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  1. Article ; Online: Causes of Thrombocytopenia in Cardiac Surgery: Looking for the Holy Grail?

    Jiritano, Federica / Lorusso, Roberto / Santarpino, Giuseppe

    The Annals of thoracic surgery

    2020  Volume 110, Issue 2, Page(s) 751–752

    MeSH term(s) Anemia ; Cardiac Surgical Procedures ; Cardiopulmonary Bypass ; Humans ; Morbidity ; Thrombocytopenia
    Language English
    Publishing date 2020-02-25
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 211007-6
    ISSN 1552-6259 ; 0003-4975
    ISSN (online) 1552-6259
    ISSN 0003-4975
    DOI 10.1016/j.athoracsur.2020.01.018
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 252: Show issues Location:
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  2. Article: Managing and repairing ventricular free-wall rupture: the triple-patch technique.

    Lorusso, Roberto / Ronco, Daniele / Massimi, Giulio / Di Mauro, Michele / Jiritano, Federica / Matteucci, Matteo

    Annals of cardiothoracic surgery

    2022  Volume 11, Issue 3, Page(s) 346–348

    Language English
    Publishing date 2022-06-13
    Publishing country China
    Document type Editorial
    ZDB-ID 2713627-9
    ISSN 2304-1021 ; 2225-319X
    ISSN (online) 2304-1021
    ISSN 2225-319X
    DOI 10.21037/acs-2021-ami-22
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  3. Article ; Online: Metalloproteinases and Hypertrophic Cardiomyopathy: A Systematic Review.

    Serraino, Giuseppe Filiberto / Jiritano, Federica / Costa, Davide / Ielapi, Nicola / Napolitano, Desirèe / Mastroroberto, Pasquale / Bracale, Umberto Marcello / Andreucci, Michele / Serra, Raffaele

    Biomolecules

    2023  Volume 13, Issue 4

    Abstract: Hypertrophic cardiomyopathy (HCM) is a genetic condition determined by an altered collagen turnover of the extracellular matrix. Matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) are abnormally released in patients with HCM. The purpose of ... ...

    Abstract Hypertrophic cardiomyopathy (HCM) is a genetic condition determined by an altered collagen turnover of the extracellular matrix. Matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) are abnormally released in patients with HCM. The purpose of this systematic review was to thoroughly summarize and discuss the existing knowledge of MMPs profile in patients with HCM. All studies meeting the inclusion criteria (detailed data regarding MMPs in patients with HCM) were selected, after screening the literature from July 1975 to November 2022. Sixteen trials that enrolled a total of 892 participants were included. MMPs-particularly MMP2-levels were found higher in HCM patients compared to healthy subjects. MMPs were used as biomarkers after surgical and percutaneous treatments. Understanding the molecular processes that control the cardiac ECM's collagen turnover allows for a non-invasive evaluation of HCM patients through the monitoring of MMPs and TIMPs.
    MeSH term(s) Humans ; Cardiomyopathy, Hypertrophic ; Heart ; Collagen ; Matrix Metalloproteinases
    Chemical Substances Collagen (9007-34-5) ; Matrix Metalloproteinases (EC 3.4.24.-)
    Language English
    Publishing date 2023-04-11
    Publishing country Switzerland
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom13040665
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  4. Article ; Online: Metalloproteinases in Cardiac Surgery: A Systematic Review.

    Serraino, Giuseppe Filiberto / Jiritano, Federica / Costa, Davide / Ielapi, Nicola / Battaglia, Domenica / Bracale, Umberto Marcello / Mastroroberto, Pasquale / Andreucci, Michele / Serra, Raffaele

    Biomolecules

    2023  Volume 13, Issue 1

    Abstract: The role of matrix metalloproteinases (MMPs) in routine cardiac operations including cardiopulmonary bypass (CPB) is still poorly explored. The purpose of this systematic review was to thoroughly summarize and discuss the existing knowledge of the MMP ... ...

    Abstract The role of matrix metalloproteinases (MMPs) in routine cardiac operations including cardiopulmonary bypass (CPB) is still poorly explored. The purpose of this systematic review was to thoroughly summarize and discuss the existing knowledge of the MMP profile in cardiac surgery. All studies meeting the inclusion criteria (i.e., those reporting detailed data about MMP release during and after CPB) were selected after screening the literature published between July 1975 and August 2022. Fifteen trials that enrolled a total of 431 participants were included. MMP levels were found to be significantly correlated with CPB in all included studies. The gelatinases MMP-2 and MMP-9 were highly released in cardiac surgery with CPB. MMP-9 levels were found to be increased after CPB start and during the duration of CPB. Particularly, it is overexpressed both in the myocardial tissue and circulating in the bloodstream. Also, MMP-2 levels increased after CPB both in plasma and in myocardial tissue. MMP-7, MMP-8, and MMP-13 levels increased after CPB start and remained elevated up to 6 h later. Increased levels of MMPs were associated with adverse post-operative outcomes. Conversely, TIMP-1 decreased with CPB. Mechanical and pharmacological strategies were applied in two studies to analyze their effect on the inflammatory response to cardiac surgery and CPB and on postoperative outcomes. New targeted MMP inhibitor therapies could protect against systemic inflammatory response syndrome after CPB and should be the subject of future large prospective multicenter randomized clinical trials.
    MeSH term(s) Humans ; Matrix Metalloproteinase 9 ; Matrix Metalloproteinase 2 ; Prospective Studies ; Cardiac Surgical Procedures/adverse effects ; Myocardium ; Multicenter Studies as Topic
    Chemical Substances Matrix Metalloproteinase 9 (EC 3.4.24.35) ; Matrix Metalloproteinase 2 (EC 3.4.24.24)
    Language English
    Publishing date 2023-01-05
    Publishing country Switzerland
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom13010113
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  5. Article: Quantitative and Qualitative Platelet Derangements in Cardiac Surgery and Extracorporeal Life Support.

    Squiccimarro, Enrico / Jiritano, Federica / Serraino, Giuseppe Filiberto / Ten Cate, Hugo / Paparella, Domenico / Lorusso, Roberto

    Journal of clinical medicine

    2021  Volume 10, Issue 4

    Abstract: Thrombocytopenia and impaired platelet function are known as intrinsic drawbacks of cardiac surgery and extracorporeal life supports (ECLS). A number of different factors influence platelet count and function including the inflammatory response to a ... ...

    Abstract Thrombocytopenia and impaired platelet function are known as intrinsic drawbacks of cardiac surgery and extracorporeal life supports (ECLS). A number of different factors influence platelet count and function including the inflammatory response to a cardiopulmonary bypass (CPB) or to ECLS, hemodilution, hypothermia, mechanical damage and preoperative treatment with platelet-inhibiting agents. Moreover, although underestimated, heparin-induced thrombocytopenia is still a hiccup in the perioperative management of cardiac surgical and, above all, ECLS patients. Moreover, recent investigations have highlighted how platelet disorders also affect patients undergoing biological prosthesis implantation. Though many hypotheses have been suggested, the mechanism underlying thrombocytopenia and platelet disorders is still to be cleared. This narrative review aims to offer clinicians a summary of their major causes in the cardiac surgery setting.
    Language English
    Publishing date 2021-02-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm10040615
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  6. Article: Transit time flow measurement guiding the surgical treatment for anomalous origin of the right coronary artery: A case report.

    Jiritano, Federica / Leone, Angelo / Greco, Francesco / Leporace, Mario / Bova, Carlo / Aiello, Vincenzo / Serraino, Giuseppe Filiberto / Mastroroberto, Pasquale

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 975014

    Abstract: Anomalous origin of a coronary artery from the opposite sinus of Valsalva (ACAOS) in symptomatic patients is a rare but serious finding whose treatment consists of a surgical correction. The surgical treatment has a level of complexity that could vary ... ...

    Abstract Anomalous origin of a coronary artery from the opposite sinus of Valsalva (ACAOS) in symptomatic patients is a rare but serious finding whose treatment consists of a surgical correction. The surgical treatment has a level of complexity that could vary from unroofing and ostioplasty to coronary artery bypass grafting. We present our management of a 59-year-old woman presenting with chest pain and dyspnea for right ACAOS with an interarterial route. The right coronary artery (RCA) was bypassed with the right internal thoracic artery. An intraoperative transit time flowmetry (TTFM) showed a competitive flow from the native RCA. RCA proximal ligation site was identified intraoperatively, considering the best mean graft flow (MGF) and the absence of ischemic events. The patient was discharged after a week without adverse events. The 1-year follow-up was uneventful. The intraoperative use of TTFM could guide the surgeon's hand making straightforward the surgical treatment for ACAOS.
    Language English
    Publishing date 2022-10-20
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.975014
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  7. Article: Surgical treatment of post-infarction papillary muscle rupture: systematic review and meta-analysis.

    Massimi, Giulio / Matteucci, Matteo / Kowalewski, Mariusz / Ronco, Daniele / Jiritano, Federica / Beghi, Cesare / Severgnini, Paolo / Lorusso, Roberto

    Annals of cardiothoracic surgery

    2022  Volume 11, Issue 3, Page(s) 252–260

    Abstract: Background: Papillary muscle rupture (PMR) is a rare but potentially fatal complication following acute myocardial infarction (AMI). Surgical treatment is considered the standard of care. This systematic review and meta-analysis aims to evaluate the ... ...

    Abstract Background: Papillary muscle rupture (PMR) is a rare but potentially fatal complication following acute myocardial infarction (AMI). Surgical treatment is considered the standard of care. This systematic review and meta-analysis aims to evaluate the early outcomes after surgical correction of post-AMI PMR.
    Methods: Electronic databases were searched from January 1990 to December 2020. Studies reporting patients undergoing mitral valve surgery for post-AMI PMR were analysed. The primary outcome assessed was operative mortality. Differences were expressed as risk ratio (RR) with 95% confidence interval (CI) to assess the relationships between predefined surgical variables and clinical prognosis.
    Results: A total of 1,851 adult patients, from 12 observational studies, were identified. Operative mortality was 21%. Meta-analysis revealed reduced operative risk in patients undergoing mitral valve repair (MVr) as compared to replacement (MVR) (RR, 0.33; 95% CI: 0.14 to 0.79; P=0.01), and an increased risk of operative mortality in patients with complete PMR (RR, 2.54; 95% CI: 1.12 to 5.74; P=0.03). No significant differences in terms of operative mortality were observed between patients with or without pre/peri-operative intra-aortic balloon pump (IABP) support and between subjects who underwent mitral valve surgery with or without concomitant coronary artery bypass grafting (CABG).
    Conclusions: Mitral valve surgery for post-AMI PMR carries a high operative mortality. Patients with complete PMR and subjects undergoing MVR have increased risks of operative mortality. The preoperative use of IABP and concomitant CABG seem not to influence the early postoperative course in this context.
    Language English
    Publishing date 2022-06-13
    Publishing country China
    Document type Journal Article
    ZDB-ID 2713627-9
    ISSN 2304-1021 ; 2225-319X
    ISSN (online) 2304-1021
    ISSN 2225-319X
    DOI 10.21037/acs-2021-ami-15
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  8. Article: Platelet Reduction after Transcatheter Aortic Valve Implantation: Results from the PORTRAIT Study.

    Jiritano, Federica / Di Mauro, Michele / Serraino, Giuseppe Filiberto / Mastroroberto, Pasquale / Caporali, Elena / Ferrari, Enrico / Kowalewski, Mariusz / Scrofani, Roberto / Patanè, Leonardo / Visicchio, Giuseppe / Paparella, Domenico / Falcetta, Giosuè / Colli, Andrea / Matteucci, Matteo / Cappabianca, Giangiuseppe / Pollari, Francesco / Fischlein, Theodor / Lorusso, Roberto

    Journal of clinical medicine

    2024  Volume 13, Issue 6

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-03-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13061579
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  9. Article: Temporary Mechanical Circulatory Support in Acute Heart Failure.

    Jiritano, Federica / Lo Coco, Valeria / Matteucci, Matteo / Fina, Dario / Willers, Anne / Lorusso, Roberto

    Cardiac failure review

    2020  Volume 6, Page(s) e01

    Abstract: Cardiogenic shock (CS) is a challenging syndrome, associated with significant morbidity and mortality. Although pharmacological therapies are successful and can successfully control this acute cardiac illness, some patients remain refractory to drugs. ... ...

    Abstract Cardiogenic shock (CS) is a challenging syndrome, associated with significant morbidity and mortality. Although pharmacological therapies are successful and can successfully control this acute cardiac illness, some patients remain refractory to drugs. Therefore, a more aggressive treatment strategy is needed. Temporary mechanical circulatory support (TCS) can be used to stabilise patients with decompensated heart failure. In the last two decades, the increased use of TCS has led to several kinds of devices becoming available. However, indications for TCS and device selection are part of a complex process. It is necessary to evaluate the severity of CS, any early and prompt haemodynamic resuscitation, prior TCS, specific patient risk factors, technical limitations and adequacy of resources and training, as well as an assessment of whether care would be futile. This article examines options for commonly used TCS devices, including intra-aortic balloon pumps, a pulsatile percutaneous ventricular assist device (the iVAC), veno-arterial extra-corporeal membrane oxygenation and Impella (Abiomed) and TandemHeart (LivaNova) percutaneous ventricular assist device.
    Language English
    Publishing date 2020-03-16
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2960293-2
    ISSN 2057-7559 ; 2057-7540
    ISSN (online) 2057-7559
    ISSN 2057-7540
    DOI 10.15420/cfr.2019.02
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  10. Article ; Online: Bedside Emergency Percutaneous Extracorporeal Membrane Oxygenator with Bicaval Dual-Lumen Cannula.

    Serraino, Giuseppe Filiberto / Jiritano, Federica / Rossi, Michele / Mastroroberto, Pasquale

    The heart surgery forum

    2018  Volume 21, Issue 4, Page(s) E290–E293

    Abstract: Background: Veno-venous extracorporeal membrane oxygenation (VV-ECMO) support has emerged as a valuable rescue therapy in patients with severe acute lung failure. A new bicaval dual-lumen percutaneous cannula can be instituted with a single puncture of ... ...

    Abstract Background: Veno-venous extracorporeal membrane oxygenation (VV-ECMO) support has emerged as a valuable rescue therapy in patients with severe acute lung failure. A new bicaval dual-lumen percutaneous cannula can be instituted with a single puncture of the right internal jugular vein under image guidance (fluoroscopy and/or trans-esophageal echocardiography) to support VV-ECMO. However, malpositioning of the dual-lumen catheter can jeopardize the efficacy of the ECMO therapy.
    Case report: We report an emergency VV-ECMO instituted at a patient's bedside in the intensive care unit. Percutaneous insertion of a dual lumen-cannula was performed on a young patient that had undergone cardiac surgery. The patient had developed a fulminant post-operative pneumonia, leading to respiratory failure and septic shock. The procedure was done at night, without any image guidance other than a post-insertion chest x-ray. We compared the oxygen saturation of arterial blood gas taken from both the outflow and inflow ECMO ends, and the saturations were used as indirect proof of correct cannula placement. The VV-ECMO was successfully removed after nine days, as the patient was clinically and radiologically recovered.
    Conclusion: This case reports a dual-lumen cannula insertion in an emergency setting, with minimal image support. It confirms the efficacy and the safety of VV-ECMO in the treatment of post-operative acute respiratory failure.
    MeSH term(s) Acute Disease ; Adult ; Cannula ; Echocardiography, Transesophageal ; Emergencies ; Equipment Design ; Extracorporeal Membrane Oxygenation/instrumentation ; Humans ; Jugular Veins ; Male ; Oxygenators, Membrane ; Point-of-Care Systems ; Respiratory Insufficiency/diagnosis ; Respiratory Insufficiency/therapy ; Vena Cava, Superior
    Language English
    Publishing date 2018-06-26
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2069188-9
    ISSN 1522-6662 ; 1098-3511
    ISSN (online) 1522-6662
    ISSN 1098-3511
    DOI 10.1532/hsf.1927
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5745: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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