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Article ; Online: Design of Flute Music Remote Teaching System Based on Multi-Pass Scheduling Optimization.

Jing, Zhao

Computational intelligence and neuroscience

2022 Volume 2022, Page(s) 1126785

Abstract: With the gradual development of the Internet industry, every aspect of people's life has been affected by the Internet, playing increasingly irreplaceable functions in people's entertainment, office, and other aspects. Judging from the current ... ...

Abstract	With the gradual development of the Internet industry, every aspect of people's life has been affected by the Internet, playing increasingly irreplaceable functions in people's entertainment, office, and other aspects. Judging from the current development situation, the old Internet digital teaching system has many problems, such as low artificial intelligence, weak information processing ability, and lack of effective learning ability. This paper designs the flute music remote teaching system, which can realize remote music teaching and provide help in providing real-time music teaching. The music learning system includes the user's access records, the user's operation and the completion of the test data, the discussion and communication of online participation, the user's interests, specialties and operation methods, learning progress and scoring, and so on. In addition, it explores and explains all the key steps required by the current distance education model and invents a sample of the distance education model. On this basis, Internet algorithm programs will be used for all key processing functions of the system. The use of Internet algorithm programs is interactive and automated, which greatly enhances the role of the education system. This article first discusses the unique teaching and automated teaching mode of the system, which lays the cornerstone for further reforms in this field in the future.
MeSH term(s)	Algorithms ; Artificial Intelligence ; Education, Distance/methods ; Humans ; Learning ; Music ; Teaching
Language	English
Publishing date	2022-09-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2388208-6
ISSN	1687-5273 ; 1687-5273
ISSN (online)	1687-5273
ISSN	1687-5273
DOI	10.1155/2022/1126785
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Geostrophic flows control future changes of oceanic eastern boundary upwelling. Zhao Jing et al.

Jing, Zhao

Nature climate change

2023 Volume 13, Issue 2, Page(s) 148

Language	English
Document type	Article
ZDB-ID	2614383-5
ISSN	1758-678x
Database	Current Contents Nutrition, Environment, Agriculture

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Article ; Online: Risk Assessment Method of Agricultural Management Investment Based on Genetic Neural Network

JingJing Zhao

Security and Communication Networks, Vol

2022 Volume 2022

Abstract: At present, the economy has entered the new normal. In the environment of economic slowdown, agricultural operation and investment risk management is of great significance in investment activities. In order to avoid the related risks of the agricultural ... ...

Abstract	At present, the economy has entered the new normal. In the environment of economic slowdown, agricultural operation and investment risk management is of great significance in investment activities. In order to avoid the related risks of the agricultural operation and investment, improve the stability of agricultural operation and investment risk assessment, and ensure the effect of the agricultural operation and investment risk assessment, an agricultural operation and investment risk assessment method based on genetic neural network is proposed. This method fully considers the global optimization capability of the genetic algorithm and optimizes the weights and thresholds of the BP neural network. According to the construction principle of the index system, from the perspective of systemic risk and nonsystematic risk, a risk assessment index system for agricultural business investment has been established. Based on the establishment of risk evaluation index system, using the genetic neural network method, the agricultural operation investment risk evaluation model is established to realize the agricultural operation investment risk evaluation. The experimental results show that the proposed method has a good effect on the risk assessment of the agricultural operation and investment and can effectively improve the stability of the risk assessment of agricultural operation and investment.
Keywords	Technology (General) ; T1-995 ; Science (General) ; Q1-390
Subject code	650
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi-Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A study on the current status and suggestions of students’ character development education in secondary vocational school

Jing Zhao / Xinyi Liu

Cogent Education, Vol 10, Iss

2023 Volume 2

Abstract: AbstractThis study aims to understand the current situation of character development education for students in the direction of agriculture, forestry, animal husbandry, and fishing in secondary vocational schools. A questionnaire was administered to 303 ... ...

Abstract	AbstractThis study aims to understand the current situation of character development education for students in the direction of agriculture, forestry, animal husbandry, and fishing in secondary vocational schools. A questionnaire was administered to 303 students in such vocational schools in Lanzhou city to collect data on their daily behavior, learning ability, psychological health, and vocational competence. The results indicate that students continue to face some issues in these four aspects. Therefore, educational suggestions have been put forward for schools, parents, and students to implement character development education, to help these vocational students form good behavior habits, maintain a healthy psychological state, and possess excellent professional qualities.
Keywords	agriculture ; forestry ; animal husbandry ; fishing ; secondary vocational students ; character development education ; Education (General) ; L7-991
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: NR1H4 disease: rapidly progressing neonatal intrahepatic cholestasis and early death.

Li, Zhong-Die / Li, Yu-Chuan / Jing-Zhao / Wang, Jian-She / Xie, Xin-Bao

Orphanet journal of rare diseases

2024 Volume 19, Issue 1, Page(s) 171

Abstract: Background: Clinical studies on progressive familial intrahepatic cholestasis (PFIC) type 5 caused by mutations in NR1H4 are limited.: Methods: New patients with biallelic NR1H4 variants from our center and all patients from literature were ... ...

Abstract	Background: Clinical studies on progressive familial intrahepatic cholestasis (PFIC) type 5 caused by mutations in NR1H4 are limited. Methods: New patients with biallelic NR1H4 variants from our center and all patients from literature were retrospectively analyzed. Results: Three new patients were identified to be carrying five new variants. Liver phenotypes of our patients manifests as low-γ-glutamyl transferase cholestasis, liver failure and related complications. One patient underwent liver transplantation (LT) and survived, and two other patients died without LT. Nine other patients were collected through literature review. Twelve out of 13 patients showed neonatal jaundice, with the median age of onset being 7 days after birth. Reported clinical manifestations included cholestasis (13/13, 100%), elevated AFP (11/11, 100%), coagulopathy (11/11, 100%), hypoglycemia (9/13, 69%), failure to thrive (8/13, 62%), splenomegaly (7/13, 54%), hyperammonemia (7/13, 54%), and hepatomegaly (6/13, 46%). Six of 13 patients received LT at a median age of 6.2 months, and only one patient died of acute infection at one year after LT. Other 7 patients had no LT and died with a median age of 5 months (range 1.2-8). There were 8 patients with homozygous genotype and 5 patients with compound heterozygous genotype. In total, 13 different variants were detected, and 5 out of 12 single or multiple nucleotides variants were located in exon 5. Conclusions: We identified three newly-diagnosed patients and five novel mutations. NR1H4-related PFIC typically cause progressive disease and early death. LT may be the only lifesaving therapy leading to cure.
MeSH term(s)	Humans ; Infant, Newborn ; Infant ; Retrospective Studies ; Cholestasis, Intrahepatic/genetics ; Cholestasis, Intrahepatic/diagnosis ; Cholestasis, Intrahepatic/therapy ; Cholestasis/genetics
Language	English
Publishing date	2024-04-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2225857-7
ISSN	1750-1172 ; 1750-1172
ISSN (online)	1750-1172
ISSN	1750-1172
DOI	10.1186/s13023-024-03166-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Can directors’ and officers’ liability insurance improve corporate ESG performance?

Hanyou Xu / Jing Zhao

Frontiers in Environmental Science, Vol

2022 Volume 10

Abstract: Directors’ and Officers’ liability insurance (abbreviated as “D&O insurance”) was born in the United States in the 1930s and has been widely used in Western countries. In contrast, China introduced D&O insurance in 2002, and its development has been ... ...

Abstract	Directors’ and Officers’ liability insurance (abbreviated as “D&O insurance”) was born in the United States in the 1930s and has been widely used in Western countries. In contrast, China introduced D&O insurance in 2002, and its development has been relatively slow. With the revision and improvement of Chinese regulatory laws and regulations, such as the new Securities Law in March 2020, which further regulates the obligations and responsibilities of corporate management, and increases the penalties for information disclosure violations of listed companies, the risk to directors and executives performing their duties is promoted. This makes D&O insurance the focus of China’s capital market, with huge potential for future development. Therefore, it is of urgent practical importance to study the impact of director liability insurance on corporate governance in China. At the same time, D&O insurance, as an effective risk management mechanism, has not yet reached a unified conclusion in the academic circles on its corporate governance effectiveness. On the one hand, D&O insurance may encourage directors and senior executives to be proactive to enhance the company’s market value by taking risks, and on the other hand, it may induce opportunistic behavior of managers and reduce the company’s value. Under the new development form, analyzing and researching the governance effect of D&O insurance from different angles will help to provide a theoretical basis for its further development and popularization in China’s capital market. Thus, using a sample of Chinese A-share listed companies from 2011 to 2020, this study investigates the impact of D&O insurance on corporate ESG performance. The results show that D&O insurance significantly improves corporate ESG performance. Additional analysis suggests that the contribution of D&O insurance to ESG performance is achieved by improving independent director function-performing effectiveness and increasing corporate risk-taking. The findings ...
Keywords	directors’ and officers’ liability insurance ; ESG ; independent director function-performing effectiveness ; corporate risk-taking ; economic policy uncertainty ; industry competition ; Environmental sciences ; GE1-350
Subject code	650
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Intelligent Assessment for Visual Quality of Streets

Jing Zhao / Qi Guo

Sustainability, Vol 14, Iss 13, p

Exploration Based on Machine Learning and Large-Scale Street View Data

2022 Volume 8166

Abstract: At present, the collection and analysis of large amounts of key data for the visual quality assessment of streets are performed manually. The assessment efficiency is not high, and the effective information is not fully explored. This study aims to ... ...

Abstract	At present, the collection and analysis of large amounts of key data for the visual quality assessment of streets are performed manually. The assessment efficiency is not high, and the effective information is not fully explored. This study aims to establish an intelligent method for assessing the visual quality of streets. Taking the Hexi District of Tianjin as an example and using street view images as the assessment medium, an assessment model of objective physical indicators is established based on PaddleSeg, an assessment model of subjective perceptual indicators is established based on neural image assessment, and a visual quality assessment model of streets is established based on a random forest. The above models can intelligently evaluate the visual quality of streets and key indicators affecting visual quality. The influence of each key indicator on the visual quality of streets and the relationship between objective physical indicators and subjective perceptual indicators are analyzed. Through a combination of subjective and objective as well as qualitative and quantitative methods, the results show satisfactory assessment accuracy. In short, this study uses machine-learning techniques to improve the scientific rigor and efficiency of visual quality assessment and expand the scale of visual quality assessment data.
Keywords	visual quality ; assessment method ; machine learning ; street ; landscape ; street view images ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	600
Language	English
Publishing date	2022-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Prediction of Response to Chemoradiotherapy by Dynamic Changes of Circulating Exosome Levels in Patients with Esophageal Squamous Cell Carcinoma.

Zhang, Chuanfeng / Guo, Zhen / Jing, Zhao

International journal of nanomedicine

2024 Volume 19, Page(s) 1351–1362

Abstract: Background: The exosomes-based liquid biopsy represents a prospective biomarker for tumor screening, prognosis prediction, and tumor regression. This study aimed to isolate circulating exosomes (CEs) from plasma of the esophageal squamous cell carcinoma ...

Abstract	Background: The exosomes-based liquid biopsy represents a prospective biomarker for tumor screening, prognosis prediction, and tumor regression. This study aimed to isolate circulating exosomes (CEs) from plasma of the esophageal squamous cell carcinoma (ESCC) patients who received chemoradiotherapy through exosome detection method via the ultrafast-isolation system (EXODUS) and investigated the association between the dynamic changes of CE levels and therapeutic effect. Methods: We isolated and quantitatively analyzed CEs from plasma of locally advanced ESCC patients received chemoradiotherapy at 2 time points: baseline (pre-chemoradiotherapy) and 2 months after the chemoradiotherapy (post-chemoradiotherapy). We isolated exosomes from plasma by EXODUS platform and confirmed them through nanoparticle tracking analysis (NTA), transmission electron microscope (TEM), and Western blot. The associations of CE level with clinicopathological characteristics, tumor regression, and progression-free survival (PFS) were analyzed. Results: The average diameter of CEs was 107.4±14.3 nm at baseline and 101.7±17.1 nm at post-chemoradiotherapy. The mean exosome concentration significantly decreased after chemoradiotherapy (7.3×10 Conclusion: Here, we demonstrated EXODUS platform isolated and enriched CEs from plasma of ESCC patients with high-purity and high-yield. The EXODUS platform can facilitate liquid biopsy based on exosomes translation to the clinic. Baseline CE levels can reflect ESCC tumor burden. The dynamic changes of CE levels during chemoradiotherapy allow the prediction of treatment effect and PFS of ESCC patients, requiring further investigations in larger patient cohorts.
MeSH term(s)	Humans ; Esophageal Squamous Cell Carcinoma/drug therapy ; Esophageal Neoplasms/drug therapy ; Exosomes/pathology ; Prognosis ; Chemoradiotherapy
Language	English
Publishing date	2024-02-09
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2364941-0
ISSN	1178-2013 ; 1176-9114
ISSN (online)	1178-2013
ISSN	1176-9114
DOI	10.2147/IJN.S440684
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Article ; Online: The role of antipsychotics and other drugs on the development and progression of neuroleptic malignant syndrome

Yoji Kyotani / Jing Zhao / Kiichi Nakahira / Masanori Yoshizumi

Scientific Reports, Vol 13, Iss 1, Pp 1-

2023 Volume 8

Abstract: Abstract Neuroleptic malignant syndrome (NMS) is a rare but serious and sometimes fatal complication in patients taking antipsychotic drugs, and its underlying mechanism still remains unclear. The pharmacotherapy for psychotic disorders is complicated ... ...

Abstract	Abstract Neuroleptic malignant syndrome (NMS) is a rare but serious and sometimes fatal complication in patients taking antipsychotic drugs, and its underlying mechanism still remains unclear. The pharmacotherapy for psychotic disorders is complicated and often involves a combination of two or more drugs, including drugs other than antipsychotics. In the present study, we used the Japanese Adverse Drug Event Report (JADER) database to broadly investigate the drugs associated with NMS, following their related pathways, as well as the drug-drug interactions (DDIs) in NMS. All analyses were performed using data from the JADER database from April 2004 to May 2022. Single-drug signals were evaluated using the reporting odds ratio (ROR) and proportional reporting ratio (PRR), and drug pathways were investigated using the Kyoto Encyclopedia of Genes and Genomes (KEGG). DDIs were evaluated using the Ω shrinkage measure and Chi-square statistics models. All drugs associated with 20 or more NMS cases in the JADER database exhibited signals for NMS, including non-antipsychotics. Pathways associated with the drugs included the dopaminergic or serotonergic synapses related to antipsychotics. DDIs leading to NMS were confirmed for several drug combinations exhibiting single-drug signals. This study confirmed the significant association of various drugs, including non-psychotics, with NMS and suggested that various pathways related to these drugs may be involved in the progression of NMS. In addition, several combinations of these drugs were found to interact (DDI), increasing the risk of NMS, which suggests that appropriate caution should be taken when administering these drugs.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Electroacupuncture-induced activation of GABAergic system alleviates airway inflammation in asthma model by suppressing TLR4/MyD88/NF-κB signaling pathway

Ruisong Gong / Xiaowen Liu / Jing Zhao / Jing Ni

Chinese Medical Journal, Vol 136, Iss 4, Pp 451-

2023 Volume 460

Abstract: Abstract. Background:. Electroacupuncture (EA) has been shown to attenuate airway inflammation in asthmatic mice; however, the underlying mechanism is not fully understood. Studies have shown that EA can significantly increase the inhibitory ... ...

Abstract	Abstract. Background:. Electroacupuncture (EA) has been shown to attenuate airway inflammation in asthmatic mice; however, the underlying mechanism is not fully understood. Studies have shown that EA can significantly increase the inhibitory neurotransmitter γ-aminobutyric acid (GABA) content in mice, and can also increase the expression level of GABA type A receptor (GABAAR). Furthermore, activating GABAAR may relieve inflammation in asthma by suppressing toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88)/nuclear factor-kappa B (NF-κB) signaling pathway. Therefore, this study aimed to investigate the role of GABAergic system and TLR4/MyD88/NF-κB signaling pathway in asthmatic mice treated with EA. Methods:. A mouse model of asthma was established, and a series of methods including Western blot and histological staining assessment were employed to detect the level of GABA, and expressions of GABAAR and TLR4/MyD88/NF-κB in lung tissue. In addition, GABAAR antagonist was used to further validate the role and mechanism of GABAergic system in mediating the therapeutic effect of EA in asthma. Results:. The mouse model of asthma was established successfully, and EA was verified to alleviate airway inflammation in asthmatic mice. The release of GABA and the expression of GABAAR were significantly increased in asthmatic mice treated with EA compared with untreated asthmatic mice (P < 0.01), and the TLR4/MyD88/NF-κB signaling pathway was down-regulated. Moreover, inhibition of GABAAR attenuated the beneficial effects of EA in asthma, including the regulation of airway resistance and inflammation, as well as the inhibitory effects on TLR4/MyD88/NF-κB signaling pathway. Conclusion:. Our findings suggest that GABAergic system may be involved in mediating the therapeutic effect of EA in asthma, possibly by suppressing the TLR4/MyD88/NF-κB signaling pathway.
Keywords	Medicine ; R
Subject code	570
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	Wolters Kluwer
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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