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  1. Article ; Online: Heterologous BBIBP-CorV/ZF2001 vaccination augments neutralization against SARS-CoV-2 variants

    Yingze Zhao / Xin Zhao / Rong Zhang / Beiwei Ye / Xiaoju Yuan / Danni Zhang / Lei Li / Jinmin Tian / Yaxin Guo / George F. Gao / William J. Liu

    The Lancet Regional Health. Western Pacific, Vol 21, Iss , Pp 100440- (2022)

    A preliminary observation

    2022  

    Keywords Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Long-lasting humoral and cellular memory immunity to vaccinia virus Tiantan provides pre-existing immunity against mpox virus in Chinese population

    Min Li / Yaxin Guo / Yao Deng / Wenhui Gao / Baoying Huang / Weiyong Yao / Yingze Zhao / Qing Zhang / Mengkun Huang / Maoshun Liu / Lei Li / Peipei Guo / Jinmin Tian / Xin Wang / Ying Lin / Jinxian Gan / Yuanyuan Guo / Yuechao Hu / Jianing Zhang /
    Xiaonan Yang / Bingli Shang / Mengjie Yang / Yang Han / Yalan Wang / Peilei Cong / Mengzhe Li / Qiaohong Chu / Danni Zhang / Qihui Wang / Tong Zhang / Guizhen Wu / Wenjie Tan / George F. Gao / Jun Liu

    Cell Reports, Vol 43, Iss 1, Pp 113609- (2024)

    2024  

    Abstract: Summary: Investigating immune memory to vaccinia virus and pre-existing immunity to mpox virus (MPXV) among the population is crucial for the global response to this ongoing mpox epidemic. Blood was sampled from vaccinees inoculated with vaccinia virus ... ...

    Abstract Summary: Investigating immune memory to vaccinia virus and pre-existing immunity to mpox virus (MPXV) among the population is crucial for the global response to this ongoing mpox epidemic. Blood was sampled from vaccinees inoculated with vaccinia virus Tiantan (VTT) strain born before 1981 and unvaccinated control subjects born since 1982. After at least 40 years of the inoculation, 60% or 5% VTT vaccinees possess neutralizing antibodies (NAbs) to VTT or MPXV, with at least 50% having T cell memory to VTT protein antigens. Notably, 46.7% vaccinees show pre-existing T cell responses to MPXV. Broad pre-existing CD8+ T cell reactivities to MPXV are detected not only against conserved epitopes but also against variant epitopes between VTT and MPXV. Persistent NAbs and T cell memory to VTT among vaccinees, along with pre-existing T cells to MPXV among both vaccinees and the unvaccinated population, indicate a particular immune barrier to mpox.
    Keywords CP: Microbiology ; CP: Immunology ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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