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  1. AU="Jin-cai Hou"
  2. AU="Kolb, Jennifer M"
  3. AU=Kalra Paul R
  4. AU="Miller, Mona"
  5. AU="Tao Ming Sim"
  6. AU="Simen, Susanne"
  7. AU="Jole Costanza"
  8. AU="Paula, Camila S Y"
  9. AU="Azevedo, Helena S"
  10. AU=Molyneaux Phillip L.
  11. AU=Shimizu Kazuki
  12. AU=Pell Robert AU=Pell Robert
  13. AU="Aguiar, Liza"
  14. AU="Bahls, Christine"
  15. AU="Dongho Lee"
  16. AU=Houser Steven R.
  17. AU="Morgom M.M."
  18. AU="Jordana-Comajuncosa, Rosa"
  19. AU="Kaushansky, Alexis"
  20. AU="Bhatjiwale, Mohinish"
  21. AU="Velu, Chinavenmeni S"
  22. AU=Trayanova Natalia A
  23. AU=Jimeno-Gonzlez Silvia
  24. AU=Bussolino F
  25. AU="Almulla, Hanan"
  26. AU="Chen, Wenmei"
  27. AU=Zeng Weiqing

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  1. Artikel ; Online: Current strategies against COVID-19

    Shahid Hussain / Ya-Jia Xie / Dan Li / Shaukat Iqbal Malik / Jin-cai Hou / Elaine Lai-Han Leung / Xing-Xing Fan

    Chinese Medicine, Vol 15, Iss 1, Pp 1-

    2020  Band 12

    Abstract: Abstract Coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) recently was declared a pandemic by world health organization (WHO) Due to sudden outbreaks, currently, no completely effective vaccine or drug ...

    Abstract Abstract Coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) recently was declared a pandemic by world health organization (WHO) Due to sudden outbreaks, currently, no completely effective vaccine or drug is clinically approved. Several therapeutic strategies can be envisaged to prevent further mortality and morbidity. Based on the past contribution of traditional Chinese medicines (TCM) and immune-based therapies as a treatment option in crucial pathogen outbreaks, we aimed to summarize potential therapeutic strategies that could be helpful to stop further spread of SARS-CoV-2 by effecting its structural components or modulation of immune responses. Several TCM with or without modification could be effective against the structural protein, enzymes, and nucleic acid should be tested from available libraries or to identify their immune-stimulatory activities to enhance several antiviral biological agents for effective elimination of SARS-CoV-2 from the host. TCM is not only effective in the direct inhibition of virus attachment and internalization in a cell but can also prevent their replication and can also help to boost up host immune response. Immune-modulatory effects of TCMs may lead to new medications and can guide us for the scientific validity of drug development. Besides, we also summarized the effective therapies in clinical for controlling inflammation. This review will be not only helpful for the current situation of COVID-19, but can also play a major role in such epidemics in the future.
    Schlagwörter COVID-19 ; Therapeutic strategies ; Traditional Chinese medicines ; Immune-therapy ; Other systems of medicine ; RZ201-999 ; covid19
    Thema/Rubrik (Code) 570
    Sprache Englisch
    Erscheinungsdatum 2020-07-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Herbal Extracts Combination (WNK) Prevents Decline in Spatial Learning and Memory in APP/PS1 Mice through Improvement of Hippocampal Aβ Plaque Formation, Histopathology, and Ultrastructure

    Wei-hong Cong / Bin Yang / Li Xu / Xiao-xia Dong / Li-song Sheng / Jin-cai Hou / Jian-xun Liu

    Evidence-Based Complementary and Alternative Medicine, Vol

    2012  Band 2012

    Abstract: To investigate the cognitive enhancement effect of WNK, an extracts combination of P. ginseng, G. biloba, and C. sativus L. and possible mechanisms, 5-month-old APP/PS1 transgenic mice were used in this study. After 3 months of administration, all mice ... ...

    Abstract To investigate the cognitive enhancement effect of WNK, an extracts combination of P. ginseng, G. biloba, and C. sativus L. and possible mechanisms, 5-month-old APP/PS1 transgenic mice were used in this study. After 3 months of administration, all mice received Morris water maze (MWM) training and a probe test. Mouse brain sections were detected by immunohistochemistry, HE staining, and transmission electron microscopy. MWM results showed significant difference between transgenic mice and nontransgenic littermates (P<0.05, P<0.01). WNK-treated mice exhibited enhanced maze performance over the training progression, especially better spatial memory retention in probe test compared to transgenic mice (P<0.05, P<0.01) and better spatial learning and memory at the fourth day of MWM test compared to EGB761- (G. biloba extract-) treated ones (P<0.05). Hippocampal Aβ plaque burden significantly differed between APP/PS1 and littermate mice (P<0.001), while decreased Aβ plaque appeared in WNK- or EGB761-treated transgenic brains (P<0.05). Neurodegenerative changes were evident from light microscopic and ultrastructural observations in transgenic brains, which were improved by WNK or EGB761 treatment. These data indicate WNK can reduce the decline in spatial cognition, which might be due to its effects on reducing Aβ plaque formation and ameliorating histopathology and ultrastructure in hippocampus of APP/PS1 mouse brain.
    Schlagwörter Other systems of medicine ; RZ201-999
    Thema/Rubrik (Code) 572
    Sprache Englisch
    Erscheinungsdatum 2012-01-01T00:00:00Z
    Verlag Hindawi Limited
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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