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Article ; Online: Research on the Hydrodynamic Performance of a Pentamaran in Calm Water and Regular Waves

Bowen Zhao / Haoyu Jiang / Jiyuan Sun / Dapeng Zhang

Applied Sciences, Vol 13, Iss 4461, p

2023 Volume 4461

Abstract: As a typical multi-hull ship, the pentamaran has a wider deck, higher damage stability, and low-speed seaworthiness in harsh sea conditions compared with other multi-hull types such as the catamaran and trimaran, having more potential for becoming a new ... ...

Abstract	As a typical multi-hull ship, the pentamaran has a wider deck, higher damage stability, and low-speed seaworthiness in harsh sea conditions compared with other multi-hull types such as the catamaran and trimaran, having more potential for becoming a new type of freight merchant ship in line with the development trend of the marine economy. In this paper, on the basis of the finite volume method, the numerical simulations and detailed comparative analysis of the monohull and pentamaran in viscous flow were carried out. The resistance prediction in calm water and regular waves and the changes of each resistance component of the pentamaran were explored. The dynamic fluid body interaction (DFBI) module was used for the calculations in calm water, and the overset mesh was used for the calculations in regular waves. The results show that in calm water, the adverse effect of the side hulls on the resistance was mainly reflected in the low-speed range. In the high-speed range, the influence of the side hulls on the resistance can be ignored. At high speeds, the main hull and side hulls of the pentamaran will produce favorable wave-making interference, thereby improving the wave-making performance of the pentamaran. In regular waves, although the added resistance of the pentamaran increased most of the time, its amplitude was smaller than that of the monohull under the same wave condition. This work provides a technical basis for the research on the design and hydrodynamic performance of the pentamaran.
Keywords	pentamaran ; monohull ; RANS ; regular waves ; hydrodynamic performance ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	621
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Dynamic Analysis of Underwater Torpedo during Straight-Line Navigation

Bowen Zhao / Jiyuan Sun / Dapeng Zhang / Keqiang Zhu / Haoyu Jiang

Applied Sciences, Vol 13, Iss 4169, p

2023 Volume 4169

Abstract: Torpedoes play an irreplaceable role in naval warfare; therefore, it is significant to study the dynamic response of the direct navigation of torpedoes. In order to study the dynamic response of torpedoes under different Munk moment coefficients, the ... ...

Abstract	Torpedoes play an irreplaceable role in naval warfare; therefore, it is significant to study the dynamic response of the direct navigation of torpedoes. In order to study the dynamic response of torpedoes under different Munk moment coefficients, the dynamic equation of torpedoes is established based on the momentum theorem and the momentum moment theorem. The linear motion mathematical model of torpedoes is obtained. The relationship between the torpedo and the Munk moment coefficient is derived. The straight-line motion model of the torpedo under different Munk moments is established, and the dynamic properties of the space motion of the torpedo are analyzed. It is found that the Munk moment coefficient increase will lead to an increase in the deflection of the torpedo’s direct motion on each degree of freedom, and the Munk moment coefficient is related to the additional mass matrix. During the design of the torpedo, the added mass should be reduced by changing the shape of the torpedo as much as possible so as to reduce the pitch moment, yaw, and roll moments of the torpedo.
Keywords	torpedo ; dynamic response ; Munk moment ; lumped-mass method ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	629
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: CPLD-Based Displacement Measurement System for Nanoscale Grating Ruler

Jiyuan Sun / Chunlin Tian

Journal of Chemistry, Vol

2020 Volume 2020

Abstract: With the continuous development of science and technology, industrial production has higher and higher requirements for precision. Many high-precision measurement technologies emerge as the times require, and nanoscale grating ruler displacement ... ...

Abstract	With the continuous development of science and technology, industrial production has higher and higher requirements for precision. Many high-precision measurement technologies emerge as the times require, and nanoscale grating ruler displacement measurement technology is one of them. As a kind of precision sensor, nanoscale grating ruler has important application in displacement measurement system. CPLD has the advantages of high integration and fast programming speed, which is often used to control the displacement measurement system of nanoscale grating ruler. The purpose of this paper is to deeply explore the measurement effect and related application principle of nanoscale grating ruler displacement measurement system based on CPLD technology. A set of nanoscale grating ruler displacement measurement system is designed based on CPLD technology. The output signal of grating ruler is programmed by CPLD. The x-axis displacement of the experimental platform controlled by stepping motor is measured, and the measured data are recorded by carrying out analysis and research. The results show that compared with the traditional phase difference measurement system, the measurement accuracy of the system based on CPLD is improved by 24.7%, the robustness of the measurement system is improved by 18.6%, and the measurement speed is increased by 27.3%. Therefore, this kind of nanoscale measurement precision grating ruler displacement measurement control system based on CPLD has three characteristics: high measurement accuracy, strong anti-interference ability, and high measurement motion efficiency, which can effectively meet the requirements of grating ruler displacement measurement system for high-precision manufacturing technology.
Keywords	Chemistry ; QD1-999
Subject code	600
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: CARMA3

Jiyuan Sun

World Journal of Biological Chemistry, Vol 1, Iss 12, Pp 353-

A novel scaffold protein in regulation of NF-κB activation and diseases

2010 Volume 361

Abstract: CARD recruited membrane associated protein 3 (CARMA3) is a novel scaffold protein. It belongs to the CARMA protein family, and is known to activate nuclear factor (NF)-κB. However, it is still unknown which receptor functions upstream of CARMA3 to ... ...

Abstract	CARD recruited membrane associated protein 3 (CARMA3) is a novel scaffold protein. It belongs to the CARMA protein family, and is known to activate nuclear factor (NF)-κB. However, it is still unknown which receptor functions upstream of CARMA3 to trigger NF-κB activation. Recently, several studies have demonstrated that CARMA3 serves as an indispensable adaptor protein in NF-κB signaling under some G protein-coupled receptors (GPCRs), such as lysophosphatidic acid (LPA) receptor and angiotensin (Ang) II receptor. Mechanistically, CARMA3 recruits its essential downstream molecules Bcl10 and MALT1 to form the CBM (CARMA3-Bcl10-MALT1) signalosome whereby it triggers NF-κB activation. GPCRs and NF-κB play pivotal roles in the regulation of various cellular functions, therefore, aberrant regulation of the GPCR/NF-κB signaling axis leads to the development of many types of diseases, such as cancer and atherogenesis. Recently, the GPCR/CARMA3/NF-κB signaling axis has been confirmed in these specific diseases and it plays crucial roles in the pathogenesis of disease progression. In ovarian cancer cell lines, knockdown of CARMA3 abolishes LPA receptor-induced NF-κB activation, and reduces LPA-induced ovarian cancer invasion. In vascular smooth cells, downregulation of CARMA3 substantially impairs Ang-II-receptor-induced NF-κB activation, and in vivo studies have confirmed that Bcl10-deficient mice are protected from developing Ang-II-receptor-induced atherosclerosis and aortic aneurysms. In this review, we summarize the biology of CARMA3, describe the role of the GPCR/CARMA3/NF-κB signaling axis in ovarian cancer and atherogenesis, and speculate about the potential roles of this signaling axis in other types of cancer and diseases. With a significant increase in the identification of LPA- and Ang-II-like ligands, such as endothelin-1, which also activates NF-κB via CARMA3 and contributes to the development of many diseases, CARMA3 is emerging as a novel therapeutic target for various types of cancer and other diseases.
Keywords	G protein-coupled receptor ; β-arrestin ; CARD recruited membrane associated protein 3 ; Nuclear factor-κB ; Cancer ; Atherogenesis ; Biochemistry ; QD415-436 ; Organic chemistry ; QD241-441 ; Chemistry ; QD1-999 ; Science ; Q ; DOAJ:Biochemistry ; DOAJ:Life Sciences ; DOAJ:Biology and Life Sciences
Subject code	616
Language	English
Publishing date	2010-12-01T00:00:00Z
Publisher	Baishideng Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Mathematical model for the tensile strength of the crimping assembly of aviation wiring harness end

Pin Li / Gongping Liu / Junhua Fan / Jiyuan Sun / Hang Xiu / Chunlin Tian

Scientific Reports, Vol 11, Iss 1, Pp 1-

2021 Volume 11

Abstract: Abstract In this study, the relationship between the tensile strength and the indentation depth was studied by analysing the deformation mechanism of the crimping assembly of the aviation wiring harness end. Tensile strength tests were performed on ... ...

Abstract	Abstract In this study, the relationship between the tensile strength and the indentation depth was studied by analysing the deformation mechanism of the crimping assembly of the aviation wiring harness end. Tensile strength tests were performed on samples of crimping assemblies with different indentation depths. The results showed that the experimental and theoretical values were in good agreement, verifying the validity of the established mathematical model for tensile strength. Based on this model, a reasonable design range for the indentation depth corresponding to the specific combination of contacts and strands was determined.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Occurrence of Propyl Lactate in Chinese Baijius (Chinese Liquors) Detected by Direct Injection Coupled with Gas Chromatography-Mass Spectrometry

Jihong Wu / Yang Zheng / Baoguo Sun / Xiaotao Sun / Jiyuan Sun / Fuping Zheng / Mingquan Huang

Molecules, Vol 20, Iss 10, Pp 19002-

2015 Volume 19013

Abstract: As one of the oldest distillates in the world, flavor compounds of Chinese Baijiu (Chinese liquor) were extremely complex. Propyl lactate was ﬁrstly detected by direct injection and gas chromatography-mass spectrometry (GC-MS) in 72 Chinese Baijius. The ... ...

Abstract	As one of the oldest distillates in the world, flavor compounds of Chinese Baijiu (Chinese liquor) were extremely complex. Propyl lactate was ﬁrstly detected by direct injection and gas chromatography-mass spectrometry (GC-MS) in 72 Chinese Baijius. The objectives were to detect the contents of propyl lactate and evaluate its contribution to the aroma of Chinese Baijiu based on odor activity values (OAVs). The levels of propyl lactate in these distillates were determined by internal standard method and selective ion monitoring (SIM), which ranged from 0.050 to 1.900 mg∙L−1 under investigation. Its detection threshold was determined by Three-Alternative Forced-Choice (3-AFC) and curve fitting (CF), which was 0.740 mg∙L−1 in 38% ethanol solution. The contribution of propyl lactate on the aroma of these distillate drinks was evaluated by their odor activity values (OAVs), which varied from 0.066 to 4.440. The OAVs of propyl lactate were found to exceed 1 in 13 Chinese Baijius, including 50° Jingzhi Guniang 5 years (4.440), 52° Jingzhi Guniang 10 years (3.024), Jingyanggang (2.568), Xianghe Ronghe Shaofang (2.313), and 1956 Laolang (1.431), which indicated that propyl lactate was one of odor-active components in these Chinese Baijius.
Keywords	Chinese Baijiu ; propyl lactate ; gas chromatography-mass spectrometry (GC-MS) ; threshold ; odor activity values (OAVs) ; Organic chemistry ; QD241-441
Language	English
Publishing date	2015-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Cardiac stem cell transplantation with 2,3,5,4′-tetrahydroxystilbehe-2-O-β-d-glucoside improves cardiac function in rat myocardial infarction model

Song, Fan / Fei Hua / Hua Li / Jiyuan Sun / Li Yan / Qian Yang / Siwang Wang / Weixun Duan / Xuanxuan Zhou / Yanhua Xie

Life sciences. 2016 Aug. 01, v. 158

2016

Abstract: Cardiac stem cells (CSCs)-transplanted therapy provides a promising therapy for the ischemic heart disease (IHD), especially in the epidemic of myocardial infarction (MI). The compound 2,3,5,4′-tetrahydroxystilbene-2-O-β-d-glucoside (THSG) can induce CSC ...

Abstract	Cardiac stem cells (CSCs)-transplanted therapy provides a promising therapy for the ischemic heart disease (IHD), especially in the epidemic of myocardial infarction (MI). The compound 2,3,5,4′-tetrahydroxystilbene-2-O-β-d-glucoside (THSG) can induce CSC proliferation in vitro based on our previous study, so we aimed to study the induce effect of THSG on CSCs-transplanted MI rat in vivo.Using a murine model of MI, this study was designed to evaluate the impact of THSG (30, 60, 120mg/kg) on CSCs-based therapy for MI and the underlying mechanism in this process.The results showed that THSG on CSCs-transplanted therapy groups (THSG+CSCs groups) can significantly reduce S-T segment elevation, and increase heart rate compared with MI group. The left ventricular ejection fraction (LVEF) and the left ventricular fractional shortening (LVFS) were significantly reduced in THSG+CSCs groups compared to the MI group. The levels of enzyme expression (CK-MB, LDH), the heart weight index (HWI) and myocardial infarct size (IS) were all reduced in THSG+CSCs groups. Moreover, other changes noted during these 28days post-MI, included pathologic changes, as well as increased stem cell antigen-1 (Sca-1) expression, or expression of Nkx2.5, GATA-4, and Connexin 43 in myocardial tissue, and reduced the Caspase-3 expression.Our findings indicated that THSG facilitated CSCs-transplanted therapy in MI. These observations may be associated with the inducted of THSG on the proliferation of CSCs in vivo and also, with the subsequent differentiation of additional intrinsic neonatal cardiomyocytes to replace damaged heart tissue.
Keywords	animal models ; cardiac output ; cardiomyocytes ; caspase-3 ; cell transplantation ; connexins ; GATA transcription factors ; heart rate ; myocardial infarction ; rats ; stem cells
Language	English
Dates of publication	2016-0801
Size	p. 37-45.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2016.06.011
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Proliferation-Attenuating and Apoptosis-Inducing Effects of Tryptanthrin on Human Chronic Myeloid Leukemia K562 Cell Line in Vitro

Xiaopeng Shi / Caiqin Zhang / Yong Zhao / Wei Hua / Qing Miao / Hai Zhang / Siwang Wang / Jiyuan Sun / Shan Miao

International Journal of Molecular Sciences, Vol 12, Iss 6, Pp 3831-

2011 Volume 3845

Abstract: Tryptanthrin, a kind of indole quinazoline alkaloid, has been shown to exhibit anti-microbial, anti-inflammation and anti-tumor effects both in vivo and in vitro. However, its biological activity on human chronic myeloid leukemia cell line K562 is not ... ...

Abstract	Tryptanthrin, a kind of indole quinazoline alkaloid, has been shown to exhibit anti-microbial, anti-inflammation and anti-tumor effects both in vivo and in vitro. However, its biological activity on human chronic myeloid leukemia cell line K562 is not fully understood. In the present study, we investigated the proliferation-attenuating and apoptosis-inducing effects of tryptanthrin on leukemia K562 cells in vitro and explored the underlying mechanisms. The results showed that tryptanthrin could significantly inhibit K562 cells proliferation in a time- and dose-dependent manner as evidenced by MTT assay and flow cytometry analysis. We also observed pyknosis, chromatin margination and the formation of apoptotic bodies in the presence of tryptanthrin under the electron microscope. Nuclei fragmentation and condensation by Hoechst 33258 staining were detected as well. The amount of apoptotic cells significantly increased whereas the mitochondrial membrane potential decreased dramatically after tryptanthrin exposure. K562 cells in the tryptanthrin treated group exhibited an increase in cytosol cyt-c, Bax and activated caspase-3 expression while a decrease in Bcl-2, mito cyt-c and pro-caspase-3 contents. However, the changes of pro-caspase-3 and activated caspase-3 could be abolished by a pan-caspase inhibitor ZVAD-FMK. These results suggest that tryptanthrin has proliferation-attenuating and apoptosis-inducing effects on K562 cells. The underlying mechanism is probably attributed to the reduction in mitochondria membrane potential, the release of mito cyt-c and pro-caspase-3 activation.
Keywords	tryptanthrin ; chronic myeloid leukemia ; proliferation ; apoptosis ; K562 cells ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	610 ; 570
Language	English
Publishing date	2011-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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