ping Ma / Fu-Sheng Wang

    Heliyon, Vol 9, Iss 10, Pp e20790- (2023)

    2023  

    Abstract: The intestinal epithelial barrier plays an important role during human immunodeficiency virus (HIV) disease progression. However, the extent to which the intestinal epithelial barrier is damaged in immunological non-responders (INRs) and immunological ... ...

    Abstract The intestinal epithelial barrier plays an important role during human immunodeficiency virus (HIV) disease progression. However, the extent to which the intestinal epithelial barrier is damaged in immunological non-responders (INRs) and immunological responders (IRs) is largely unknown. In this study, we investigated and compared the levels of intestinal gland damage and related molecules, including the tight junction protein claudin-1, apoptosis marker caspase-3, HIV DNA, CD4+ T cell count, and inflammation marker tumor necrosis factor-α (TNF-α) among the IRs (n = 10), INRs (n = 8), and healthy controls (HCs, n = 7). Intestinal damage was not completely restored in both INRs and IRs and was more serious in INRs than that in IRs. Moreover, intestinal damage was positively correlated with HIV DNA levels and negatively correlated with CD4+ T cell counts. These results provide insight into understanding the characteristics of intestinal epithelial barrier damage between IRs and INRs.
    Keywords HIV ; Intestinal damage ; Immunological responders ; Immunological non-responders ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Subject code 610
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Implications of the accumulation of CXCR5+ NK cells in lymph nodes of HIV-1 infected patients

    An-Liang Guo / Yan-Mei Jiao / Qi-Wen Zhao / Hui-Huang Huang / Jian-Ning Deng / Chao Zhang / Xing Fan / Ruo-Nan Xu / Ji-Yuan Zhang / Cheng Zhen / Zhi-Man Xie / Ying-Mei Qin / Jian-Qing Xu / Yu Yang / Ming Shi / Lei Huang / Jin-Wen Song / Fu-Sheng Wang

    EBioMedicine, Vol 75, Iss , Pp 103794- (2022)

    2022  

    Abstract: Summary: Background: B cell follicles are immune-privileged sites where intensive HIV-1 replication and latency occur, preventing a permanent cure. Recent study showed that CXCR5+ NK cells in B cell follicles can inhibit SIV replication in African green ... ...

    Abstract Summary: Background: B cell follicles are immune-privileged sites where intensive HIV-1 replication and latency occur, preventing a permanent cure. Recent study showed that CXCR5+ NK cells in B cell follicles can inhibit SIV replication in African green monkeys, but this has not been reported in HIV-1 infected patients. Methods: Lymphocytes and tissue sections of lymph node were collected from 11 HIV-1 positive antiretroviral therapy (ART)-naive and 19 HIV-1 negative donors. We performed immunofluorescence and RNA-scope to detect the location of CXCR5+ NK cells and its relationship with HIV-1 RNA, and performed flow cytometry and RNA-seq to analyze the frequency, phenotypic and functional characteristics of CXCR5+ NK cells. The CXCL13 expression were detected by immunohistochemistry. Findings: CXCR5+ NK cells, which accumulated in LNs from HIV-1 infected individuals, expressed high levels of activating receptors such as NKG2D and NKp44. CXCR5+ NK cells had upregulated expression of CD107a and β-chemokines, which were partially impaired in HIV-1 infection. Importantly, the frequency of CXCR5+NK cells was inversely related to the HIV-1 viral burden in LNs. In addition, CXCL13—the ligand of CXCR5—was upregulated in HIV-1 infected individuals and positively correlated with the frequency of CXCR5+ NK cells. Interpretation: During chronic HIV-1 infection, CXCR5+ NK cells accumulated in lymph node, exhibit altered immune characteristics and underlying anti-HIV-1 effect, which may be an effective target for a functional cure of HIV-1.
    Keywords HIV-1 ; CXCR5 ; NK cells ; CXCL13 ; Lymph node ; B cell follicle ; Medicine ; R ; Medicine (General) ; R5-920
    Subject code 570
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Activation-induced pyroptosis contributes to the loss of MAIT cells in chronic HIV-1 infected patients

    Peng Xia / Xu-Dong Xing / Cui-Xian Yang / Xue-Jiao Liao / Fu-Hua Liu / Hui-Huang Huang / Chao Zhang / Jin-Wen Song / Yan-Mei Jiao / Ming Shi / Tian-Jun Jiang / Chun-Bao Zhou / Xi-Cheng Wang / Qing He / Qing-Lei Zeng / Fu-Sheng Wang / Ji-Yuan Zhang

    Military Medical Research, Vol 9, Iss 1, Pp 1-

    2022  Volume 19

    Abstract: Abstract Background Mucosal-associated invariant T (MAIT) cells are systemically depleted in human immunodeficiency virus type 1 (HIV-1) infected patients and are not replenished even after successful combined antiretroviral therapy (cART). This study ... ...

    Abstract Abstract Background Mucosal-associated invariant T (MAIT) cells are systemically depleted in human immunodeficiency virus type 1 (HIV-1) infected patients and are not replenished even after successful combined antiretroviral therapy (cART). This study aimed to identify the mechanism underlying MAIT cell depletion. Methods In the present study, we applied flow cytometry, single-cell RNA sequencing and immunohistochemical staining to evaluate the characteristics of pyroptotic MAIT cells in a total of 127 HIV-1 infected individuals, including 69 treatment-naive patients, 28 complete responders, 15 immunological non-responders, and 15 elite controllers, at the Fifth Medical Center of Chinese PLA General Hospital, Beijing, China. Results Single-cell transcriptomic profiles revealed that circulating MAIT cells from HIV-1 infected subjects were highly activated, with upregulation of pyroptosis-related genes. Further analysis revealed that increased frequencies of pyroptotic MAIT cells correlated with markers of systemic T-cell activation, microbial translocation, and intestinal damage in cART-naive patients and poor CD4+ T-cell recovery in long-term cART patients. Immunohistochemical staining revealed that MAIT cells in the gut mucosa of HIV-1 infected patients exhibited a strong active gasdermin-D (GSDMD, marker of pyroptosis) signal near the cavity side, suggesting that these MAIT cells underwent active pyroptosis in the colorectal mucosa. Increased levels of the proinflammatory cytokines interleukin-12 (IL-12) and IL-18 were observed in HIV-1 infected patients. In addition, activated MAIT cells exhibited an increased pyroptotic phenotype after being triggered by HIV-1 virions, T-cell receptor signals, IL-12 plus IL-18, and combinations of these factors, in vitro. Conclusions Activation-induced MAIT cell pyroptosis contributes to the loss of MAIT cells in HIV-1 infected patients, which could potentiate disease progression and poor immune reconstitution.
    Keywords Acquired immune deficiency syndrome ; Human immunodeficiency virus ; Mucosal-associated invariant T cells ; Pyroptosis ; Immune reconstitution ; Medicine (General) ; R5-920 ; Military Science ; U
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Elevated glutamate impedes anti-HIV-1 CD8 + T cell responses in HIV-1-infected individuals on antiretroviral therapy

    You-Yuan Wang / Cheng Zhen / Wei Hu / Hui-Huang Huang / Yan-Jun Li / Ming-Ju Zhou / Jing Li / Yu-Long Fu / Peng Zhang / Xiao-Yu Li / Tao Yang / Jin-Wen Song / Xing Fan / Jun Zou / Si-Run Meng / Ya-Qin Qin / Yan-Mei Jiao / Ruonan Xu / Ji-Yuan Zhang /
    Chun-Bao Zhou / Jin-Hong Yuan / Lei Huang / Ming Shi / Liang Cheng / Fu-Sheng Wang / Chao Zhang

    Communications Biology, Vol 6, Iss 1, Pp 1-

    2023  Volume 12

    Abstract: Abstract CD8 + T cells are essential for long-lasting HIV-1 control and have been harnessed to develop therapeutic and preventive approaches for people living with HIV-1 (PLWH). HIV-1 infection induces marked metabolic alterations. However, it is unclear ...

    Abstract Abstract CD8 + T cells are essential for long-lasting HIV-1 control and have been harnessed to develop therapeutic and preventive approaches for people living with HIV-1 (PLWH). HIV-1 infection induces marked metabolic alterations. However, it is unclear whether these changes affect the anti-HIV function of CD8 + T cells. Here, we show that PLWH exhibit higher levels of plasma glutamate than healthy controls. In PLWH, glutamate levels positively correlate with HIV-1 reservoir and negatively correlate with the anti-HIV function of CD8 + T cells. Single-cell metabolic modeling reveals glutamate metabolism is surprisingly robust in virtual memory CD8 + T cells (TVM). We further confirmed that glutamate inhibits TVM cells function via the mTORC1 pathway in vitro. Our findings reveal an association between metabolic plasticity and CD8 + T cell-mediated HIV control, suggesting that glutamate metabolism can be exploited as a therapeutic target for the reversion of anti-HIV CD8 + T cell function in PLWH.
    Keywords Biology (General) ; QH301-705.5
    Subject code 570
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: [Application effect of pericardial devascularization plus gastric fundus transaction in advanced schistosomiasis].

    Xiang-Wen, Li / Jian-Fang, Luo / Jin-Wen, Song / Hua, Wang / Ting-Jia, Cao

    Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control

    2016  Volume 28, Issue 6, Page(s) 738–740

    Abstract: Objective: To discuss the effect of pericardial devascularization plus gastric fundus transaction in advance schistosomiasis patients with portal hypertension.: Methods: Thirty-six advanced schistosomiasis patients with portal hypertension treated ... ...

    Abstract Objective: To discuss the effect of pericardial devascularization plus gastric fundus transaction in advance schistosomiasis patients with portal hypertension.
    Methods: Thirty-six advanced schistosomiasis patients with portal hypertension treated with devascularization plus gastric fundus transaction (a portal hypertension group), as well as 10 patients treated with modified Sugiura operation (a modified Sugiura operation group) in the Third People's Hospital of Yangxin County since 2006 were chosen as the observation objects, and the clinical effects of the two groups were observed and compared.
    Results: The operation time, indwelling time of stomach tube, time to taking food after operation, drainage tube removal time of the portal hypertension group were all shorten than those of the modified Sugiura operation group (all
    Conclusions: Pericardial devascularization plus gastric fundus is a relatively easy procedure which has a good short-term clinical effect, and therefore it is suitable for application in primary hospitals. However, its long-term effect still needs further observation.
    MeSH term(s) Esophagus ; Gastric Fundus/parasitology ; Gastrointestinal Hemorrhage ; Humans ; Hypertension, Portal ; Pericardium/surgery ; Schistosomiasis/surgery
    Language Chinese
    Publishing date 2016-11-24
    Publishing country China
    Document type Journal Article
    ISSN 1005-6661
    ISSN 1005-6661
    DOI 10.16250/j.32.1374.2016219
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Immunological and inflammatory profiles in mild and severe cases of COVID-19

    Jin-Wen Song / Chao Zhang / Xing Fan / Fan-Ping Meng / Zhe Xu / Peng Xia / Wen-Jing Cao / Tao Yang / Xiao-Peng Dai / Si-Yu Wang / Ruo-Nan Xu / Tian-Jun Jiang / Wen-Gang Li / Da-Wei Zhang / Peng Zhao / Ming Shi / Chiara Agrati / Giuseppe Ippolito / Markus Maeurer /
    Alimuddin Zumla / Fu-Sheng Wang / Ji-Yuan Zhang

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 10

    Abstract: Immunophenotyping of patients with COVID-19 is ongoing, but much remains to be learned. Here the authors analyze 41 hospitalized patients with COVID-19 and show a higher degree of lymphopenia in various immune cell subsets as well as cytotoxicity and T ... ...

    Abstract Immunophenotyping of patients with COVID-19 is ongoing, but much remains to be learned. Here the authors analyze 41 hospitalized patients with COVID-19 and show a higher degree of lymphopenia in various immune cell subsets as well as cytotoxicity and T cell inhibitory marker expression in severe cases compared with mild.
    Keywords Science ; Q
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Immunological and inflammatory profiles in mild and severe cases of COVID-19

    Jin-Wen Song / Chao Zhang / Xing Fan / Fan-Ping Meng / Zhe Xu / Peng Xia / Wen-Jing Cao / Tao Yang / Xiao-Peng Dai / Si-Yu Wang / Ruo-Nan Xu / Tian-Jun Jiang / Wen-Gang Li / Da-Wei Zhang / Peng Zhao / Ming Shi / Chiara Agrati / Giuseppe Ippolito / Markus Maeurer /
    Alimuddin Zumla / Fu-Sheng Wang / Ji-Yuan Zhang

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 10

    Abstract: Immunophenotyping of patients with COVID-19 is ongoing, but much remains to be learned. Here the authors analyze 41 hospitalized patients with COVID-19 and show a higher degree of lymphopenia in various immune cell subsets as well as cytotoxicity and T ... ...

    Abstract Immunophenotyping of patients with COVID-19 is ongoing, but much remains to be learned. Here the authors analyze 41 hospitalized patients with COVID-19 and show a higher degree of lymphopenia in various immune cell subsets as well as cytotoxicity and T cell inhibitory marker expression in severe cases compared with mild.
    Keywords Science ; Q ; covid19
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
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