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Article ; Online: Dysnatremia in children, why is it so hard to stay normal?

Karlsson, Jacob / Johansen, Mathias

2022 Volume 66, Issue 5, Page(s) 548–549

MeSH term(s)	Child ; Hospital Mortality ; Humans ; Hypernatremia ; Hyponatremia ; Sodium
Chemical Substances	Sodium (9NEZ333N27)
Language	English
Publishing date	2022-02-24
Publishing country	England
Document type	Editorial
ZDB-ID	80002-8
ISSN	1399-6576 ; 0001-5172
ISSN (online)	1399-6576
ISSN	0001-5172
DOI	10.1111/aas.14044
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Article ; Online: Use of nasal high flow in upper airway surgery with laser.

Johansen, Mathias / Daniel, Sam J / Engelhardt, Thomas

Paediatric anaesthesia

2021 Volume 32, Issue 1, Page(s) 90–91

MeSH term(s)	Anesthesia, Intravenous ; Humans ; Larynx ; Lasers ; Nose ; Trachea
Language	English
Publishing date	2021-11-09
Publishing country	France
Document type	Letter ; Comment
ZDB-ID	1086049-6
ISSN	1460-9592 ; 1155-5645
ISSN (online)	1460-9592
ISSN	1155-5645
DOI	10.1111/pan.14317
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Article ; Online: Congenital anomalies of the large intrathoracic airways.

Johansen, Mathias / Veyckemans, Francis / Engelhardt, Thomas

Paediatric anaesthesia

2021 Volume 32, Issue 2, Page(s) 126–137

Abstract: Congenital lung lesions are numerous but rare in individual clinical practice. They do require close multidisciplinary collaboration between health care professionals. This educational review will focus on the pathophysiology, clinical manifestations, ... ...

Abstract	Congenital lung lesions are numerous but rare in individual clinical practice. They do require close multidisciplinary collaboration between health care professionals. This educational review will focus on the pathophysiology, clinical manifestations, surgical approaches, and anesthetic management of congenital anomalies of the large intrathoracic airways: congenital tracheal stenosis, tracheal agenesis, tracheal diverticulum, bronchial anomalies (tracheal, esophageal, or bridging bronchus), congenital lung malformations, lung sequestrations and Scimitar syndrome, lobar emphysema, Williams-Campbell syndrome, and pleuropulmonary blastoma. In addition, this review will illustrate common pitfalls and challenges related to the anesthesia management with emphasis on ventilation and correct endotracheal tube positioning.
MeSH term(s)	Bronchi/abnormalities ; Humans ; Lung/diagnostic imaging ; Lung Diseases ; Pulmonary Blastoma/pathology ; Trachea/abnormalities
Language	English
Publishing date	2021-11-29
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	1086049-6
ISSN	1460-9592 ; 1155-5645
ISSN (online)	1460-9592
ISSN	1155-5645
DOI	10.1111/pan.14339
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Article ; Online: Report of two cases of endobronchial tumour mass resection in children.

Johansen, Mathias / Lakheeram, Indrani / Buu, Natalie

Canadian journal of anaesthesia = Journal canadien d'anesthesie

2021 Volume 68, Issue 9, Page(s) 1368–1372

Abstract: Purpose: Anesthesia for endotracheal tumour mass resection in pediatric patients is a rare, complex, and high-risk procedure. The purpose of this case report is to emphasize the importance of multidisciplinary team collaboration and close communication ... ...

Title translation	Compte rendu de deux cas de résection de masse tumorale endobronchique chez des enfants.
Abstract	Purpose: Anesthesia for endotracheal tumour mass resection in pediatric patients is a rare, complex, and high-risk procedure. The purpose of this case report is to emphasize the importance of multidisciplinary team collaboration and close communication during the perioperative management of shared airway surgery. Clinical features: A six-year-old boy with no previous history of comorbidity and a 13-yr-old boy with a six-month history of upper respiratory tract infection, refractory asthma, chronic wheeze, and exercise-related dyspnea presented for acute endobronchial tumour mass resection. Decreased pulmonary function, religious beliefs (Jehovah's Witness), risk of intraluminal bleeding, and imminent complete airway collapse constitute areas of specific interest. Conclusion: Anesthesia for endotracheal tumour mass resection in pediatric patients is a rare, complex, and high-risk procedure. Decreased pulmonary function and low respiratory reserves combined with the need for extensive surgical airway access warrants multidisciplinary team collaboration and close communication. Maintaining spontaneous respiration is paramount to reduce the risk of hypoxemia-induced adverse events and preoperative considerations should include the possible need for extracorporeal membrane oxygenation. Finally, the use of nasal high flow for shared airway surgery shows promising prospects warranting further investigation.
MeSH term(s)	Adolescent ; Anesthesia ; Child ; Extracorporeal Membrane Oxygenation ; Humans ; Hypoxia ; Jehovah's Witnesses ; Male ; Neoplasms
Language	English
Publishing date	2021-06-14
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	91002-8
ISSN	1496-8975 ; 0832-610X
ISSN (online)	1496-8975
ISSN	0832-610X
DOI	10.1007/s12630-021-02055-6
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Article ; Online: Journal of pediatric surgery letter to the editor: Operating room limited resources utilization stratification system.

Johansen, Mathias / Emil, Sherif / Engelhardt, Thomas

Journal of pediatric surgery

2021 Volume 56, Issue 8, Page(s) 1471

MeSH term(s)	Child ; Humans ; Operating Rooms ; Specialties, Surgical
Language	English
Publishing date	2021-03-18
Publishing country	United States
Document type	Letter
ZDB-ID	80165-3
ISSN	1531-5037 ; 0022-3468
ISSN (online)	1531-5037
ISSN	0022-3468
DOI	10.1016/j.jpedsurg.2021.02.068
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Article ; Online: In vitro investigation of endocrine disrupting effects of pesticides on Ca2+-signaling in human sperm cells through actions on the sperm-specific and steroid-activated CatSper Ca2+-channel

Birch, Michala R. / Johansen, Mathias / Skakkebaek, Niels E. / Andersson, Anna-Maria / Rehfeld, Anders

Environment International. 2022 Sept., v. 167 p.107399-

2022

Abstract: Ca²⁺-signaling controls sperm cell functions necessary for successful fertilization. Multiple endocrine disrupting chemicals have been found to interfere with normal Ca²⁺-signaling in human sperm cells through an activation of the sperm-specific CatSper ... ...

Abstract	Ca²⁺-signaling controls sperm cell functions necessary for successful fertilization. Multiple endocrine disrupting chemicals have been found to interfere with normal Ca²⁺-signaling in human sperm cells through an activation of the sperm-specific CatSper Ca²⁺-channel, which is vital for normal male fertility. We investigated 53 pesticides for their ability to interfere with CatSper mediated Ca²⁺-signaling and function in human sperm cells. Effects of the pesticides on Ca²⁺-signaling in human sperm cells were evaluated using a Ca²⁺-fluorometric assay. Effects via CatSper were assessed using the specific CatSper inhibitor RU1968. Effects on human sperm function and viability were assessed using an image cytometry-based acrosome reaction assay and the modified Kremer's sperm-mucus penetration assay. 28 of 53 pesticides were found to induce Ca²⁺-signals in human sperm cells at 10 µM. The majority of these 28 active pesticides induced Ca²⁺-signals through CatSper and interfered with subsequent Ca²⁺-signals induced by the two endogenous CatSper ligands progesterone and prostaglandin E₁. Multiple active pesticides were found to affect Ca²⁺-mediated sperm functions and viability at 10 µM. Low nM dose mixtures of the active pesticides alone or in combination with other environmental chemicals were found to significantly induce Ca²⁺-signals and inhibit Ca²⁺-signals induced subsequently by progesterone and prostaglandin E₁. Our results show that pesticides, both alone and in low nM dose mixtures, interfere with normal Ca²⁺-signaling in human sperm cells in vitro in low nM concentrations. Biomonitoring of the active pesticides in relevant matrices such as blood and reproductive fluids is very limited and the effects of real time human pesticide exposure on human sperm cells and fertility thus remains largely unknown. To which extent human pesticide exposure affects the chances of a successful fertilization in humans in vivo needs further research.
Keywords	acrosome reaction ; blood ; environment ; environmental monitoring ; humans ; ligands ; male fertility ; pesticides ; progesterone ; prostaglandins ; spermatozoa ; viability ; Endocrine disruption ; Fertility ; CatSper ; Male reproduction
Language	English
Dates of publication	2022-09
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	554791-x
ISSN	1873-6750 ; 0160-4120
ISSN (online)	1873-6750
ISSN	0160-4120
DOI	10.1016/j.envint.2022.107399
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Long-term IV access in paediatrics - why, what, where, who and how.

Johansen, Mathias / Classen, Volker / Muchantef, Karl

Acta anaesthesiologica Scandinavica

2020 Volume 65, Issue 3, Page(s) 282–291

Abstract: Establishment of long-term central venous access imposes the risk of procedural adverse events (air embolism, pneumothorax, accidental arterial cannulation of the great vessels, tricuspid valve damage and cardiac tamponade) as well as the risk of ... ...

Abstract	Establishment of long-term central venous access imposes the risk of procedural adverse events (air embolism, pneumothorax, accidental arterial cannulation of the great vessels, tricuspid valve damage and cardiac tamponade) as well as the risk of increased morbidity and mortality due to catheter related blood stream infections, vessel stenosis, deep vein thrombosis and the often high risk anaesthetic management of syndromic children. This narrative review aims to provide a historical and clinical background for the development and use of CVADs (central venous access devices), origin and management of the most common complications (catheter related thrombosis, infections and persistent withdrawal occlusion) and present the reader with an update on the "why, what, where, who and how" in paediatric long-term central venous access. Finally, we will present the reader with a clinical method for applying a retrograde inserted tunnelled and cuffed catheter using the left brachiocephalic vein access.
MeSH term(s)	Catheterization, Central Venous/adverse effects ; Child ; Humans ; Pediatrics ; Thrombosis
Language	English
Publishing date	2020-11-17
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	80002-8
ISSN	1399-6576 ; 0001-5172
ISSN (online)	1399-6576
ISSN	0001-5172
DOI	10.1111/aas.13729
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Article ; Online: Optical 4D oxygen mapping of microperfused tissue models with tunable <i>in vivo</i>-like 3D oxygen microenvironments.

Wesseler, Milan Finn / Johansen, Mathias Nørbæk / Kızıltay, Aysel / Mortensen, Kim I / Larsen, Niels B

Lab on a chip

2022 Volume 22, Issue 21, Page(s) 4167–4179

Abstract: Sufficient and controllable oxygen supply is essential for ... in vitro ... 3D cell and tissue culture at high cell densities, which calls for volumetric ... in situ ... oxygen analysis methods to quantitatively assess the oxygen distribution. This paper ... ...

Abstract	Sufficient and controllable oxygen supply is essential for in vitro 3D cell and tissue culture at high cell densities, which calls for volumetric in situ oxygen analysis methods to quantitatively assess the oxygen distribution. This paper presents a general approach for accurate and precise non-contact 3D mapping of oxygen tension in high cell-density cultures via embedded commercially available oxygen microsensor beads read out by confocal phosphorescence lifetime microscopy (PLIM). Optimal acquisition conditions and data analysis procedures are established and implemented in a publicly available software package. The versatility of the established method is first demonstrated in model-assisted fluidic design of microperfused 3D printed hydrogel culture chips with the aim of full culture oxygenation, and subsequently for monitoring and maintenance of physiologically relevant spatial and temporal oxygen gradients in the 3D printed chips controlled by static or dynamic flow conditions during 3D culture.
MeSH term(s)	Oxygen ; Microscopy, Confocal ; Hydrogels
Chemical Substances	Oxygen (S88TT14065) ; Hydrogels
Language	English
Publishing date	2022-10-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2056646-3
ISSN	1473-0189 ; 1473-0197
ISSN (online)	1473-0189
ISSN	1473-0197
DOI	10.1039/d2lc00063f
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Article ; Online: In vitro investigation of endocrine disrupting effects of pesticides on Ca

Birch, Michala R / Johansen, Mathias / Skakkebæk, Niels E / Andersson, Anna-Maria / Rehfeld, Anders

Environment international

2022 Volume 167, Page(s) 107399

Abstract: Background: Ca: Objectives: We investigated 53 pesticides for their ability to interfere with CatSper mediated Ca: Methods: Effects of the pesticides on Ca: Results: 28 of 53 pesticides were found to induce Ca: Conclusions: Our results show ... ...

Abstract	Background: Ca Objectives: We investigated 53 pesticides for their ability to interfere with CatSper mediated Ca Methods: Effects of the pesticides on Ca Results: 28 of 53 pesticides were found to induce Ca Conclusions: Our results show that pesticides, both alone and in low nM dose mixtures, interfere with normal Ca
MeSH term(s)	Calcium ; Calcium Channels/metabolism ; Calcium Signaling ; Humans ; Male ; Pesticides/metabolism ; Progesterone ; Prostaglandins/metabolism ; Prostaglandins/pharmacology ; Semen/metabolism ; Sperm Motility ; Spermatozoa
Chemical Substances	Calcium Channels ; Pesticides ; Prostaglandins ; Progesterone (4G7DS2Q64Y) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2022-07-09
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	554791-x
ISSN	1873-6750 ; 0160-4120
ISSN (online)	1873-6750
ISSN	0160-4120
DOI	10.1016/j.envint.2022.107399
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Article ; Online: Perioperative anaesthetic management and short-term outcome of neonatal repair of oesophageal atresia with or without tracheo-oesophageal fistula in Europe: A sub-analysis of the neonate and children audit of anaesthesia practice in Europe (NECTARINE) prospective multicenter observational study.

van den Berg, Johanneke / Johansen, Mathias / Disma, Nicola / Engelhardt, Thomas / Hansen, Tom Giedsing / Veyckemans, Francis / Zielinska, Marzena / de Graaff, Jurgen C

European journal of anaesthesiology

2023 Volume 40, Issue 12, Page(s) 936–945

Abstract: Background: Oesophageal atresia with or without a tracheo-oesophageal fistula is a congenital abnormality that usually requires surgical repair within the first days of life.: Objective: Description of the perioperative anaesthetic management and ... ...

Abstract	Background: Oesophageal atresia with or without a tracheo-oesophageal fistula is a congenital abnormality that usually requires surgical repair within the first days of life. Objective: Description of the perioperative anaesthetic management and outcomes of neonates undergoing surgery for oesophageal atresia with or without a tracheo-oesophageal fistula, included in the 'neonate and children audit of anaesthesia practice in Europe' (NECTARINE) database. Design: Sub-analyses of prospective observational NECTARINE study. Setting: European multicentre study. Patients: Neonates who underwent surgery for oesophageal atresia with or without a tracheo-oesophageal fistula in the NECTARINE cohort were selected. Main outcome measures: Incidence rates with 95% confidence intervals were calculated for peri-operative clinical events which required a predetermined intervention, postoperative complications, and mortality. Results: One hundred and three neonates undergoing a first surgical intervention for oesophageal atresia with or without a tracheo-oesophageal fistula repair were identified. Their median gestational age was 38 weeks with a median birth weight of 2840 [interquartile range 2150 to 3150] grams. Invasive monitoring was used in 66% of the procedures. The incidence of perioperative clinical events was 69% (95% confidence interval 59 to 77%), of 30-day postoperative complications 47% (95% confidence interval 38 to 57%) and the 30- and 90 days mortality rates were 2.1% and 2.6%, respectively. Conclusion: Oesophageal atresia with or without a tracheo-oesophageal fistula repair in neonates is associated with a high number of perioperative interventions in response to clinical events, a high incidence of postoperative complications, and a substantial mortality rate.
MeSH term(s)	Humans ; Infant ; Infant, Newborn ; Anesthesia ; Anesthetics ; Esophageal Atresia/surgery ; Esophageal Atresia/complications ; Postoperative Complications/epidemiology ; Prospective Studies ; Tracheoesophageal Fistula/diagnosis ; Tracheoesophageal Fistula/epidemiology ; Tracheoesophageal Fistula/surgery
Chemical Substances	Anesthetics
Language	English
Publishing date	2023-09-28
Publishing country	England
Document type	Observational Study ; Multicenter Study ; Journal Article
ZDB-ID	605770-6
ISSN	1365-2346 ; 0265-0215
ISSN (online)	1365-2346
ISSN	0265-0215
DOI	10.1097/EJA.0000000000001905
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