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  1. Article ; Online: Cytosine base editors induce off-target mutations and adverse phenotypic effects in transgenic mice

    Nana Yan / Hu Feng / Yongsen Sun / Ying Xin / Haihang Zhang / Hongjiang Lu / Jitan Zheng / Chenfei He / Zhenrui Zuo / Tanglong Yuan / Nana Li / Long Xie / Wu Wei / Yidi Sun / Erwei Zuo

    Nature Communications, Vol 14, Iss 1, Pp 1-

    2023  Volume 12

    Abstract: The potential off-target effects of long-term expression of base editors in vivo are unclear. Here the authors report SAFETI, Systematic evaluation Approach For gene Editing tools by Transgenic mIce, to examine off-target effects of base editors over ... ...

    Abstract The potential off-target effects of long-term expression of base editors in vivo are unclear. Here the authors report SAFETI, Systematic evaluation Approach For gene Editing tools by Transgenic mIce, to examine off-target effects of base editors over time in mice, and see abnormal side effects.
    Keywords Science ; Q
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Optimization of C-to-G base editors with sequence context preference predictable by machine learning methods

    Tanglong Yuan / Nana Yan / Tianyi Fei / Jitan Zheng / Juan Meng / Nana Li / Jing Liu / Haihang Zhang / Long Xie / Wenqin Ying / Di Li / Lei Shi / Yongsen Sun / Yongyao Li / Yixue Li / Yidi Sun / Erwei Zuo

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Volume 11

    Abstract: C->G transversions can be highly desirable editing outcomes. Here the authors optimise CGBEs and provide a deep learning model for predicting editing outcomes based on sequence context. ...

    Abstract C->G transversions can be highly desirable editing outcomes. Here the authors optimise CGBEs and provide a deep learning model for predicting editing outcomes based on sequence context.
    Keywords Science ; Q
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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