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  1. Article ; Online: Botanical characteristics, chemical components, biological activity, and potential applications of mangosteen

    Chenchen Bi / Hang Xu / Jingru Yu / Zhinan Ding / Zheng Liu

    PeerJ, Vol 11, p e

    2023  Volume 15329

    Abstract: Garcinia mangostana L. (Mangosteen), a functional food, belongs to the Garcinaceae family and has various pharmacological effects, including anti-oxidative, anti-inflammatory, anticancer, antidiabetic, and neuroprotective effects. Mangosteen has abundant ...

    Abstract Garcinia mangostana L. (Mangosteen), a functional food, belongs to the Garcinaceae family and has various pharmacological effects, including anti-oxidative, anti-inflammatory, anticancer, antidiabetic, and neuroprotective effects. Mangosteen has abundant chemical constituents with powerful pharmacological effects. After searching scientific literature databases, including PubMed, Science Direct, Research Gate, Web of Science, VIP, Wanfang, and CNKI, we summarized the traditional applications, botanical features, chemical composition, and pharmacological effects of mangosteen. Further, we revealed the mechanism by which it improves health and treats disease. These findings provide a theoretical basis for mangosteen’s future clinical use and will aid doctors and researchers who investigate the biological activity and functions of food.
    Keywords Mangosteen ; Botanical features ; Phytochemistry ; Biological activity ; Application ; Molecular mechanisms ; Medicine ; R ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher PeerJ Inc.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Insights into the pharmacological and therapeutic effects of apigenin in liver injuries and diseases

    Chenchen Bi / Wenwen Han / Jingru Yu / Huafang Zhang / Guiying Xing / Zheng Liu

    Heliyon, Vol 9, Iss 5, Pp e15609- (2023)

    2023  

    Abstract: Background: Liver diseases are a spectrum of diseases that include hepatic steatosis, nonalcoholic fatty liver disease, hepatitis, liver fibrosis, cirrhosis, and hepatic cancer. These diseases not only severely decrease the quality of life for patients, ... ...

    Abstract Background: Liver diseases are a spectrum of diseases that include hepatic steatosis, nonalcoholic fatty liver disease, hepatitis, liver fibrosis, cirrhosis, and hepatic cancer. These diseases not only severely decrease the quality of life for patients, but also cause financial burden. Although apigenin (APG) has recently become the primary treatment for liver injuries and diseases (LIADs), there has been no systematic review of its use. Purpose: To review the existing literature and put forward novel strategies for future APG research on LIADs. Methods: A search was conducted in PubMed, Science Direct, Research Gate, Web of Science, VIP, Wanfang, and CNKI, and 809 articles were obtained. After applying inclusion and exclusion criteria, 135 articles were included. Results: APG is promising in treating LIADs via various mechanisms arising from its anti-inflammation, anti-proliferation, anti-infection, anti-oxidation, and anti-cancer properties. Conclusion: This review summarizes the evidence supporting the use of APG as a treatment for LIADs and provides an insight into the intestinal microbiota, which may have important implications in its future clinical use.
    Keywords Apigenin ; Liver injuries and diseases ; Phytochemistry ; Pharmacological effects ; Toxicology ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Subject code 610
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Total mercury concentration in placental tissue, a good biomarker of prenatal mercury exposure, is associated with risk for neural tube defects in offspring

    Mingkun Tong / Jingru Yu / Ming Liu / Zhiwen Li / Linlin Wang / Chenghong Yin / Aiguo Ren / Laiguo Chen / Lei Jin

    Environment International, Vol 150, Iss , Pp 106425- (2021)

    2021  

    Abstract: Objective: To examine the role of total mercury (T-Hg) in placenta as a biomarker of prenatal mercury (Hg) exposure and determine the association between prenatal Hg exposure and risk for neural tube defects (NTDs) in offspring. Methods: Total Hg ... ...

    Abstract Objective: To examine the role of total mercury (T-Hg) in placenta as a biomarker of prenatal mercury (Hg) exposure and determine the association between prenatal Hg exposure and risk for neural tube defects (NTDs) in offspring. Methods: Total Hg concentrations in placental tissue were detected in 408 NTD cases and 593 healthy controls enrolled in Shanxi province in northern China. Methylmercury (MeHg) and T-Hg were also detected in the umbilical cord of 147 NTD cases and 140 healthy controls. In addition, MeHg and T-Hg were detected in fetal kidney, liver, and brain tissues of 51 NTD cases. Spearman’s rank correlation (rs) was used to evaluate the correlations between placental T-Hg and T-Hg in umbilical cord and fetal kidney, liver, and brain tissues. The Wilcoxon rank-sum test was used to compare T-Hg amounts between case and control groups. Logistic regression was used to examine the association between placental T-Hg and risk for NTDs. Results: Placental T-Hg was significantly correlated with T-Hg in umbilical cord (rs = 0.479), kidney (rs = 0.718), liver (rs = 0.656), and brain (rs = 0.512) tissues (all p < 0.001). The median (25th percentile–75th percentile) concentration for placental T-Hg in the NTD case group was 8.91 (5.00–17.1) ng/g dry weight (d.w.), significantly higher than that in the healthy control group (4.99 [3.26–7.93] ng/g d.w., p < 0.001). After adjusting for potential confounders, higher levels of T-Hg in placenta were associated with increased risk for NTDs in offspring (OR = 1.76, 95% CI: 1.13–2.76), and a dose–response relationship was found (p < 0.001). Conclusion: The concentration of T-Hg in placenta is a good biomarker for estimating prenatal Hg exposure, which is associated with increased risk for NTDs.
    Keywords Fetus ; Placenta ; Mercury ; Brain ; Neural tube defects ; Kidney ; Environmental sciences ; GE1-350
    Subject code 610
    Language English
    Publishing date 2021-05-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Risk of esophageal and gastric adenocarcinoma in men receiving androgen deprivation therapy for prostate cancer

    Richard Shore / Jingru Yu / Weimin Ye / Jesper Lagergren / Martin Rutegård / Olof Akre / Pär Stattin / Mats Lindblad

    Scientific Reports, Vol 11, Iss 1, Pp 1-

    2021  Volume 8

    Abstract: Abstract The aim of this study was to explore the male predominance in esophageal and gastric adenocarcinoma by evaluating the preventive potential of androgen deprivation therapy (ADT). This matched cohort study was based on a national Swedish database ... ...

    Abstract Abstract The aim of this study was to explore the male predominance in esophageal and gastric adenocarcinoma by evaluating the preventive potential of androgen deprivation therapy (ADT). This matched cohort study was based on a national Swedish database of prostate cancer patients in 2006–2013. Prostate cancer patients receiving ADT were the exposed group. Prostate cancer-free men from the general population were randomly selected and matched to the index case by birth year and county of residence, forming the unexposed control group. The participants were followed until a diagnosis of esophageal or gastric cancer, death, emigration, or end of the study period. The risk of esophageal adenocarcinoma, cardia gastric adenocarcinoma, non-cardia gastric adenocarcinoma, and esophageal squamous-cell carcinoma among ADT-exposed compared to unexposed was calculated by multivariable Cox proportional hazard regression. The hazard ratios (HRs) and 95% confidence intervals (CIs) were adjusted for confounders. There was a risk reduction of non-cardia gastric adenocarcinoma among ADT-users compared to non-users (HR 0.49 [95% CI 0.24–0.98]). No such decreased risk was found for esophageal adenocarcinoma (HR 1.17 [95% CI 0.60–2.32]), cardia gastric adenocarcinoma (HR 0.99 [95% CI 0.40–2.46]), or esophageal squamous cell carcinoma (HR 0.99 [95% CI 0.31–3.13]). This study indicates that androgen deprivation therapy decreases the risk of non-cardia gastric adenocarcinoma, while no decreased risk was found for esophageal adenocarcinoma, cardia gastric adenocarcinoma, or esophageal squamous-cell carcinoma.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Cardiovascular disease and subsequent risk of psychiatric disorders

    Qing Shen / Huan Song / Thor Aspelund / Jingru Yu / Donghao Lu / Jóhanna Jakobsdóttir / Jacob Bergstedt / Lu Yi / Patrick Sullivan / Arvid Sjölander / Weimin Ye / Katja Fall / Fang Fang / Unnur Valdimarsdóttir

    eLife, Vol

    a nationwide sibling-controlled study

    2022  Volume 11

    Abstract: Background: The association between cardiovascular disease (CVD) and selected psychiatric disorders has frequently been suggested while the potential role of familial factors and comorbidities in such association has rarely been investigated. Methods: We ...

    Abstract Background: The association between cardiovascular disease (CVD) and selected psychiatric disorders has frequently been suggested while the potential role of familial factors and comorbidities in such association has rarely been investigated. Methods: We identified 869,056 patients newly diagnosed with CVD from 1987 to 2016 in Sweden with no history of psychiatric disorders, and 910,178 full siblings of these patients as well as 10 individually age- and sex-matched unrelated population controls (N = 8,690,560). Adjusting for multiple comorbid conditions, we used flexible parametric models and Cox models to estimate the association of CVD with risk of all subsequent psychiatric disorders, comparing rates of first incident psychiatric disorder among CVD patients with rates among unaffected full siblings and population controls. Results: The median age at diagnosis was 60 years for patients with CVD and 59.2% were male. During up to 30 years of follow-up, the crude incidence rates of psychiatric disorder were 7.1, 4.6, and 4.0 per 1000 person-years for patients with CVD, their siblings and population controls. In the sibling comparison, we observed an increased risk of psychiatric disorder during the first year after CVD diagnosis (hazard ratio [HR], 2.74; 95% confidence interval [CI], 2.62–2.87) and thereafter (1.45; 95% CI, 1.42–1.48). Increased risks were observed for all types of psychiatric disorders and among all diagnoses of CVD. We observed similar associations in the population comparison. CVD patients who developed a comorbid psychiatric disorder during the first year after diagnosis were at elevated risk of subsequent CVD death compared to patients without such comorbidity (HR, 1.55; 95% CI, 1.44–1.67). Conclusions: Patients diagnosed with CVD are at an elevated risk for subsequent psychiatric disorders independent of shared familial factors and comorbid conditions. Comorbid psychiatric disorders in patients with CVD are associated with higher risk of cardiovascular mortality suggesting that surveillance ...
    Keywords cardiovascular disease ; psychiatric disorder ; cohort ; sibling ; family design ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2022-10-01T00:00:00Z
    Publisher eLife Sciences Publications Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Near-infrared probes based on fluorinated Si-rhodamine for live cell imaging

    Shen, Suxia / Jingru Yu / Yaomin Lu / Shuchen Zhang / Xuegang Yi / Baoxiang Gao

    RSC advances. 2017 Feb. 09, v. 7, no. 18

    2017  

    Abstract: The syntheses and biological applications of three Si-rhodamine probes with substituent groups on the pendant phenyl ring are reported. In solution, these Si-rhodamine probes (AZSiR) show slight aggregation. By introducing a methyl group at the 2- ... ...

    Abstract The syntheses and biological applications of three Si-rhodamine probes with substituent groups on the pendant phenyl ring are reported. In solution, these Si-rhodamine probes (AZSiR) show slight aggregation. By introducing a methyl group at the 2-position of the pendant phenyl ring, the AZSiR-2 probe shows almost unchanged absorption and emission peaks, and a three times higher fluorescence quantum yield than that of AZSiR-1. However, the photostability of the AZSiR-2 probe becomes poor. By changing the substituent groups from methyl to trifluoromethyl, the AZSiR-3 probe displays slightly red-shifted absorption and emission peaks, and good photostability. Furthermore, the bulky groups on the phenyl ring of Si-rhodamine prevent nucleophilic attack through steric hindrance, and endow Si-rhodamine probes good chemical stability in nucleophilic systems. These Si-rhodamine probes have excellent live cell permeability and low cytotoxicity. Importantly, the Si-rhodamine probe with trifluoromethyl at the 2-position of the pendant phenyl ring retains high brightness and excellent stability even in a harsh physiological environment.
    Keywords Lewis bases ; cytotoxicity ; fluorescence ; image analysis ; moieties ; permeability ; photostability
    Language English
    Dates of publication 2017-0209
    Size p. 10922-10927.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ISSN 2046-2069
    DOI 10.1039/c6ra28455h
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: A multilayered post-GWAS assessment on genetic susceptibility to pancreatic cancer

    Evangelina López de Maturana / Juan Antonio Rodríguez / Lola Alonso / Oscar Lao / Esther Molina-Montes / Isabel Adoración Martín-Antoniano / Paulina Gómez-Rubio / Rita Lawlor / Alfredo Carrato / Manuel Hidalgo / Mar Iglesias / Xavier Molero / Matthias Löhr / Christopher Michalski / José Perea / Michael O’Rorke / Victor Manuel Barberà / Adonina Tardón / Antoni Farré /
    Luís Muñoz-Bellvís / Tanja Crnogorac-Jurcevic / Enrique Domínguez-Muñoz / Thomas Gress / William Greenhalf / Linda Sharp / Luís Arnes / Lluís Cecchini / Joaquim Balsells / Eithne Costello / Lucas Ilzarbe / Jörg Kleeff / Bo Kong / Mirari Márquez / Josefina Mora / Damian O’Driscoll / Aldo Scarpa / Weimin Ye / Jingru Yu / PanGenEU Investigators / Montserrat García-Closas / Manolis Kogevinas / Nathaniel Rothman / Debra T Silverman / SBC/EPICURO Investigators / Demetrius Albanes / Alan A Arslan / Laura Beane-Freeman / Paige M Bracci / Paul Brennan / Bas Bueno-de-Mesquita

    Genome Medicine, Vol 13, Iss 1, Pp 1-

    2021  Volume 18

    Abstract: Abstract Background Pancreatic cancer (PC) is a complex disease in which both non-genetic and genetic factors interplay. To date, 40 GWAS hits have been associated with PC risk in individuals of European descent, explaining 4.1% of the phenotypic ... ...

    Abstract Abstract Background Pancreatic cancer (PC) is a complex disease in which both non-genetic and genetic factors interplay. To date, 40 GWAS hits have been associated with PC risk in individuals of European descent, explaining 4.1% of the phenotypic variance. Methods We complemented a new conventional PC GWAS (1D) with genome spatial autocorrelation analysis (2D) permitting to prioritize low frequency variants not detected by GWAS. These were further expanded via Hi-C map (3D) interactions to gain additional insight into the inherited basis of PC. In silico functional analysis of public genomic information allowed prioritization of potentially relevant candidate variants. Results We identified several new variants located in genes for which there is experimental evidence of their implication in the biology and function of pancreatic acinar cells. Among them is a novel independent variant in NR5A2 (rs3790840) with a meta-analysis p value = 5.91E−06 in 1D approach and a Local Moran’s Index (LMI) = 7.76 in 2D approach. We also identified a multi-hit region in CASC8—a lncRNA associated with pancreatic carcinogenesis—with a lowest p value = 6.91E−05. Importantly, two new PC loci were identified both by 2D and 3D approaches: SIAH3 (LMI = 18.24), CTRB2/BCAR1 (LMI = 6.03), in addition to a chromatin interacting region in XBP1—a major regulator of the ER stress and unfolded protein responses in acinar cells—identified by 3D; all of them with a strong in silico functional support. Conclusions This multi-step strategy, combined with an in-depth in silico functional analysis, offers a comprehensive approach to advance the study of PC genetic susceptibility and could be applied to other diseases.
    Keywords Pancreatic cancer risk ; Genome-wide association analysis ; Genetic susceptibility ; 3D genomic structure ; Local indices of genome spatial autocorrelation ; Medicine ; R ; Genetics ; QH426-470
    Subject code 610
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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