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  1. Article ; Online: Control of the signaling role of PtdIns(4)P at the plasma membrane through H

    Jo, Su In / Kim, Suree / Lim, Jung Mi / Rhee, Sue Goo / Jeong, Bo-Gyeong / Cha, Sun-Shin / Chang, Jae-Byum / Kang, Dongmin

    Redox biology

    2024  Volume 71, Page(s) 103097

    Abstract: Phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5) ... ...

    Abstract Phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P
    MeSH term(s) Phosphatidylinositols ; Hydrogen Peroxide/metabolism ; Phosphatidylinositol 4,5-Diphosphate/metabolism ; Phosphoric Monoester Hydrolases/metabolism ; Cell Membrane/metabolism ; Signal Transduction ; Endocytosis ; Nerve Tissue Proteins
    Chemical Substances Phosphatidylinositols ; synaptojanin (EC 3.1.3.-) ; Hydrogen Peroxide (BBX060AN9V) ; Phosphatidylinositol 4,5-Diphosphate ; Phosphoric Monoester Hydrolases (EC 3.1.3.2) ; Nerve Tissue Proteins
    Language English
    Publishing date 2024-02-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2701011-9
    ISSN 2213-2317 ; 2213-2317
    ISSN (online) 2213-2317
    ISSN 2213-2317
    DOI 10.1016/j.redox.2024.103097
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Clinical Usefulness of Immune Profiling for Differential Diagnosis between Crohn's Disease, Intestinal Tuberculosis, and Behcet's Disease.

    Yoo, Ji Won / Jo, Su In / Shin, Dong Woo / Park, Ji Won / Kim, Sung-Eun / Lim, Hyun / Kang, Ho Suk / Moon, Sung-Hoon / Kim, Min Kyu / Kim, Sang-Yeob / Hwang, Sung Wook / Soh, Jae Seung

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 18

    Abstract: It is important to make a differential diagnosis between inflammatory diseases of the bowel with similar clinical and endoscopic features. The profiling of immune cells could be helpful for accurately diagnosing inflammatory bowel diseases. We compared ... ...

    Abstract It is important to make a differential diagnosis between inflammatory diseases of the bowel with similar clinical and endoscopic features. The profiling of immune cells could be helpful for accurately diagnosing inflammatory bowel diseases. We compared immune marker expression between Crohn's disease (CD), intestinal Behcet's disease (BD), and intestinal tuberculosis (TB) and evaluated the usefulness of immune profiling in differentiating between these diseases. Biopsy specimens were acquired around ulcerations on the terminal ileum or cecum from five patients with each disease. Panel 1 included multiplex immunohistochemistry staining for CD8, CD4, Foxp3, CD20, programmed death-1, and granzyme B. CD56, CD68, CD163, CD11c, and HLA-DR were analyzed in panel 2. The differences in cytotoxic T cells (CD8
    Language English
    Publishing date 2023-09-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13182904
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: PD-1-positive cells contribute to the diagnosis of inflammatory bowel disease and can aid in predicting response to vedolizumab.

    Kim, Min Kyu / Jo, Su In / Kim, Sang-Yeob / Lim, Hyun / Kang, Ho Suk / Moon, Sung-Hoon / Ye, Byong Duk / Soh, Jae Seung / Hwang, Sung Wook

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 21329

    Abstract: Differentiating inflammatory bowel disease (IBD) from other inflammatory diseases is often challenging. Programmed cell death protein-1 (PD-1) is expressed in T cells and is an indicator of their exhaustion. The role of PD-1 expression in diagnosing IBD ... ...

    Abstract Differentiating inflammatory bowel disease (IBD) from other inflammatory diseases is often challenging. Programmed cell death protein-1 (PD-1) is expressed in T cells and is an indicator of their exhaustion. The role of PD-1 expression in diagnosing IBD and predicting the response of biologic agents remains inconclusive. In this study, endoscopic biopsy samples of 19 patients diagnosed with IBD, intestinal tuberculosis, and intestinal Behcet's disease were analyzed using multiplexed immunohistochemistry. Additionally, a separate "vedolizumab (VDZ) cohort" established in ulcerative colitis patients who underwent endoscopic biopsy before VDZ administration was analyzed to predict response to VDZ. In the immunohistochemistry analysis, the cell density of T cell subsets, including PD-1 + cells, was investigated and compared between IBD and other inflammatory diseases (OID). Cell densities of PD-1 + cells (p = 0.028), PD-1 + helper T cells (p = 0.008), and PD-1 + regulatory T cells (p = 0.024) were higher in IBD compared with OID. In the VDZ cohort, patients with a 14-week steroid-free clinical response had higher levels of PD-1 + cells (p = 0.026), PD-1 + helper T cells (p = 0.026), and PD-1 + regulatory T cells (p = 0.041) than the no response group. PD-1 + immune cells may contribute to the diagnosis of IBD and could be used to predict response to VDZ in ulcerative colitis patients.
    MeSH term(s) Humans ; Colitis, Ulcerative/diagnosis ; Colitis, Ulcerative/drug therapy ; Programmed Cell Death 1 Receptor ; Gastrointestinal Agents/therapeutic use ; Inflammatory Bowel Diseases/diagnosis ; Inflammatory Bowel Diseases/drug therapy ; Retrospective Studies ; Treatment Outcome
    Chemical Substances vedolizumab (9RV78Q2002) ; Programmed Cell Death 1 Receptor ; Gastrointestinal Agents
    Language English
    Publishing date 2023-12-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-48651-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Effects of the purified dry extract of fermented ginseng BST204 on muscle fiber regeneration.

    Jo, Su In / Park, Yoon Sun / Chang, Yeeun / Moon, Jai-Hee / Lee, Slee / Lee, Hyejin / Kim, MiYeon / Kim, Do Yeon / Bae, SangMun / Park, Se Yeong / Yun, Hyeseon / You, Ji-Eun / Im, Minju / Han, Hae-Jung / Kim, Sang-Yeob / Jin, Dong-Hoon

    Biochemistry and biophysics reports

    2023  Volume 35, Page(s) 101525

    Abstract: Background: Sarcopenia and muscular dystrophy are two muscle diseases. In cancer patients, cancer cachexia induces continuous weight loss and muscle loss due to the disease itself or the use of anticancer drugs. Cachexia occurs in up to 80% of cancer ... ...

    Abstract Background: Sarcopenia and muscular dystrophy are two muscle diseases. In cancer patients, cancer cachexia induces continuous weight loss and muscle loss due to the disease itself or the use of anticancer drugs. Cachexia occurs in up to 80% of cancer patients. It is recognized as a direct cause of reduced quality of life, contributing to at least 20% of cancer-associated deaths and limiting therapeutic options for cancer patients. Cancer cachexia is associated with multiple chronic or end-stage conditions and develops similarly. There are various options for the treatment of cancer cachexia, but there are still many issues to be solved. Hence, to determine its potential to overcome the muscle wasting during cancer cachexia, we studied the effect of BST204, a refined dry ginseng extract, on muscle fiber regeneration.
    Experimental procedure: We checked the muscle regeneration efficacy of BST204. First, BaCl
    Results and conclusion: These results showed that BST204 induced muscle fiber regeneration in BaCl
    Language English
    Publishing date 2023-08-14
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2831046-9
    ISSN 2405-5808 ; 2405-5808
    ISSN (online) 2405-5808
    ISSN 2405-5808
    DOI 10.1016/j.bbrep.2023.101525
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Crizotinib attenuates cancer metastasis by inhibiting TGFβ signaling in non-small cell lung cancer cells.

    Park, Soonbum / Cho, Eun A / Chun, Jung Nyeo / Lee, Da Young / Lee, Sanghoon / Kim, Mi Yeon / Bae, Sang Mun / Jo, Su In / Lee, So Hee / Park, Hyun Ho / Kim, Tae Min / So, Insuk / Kim, Sang-Yeob / Jeon, Ju-Hong

    Experimental & molecular medicine

    2022  Volume 54, Issue 8, Page(s) 1225–1235

    Abstract: Crizotinib is a clinically approved tyrosine kinase inhibitor for the treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) harboring EML4-ALK fusion. Crizotinib was originally developed as an inhibitor of MET (HGF ... ...

    Abstract Crizotinib is a clinically approved tyrosine kinase inhibitor for the treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) harboring EML4-ALK fusion. Crizotinib was originally developed as an inhibitor of MET (HGF receptor), which is involved in the metastatic cascade. However, little is known about whether crizotinib inhibits tumor metastasis in NSCLC cells. In this study, we found that crizotinib suppressed TGFβ signaling by blocking Smad phosphorylation in an ALK/MET/RON/ROS1-independent manner in NSCLC cells. Molecular docking and in vitro enzyme activity assays showed that crizotinib directly inhibited the kinase activity of TGFβ receptor I through a competitive inhibition mode. Cell tracking, scratch wound, and transwell migration assays showed that crizotinib simultaneously inhibited TGFβ- and HGF-mediated NSCLC cell migration and invasion. In addition, in vivo bioluminescence imaging analysis showed that crizotinib suppressed the metastatic capacity of NSCLC cells. Our results demonstrate that crizotinib attenuates cancer metastasis by inhibiting TGFβ signaling in NSCLC cells. Therefore, our findings will help to advance our understanding of the anticancer action of crizotinib and provide insight into future clinical investigations.
    MeSH term(s) Antineoplastic Agents/pharmacology ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/pathology ; Crizotinib/pharmacology ; Crizotinib/therapeutic use ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/pathology ; Molecular Docking Simulation ; Protein Kinase Inhibitors/pharmacology ; Proto-Oncogene Proteins ; Pyrazoles/pharmacology ; Pyrazoles/therapeutic use ; Pyridines/pharmacology ; Pyridines/therapeutic use ; Transforming Growth Factor beta
    Chemical Substances Antineoplastic Agents ; Protein Kinase Inhibitors ; Proto-Oncogene Proteins ; Pyrazoles ; Pyridines ; Transforming Growth Factor beta ; Crizotinib (53AH36668S)
    Language English
    Publishing date 2022-08-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1328915-9
    ISSN 2092-6413 ; 1226-3613 ; 0378-8512
    ISSN (online) 2092-6413
    ISSN 1226-3613 ; 0378-8512
    DOI 10.1038/s12276-022-00835-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4775: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Immunoprofiling of Colitis-associated and Sporadic Colorectal Cancer and its Clinical Significance.

    Soh, Jae Seung / Jo, Su In / Lee, Hyejin / Do, Eun-Ju / Hwang, Sung Wook / Park, Sang Hyoung / Ye, Byong Duk / Byeon, Jeong-Sik / Yang, Suk-Kyun / Kim, Ji Hun / Yang, Dong-Hoon / Kim, Sang-Yeob / Myung, Seung-Jae

    Scientific reports

    2019  Volume 9, Issue 1, Page(s) 6833

    Abstract: Immunoprofiling is useful for predicting prognosis in various malignancies and provides targets for immunotherapy. Quantitative multispectral imaging system, which allows simultaneous detection of multiple immune markers, is a novel method for examining ... ...

    Abstract Immunoprofiling is useful for predicting prognosis in various malignancies and provides targets for immunotherapy. Quantitative multispectral imaging system, which allows simultaneous detection of multiple immune markers, is a novel method for examining the tumor immune environment. We compared the expression levels of various surface markers in immune cells between colitis-associated cancer (CAC) and sporadic colorectal cancer (CRC) and evaluated the clinical usefulness of immunoprofiling in CRC. Tumor specimens from 24 CAC patients and 48 sporadic CRC patients, matched by age, sex, and tumor location to CAC, were included in the analysis. The expression levels of CD3, CD8, Foxp3, and programmed death-ligand 1 (PD-L1) in immune cells at the invasive margins of tumor tissues were evaluated by quantitative multispectral imaging. The CAC group had significantly less levels of cells expressing CD3, CD8, Foxp3, or PD-L1 (all, p < 0.01). In the CAC group, patients whose immune cells had high expression of CD3
    MeSH term(s) Adult ; Aged ; CD3 Complex/metabolism ; CD8-Positive T-Lymphocytes/metabolism ; Colitis/immunology ; Colitis/mortality ; Colitis/pathology ; Colorectal Neoplasms/immunology ; Colorectal Neoplasms/mortality ; Colorectal Neoplasms/pathology ; Female ; Forkhead Transcription Factors/metabolism ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Neoplasms/immunology ; Neoplasms/mortality ; Neoplasms/pathology ; Programmed Cell Death 1 Receptor/metabolism
    Chemical Substances CD3 Complex ; FOXP3 protein, human ; Forkhead Transcription Factors ; PDCD1 protein, human ; Programmed Cell Death 1 Receptor
    Language English
    Publishing date 2019-05-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-019-42986-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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