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  1. AU="Jinhua Xu"
  2. AU="Lai, Tsz-Wah"
  3. AU="Bhudia, Nisha"
  4. AU="Gee, Bruce"
  5. AU="Baogang Sun"
  6. AU="Suszycki, L"
  7. AU="Edward G. Clark"
  8. AU="Regan, Anthony"
  9. AU="Hammoudi Halat, Dalal"
  10. AU="Lanata, Claudio F"
  11. AU="Bao, Ho The"
  12. AU="Morin, Cory W"
  13. AU="Deniskina, N."
  14. AU="Filipović, Nenad R"
  15. AU="Stülke, Jörg"
  16. AU="Tran Kiem, Cécile"
  17. AU="Trivedi, Pritesh S"
  18. AU="Seemann, Stefan E"
  19. AU="Lotfi Chouchane"
  20. AU="Fay, Bianca"
  21. AU="Dahlke, Marc-H"
  22. AU="Foell, Jens"
  23. AU="Bruno Alessandro Rivieccio"
  24. AU="Cristea, Alexandra I"
  25. AU="Sakr, Hader I"
  26. AU="Shikora, Scott A."
  27. AU="Raza Naqvi"
  28. AU="Chin Fatt, Cherise R"
  29. AU="Leena Sahlström"
  30. AU="Karkare, Siddharth"
  31. AU="Corrêa, Diogo G"
  32. AU="Choi, Sun Ha"

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  1. Artikel ; Online: Analysis of the Influencing Factors of Crystalline Blockages in Mountain Tunnel Drainage Systems Based on Decision Analysis Methods

    Chen Lu / Jinhua Xu / Long Wang / Hongjie Wang / Biao He / Chongming Tian / Wangping Qian

    Applied Sciences, Vol 13, Iss 3721, p

    2023  Band 3721

    Abstract: Crystalline blockages in mountain tunnel drainage systems are becoming a common environmental problem. Considering the lack of research on the influence degree of the factors affecting crystalline blockages in mountain tunnel drainage systems, this paper ...

    Abstract Crystalline blockages in mountain tunnel drainage systems are becoming a common environmental problem. Considering the lack of research on the influence degree of the factors affecting crystalline blockages in mountain tunnel drainage systems, this paper classified and evaluated the importance of relevant factors through decision analysis methods. Our purpose is to provide a comprehensive understanding of the primary factors causing crystalline blockages in tunnels. The influence factors are selected and categorized through a literature review, and then the influence factors are screened twice by the expert scoring method and the gray-whitening weighted function clustering method to eliminate the less important influence factors. Finally, the influence factors are evaluated systematically according to the hierarchical analysis method. The results indicate that the factors affecting the crystalline blockage of the drainage system can be divided into five categories: hydrology, geology, shotcrete materials, drainage facilities, and the cave environment. Among these factors, shotcrete materials are the key factors affecting the problem of crystalline blockages. Specifically, the density of shotcrete and the content of calcium in cement have a significant impact on the crystalline blockages, which have the following comprehensive weights: 0.221 and 0.152, respectively. Since the shotcrete materials are human controllable factors, they can be taken as the key research objects to solve the problem of crystalline blockages.
    Schlagwörter environmental problem ; mountain tunnels ; drainage systems ; crystalline blockage ; decision analysis ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 910
    Sprache Englisch
    Erscheinungsdatum 2023-03-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
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  2. Artikel ; Online: Construction and Validation of a Ferroptosis-Related Prognostic Signature for Melanoma Based on Single-Cell RNA Sequencing

    Yating Liu / Yanhong Shou / Ronghui Zhu / Zhuoqiong Qiu / Qi Zhang / Jinhua Xu

    Frontiers in Cell and Developmental Biology, Vol

    2022  Band 10

    Abstract: Melanoma, the deadliest type of skin cancer, is on the rise globally. The generally poor prognosis makes melanoma still an enormous public health problem. Ferroptosis is a newly emerging form of iron-dependent regulated cell death, which has been ... ...

    Abstract Melanoma, the deadliest type of skin cancer, is on the rise globally. The generally poor prognosis makes melanoma still an enormous public health problem. Ferroptosis is a newly emerging form of iron-dependent regulated cell death, which has been implicated in the development and treatment of several tumors. However, whether there is a connection between ferroptosis-related genes and the prognosis of melanoma patients remains an enigma. In the present study, we identified a ferroptosis-related genes signature to predict the prognosis of melanoma patients by analyzing single-cell RNA-sequencing data from the Gene Expression Omnibus (GEO). Single-cell trajectory analysis was performed to explore malignant differentiation. CellChat was used to investigate intercellular communications in melanoma. Collectively, a novel four-gene signature (CP, MAP1LC3A, transferrin, and TP53) was constructed for prognosis prediction. COX proportional hazards regression analysis showed that the established ferroptosis-associated risk model was an independent prognostic predictor for melanoma patients (HR = 2.3293; 95%CI 1.1528–4.706) (p < 0.018). Patients with low-risk scores had significantly better overall survival (OS) than those with high-risk scores in The Cancer Genome Atlas, GSE59455, and GSE22153 dataset (p = 0.0015, p = 0.031, p = 0.077). Furthermore, the gene expression level of the four genes were verified in multistrain melanoma cell lines and normal human epidermal melanocytes (NHEM). The protein expression level of the four genes in clinical samples were further verified in the Human Protein Atlas (HPA) databases. Taken together, our study identified the prognostic significance of the ferroptosis-related genes in melanoma and developed a novel four-gene prognostic signature, which may shed light on the prognostic assessment and clinical decision making for melanoma patients.
    Schlagwörter ferroptosis ; prognosis ; melanoma ; single cell ; gene signature ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-03-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Zinc complex of 3,5-di-tert-butyl salicylate inhibits viability, migration, and invasion in triple-negative breast cancer cells

    Heng Chen / Dong Wang / Limei Fan / Zixin Liu / Weiran Zhang / Jinhua Xu / Yunyi Liu

    Scientific Reports, Vol 12, Iss 1, Pp 1-

    2022  Band 9

    Abstract: Abstract The zinc complex of 3,5-di-tert-butyl salicylate (Zn{[CH3)3C]2Sal}2 2−) is a zinc ion chelate of salicylate. In this study, we found that this compound inhibits viability, invasion, and migration and induces apoptosis in triple-negative breast ... ...

    Abstract Abstract The zinc complex of 3,5-di-tert-butyl salicylate (Zn{[CH3)3C]2Sal}2 2−) is a zinc ion chelate of salicylate. In this study, we found that this compound inhibits viability, invasion, and migration and induces apoptosis in triple-negative breast cancer 4T1 cells. RNA-seq showed that the expression of 17 genes was upregulated and 26 genes were downregulated significantly by Zn{[CH3)3C]2Sal}2 2− treatment. Further GO and KEGG analysis showed that the activity of Zn{[CH3)3C]2Sal}2 2− against triple-negative breast cancer cells may be involved in the JAK-STAT3, HIF-1, and TNF signaling pathways. The expression of key genes was verified by RT–PCR. The phosphorylation of STAT3 and its upstream SRC decreased drastically upon Zn{[CH3)3C]2Sal}2 2− treatment, as demonstrated by western blot. Our results indicate that Zn{[CH3)3C]2Sal}2 2− inhibits the activity of TNBC cells by downregulating the STAT3 signaling through the SRC pathway.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2022-03-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
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  4. Artikel ; Online: The Resistance Mechanism of Mycoplasma bovis From Yaks in Tibet to Fluoroquinolones and Aminoglycosides

    Jiaqiang Niu / Mingshuai Yan / Jinhua Xu / Yefen Xu / Zhenyu Chang / Suolang Sizhu

    Frontiers in Veterinary Science, Vol

    2022  Band 9

    Abstract: Mycoplasma bovis (M. bovis) is one of the important pathogens for yaks. Aminoglycosides and fluoroquinolones are frequently used medications for the treatment of M. bovis. Drug-resistant strains were inevitable with the abuse of antibiotics. The ... ...

    Abstract Mycoplasma bovis (M. bovis) is one of the important pathogens for yaks. Aminoglycosides and fluoroquinolones are frequently used medications for the treatment of M. bovis. Drug-resistant strains were inevitable with the abuse of antibiotics. The resistance of M. bovis to aminoglycosides was related to the base mutations in drug target genes. Amino acid mutations at the quinolone resistance-determining region (QRDR) in gyrA, gyrB, parC, and parE conferred resistance to fluoroquinolones. In order to investigate the resistance mechanism of M. bovis from yaks in Tibet to aminoglycosides and fluoroquinolones, six frequently used antibiotics and ten clinical M. bovis strains were administered for a drug sensitivity test for in vitro-induced highly resistant strains, a drug stable-resistance test, cross-resistance test, and analysis of target gene mutations. The results showed that the clinical strains of M. bovis from yaks in Tibet had varying degrees of resistance to fluoroquinolones and aminoglycosides. The mechanism of resistance to fluoroquinolones and aminoglycosides was identified preliminarily for M. bovis from yaks: the single-site base mutation mediated the resistance of M. bovis from yaks and both base mutations led to highly resistant strains (aminoglycosides: rrs3 and rrs4; fluoroquinolones: gyrA and parC). The active efflux system results of M. bovis showed that there was no active efflux system based on fluoroquinolones and aminoglycosides expressed in M. bovis from yaks. The research could provide a reference for clinical treatment of M. bovis.
    Schlagwörter fluoroquinolones ; resistance mechanism ; yak ; Mycoplasma bovis ; aminoglycosides ; Veterinary medicine ; SF600-1100
    Thema/Rubrik (Code) 630
    Sprache Englisch
    Erscheinungsdatum 2022-08-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
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  5. Artikel ; Online: Single-cell sequencing reveals increased LAMB3-positive basal keratinocytes and ZNF90-positive fibroblasts in autologous cultured epithelium

    Weiling Lian / Xuanhao Zeng / Jian Li / Qing Zang / Yating Liu / Haozhen Lv / Shujun Chen / Shiyi Huang / Jiayi Shen / Luyan Tang / Yu Xu / Fuyue Wu / Qi Zhang / Jinhua Xu

    Communications Biology, Vol 7, Iss 1, Pp 1-

    2024  Band 13

    Abstract: Abstract Autologous cultured epithelium grafting (ACEG) presents a promising treatment for refractory vitiligo, yet concerns regarding infections and immunological reactions hinder its surgical use due to serum and feeder dependencies. Addressing this, ... ...

    Abstract Abstract Autologous cultured epithelium grafting (ACEG) presents a promising treatment for refractory vitiligo, yet concerns regarding infections and immunological reactions hinder its surgical use due to serum and feeder dependencies. Addressing this, we culture autologous epithelium under serum- and feeder-free (SFF) conditions, comparing its safety and efficacy with serum- and feeder-dependent (SFD) conditions in stable vitiligo patients, and we discover no significant differences in repigmentation between the SFF and SFD grafts. Single-cell RNA transcriptomics on SFF- and SFD-cultured epithelium alongside healthy skin reveal increased populations of LAMB3+ basal keratinocytes and ZNF90+ fibroblasts in the SFF sheets. Functional analyses showcase active cellular metabolism in LAMB3+ basal keratinocytes, vital in extracellular matrix homeostasis, while ZNF90+ fibroblasts demonstrate increased differentiation, essential in collagen formation for cell adhesion. Importantly, these cell populations in SFF sheets exhibit enhanced interactions with melanocytes compared to SFD sheets. Further, knockdown experiments of LAMB3 in keratinocytes and ZNF90 in fibroblasts lead to a downregulation in melanocyte ligand-receptor-related genes. Overall, SFF sheets demonstrate comparable efficacy to SFD sheets, offering superior safety. LAMB3+ basal keratinocytes and ZNF90+ fibroblasts act as potential drivers behind repigmentation in ACEG under SFF conditions. This study provides translational insights into ACEG repigmentation and potential therapeutic targets for vitiligo.
    Schlagwörter Biology (General) ; QH301-705.5
    Sprache Englisch
    Erscheinungsdatum 2024-01-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
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  6. Artikel ; Online: Correlation between circulating interleukin-18 level and systemic lupus erythematosus

    Mengmeng Xiang / Yang Feng / Yilun Wang / Jie Wang / Zhixiong Zhang / Jun Liang / Jinhua Xu

    Scientific Reports, Vol 11, Iss 1, Pp 1-

    a meta-analysis

    2021  Band 9

    Abstract: Abstract This study is a meta-analysis aimed at pooling reported data and clarifying the association between circulating level of interleukin-18 and systemic lupus erythematosus (SLE). We searched medical databases including Medline/Pubmed, Embase, ... ...

    Abstract Abstract This study is a meta-analysis aimed at pooling reported data and clarifying the association between circulating level of interleukin-18 and systemic lupus erythematosus (SLE). We searched medical databases including Medline/Pubmed, Embase, Scopus, The Cochrane Library, and Web of Science thoroughly to obtain all related articles published before July 15th, 2020. We pooled computed standardized mean difference (SMD) and its 95% confidence interval using STATA 13.0 and exhibited in the form of forest graph. Meta-regression and subgroup analysis were also performed to explore the source of heterogeneity. Publication bias was first evaluated by the symmetry of the funnel plot and then Egger’s linear regression test. Thirty eligible studies from eighteen regions were finally included and the relevant data from these studies were pooled. The analysis results displayed that SLE patients showed a significantly higher level of circulating IL-18 level in comparison with healthy controls (SMD = 1.56, 95% CI [1.20–1.93]; I2 = 94.9%, p < 0.01). The conclusion was equally applicable in subgroups divided based on sample type, mean age, disease duration, and testing method. Patients with SLEDAI score higher than five, or who were Asian, White, Arab, or mixed ethnicity had an elevated level of IL-18, while the others didn’t. This meta-analysis has elucidated that compared with healthy people, the circulating level of IL-18 is considerably higher in SLE patients, which indicates the underlying role of IL-18 in SLE pathogenesis.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 310
    Sprache Englisch
    Erscheinungsdatum 2021-02-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
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  7. Artikel ; Online: The Role of Extracellular Vesicles in Systemic Lupus Erythematosus

    Chenghui Zheng / Lin Xie / Haihong Qin / Xiao Liu / Xi Chen / Fan Lv / Li Wang / Xiaohua Zhu / Jinhua Xu

    Frontiers in Cell and Developmental Biology, Vol

    2022  Band 10

    Abstract: Extracellular Vesicles (EVs) are small vesicles that can be actively secreted by most cell types into the extracellular environment. Evidence indicates that EVs can carry microRNAs (miRNAs), long non-coding RNAs (lncRNAs), tRNA-derived small RNAs (tsRNAs) ...

    Abstract Extracellular Vesicles (EVs) are small vesicles that can be actively secreted by most cell types into the extracellular environment. Evidence indicates that EVs can carry microRNAs (miRNAs), long non-coding RNAs (lncRNAs), tRNA-derived small RNAs (tsRNAs), proteins, and lipids to target cells or tissue organizations. Latest studies show that EVs play a vital role in the immune modulation and may contribute to the pathogenesis of autoimmune diseases. Systemic lupus erythematosus (SLE) is a common autoimmune disease characterized by abnormal T cell activation and sustained production of autoantibodies against self-antigens, resulting in inflammation and damage to multiple systems. Pathogenic mechanisms of SLE, however, are still not well understood. In this review, we summarize the latest research advances on the functions and mechanisms of EVs, and its role in the pathogenesis, diagnosis, and treatment of SLE.
    Schlagwörter exosome ; systemic erythematosus lupus ; lupus nephritis ; intercellular communication ; research progress ; extracellular vesicle ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-03-01T00:00:00Z
    Verlag Frontiers Media S.A.
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  8. Artikel: Antifungal properties of a thaumatin-like protein from watermelon

    Zhang, Man / Jinhua Xu / Guang Liu / Xingping Yang

    Acta physiologiae plantarum. 2018 Nov., v. 40, no. 11

    2018  

    Abstract: Fusarium wilt is a causal disease that threatens watermelon production. In this work, we report the identification and antifungal activity of a thaumatin-like protein (ClTLP27) that was identified from a Fusarium oxysporum (F. oxysporum)-responsive ... ...

    Abstract Fusarium wilt is a causal disease that threatens watermelon production. In this work, we report the identification and antifungal activity of a thaumatin-like protein (ClTLP27) that was identified from a Fusarium oxysporum (F. oxysporum)-responsive proteomic analysis during watermelon and F. oxysporum interaction. A two-dimensional gel electrophoresis approach was used to compare changes in the leaf proteome profiles of rootstock-grafted watermelon upon F. oxysporum inoculation, and the abundance of a thaumatin-like protein was found to be differentially accumulated. This thaumatin-like protein gene was further cloned from watermelon and named ClTLP27 (accession no. MF445020). ClTLP27 contains 807 nucleotides and encodes a putative polypeptide of 268 amino acids with a calculated molecular mass of 28.93 kDa and a theoretical pI of 7.65. Sequence alignment showed that ClTLP27 contains the conserved motif with 16 cysteines. Phylogenetic analysis indicated that ClTLP27 belongs to the thaumatin-like protein cluster, and is closely related to the Cucumis TLP gene with a sequence identity of 90%. Real-time PCR analysis revealed that ClTLP27 was expressed in all tissues examined, with the highest levels of expression occurring in the roots. Expression profiles of ClTLP27 following F. oxysporum inoculation revealed that the transcript level of ClTLP27 varied in susceptible and resistant seedlings. ClTLP27 was further cloned into the PET28a(+) vector to obtain a bacterially expressed recombinant His-ClTLP27 protein. Antifungal activity analysis showed that the His-ClTLP27 protein significantly inhibited the mycelial growth of F. oxysporum f.sp. niveum race 1, Fusarium solani f.sp. cucurbitae race 1, F. oxysporum f.sp. melonis, Fusarium verticillioides and Didymella bryoniae. This work implies that ClTLP27 could be used as botanical fungicide or as a potential gene in the engineering of disease-resistant watermelon.
    Schlagwörter Cucumis ; Didymella bryoniae ; Fusarium oxysporum f. sp. melonis ; Fusarium oxysporum f. sp. niveum ; Fusarium solani ; Fusarium verticillioides ; Fusarium wilt ; amino acids ; antifungal properties ; disease resistance ; engineering ; fungicides ; genes ; leaves ; molecular weight ; mycelium ; nucleotides ; phylogeny ; polypeptides ; proteome ; proteomics ; quantitative polymerase chain reaction ; roots ; seedlings ; sequence alignment ; tissues ; two-dimensional gel electrophoresis ; watermelons
    Sprache Englisch
    Erscheinungsverlauf 2018-11
    Umfang p. 186.
    Erscheinungsort Springer Berlin Heidelberg
    Dokumenttyp Artikel
    ZDB-ID 783102-x
    ISSN 1861-1664 ; 0137-5881
    ISSN (online) 1861-1664
    ISSN 0137-5881
    DOI 10.1007/s11738-018-2759-8
    Datenquelle NAL Katalog (AGRICOLA)

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  9. Artikel ; Online: Author Correction

    Jinlong Song / Guijie Hao / Lu Liu / Hongyu Zhang / Dongxue Zhao / Xingyang Li / Zhen Yang / Jinhua Xu / Zhiyong Ruan / Yingchun Mu

    Scientific Reports, Vol 11, Iss 1, Pp 1-

    Biodegradation and metabolic pathway of sulfamethoxazole by Sphingobacterium mizutaii

    2021  Band 1

    Schlagwörter Medicine ; R ; Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2021-12-01T00:00:00Z
    Verlag Nature Portfolio
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  10. Artikel ; Online: Biodegradation and metabolic pathway of sulfamethoxazole by Sphingobacterium mizutaii

    Jinlong Song / Guijie Hao / Lu Liu / Hongyu Zhang / Dongxue Zhao / Xingyang Li / Zhen Yang / Jinhua Xu / Zhiyong Ruan / Yingchun Mu

    Scientific Reports, Vol 11, Iss 1, Pp 1-

    2021  Band 12

    Abstract: Abstract Sulfamethoxazole (SMX) is the most commonly used antibiotic in worldwide for inhibiting aquatic animal diseases. However, the residues of SMX are difficult to eliminate and may enter the food chain, leading to considerable threats on human ... ...

    Abstract Abstract Sulfamethoxazole (SMX) is the most commonly used antibiotic in worldwide for inhibiting aquatic animal diseases. However, the residues of SMX are difficult to eliminate and may enter the food chain, leading to considerable threats on human health. The bacterial strain Sphingobacterium mizutaii LLE5 was isolated from activated sludge. This strain could utilize SMX as its sole carbon source and degrade it efficiently. Under optimal degradation conditions (30.8 °C, pH 7.2, and inoculum amount of 3.5 × 107 cfu/mL), S. mizutaii LLE5 could degrade 93.87% of 50 mg/L SMX within 7 days. Four intermediate products from the degradation of SMX were identified and a possible degradation pathway based on these findings was proposed. Furthermore, S. mizutaii LLE5 could also degrade other sulfonamides. This study is the first report on (1) degradation of SMX and other sulfonamides by S. mizutaii, (2) optimization of biodegradation conditions via response surface methodology, and (3) identification of sulfanilamide, 4-aminothiophenol, 5-amino-3-methylisoxazole, and aniline as metabolites in the degradation pathway of SMX in a microorganism. This strain might be useful for the bioremediation of SMX-contaminated environment.
    Schlagwörter Medicine ; R ; Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2021-11-01T00:00:00Z
    Verlag Nature Portfolio
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