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  1. Article: Clinical feasibility of modified extended left hemihepatectomy in advanced perihilar cholangiocarcinoma.

    Jo, Hye-Sung / Kim, Dong-Sik

    Hepatobiliary surgery and nutrition

    2024  Volume 13, Issue 1, Page(s) 165–167

    Language English
    Publishing date 2024-01-12
    Publishing country China (Republic : 1949- )
    Document type Editorial
    ZDB-ID 2812398-0
    ISSN 2304-389X ; 2304-3881
    ISSN (online) 2304-389X
    ISSN 2304-3881
    DOI 10.21037/hbsn-23-610
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Left liver graft in adult-to-adult living donor liver transplantation with an optimal portal flow modulation strategy to overcome the small-for-size syndrome - A retrospective cohort study.

    Jo, Hye-Sung / Yu, Young-Dong / Choi, Yoo Jin / Kim, Dong-Sik

    International journal of surgery (London, England)

    2022  Volume 106, Page(s) 106953

    Abstract: Background: Adult-to-adult living donor liver transplantation (LDLT) is a notable type of liver transplantation. Several centers prefer the right liver graft (RLG) over the left liver graft (LLG) for better recovery of recipients. We compared the ... ...

    Abstract Background: Adult-to-adult living donor liver transplantation (LDLT) is a notable type of liver transplantation. Several centers prefer the right liver graft (RLG) over the left liver graft (LLG) for better recovery of recipients. We compared the outcomes of donors and recipients between LDLT using LLGs and RLGs.
    Materials and methods: The study cohort comprised of 25 patients in the LLG group and 93 in the RLG group. When both hemiliver grafts met the selection criteria, an LLG was preferred. When portal flow (≥300 ml/min/100gLW) and hepatic venous pressure gradient (≥10 mmHg) were increased, intraoperative splenic artery ligation was performed for portal modulation. Postoperatively, somatostatin was administered when small-for-size syndrome (SFSS) was highly suspected.
    Results: The graft-to-recipient weight ratio was lower in the LLG group than in the RLG group. There was no significant complication above Clavien-Dindo grade IIIA in donors. Regarding recipient outcomes, SFSS occurred in four (16.0%) patients in the LLG group and three (3.2%) in the RLG group (P = 0.036). Splenic artery ligation was frequently performed in the LLG group than the RLG group (5 [20.0%] vs. 12 [12.9%], P = 0.035) and 5 patients received intravenous continuous somatostatin for 7 (5-12) days. SFSS-related hospital mortality did not occur. There was no significant difference in the short-term and long-term outcomes between the groups.
    Conclusion: This study demonstrates the comparable outcomes of donors and recipients between the LLG and RLG groups although with a higher risk of SFSS that needs high experience to avoid severe complications and graft loss. We expect LLG to be used more actively in adult-to-adult LDLT with portal flow modulation strategies to overcome fatal SFSS.
    MeSH term(s) Humans ; Adult ; Living Donors ; Liver Transplantation/adverse effects ; Retrospective Studies ; Organ Size ; Liver/surgery ; Somatostatin
    Chemical Substances Somatostatin (51110-01-1)
    Language English
    Publishing date 2022-10-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1016/j.ijsu.2022.106953
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  3. Article ; Online: Single-port robot plus one port (SP + 1) distal pancreatectomy using the new da Vinci SP system.

    Choi, Yoo Jin / Jo, Hye-Sung / Kim, Dong-Sik / Yu, Young-Dong

    Langenbeck's archives of surgery

    2022  Volume 407, Issue 3, Page(s) 1271–1276

    Abstract: Purpose: Single-incision laparoscopic distal pancreatectomy has not been widely applied due to technical challenges and increased operative risks. The newly released da Vinci SP system has been introduced to overcome these limitations and offer ... ...

    Abstract Purpose: Single-incision laparoscopic distal pancreatectomy has not been widely applied due to technical challenges and increased operative risks. The newly released da Vinci SP system has been introduced to overcome these limitations and offer improvements for established robotic single-site procedures. We report our experience of robotic single port plus one port distal pancreatectomy using the da Vinci SP system.
    Methods: We performed robotic distal pancreatectomy in three patients using the da Vinci SP surgical system with one additional port used for applying the energy device and stapling. Technical and clinical feasibility were examined.
    Results: The mean age and body mass index were 70.7 years and 27.8 kg/m
    Conclusion: Robotic distal pancreatectomy using the da Vinci SP system is safe and feasible, with acceptable perioperative outcomes.
    MeSH term(s) Humans ; Laparoscopy/methods ; Operative Time ; Pancreatectomy/methods ; Robotic Surgical Procedures/methods ; Robotics
    Language English
    Publishing date 2022-03-14
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1423681-3
    ISSN 1435-2451 ; 1435-2443
    ISSN (online) 1435-2451
    ISSN 1435-2443
    DOI 10.1007/s00423-022-02477-w
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  4. Article ; Online: A single-center experience of over 300 cases of single-incision robotic cholecystectomy comparing the da Vinci SP with the Si/Xi systems.

    Choi, Yoo Jin / Sang, Nguyen Thanh / Jo, Hye-Sung / Kim, Dong-Sik / Yu, Young-Dong

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 9482

    Abstract: Minimally invasive surgery is usually more beneficial than open surgeries in various fields of surgery. With the newly developed Single-Port (SP) robotic surgical system, even single-site surgery has become easier to access. We compared single-incision ... ...

    Abstract Minimally invasive surgery is usually more beneficial than open surgeries in various fields of surgery. With the newly developed Single-Port (SP) robotic surgical system, even single-site surgery has become easier to access. We compared single-incision robotic cholecystectomy between the Si/Xi and SP systems. This retrospective single-center study enrolled patients who underwent single-incision robotic cholecystectomy between July 2014 and July 2021. The clinical outcomes of the da Vinci Si/Xi and SP systems were compared. In total, 334 patients underwent single-incision robotic cholecystectomy (118 Si/Xi vs. 216 SP). The SP group had more chronic or acute cholecystitis than the Si/Xi group did. There was more bile spillage in the Si/Xi group during the surgery. The total operative and docking times were significantly shorter in the SP group. There was no difference in the postoperative outcomes. The SP system is safe and feasible regarding comparable postoperative complication rates and is more convenient regarding docking and techniques.
    MeSH term(s) Humans ; Robotic Surgical Procedures/adverse effects ; Robotic Surgical Procedures/methods ; Retrospective Studies ; Robotics ; Cholecystectomy/adverse effects ; Surgical Wound ; Treatment Outcome
    Language English
    Publishing date 2023-06-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-36055-x
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  5. Article ; Online: Clinical outcome of surgical resection for multifocal T2-T3 hepatocellular carcinoma up to 3 nodules: a comparative analysis with a single nodule.

    Yu, Sehyeon / Jo, Hye-Sung / Yu, Young-Dong / Choi, Yoo Jin / Kim, Dong-Sik

    Journal of liver cancer

    2023  Volume 23, Issue 2, Page(s) 377–388

    Abstract: Background/aims: Although the Barcelona Clinic Liver Cancer staging system seems to underestimate the impact of curative-intent surgical resection for multifocal hepatocellular carcinoma (HCC), recent studies have indicated favorable results for the ... ...

    Abstract Background/aims: Although the Barcelona Clinic Liver Cancer staging system seems to underestimate the impact of curative-intent surgical resection for multifocal hepatocellular carcinoma (HCC), recent studies have indicated favorable results for the surgical resection of multiple HCC. This study aimed to assess clinical outcomes and feasibility of surgical resection for multifocal HCC with up to three nodules compared with single tumor cases.
    Methods: Patients who underwent surgical resection for HCC with up to three nodules between 2009 and 2020 were included, and those with the American Joint Committee on Cancer (AJCC) 8th edition, T1 and T4 stages were excluded to reduce differences in disease distribution and severity. Finally, 81 and 52 patients were included in the single and multiple treatment groups, respectively. Short- and long-term outcomes including recurrence-free survival (RFS) and overall survival (OS), were evaluated.
    Results: All patients were classified as Child-Pugh class A. RFS and OS were not significantly different between the two groups (P=0.176 and P=0.966, respectively). Multivariate analysis revealed that transfusion and intrahepatic metastasis were significantly associated with recurrence (P=0.046 and P=0.005, respectively). Additionally, intrahepatic metastasis was significantly associated with OS (hazard ratio, 1.989; 95% confidence interval, 1.040-3.802; P=0.038).
    Conclusions: Since there was no significant difference in survival between the single and multiple groups among patients with AJCC 8th stage T2 and T3, surgical resection with curative intent could be considered with acceptable long-term survival for selected patients with multiple HCC of up to three nodules.
    Language English
    Publishing date 2023-09-15
    Publishing country Korea (South)
    Document type Journal Article
    ISSN 2383-5001
    ISSN (online) 2383-5001
    DOI 10.17998/jlc.2023.08.24
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  6. Article ; Online: Right posterior bile duct stricture after central bisectionectomy or anterior sectionectomy.

    Yoon, Kyung Chul / Yu, Young-Dong / Kang, Woo-Hyoung / Jo, Hye-Sung / Kim, Dong-Sik

    Langenbeck's archives of surgery

    2022  Volume 407, Issue 7, Page(s) 2873–2880

    Abstract: Purpose: Before performing anterior sectionectomy (AS) or central bisectionectomy (CBS), the anatomy of the right posterior bile duct (RPBD) must be cautiously assessed owing to the many variations of the RPBD and its variations could be related to bile ...

    Abstract Purpose: Before performing anterior sectionectomy (AS) or central bisectionectomy (CBS), the anatomy of the right posterior bile duct (RPBD) must be cautiously assessed owing to the many variations of the RPBD and its variations could be related to bile duct injury.
    Methods: Clinical data of patients who underwent AS or CBS from 2009 to 2018 were reviewed. The bile duct anatomy according to Okubo's criteria and the right bile duct (RBD) length were evaluated using MRI, and we performed a risk factor analysis of the RPBD stricture (RPBDS).
    Results: A total of 68 patients were included. Type A bile ducts were the most common (n = 36, 52.9%). Five (7.2%) patients had RPBDS requiring intervention. RPBDS only occurred in patients with a type A bile duct and a type A portal vein undergoing surgery using the Glissonian sheath approach. Moreover, when the RBD length was > 12 mm, the sensitivity and specificity were 0.8 and 0.889, respectively. In multivariate analysis, RBD length of > 12 mm was significant.
    Conclusion: A careful review of RPBD anatomy especially in patient with long RBD and caution when using the anterior Glissonian sheath approach might be helpful to prevent RPBDS during AS or CBS.
    MeSH term(s) Humans ; Hepatectomy ; Constriction, Pathologic/etiology ; Constriction, Pathologic/surgery ; Portal Vein ; Bile Ducts/diagnostic imaging ; Bile Ducts/surgery ; Risk Factors
    Language English
    Publishing date 2022-06-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1423681-3
    ISSN 1435-2451 ; 1435-2443
    ISSN (online) 1435-2451
    ISSN 1435-2443
    DOI 10.1007/s00423-022-02586-6
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  7. Article ; Online: Surgical outcome and risk scoring to predict survival after hepatic resection for hepatocellular carcinoma with portal vein tumor thrombosis.

    Kim, Tae-Seok / Yang, Kwangho / Choi, Gi Hong / Yang, Hye Yeon / Kim, Dong-Sik / Jo, Hye-Sung / Choi, Gyu-Seong / Kim, Kwan Woo / Yoon, Young Chul / Han, Jaryung / Kim, Doo Jin / Hwang, Shin / Kang, Koo Jeong

    Annals of hepato-biliary-pancreatic surgery

    2024  

    Abstract: Backgrounds/aims: The hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT) is classified as the advanced stage (BCLC stage C) with extremely poor prognosis, and in current guidelines is recommended for systemic therapy. This study ... ...

    Abstract Backgrounds/aims: The hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT) is classified as the advanced stage (BCLC stage C) with extremely poor prognosis, and in current guidelines is recommended for systemic therapy. This study aimed to evaluate the surgical outcomes and long-term prognosis after hepatic resection (HR) for patients who have HCC combined with PVTT.
    Methods: We retrospectively analyzed 332 patients who underwent HR for HCC with PVTT at ten tertiary referral hospitals in South Korea.
    Results: The median overall and recurrence-free survival after HR were 32.4 and 8.6 months, while the 1-, 3-, and 5-year overall survival rates were 75%, 48%, and 39%, respectively. In multivariate analysis, tumor number, tumor size, AFP, PIVKA-II, neutrophil-to-lymphocyte ratio, and albumin-bilirubin (ALBI) grade were significant prognostic factors. The risk scoring was developed using these seven factors-tumor, inflammation and hepatic function (TIF), to predict patient prognosis. The prognosis of the patients was well stratified according to the scores (log-rank test,
    Conclusions: HR for patients who have HCC combined with PVTT provided favorable survival outcomes. The risk scoring was useful in predicting prognosis, and determining the appropriate treatment strategy for those patients who have HCC with PVTT.
    Language English
    Publishing date 2024-05-09
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 3012179-6
    ISSN 2508-5859 ; 2508-5778
    ISSN (online) 2508-5859
    ISSN 2508-5778
    DOI 10.14701/ahbps.24-048
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  8. Article ; Online: Efficacy and Safety of Hepatitis B Virus Vaccination Following Hepatitis B Immunoglobulin Withdrawal After Liver Transplantation.

    Jo, Hye-Sung / Khan, Johann Faizal / Han, Jae Hyun / Yu, Young-Dong / Kim, Dong-Sik

    Transplantation proceedings

    2021  Volume 53, Issue 10, Page(s) 3016–3021

    Abstract: Background: Hepatitis B immunoglobulin (HBIG) and oral nucleoside/nucleotide analogs have been the mainstay of hepatitis B virus (HBV) prophylaxis after liver transplantation. However, long-term HBIG administration could have disadvantages, such as an ... ...

    Abstract Background: Hepatitis B immunoglobulin (HBIG) and oral nucleoside/nucleotide analogs have been the mainstay of hepatitis B virus (HBV) prophylaxis after liver transplantation. However, long-term HBIG administration could have disadvantages, such as an increase in medical costs and the development of mutant HBV strains. This study aimed to investigate the safety and efficacy of HBV vaccination after the withdrawal of HBIG after liver transplantation.
    Methods: This prospective open-label single-arm observational clinical trial enrolled 41 patients who underwent liver transplantation between 2010 and 2016 because of a condition related to chronic HBV infection. At the time of enrollment, all patients had taken entecavir and discontinued HBIG administration. When hepatitis B surface antibody titer was undetectable after the withdrawal of HBIG, a recombinant HBV vaccine was injected intramuscularly at month 0, 1, and 6.
    Results: After excluding 5 patients who dropped out and 2 patients who had a persistent hepatitis B surface antibody titer, 9 (26.5%) of 34 patients had a positive vaccination response. The median hepatitis B surface antibody titer at seroconversion was 86 (12-1000) IU/L, and those at the end of follow-up were 216 (30-1000) IU/L. No patients experienced HBV recurrence during the study period. Sex (female, odds ratio 32.91 [1.83-592.54], P = .018) and the dosing interval of HBIG before withdrawal (≥90 days, 16.21 [1.21-217.31], P = .035) were independent contributing factors for positive response to the vaccination.
    Conclusion: HBV vaccination still deserves consideration as active immunoprophylaxis after liver transplantation because it could provide added immunity to nucleoside/nucleotide analogs monotherapy with excellent cost-effectiveness.
    MeSH term(s) Antiviral Agents/therapeutic use ; Female ; Hepatitis B/drug therapy ; Hepatitis B/prevention & control ; Hepatitis B virus/genetics ; Humans ; Immunoglobulins ; Liver Transplantation/adverse effects ; Prospective Studies ; Recurrence ; Treatment Outcome ; Vaccination
    Chemical Substances Antiviral Agents ; Immunoglobulins ; hepatitis B hyperimmune globulin (XII270YC6M)
    Language English
    Publishing date 2021-11-02
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 82046-5
    ISSN 1873-2623 ; 0041-1345
    ISSN (online) 1873-2623
    ISSN 0041-1345
    DOI 10.1016/j.transproceed.2021.09.038
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  9. Article: Should we be reluctant to perform pancreatectomy in patients with chronic liver disease? A single center 10-year experience.

    Kang, Woo-Hyoung / Yu, Young-Dong / Yoon, Kyung-Chul / Jo, Hye-Sung / Kim, Dong-Sik

    Acta chirurgica Belgica

    2021  Volume 123, Issue 2, Page(s) 156–162

    Abstract: Purpose: Many studies have shown extra-hepatic surgery in patients with chronic liver disease (CLD) with or without portal hypertension can result in complications. The aim of this study was to analyze the results of major pancreatectomy in patients ... ...

    Abstract Purpose: Many studies have shown extra-hepatic surgery in patients with chronic liver disease (CLD) with or without portal hypertension can result in complications. The aim of this study was to analyze the results of major pancreatectomy in patients with CLD including cirrhosis and to evaluate their efficacy and safety.
    Methods: We retrospectively reviewed 319 patients undergoing open pancreatoduodenectomy (PD) or distal pancreatectomy (DP) in our center. Those who received PD and DP in patients without CLD were classified into groups A and D, and those with CLD into groups B and C, respectively. Group B and C were subdivided into groups 1 and 2 according to the presence of portal hypertension.
    Results: Forty-three patients (13.5%) had CLD. Of the 221 patients who received PD, 25 had CLD. Of the 98 patients who received DP, 18 (Group C) had CLD. In the PD group, patients with portal hypertension (group B1) had longer operative time. However, the transfusion rate and complication rate were not significantly different from other groups. There was no mortality in patients with CLD without portal hypertension (group B2) and the complication and mortality rate was comparable to patients with normal liver function (group A). In the DP group, the transfusion rate, complication rate and mortality rate were significantly higher in patients with portal hypertension (group C1).
    Conclusions: Acceptable outcomes were obtainable following pancreatic surgery in cirrhotic, non-portal hypertensive patients with surgical outcomes equivalent to non-cirrhotic patients.
    AbbreviationsCLDchronic liver diseasePDpancreaticoduodenectomyDPdistal pancreatectomy.
    MeSH term(s) Humans ; Pancreatectomy/methods ; Retrospective Studies ; Pancreaticoduodenectomy/adverse effects ; Hypertension, Portal/complications ; Hypertension, Portal/surgery ; Pancreatic Neoplasms/surgery ; Postoperative Complications/etiology
    Language English
    Publishing date 2021-08-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 210274-2
    ISSN 0001-5458
    ISSN 0001-5458
    DOI 10.1080/00015458.2021.1963911
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  10. Article ; Online: Prevalence and clinical significance of pancreatic cystic lesions in immunosuppressed patients following solid organ transplantation.

    Yu, Sehyeon / Choi, Yoo Jin / Jo, Hye-Sung / Park, Pyoung-Jae / Kim, Dong-Sik / Yu, Young-Dong

    Korean journal of transplantation

    2022  Volume 36, Issue 3, Page(s) 197–202

    Abstract: Background: Pancreatic cystic lesions (PCLs) are occasionally found in solid organ transplant (SOT) recipients. In such recipients, the risk of cancer is increased due to immunosuppressive therapy. This study investigated the prevalence of PCLs and ... ...

    Abstract Background: Pancreatic cystic lesions (PCLs) are occasionally found in solid organ transplant (SOT) recipients. In such recipients, the risk of cancer is increased due to immunosuppressive therapy. This study investigated the prevalence of PCLs and described their clinical course in immunosuppressed patients following SOT.
    Methods: The presence of PCLs in a retrospective cohort of 805 consecutive SOT recipients from 2009 to 2019 was examined. The characteristics of PCLs were compared using initial and follow-up imaging, where available. These results were compared to an age- and sex-matched immunocompetent control group monitored for at least 12 months.
    Results: PCLs were present in 15 of 805 SOT patients (seven liver and eight kidney transplantations). The median diameter of the largest lesion was 20 mm (range, 0.2-60 mm) and 60% of lesions were benign. During follow-up imaging, the cyst size remained stable in 46.7%, increased in 13.3%, and decreased in 40.0% of the SOT group. Significantly more of the SOT patients showed PCL size reductions (P=0.007). Among SOT patients diagnosed with intraductal papillary mucinous neoplasms (6/15), worrisome features were noted in one patient at the time of cyst diagnosis. Differences in the development of worrisome features between the study and control groups were not statistically significant.
    Conclusions: The malignant transformation of PCLs in SOT recipients is rare and most such PCLs can be managed conservatively. The presence of a PCL should therefore not affect transplant eligibility.
    Language English
    Publishing date 2022-07-20
    Publishing country Korea (South)
    Document type Journal Article
    ISSN 2671-8804
    ISSN (online) 2671-8804
    DOI 10.4285/kjt.22.0020
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