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Article ; Online: Comparisons of the mean differences and standardized mean differences for continuous outcome measures on the same scale.

Jing, Yaqi / Lin, Lifeng

JBI evidence synthesis

2024 Volume 22, Issue 3, Page(s) 394–405

Abstract: When conducting systematic reviews and meta-analyses of continuous outcomes, the mean differences (MDs) and standardized mean differences (SMDs) are 2 commonly used choices for effect measures. The SMDs are motivated by scenarios where studies collected ... ...

Abstract	When conducting systematic reviews and meta-analyses of continuous outcomes, the mean differences (MDs) and standardized mean differences (SMDs) are 2 commonly used choices for effect measures. The SMDs are motivated by scenarios where studies collected in a systematic review do not report the continuous measures on the same scale. The standardization process transfers the MDs to be unit-free measures that can be synthesized across studies. As such, some evidence synthesis researchers tend to prefer the SMD over the MD. However, other researchers have concerns about the interpretability of the SMD. The standardization process could also yield additional heterogeneity between studies. In this paper, we use simulation studies to illustrate that, in a scenario where the continuous measures are on the same scale, the SMD could have considerably poorer performance compared with the MD in some cases. The simulations compare the MD and SMD in various settings, including cases where the normality assumption of continuous measures does not hold. We conclude that although the SMD remains useful for evidence synthesis of continuous measures on different scales, the SMD could have substantially greater biases, greater mean squared errors, and lower coverage probabilities of CIs than the MD. The MD is generally more robust to the violation of the normality assumption for continuous measures. In scenarios where continuous measures are inherently comparable or can be transformed to a common scale, the MD is the preferred choice for an effect measure.
MeSH term(s)	Humans ; Outcome Assessment, Health Care ; Bias
Language	English
Publishing date	2024-03-01
Publishing country	United States
Document type	Systematic Review ; Journal Article
ISSN	2689-8381
ISSN (online)	2689-8381
DOI	10.11124/JBIES-23-00368
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A Bayesian model for combining standardized mean differences and odds ratios in the same meta-analysis.

Jing, Yaqi / Murad, Mohammad Hassan / Lin, Lifeng

Journal of biopharmaceutical statistics

2022 Volume 33, Issue 2, Page(s) 167–190

Abstract: In meta-analysis practice, researchers frequently face studies that report the same outcome differently, such as a continuous variable (e.g., scores for rating depression) or a binary variable (e.g., counts of patients with depression dichotomized by ... ...

Abstract	In meta-analysis practice, researchers frequently face studies that report the same outcome differently, such as a continuous variable (e.g., scores for rating depression) or a binary variable (e.g., counts of patients with depression dichotomized by certain latent and unreported depression scores). For combining these two types of studies in the same analysis, a simple conversion method has been widely used to handle standardized mean differences (SMDs) and odds ratios (ORs). This conventional method uses a linear function connecting the SMD and log OR; it assumes logistic distributions for (latent) continuous measures. However, the normality assumption is more commonly used for continuous measures, and the conventional method may be inaccurate when effect sizes are large or cutoff values for dichotomizing binary events are extreme (leading to rare events). This article proposes a Bayesian hierarchical model to synthesize SMDs and ORs without using the conventional conversion method. This model assumes exact likelihoods for continuous and binary outcome measures, which account for full uncertainties in the synthesized results. We performed simulation studies to compare the performance of the conventional and Bayesian methods in various settings. The Bayesian method generally produced less biased results with smaller mean squared errors and higher coverage probabilities than the conventional method in most cases. Nevertheless, this superior performance depended on the normality assumption for continuous measures; the Bayesian method could lead to nonignorable biases for non-normal data. In addition, we used two case studies to illustrate the proposed Bayesian method in real-world settings.
MeSH term(s)	Humans ; Bayes Theorem ; Odds Ratio ; Computer Simulation ; Outcome Assessment, Health Care/methods ; Data Interpretation, Statistical
Language	English
Publishing date	2022-08-03
Publishing country	England
Document type	Meta-Analysis ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1131763-2
ISSN	1520-5711 ; 1054-3406
ISSN (online)	1520-5711
ISSN	1054-3406
DOI	10.1080/10543406.2022.2105345
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Article ; Online: Investigation into polymorphism within ethenzamide-ethylmalonic acid cocrystal using Raman and terahertz vibrational spectroscopy.

Zhang, Jiale / Jing, Yaqi / Wan, Mei / Xue, Jiadan / Liu, Jianjun / Li, Jiusheng / Du, Yong

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

2023 Volume 305, Page(s) 123478

Abstract: Two cocrystal polymorphs of ethenzamide (ETZ) and ethylmalonic acid (EMA) were synthesized by solvent evaporation. Crystal structure analysis revealed that the main amide - carboxyl heterosynthon in ETZ-EMA cocrystal Form I and Form II are the same, but ... ...

Abstract	Two cocrystal polymorphs of ethenzamide (ETZ) and ethylmalonic acid (EMA) were synthesized by solvent evaporation. Crystal structure analysis revealed that the main amide - carboxyl heterosynthon in ETZ-EMA cocrystal Form I and Form II are the same, but the crystal structure of these two polymorphs are different. Terahertz (THz) and Raman vibrational spectroscopy were used to characterize ETZ, EMA, ETZ-EMA cocrystal polymorph Form I and Form II respectively. The experimental results showed that ETZ, EMA, ETZ-EMA cocrystal Form I and ETZ-EMA cocrystal Form II exhibited completely different characteristic peaks. Both THz and Raman vibrational spectroscopy can be used to distinguish ETZ-EMA cocrystal Form I from Form II. Furthermore, the investigation of phase transition induced by temperature and solid-state grinding was also performed. In the temperature phase transition experiments, when the powder sample was heated to a temperature range of 80-82 °C, the metastable ETZ-EMA cocrystal Form I transformed into the more stable ETZ-EMA cocrystal Form II. Solid-state grinding analysis revealed that the results of the ETZ-EMA cocrystal polymorph synthesis in grinding experiments depended on the polarity of the solvents used. Grinding without solvent or with high polarity solvents tended to result in the stable ETZ-EMA cocrystal Form II. Moreover, the metastable ETZ-EMA cocrystal Form I would transform into Form II after further grinding process. These results demonstrate that THz and Raman vibrational spectroscopy have high sensitivity and accuracy in the detection of both cocrystal synthesis and cocrystal polymorph phase transitions.
Language	English
Publishing date	2023-10-06
Publishing country	England
Document type	Journal Article
ZDB-ID	210413-1
ISSN	1873-3557 ; 0370-8322 ; 0584-8539 ; 1386-1425
ISSN (online)	1873-3557
ISSN	0370-8322 ; 0584-8539 ; 1386-1425
DOI	10.1016/j.saa.2023.123478
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Article: Ultrasmall Pt Clusters Reducing Radiation-Induced Injuries via Scavenging Free Radicals.

Xu, Fujuan / Mu, Xiaoyu / Wang, Junying / Bian, Peixian / Liu, Lingfang / Liu, Haile / Jing, Yaqi / Long, Wei / Liu, Changlong / Zhang, Xiao-Dong

Journal of biomedical nanotechnology

2019 Volume 13, Issue 11, Page(s) 1512–1521

Abstract: High energy ionizing radiation was widely used in medical diagnosis and cancer radiation therapy. The high dose of X ray ... ...

Abstract	High energy ionizing radiation was widely used in medical diagnosis and cancer radiation therapy. The high dose of X ray or
Language	English
Publishing date	2019-06-26
Publishing country	United States
Document type	Journal Article
ISSN	1550-7033
ISSN	1550-7033
DOI	10.1166/jbn.2017.2468
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Article ; Online: Redox Trimetallic Nanozyme with Neutral Environment Preference for Brain Injury.

Mu, Xiaoyu / Wang, Junying / Li, Yonghui / Xu, Fujuan / Long, Wei / Ouyang, Lufei / Liu, Haile / Jing, Yaqi / Wang, Jingya / Dai, Haitao / Liu, Qiang / Sun, Yuanming / Liu, Changlong / Zhang, Xiao-Dong

ACS nano

2019 Volume 13, Issue 2, Page(s) 1870–1884

Abstract: Metal nanozyme has attracted wide interest for biomedicine, and a highly catalytic material in the physiological environment is highly desired. However, catalytic selectivity of nanozyme is still highly challenging, limiting its wide application. Here, ... ...

Abstract	Metal nanozyme has attracted wide interest for biomedicine, and a highly catalytic material in the physiological environment is highly desired. However, catalytic selectivity of nanozyme is still highly challenging, limiting its wide application. Here, we show a trimetallic (triM) nanozyme with highly catalytic activity and environmental selectivity. Enzyme-mimicked investigations find that the triM system possesses multi-enzyme-mimetic activity for removing reactive oxygen species (ROS) and reactive nitrogen species (RNS), such as
MeSH term(s)	Animals ; Brain Injuries/chemically induced ; Brain Injuries/metabolism ; Density Functional Theory ; Lipopolysaccharides ; Metal-Organic Frameworks/chemistry ; Metal-Organic Frameworks/metabolism ; Mice ; Neurons/metabolism ; Oxidation-Reduction ; Particle Size ; Reactive Nitrogen Species/isolation & purification ; Reactive Nitrogen Species/metabolism ; Reactive Oxygen Species/isolation & purification ; Reactive Oxygen Species/metabolism ; Superoxide Dismutase/metabolism ; Surface Properties
Chemical Substances	Lipopolysaccharides ; Metal-Organic Frameworks ; Reactive Nitrogen Species ; Reactive Oxygen Species ; Superoxide Dismutase (EC 1.15.1.1)
Language	English
Publishing date	2019-02-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.8b08045
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Electronic nose with a new feature reduction method and a multi-linear classifier for Chinese liquor classification.

Jing, Yaqi / Meng, Qinghao / Qi, Peifeng / Zeng, Ming / Li, Wei / Ma, Shugen

The Review of scientific instruments

2014 Volume 85, Issue 5, Page(s) 55004

Abstract: An electronic nose (e-nose) was designed to classify Chinese liquors of the same aroma style. A new method of feature reduction which combined feature selection with feature extraction was proposed. Feature selection method used 8 feature-selection ... ...

Abstract	An electronic nose (e-nose) was designed to classify Chinese liquors of the same aroma style. A new method of feature reduction which combined feature selection with feature extraction was proposed. Feature selection method used 8 feature-selection algorithms based on information theory and reduced the dimension of the feature space to 41. Kernel entropy component analysis was introduced into the e-nose system as a feature extraction method and the dimension of feature space was reduced to 12. Classification of Chinese liquors was performed by using back propagation artificial neural network (BP-ANN), linear discrimination analysis (LDA), and a multi-linear classifier. The classification rate of the multi-linear classifier was 97.22%, which was higher than LDA and BP-ANN. Finally the classification of Chinese liquors according to their raw materials and geographical origins was performed using the proposed multi-linear classifier and classification rate was 98.75% and 100%, respectively.
Language	English
Publishing date	2014-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	209865-9
ISSN	1089-7623 ; 0034-6748
ISSN (online)	1089-7623
ISSN	0034-6748
DOI	10.1063/1.4874326
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Article ; Online: Learning to rapidly re-contact the lost plume in chemical plume tracing.

Cao, Meng-Li / Meng, Qing-Hao / Wang, Jia-Ying / Luo, Bing / Jing, Ya-Qi / Ma, Shu-Gen

Sensors (Basel, Switzerland)

2015 Volume 15, Issue 4, Page(s) 7512–7536

Abstract: Maintaining contact between the robot and plume is significant in chemical plume tracing (CPT). In the time immediately following the loss of chemical detection during the process of CPT, Track-Out activities bias the robot heading relative to the upwind ...

Abstract	Maintaining contact between the robot and plume is significant in chemical plume tracing (CPT). In the time immediately following the loss of chemical detection during the process of CPT, Track-Out activities bias the robot heading relative to the upwind direction, expecting to rapidly re-contact the plume. To determine the bias angle used in the Track-Out activity, we propose an online instance-based reinforcement learning method, namely virtual trail following (VTF). In VTF, action-value is generalized from recently stored instances of successful Track-Out activities. We also propose a collaborative VTF (cVTF) method, in which multiple robots store their own instances, and learn from the stored instances, in the same database. The proposed VTF and cVTF methods are compared with biased upwind surge (BUS) method, in which all Track-Out activities utilize an offline optimized universal bias angle, in an indoor environment with three different airflow fields. With respect to our experimental conditions, VTF and cVTF show stronger adaptability to different airflow environments than BUS, and furthermore, cVTF yields higher success rates and time-efficiencies than VTF.
MeSH term(s)	Algorithms ; Temperature
Language	English
Publishing date	2015-03-27
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s150407512
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Black Phosphorus Quantum Dot Induced Oxidative Stress and Toxicity in Living Cells and Mice

Mu, Xiaoyu / Wang Jun-Ying / Bai Xueting / Xu Fujuan / Liu Haixia / Yang Jiang / Jing Yaqi / Liu Lingfang / Xue Xuhui / Dai Haitao / Liu Qiang / Sun Yuan-Ming / Liu Changlong / Zhang Xiao-Dong

ACS applied materials . 2017 June 21, v. 9, no. 24

2017

Abstract: Black phosphorus (BP), as an emerging successor to layered two-dimensional materials, has attracted extensive interest in cancer therapy. Toxicological studies on BP are of great importance for potential biomedical applications, yet not systemically ... ...

Abstract	Black phosphorus (BP), as an emerging successor to layered two-dimensional materials, has attracted extensive interest in cancer therapy. Toxicological studies on BP are of great importance for potential biomedical applications, yet not systemically explored. Herein, toxicity and oxidative stress of BP quantum dots (BPQDs) at cellular, tissue, and whole-body levels are evaluated by performing the systemic in vivo and in vitro experiments. In vitro investigations show that BPQDs at high concentration (200 Î¼g/mL) exhibit significant apoptotic effects on HeLa cells. In vivo investigations indicate that oxidative stress, including lipid peroxidation, reduction of catalase activity, DNA breaks, and bone marrow nucleated cells (BMNC) damage, can be induced by BPQDs transiently but recovered gradually to healthy levels. No apparent pathological damages are observed in all organs, especially in the spleen and kidneys, during the 30-day period. This work clearly shows that BPQDs can cause acute toxicities by oxidative stress responses, but the inflammatory reactions can be recovered gradually with time for up to 30 days. Thus, BPQDs do not give rise to long-term appreciable toxicological responses.
Keywords	DNA damage ; apoptosis ; bone marrow ; catalase ; in vitro studies ; kidneys ; lipid peroxidation ; mice ; neoplasms ; oxidative stress ; phosphorus ; quantum dots ; spleen ; stress response ; therapeutics ; toxicity
Language	English
Dates of publication	2017-0621
Size	p. 20399-20409.
Publishing place	American Chemical Society
Document type	Article
ISSN	1944-8252
DOI	10.1021/acsami.7b02900
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Ultrasmall WS

Bai, Xueting / Wang, Junying / Mu, Xiaoyu / Yang, Jiang / Liu, Haixia / Xu, Fujuan / Jing, Yaqi / Liu, Lingfang / Xue, Xuhui / Dai, Haitao / Liu, Qiang / Sun, Yuan-Ming / Liu, Changlong / Zhang, Xiao-Dong

ACS biomaterials science & engineering

2017 Volume 3, Issue 3, Page(s) 460–470

Abstract: Two-dimensional ... ...

Abstract	Two-dimensional WS
Language	English
Publishing date	2017-02-09
Publishing country	United States
Document type	Journal Article
ISSN	2373-9878
ISSN (online)	2373-9878
DOI	10.1021/acsbiomaterials.6b00714
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Black Phosphorus Quantum Dot Induced Oxidative Stress and Toxicity in Living Cells and Mice.

Mu, Xiaoyu / Wang, Jun-Ying / Bai, Xueting / Xu, Fujuan / Liu, Haixia / Yang, Jiang / Jing, Yaqi / Liu, Lingfang / Xue, Xuhui / Dai, Haitao / Liu, Qiang / Sun, Yuan-Ming / Liu, Changlong / Zhang, Xiao-Dong

ACS applied materials & interfaces

2017 Volume 9, Issue 24, Page(s) 20399–20409

Abstract	Black phosphorus (BP), as an emerging successor to layered two-dimensional materials, has attracted extensive interest in cancer therapy. Toxicological studies on BP are of great importance for potential biomedical applications, yet not systemically explored. Herein, toxicity and oxidative stress of BP quantum dots (BPQDs) at cellular, tissue, and whole-body levels are evaluated by performing the systemic in vivo and in vitro experiments. In vitro investigations show that BPQDs at high concentration (200 μg/mL) exhibit significant apoptotic effects on HeLa cells. In vivo investigations indicate that oxidative stress, including lipid peroxidation, reduction of catalase activity, DNA breaks, and bone marrow nucleated cells (BMNC) damage, can be induced by BPQDs transiently but recovered gradually to healthy levels. No apparent pathological damages are observed in all organs, especially in the spleen and kidneys, during the 30-day period. This work clearly shows that BPQDs can cause acute toxicities by oxidative stress responses, but the inflammatory reactions can be recovered gradually with time for up to 30 days. Thus, BPQDs do not give rise to long-term appreciable toxicological responses.
MeSH term(s)	Animals ; HeLa Cells ; Humans ; Lipid Peroxidation ; Mice ; Oxidative Stress ; Phosphorus ; Quantum Dots
Chemical Substances	Phosphorus (27YLU75U4W)
Language	English
Publishing date	2017-06-06
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.7b02900
Database	MEDical Literature Analysis and Retrieval System OnLINE

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