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  1. Article: Fast Absorbent and Highly Bioorthogonal Hydrogels Developed by IEDDA Click Reaction for Drug Delivery Application.

    Joo, Soo-Bin / Gulfam, Muhammad / Jo, Sung-Han / Jo, Yi-Jun / Vu, Trung Thang / Park, Sang-Hyug / Gal, Yeong-Soon / Lim, Kwon Taek

    Materials (Basel, Switzerland)

    2022  Volume 15, Issue 20

    Abstract: In this work, we engineered highly biocompatible and fast absorbent injectable hydrogels derived from norbornene (Nb)-functionalized hyaluronic acid (HA-Nb) and a water-soluble cross-linker possessing tetrazine (Tz) functional groups on both ends of ... ...

    Abstract In this work, we engineered highly biocompatible and fast absorbent injectable hydrogels derived from norbornene (Nb)-functionalized hyaluronic acid (HA-Nb) and a water-soluble cross-linker possessing tetrazine (Tz) functional groups on both ends of polyethylene glycol (PEG-DTz). The by-product (nitrogen gas) of the inverse electron demand Diels−Alder (IEDDA) cross-linking reaction carved porosity in the resulting hydrogels. By varying the molar ratio of HA-Nb and PEG-DTz (Nb:Tz = 10:10, 10:5, 10:2.5), we were able to formulate hydrogels with tunable porosity, gelation time, mechanical strength, and swelling ratios. The hydrogels formed quickly (gelation time < 100 s), offering a possibility to use them as an injectable drug delivery system. The experimental data showed rapid swelling and a high swelling ratio thanks to the existence of PEG chains and highly porous architectures of the hydrogels. The hydrogels were able to encapsulate a high amount of curcumin (~99%) and released the encapsulated curcumin in a temporal pattern. The PEG-DTz cross-linker, HA-Nb, and the resulting hydrogels showed no cytotoxicity in HEK-293 cells. These fast absorbent hydrogels with excellent biocompatibility fabricated from HA-Nb and the IEDDA click-able cross-linker could be promising drug carriers for injectable drug delivery applications.
    Language English
    Publishing date 2022-10-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma15207128
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Multi-stimuli responsive hydrogels derived from hyaluronic acid for cancer therapy application.

    Jo, Yi-Jun / Gulfam, Muhammad / Jo, Sung-Han / Gal, Yeong-Soon / Oh, Chul-Woong / Park, Sang-Hyug / Lim, Kwon Taek

    Carbohydrate polymers

    2022  Volume 286, Page(s) 119303

    Abstract: One of the most promising strategies for the controlled release of therapeutic molecules is stimuli-responsive and biodegradable hydrogels developed from natural polymers. However, current strategies to development stimuli-responsive hydrogels lack ... ...

    Abstract One of the most promising strategies for the controlled release of therapeutic molecules is stimuli-responsive and biodegradable hydrogels developed from natural polymers. However, current strategies to development stimuli-responsive hydrogels lack precise control over drug release profile and use cytotoxic materials during preparation. To address these issues, multi-stimuli responsive hydrogels derived from hyaluronic acid and diselenide based cross-linker were developed for the controlled release of doxorubicin (DOX). Hydrogels were rapidly formed via an inverse electron demand Diels-Alder click chemistry and encapsulated DOX/indocyanine green (ICG) in their porous networks. The hydrogels showed a rapid release of DOX in acidic (pH 5), reducing (10 mmol DTT), and oxidizing medium (0.5% H
    MeSH term(s) Doxorubicin/chemistry ; Doxorubicin/pharmacology ; Drug Liberation ; Humans ; Hyaluronic Acid/chemistry ; Hyaluronic Acid/pharmacology ; Hydrogels/chemistry ; Hydrogels/pharmacology ; Hydrogen Peroxide ; Neoplasms/drug therapy
    Chemical Substances Hydrogels ; Doxorubicin (80168379AG) ; Hyaluronic Acid (9004-61-9) ; Hydrogen Peroxide (BBX060AN9V)
    Language English
    Publishing date 2022-03-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 1501516-6
    ISSN 1879-1344 ; 0144-8617
    ISSN (online) 1879-1344
    ISSN 0144-8617
    DOI 10.1016/j.carbpol.2022.119303
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Dual cross-linked chitosan/alginate hydrogels prepared by Nb-Tz ‘click’ reaction for pH responsive drug delivery

    Hoang, Huong Thi / Vu, Trung Thang / Karthika, Viswanathan / Jo, Sung-Han / Jo, Yi-Jun / Seo, Jeong-Woo / Oh, Chul-Woong / Park, Sang-Hyug / Lim, Kwon Taek

    Carbohydrate polymers. 2022 Mar. 18,

    2022  

    Abstract: A novel physically and chemically double-crosslinked hydrogel derived from chitosan oligosaccharide/alginate (COS/Alg) was developed by using norbornene (Nb)-tetrazine (Tz) click reaction for ketoprofen delivery. The properties of the hydrogel were ... ...

    Abstract A novel physically and chemically double-crosslinked hydrogel derived from chitosan oligosaccharide/alginate (COS/Alg) was developed by using norbornene (Nb)-tetrazine (Tz) click reaction for ketoprofen delivery. The properties of the hydrogel were evaluated by rheological, FTIR, TGA, XRD, SEM, swelling and drug release studies. The Nb-Tz chemical cross-linking facilitated outstanding hydrophobic drug loading (44% wt/wt of ketoprofen) and sustained release through a hydrophobic interaction mechanism between the drug and the used polysaccharides. The COS/Alg electrostatics network (10/10 of NH₂/COOH molar ratio) generated the pH responsiveness, suppressing the release in simulated gastric fluid (below 10% for 2 h) and enhancing the release in simulated intestinal fluids (up to 84% for 24 h). The prepared hydrogel was non-toxic to human HEK-293 cells (95% cell viability). This work opens up a potential approach for preparing hydrophilic hydrogels from natural polysaccharides that can be used in the delivery of hydrophobic drugs.
    Keywords alginates ; cell viability ; chitosan ; crosslinking ; gastric juice ; humans ; hydrogels ; hydrophilicity ; hydrophobic bonding ; hydrophobicity ; intestines ; ketoprofen ; oligosaccharides ; pH
    Language English
    Dates of publication 2022-0318
    Publishing place Elsevier Ltd
    Document type Article
    Note Pre-press version
    ZDB-ID 1501516-6
    ISSN 1879-1344 ; 0144-8617
    ISSN (online) 1879-1344
    ISSN 0144-8617
    DOI 10.1016/j.carbpol.2022.119389
    Database NAL-Catalogue (AGRICOLA)

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  4. Article: Multi-stimuli responsive hydrogels derived from hyaluronic acid for cancer therapy application

    Jo, Yi-Jun / Gulfam, Muhammad / Jo, Sung-Han / Gal, Yeong-Soon / Oh, Chul-Woong / Park, Sang-Hyug / Lim, Kwon Taek

    Carbohydrate polymers. 2022 June 15, v. 286

    2022  

    Abstract: One of the most promising strategies for the controlled release of therapeutic molecules is stimuli-responsive and biodegradable hydrogels developed from natural polymers. However, current strategies to development stimuli-responsive hydrogels lack ... ...

    Abstract One of the most promising strategies for the controlled release of therapeutic molecules is stimuli-responsive and biodegradable hydrogels developed from natural polymers. However, current strategies to development stimuli-responsive hydrogels lack precise control over drug release profile and use cytotoxic materials during preparation. To address these issues, multi-stimuli responsive hydrogels derived from hyaluronic acid and diselenide based cross-linker were developed for the controlled release of doxorubicin (DOX). Hydrogels were rapidly formed via an inverse electron demand Diels–Alder click chemistry and encapsulated DOX/indocyanine green (ICG) in their porous networks. The hydrogels showed a rapid release of DOX in acidic (pH 5), reducing (10 mmol DTT), and oxidizing medium (0.5% H₂O₂), and after NIR irradiation. The in vitro experiments demonstrated that hydrogels were highly cytocompatible and the DOX-loaded hydrogels induced similar anti-tumor effect as compared to that of the free-DOX. Furthermore, DOX + ICG loaded hydrogels increased the antitumor efficacy of DOX after NIR irradiation.
    Keywords antineoplastic activity ; biodegradability ; cancer therapy ; cycloaddition reactions ; cytotoxicity ; doxorubicin ; hyaluronic acid ; hydrogels ; irradiation ; pH
    Language English
    Dates of publication 2022-0615
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 1501516-6
    ISSN 1879-1344 ; 0144-8617
    ISSN (online) 1879-1344
    ISSN 0144-8617
    DOI 10.1016/j.carbpol.2022.119303
    Database NAL-Catalogue (AGRICOLA)

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    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Dual cross-linked chitosan/alginate hydrogels prepared by Nb-Tz 'click' reaction for pH responsive drug delivery.

    Hoang, Huong Thi / Vu, Trung Thang / Karthika, Viswanathan / Jo, Sung-Han / Jo, Yi-Jun / Seo, Jeong-Woo / Oh, Chul-Woong / Park, Sang-Hyug / Lim, Kwon Taek

    Carbohydrate polymers

    2022  Volume 288, Page(s) 119389

    Abstract: A novel physically and chemically double-crosslinked hydrogel derived from chitosan oligosaccharide/alginate (COS/Alg) was developed by using norbornene (Nb)-tetrazine (Tz) click reaction for ketoprofen delivery. The properties of the hydrogel were ... ...

    Abstract A novel physically and chemically double-crosslinked hydrogel derived from chitosan oligosaccharide/alginate (COS/Alg) was developed by using norbornene (Nb)-tetrazine (Tz) click reaction for ketoprofen delivery. The properties of the hydrogel were evaluated by rheological, FTIR, TGA, XRD, SEM, swelling and drug release studies. The Nb-Tz chemical cross-linking facilitated outstanding hydrophobic drug loading (44% wt/wt of ketoprofen) and sustained release through a hydrophobic interaction mechanism between the drug and the used polysaccharides. The COS/Alg electrostatics network (10/10 of NH
    MeSH term(s) Alginates/chemistry ; Chitosan/chemistry ; Drug Carriers/chemistry ; Drug Delivery Systems ; Drug Liberation ; HEK293 Cells ; Humans ; Hydrogels/chemistry ; Hydrogen-Ion Concentration ; Ketoprofen ; Niobium ; Norbornanes
    Chemical Substances Alginates ; Drug Carriers ; Hydrogels ; Norbornanes ; Niobium (05175J654G) ; 2-norbornene (2Q51FLS550) ; Chitosan (9012-76-4) ; Ketoprofen (90Y4QC304K)
    Language English
    Publishing date 2022-03-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1501516-6
    ISSN 1879-1344 ; 0144-8617
    ISSN (online) 1879-1344
    ISSN 0144-8617
    DOI 10.1016/j.carbpol.2022.119389
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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