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Article ; Online: Enhanced Heterogeneous Fenton Degradation of Organic Pollutants by CRC/Fe3O4 Catalyst at Neutral pH

Chuan Wang / Rui Jiang / Jingxin Yang / Pingshan Wang

Frontiers in Chemistry, Vol

2022 Volume 10

Abstract: Fe3O4-based heterogeneous Fenton catalysts have been widely employed for degrading organic pollutants, however it is challenging to use them in highly efficient and recyclable application in wastewater treatment. In this work, carboxylate-rich carbon ( ... ...

Abstract	Fe3O4-based heterogeneous Fenton catalysts have been widely employed for degrading organic pollutants, however it is challenging to use them in highly efficient and recyclable application in wastewater treatment. In this work, carboxylate-rich carbon (CRC)-modified Fe3O4 magnetic particles are prepared by the sol-gel self-combustion method, where CRC is obtained from the carbonization of sodium gluconate. The CRC/Fe3O4 catalyst exhibits high heterogeneous Fenton degradation performance. The complete 10 mg L−1 methylene blue (MB) removal is achieved in 180 min under conditions of 10 mM H2O2 and 1.00 g of L−1 CRC/Fe3O4 at neutral pH. After five cycles, the structure and morphology of CRC/Fe3O4 composites remained unchanged and the catalytic activity also remained unaltered. Moreover, phenol, benzoic acid (BA), sulfamethazine (SMT), and tetracycline (TC) were also degraded in the heterogeneous Fenton reaction using CRC/Fe3O4 as a catalyst. The strong coordinating ability of –COOH/ –COO– functionalities of CRC formed strong bonds with Fe(II/III) ions on the surfaces of Fe3O4 particles, which was conducive to adsorption of organic matter on the surface of the catalyst and promoted the occurrence of heterogeneous Fenton reactions. It was found that CRC/Fe3O4 had higher removal rates for the adsorptive exclusions of pollutants, such as TC and MB, whereas there were lower removal rates for phenol, BA, and SMT. This work brings potential insights for development of a novel adsorption-enhanced heterogeneous Fenton reaction for wastewater treatment.
Keywords	heterogeneous fenton ; CRC@Fe3O4 catalyst ; degradation ; methylene blue ; adsorption ; Chemistry ; QD1-999
Subject code	540
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Corrigendum

Chuan Wang / Rui Jiang / Jingxin Yang / Pingshan Wang

Frontiers in Chemistry, Vol

Enhanced Heterogeneous Fenton Degradation of Organic Pollutants by CRC/Fe3O4 Catalyst at Neutral pH

2022 Volume 10

Keywords	heterogeneous fenton ; CRC/Fe3O4 ; degradation ; methylene blue ; adsorption ; Chemistry ; QD1-999
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Synthesis, antifungal activity and in vitro mechanism of novel 1-substituted-5-trifluoromethyl-1H-pyrazole-4-carboxamide derivatives

Jingxin Yang / Dewen Xie / Chengzhi Zhang / Cailong Zhao / Zhibing Wu / Wei Xue

Arabian Journal of Chemistry, Vol 15, Iss 8, Pp 103987- (2022)

2022

Abstract: Inspired by the wide application of amides in plant pathogens, a series of novel 1-substituted-5-trifluoromethyl‑1H‑pyrazole-4-carboxamide derivatives were designed and synthesized. Bioassay results indicated that some target compounds exhibited ... ...

Abstract	Inspired by the wide application of amides in plant pathogens, a series of novel 1-substituted-5-trifluoromethyl‑1H‑pyrazole-4-carboxamide derivatives were designed and synthesized. Bioassay results indicated that some target compounds exhibited excellent and broad-spectrum in vitro and certain in vivo antifungal activities. Among them, the in vitro EC50 values of Y13 against G. zeae, B. dothidea, F. prolifeatum and F. oxysporum were 13.1, 14.4, 13.3 and 21.4 mg/L, respectively. The in vivo protective activity of Y13 against G. zeae at 100 mg/L was 50.65%. SAR analysis revealed that the phenyl on the 1-position of the pyrazole ring was important for this activity. An antifungal mechanism study of Y13 against G. zeae demonstrated that this compound may disrupt the cell membrane of mycelium, thus inhibiting the growth of fungi. These mechanistic study results were inconsistent with those for traditional amides and may provide a novel view for deep study of this series of pyrazole carboxamide derivatives.
Keywords	Pyrazole carboxamides ; Molecular design ; Fungicidal activity ; Molecular docking ; SAR analysis ; Antifungal mechanism ; Chemistry ; QD1-999
Subject code	540
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Inhibition of lung cancer by vitamin D depends on downregulation of histidine-rich calcium-binding protein

Ning Liu / Xiaofeng Li / Yu Fu / Ye Li / Wanyi Lu / Yiming Pan / Jingxin Yang / Juan Kong

Journal of Advanced Research, Vol 29, Iss , Pp 13-

2021 Volume 22

Abstract: Introduction: Intrinsic vitamin D affects the proliferation, apoptosis, invasion, metastasis, and tumorigenesis of lung cancer by regulating tumor signaling pathways. Histidine-rich calcium-binding protein (HRC) maintains Ca2+ homeostasis, which plays ... ...

Abstract	Introduction: Intrinsic vitamin D affects the proliferation, apoptosis, invasion, metastasis, and tumorigenesis of lung cancer by regulating tumor signaling pathways. Histidine-rich calcium-binding protein (HRC) maintains Ca2+ homeostasis, which plays crucial roles in the occurrence and development of cancer. Objectives: Our study aims to investigate the ability of vitamin D in the regulation of HRC and the role of HRC playing in lung cancer. Methods: We investigated the effects of vitamin D on lung cancer and the underlying mechanisms, by measuring HRC and vitamin D receptor (VDR) expression in lung cancer, paracancer, and normal tissues from patients using immunohistochemistry, western blotting, and real time RT-PCR. We transfected H460 lung cancer cells (supplemented or not with vitamin D) with PX458-HRC and pcDNA3.1-HRC plasmids and injected mice with lung cancer cells harboring pcDNA3.1-vector or pcDNA3.1-HRC plasmids. Results: Vitamin D inhibited HRC expression and H460 cell migration and proliferation, and promoted apoptosis compared with controls. The expression of HRC and VDR was significantly upregulated and downregulated, respectively, in lung cancer versus paracancer or normal tissues. Cell proliferation and migration were reduced, apoptotic cells were more and tumors were smaller in mice treated with vitamin D/cholecalciferol cholesterol emulsion (CCE) than in vitamin D/CCE+HRC+/+ mice. Conclusion: Vitamin D inhibited lung cancer tumor growth, migration, and proliferation by downregulating HRC.
Keywords	Vitamin D ; Lung cancer ; Histidine-rich calcium-binding protein ; Vitamin D receptor ; Medicine (General) ; R5-920 ; Science (General) ; Q1-390
Subject code	610
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Protective Effect of 1,25(OH)2D3 on Myocardial Function is Mediated via Sirtuin 3-Regulated Fatty Acid Metabolism

Jingxin Yang / Yalin Zhang / Yiming Pan / Can Sun / Zuwang Liu / Ning Liu / Yu Fu / Xiaofeng Li / Ye Li / Juan Kong

Frontiers in Cell and Developmental Biology, Vol

2021 Volume 9

Abstract: Energy substrate imbalance is a major cause of cardiac dysfunction. Vitamin D/vitamin D receptor (VD/VDR) deficiency is involved in the pathogenesis of various cardiac diseases; however, the exact underlying mechanism remains unclear. The aim of this ... ...

Abstract	Energy substrate imbalance is a major cause of cardiac dysfunction. Vitamin D/vitamin D receptor (VD/VDR) deficiency is involved in the pathogenesis of various cardiac diseases; however, the exact underlying mechanism remains unclear. The aim of this study was to investigate whether vitamin D modulates mitochondrial fatty acid oxidase via sirtuin 3 signaling to protect the myocardium. 1-Alpha-hydroxylase-defficient mice exhibited a high metabolic rate and lower myocardial contractility than wild-type mice. Sirtuin 3 upregulation was detected in high-fat diet-fed mice receiving vitamin D3 compared with that in high-fat diet-fed mice. Both sirtuin 3 blockade and knockout inhibited the VD/VDR-induced downregulation of fatty acid oxidase in myocardial mitochondria. VD/VDR suppressed fatty acid metabolism by upregulating sirtuin 3 and lowering mitochondrial fat uptake, thereby improving myocardial function and balancing energy substrates, rather than by altering fat endocytosis and exocytosis.
Keywords	Vitamin D ; fatty acid metabolism ; Sirtuin 3 ; mitochondria ; cardiac function ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2021-04-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Advantages and Limitations of Monitoring Circulating Tumor DNA Levels to Predict the Prognosis of Patients Diagnosed With Gastric Cancer

Wan He / Jingxin Yang / Xiao Sun / Shunda Jiang / Jinchan Jiang / Ming Liu / Tianhao Mu / Yingmei Li / Xiaoni Zhang / Jingxian Duan / Ruilian Xu

Biomarker Insights, Vol

2022 Volume 17

Abstract: Next-generation sequencing-based genomic profiling facilitates biomarker detection by cell-free DNA (cfDNA) liquid biopsy. However, the efficiency of mutation calling and the prognostic value of cfDNA biomarkers are disputed. We investigated 24 patients ... ...

Abstract	Next-generation sequencing-based genomic profiling facilitates biomarker detection by cell-free DNA (cfDNA) liquid biopsy. However, the efficiency of mutation calling and the prognostic value of cfDNA biomarkers are disputed. We investigated 24 patients with gastric cancer in this study, using a 605-gene sequencing panel to sequence their plasma cfDNA and tumor tissue DNA. The mutation concordance between plasma cfDNA and tumor tissue DNA was 70.6% in stage IV gastric cancer and 30.2% in stage III gastric cancer, indicating insufficient mutation detection rates in stage III and early-stage cancer. When compared with total cfDNA load and blood tumor mutation burden (bTMB), the variant allele frequencies (VAF) of commonly mutated genes are highly accurate in representing disease burden. Further, VAF are a better prognostic indicator compared with serum biomarkers including carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), cancer antigen 125 (CA125), and alpha-fetoprotein (AFP). The use of cfDNA in molecular profiling of patients allows prediction of patient survival and clinical response, as well as the development of personalized therapy regimens.
Keywords	Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Circular RNA hsa_circ_0000848 Promotes Trophoblast Cell Migration and Invasion and Inhibits Cell Apoptosis by Sponging hsa-miR-6768-5p

Hui Wang / Jianming Zhang / Zhiyong Xu / Jingxin Yang / Yong Xu / Yang Liu / Bohong Li / Jiansheng Xie / Jing Li

Frontiers in Cell and Developmental Biology, Vol

2020 Volume 8

Abstract: BackgroundFetal growth restriction (FGR) is a worldwide problem, and a major cause of perinatal morbidity. The precise molecular mechanisms involved in placental development and function during FGR remain poorly understood. Circular RNAs (circRNAs) are ... ...

Abstract	BackgroundFetal growth restriction (FGR) is a worldwide problem, and a major cause of perinatal morbidity. The precise molecular mechanisms involved in placental development and function during FGR remain poorly understood. Circular RNAs (circRNAs) are important biological molecules associated with disease pathogenesis. However, the role of circRNAs in FGR has not been well studied.MethodscircRNA expression profiles in placental tissues with and without FGR were identified by circRNA microarray. circRNA expression was verified by quantitative reverse-transcription PCR (RT-qPCR) assay. The effect of hsa_circ_0000848 and hsa-miR-6768-5p on HTR-8 cell apoptosis, migration, and invasion was evaluated. The association between hsa_circ_0000848 and hsa-miR-6768-5p was confirmed by dual luciferase activity and anti-AGO2 RNA immunoprecipitation (RIP) assays. Protein levels were examined via western blotting.ResultsRT-qPCR results showed that hsa_circ_0000848 expression was significantly down-regulated in FGR placenta. Hsa_circ_0000848 overexpression and hsa-miR-6768-5p inhibitor suppressed apoptosis, and promoted cell migration and invasion. In addition, hsa_circ_0000848 overexpression and hsa-miR-6768-5p inhibitor increased the protein abundance of BCL2, MMP2 and MMP9, and decreased the protein abundance of cleaved caspase-3, cleaved caspase-9, and BAX, whereas hsa_circ_0000848 knockdown caused the opposite effect. Moreover, a significant increase in hsa-miR-6768-5p expression and a negative correlation between hsa_circ_0000848 and hsa-miR-6768-5p were identified in the FGR tissues. Luciferase reporter and RIP assay results revealed binding of hsa-miR-6768-5p to hsa_circ_0000848. Furthermore, hsa-miR-6768-5p overexpression eliminated the effect of hsa_circ_0000848 overexpression in HTR-8 cells.Conclusionshsa_circ_0000848 expression is significantly down-regulated in the FGR placenta. hsa_circ_0000848 promotes trophoblast cell migration and invasion, and inhibits cell apoptosis via the sponging of hsa-miR-6768-5p. Our ...
Keywords	fetal growth restriction ; circ_0000848 ; hsa-miR-6768-5p ; ceRNA ; human extravillous trophoblast cell line ; Biology (General) ; QH301-705.5
Subject code	500
Language	English
Publishing date	2020-05-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A novel SLC6A8 mutation associated with intellectual disabilities in a Chinese family exhibiting creatine transporter deficiency

Qin Wang / Jingxin Yang / Yang Liu / Xingping Li / Fuwei Luo / Jiansheng Xie

BMC Medical Genetics, Vol 19, Iss 1, Pp 1-

case report

2018 Volume 5

Abstract: Abstract Background X-linked creatine transporter deficiency (OMIM#300036,CRTR-D) is characterized by cerebral creatine deficiency, intellectual disabilities, severe speech impairment, seizures and behavioral problems. Mutations in the creatine ... ...

Abstract	Abstract Background X-linked creatine transporter deficiency (OMIM#300036,CRTR-D) is characterized by cerebral creatine deficiency, intellectual disabilities, severe speech impairment, seizures and behavioral problems. Mutations in the creatine transporter gene SLC6A8, a member of the solute-carrier family 6 mapped to Xq28, have been reported to cause the creatine transporter deficiency. Case presentation The proband presented at 5 yrs. 1 month of age with delays in intellectual and development, seizures and behavioral problems. A novel missense mutation, c.1181C > A (p.Thr394Lys), in the SLC6A8 gene (NM_005629.3) was detected via targeted exome sequencing, and then validated by Sanger sequencing. Multiple in silico variant effect analysis methods, including SIFT, PolyPhen2, PROVEAN, and Mutation Taster predicted that this variant was likely damaging or diseasing-causing. This hemizygous variation was also identified in the affected brother with the same clinical condition and inherited from the heterozygous carrier mother. The diagnosis was suggested by increased urinary creatine/creatinine (Cr:Crn) ratio and markedly reduced creatine content peak by brain proton magnetic resonance spectroscopy (MRS). The proband’s mother became pregnant with a 3rd sibling, in whom the Sanger sequencing result of c.1181C > A was negative. Conclusion The novel mutation c.1181C > A in the SLC6A8 gene reported in a Chinese family has expanded the mutation spectrum of CRTR-D. The combination of powerful new technologies such as targeted exome sequencing with thorough systematic clinical evaluation of patients will improve the diagnostic yield, and assist in genetic counselling and prenatal diagnosis for suspected genetic disorders.
Keywords	Creatine transporter deficiency (CRTR-D) ; X-linked ; Intellectual disabilities ; SLC6A8 ; Targeted exome sequencing ; Internal medicine ; RC31-1245 ; Genetics ; QH426-470
Subject code	572
Language	English
Publishing date	2018-11-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Dissimilatory nitrate reduction to ammonium conserves nitrogen in anthropogenically affected subtropical mangrove sediments in Southeast China

Cao, Wenzhi / Baoli Liu / Changtang Chang / Feifei Wang / Jingxin Yang / Ying Li

Marine pollution bulletin. 2016 Sept. 15, v. 110, no. 1

2016

Abstract: In this study, basic sediment properties, nutrient flux, and nitrogen cycle (including denitrification, anaerobic ammonium oxidation [anammox], nitrification, and dissimilatory nitrate reduction to ammonium [DNRA]) were investigated at two sampling sites ...

Abstract	In this study, basic sediment properties, nutrient flux, and nitrogen cycle (including denitrification, anaerobic ammonium oxidation [anammox], nitrification, and dissimilatory nitrate reduction to ammonium [DNRA]) were investigated at two sampling sites with different tree ages in the mangrove region of the Jiulong River Estuary, China. The results show that sediments at mangrove flat area have relatively strong capability to reduce NO3−, in which the DNRA rate is relatively high (204.53±48.32μmolNm−2h−1), which is approximately 75.7–85.9% of the total NO3− reduction, while the denitrification and anammox rates are relatively low – only approximately 5.6–9.5% and 8.5–14.8% of the total NO3− reduction, respectively. Thus, in the nitrogen-enriched subtropical mangrove system, DNRA is the main pathway to reduce NO3−, and most of the input nitrogen is conserved as NH4+ in the system, which assures high productivity of the mangrove system.
Keywords	ammonium compounds ; anaerobic ammonium oxidation ; denitrification ; estuaries ; nitrate reduction ; nitrates ; nitrogen ; nitrogen cycle ; rivers ; sediments ; trees ; water pollution ; China
Language	English
Dates of publication	2016-0915
Size	p. 155-161.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	2001296-2
ISSN	1879-3363 ; 0025-326X
ISSN (online)	1879-3363
ISSN	0025-326X
DOI	10.1016/j.marpolbul.2016.06.068
Database	NAL-Catalogue (AGRICOLA)

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Article: Biomimetic apatite formed on cobalt-chromium alloy: A polymer-free carrier for drug eluting stent

Chen, Cen / Chenxue Yao / Dandan Luo / In-Seop Lee / Jingxin Yang / Sung-Min Chung / Xiangdong Kong

Colloids and surfaces. 2017 Mar. 01, v. 151

2017

Abstract: In this study, sirolimus (SRL) was loaded within biomimetic apatite formed on cobalt-chromium (Co-Cr) alloy, which has been reported for the first time, to inhibit the in-stent restenosis. Two different groups of loading SRL within biomimetic apatite ... ...

Abstract	In this study, sirolimus (SRL) was loaded within biomimetic apatite formed on cobalt-chromium (Co-Cr) alloy, which has been reported for the first time, to inhibit the in-stent restenosis. Two different groups of loading SRL within biomimetic apatite were prepared: Group A (mono-layer of apatite/SRL) and Group B (bi-layer of apatite/SRL). Group A and Group B showed the biphasic pattern of SRL release up to 40 and 90days, respectively. The attachment of human artery smooth muscle cell (HASMC) for both Group A and Group B was significantly inhibited, and proliferation dramatically decreased with the release of SRL. Noteworthily, biomimetic apatite alone also suppressed the SMC proliferation. The porous biomimetic apatite uniformly covered Co-Cr stent without crack or webbings. After balloon expansion, the integrity of biomimetic apatite was sufficient to resist delamination or destruction. Thus, this study demonstrated that biomimetic apatite is a promising drug carrier for potential use in stents.
Keywords	alloys ; apatite ; biomimetics ; colloids ; delamination ; drug carriers ; humans ; smooth muscle
Language	English
Dates of publication	2017-0301
Size	p. 156-164.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1500523-9
ISSN	1873-4367 ; 0927-7765
ISSN (online)	1873-4367
ISSN	0927-7765
DOI	10.1016/j.colsurfb.2016.12.021
Database	NAL-Catalogue (AGRICOLA)

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