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  1. Article ; Online: Maternal exposure to a human relevant mixture of persistent organic pollutants reduces colorectal carcinogenesis in A/J Min/+ mice.

    Johanson, Silje M / Swann, Jonathan R / Umu, Özgün C O / Aleksandersen, Mona / Müller, Mette H B / Berntsen, Hanne F / Zimmer, Karin E / Østby, Gunn C / Paulsen, Jan E / Ropstad, Erik

    Chemosphere

    2020  Volume 252, Page(s) 126484

    Abstract: An increased risk of developing colorectal cancer has been associated with exposure to persistent organic pollutants (POPs) and alteration in the gut bacterial community. However, there is limited understanding about the impact of maternal exposure to ... ...

    Abstract An increased risk of developing colorectal cancer has been associated with exposure to persistent organic pollutants (POPs) and alteration in the gut bacterial community. However, there is limited understanding about the impact of maternal exposure to POPs on colorectal cancer and gut microbiota. This study characterized the influence of exposure to a human relevant mixture of POPs during gestation and lactation on colorectal cancer, intestinal metabolite composition and microbiota in the A/J Min/+ mouse model. Surprisingly, the maternal POP exposure decreased colonic tumor burden, as shown by light microscopy and histopathological evaluation, indicating a restriction of colorectal carcinogenesis.
    MeSH term(s) Animals ; Carcinogenesis ; Carcinogens/metabolism ; Carcinogens/toxicity ; Colonic Neoplasms ; Colorectal Neoplasms/chemically induced ; Environmental Pollutants/metabolism ; Environmental Pollutants/toxicity ; Female ; Gastrointestinal Microbiome/genetics ; Humans ; Lactation ; Maternal Exposure/statistics & numerical data ; Metabolomics ; Mice ; Mice, Inbred Strains ; Microbiota ; RNA, Ribosomal, 16S
    Chemical Substances Carcinogens ; Environmental Pollutants ; RNA, Ribosomal, 16S
    Language English
    Publishing date 2020-03-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 120089-6
    ISSN 1879-1298 ; 0045-6535 ; 0366-7111
    ISSN (online) 1879-1298
    ISSN 0045-6535 ; 0366-7111
    DOI 10.1016/j.chemosphere.2020.126484
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2540: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Maternal exposure to a human relevant mixture of persistent organic pollutants reduces colorectal carcinogenesis in A/J Min/+ mice

    Johanson, Silje M / Swann, Jonathan R / Umu, Özgün C.O / Aleksandersen, Mona / Müller, Mette H.B / Berntsen, Hanne F / Zimmer, Karin E / Østby, Gunn C / Paulsen, Jan E / Ropstad, Erik

    Chemosphere. 2020 Mar. 12,

    2020  

    Abstract: An increased risk of developing colorectal cancer has been associated with exposure to persistent organic pollutants (POPs) and alteration in the gut bacterial community. However, there is limited understanding about the impact of maternal exposure to ... ...

    Abstract An increased risk of developing colorectal cancer has been associated with exposure to persistent organic pollutants (POPs) and alteration in the gut bacterial community. However, there is limited understanding about the impact of maternal exposure to POPs on colorectal cancer and gut microbiota. This study characterized the influence of exposure to a human relevant mixture of POPs during gestation and lactation on colorectal cancer, intestinal metabolite composition and microbiota in the A/J Min/+ mouse model. Surprisingly, the maternal POP exposure decreased colonic tumor burden, as shown by light microscopy and histopathological evaluation, indicating a restriction of colorectal carcinogenesis. 1H nuclear magnetic resonance spectroscopy-based metabolomic analysis identified alterations in the metabolism of amino acids, lipids, glycerophospholipids and energy in intestinal tissue. In addition, 16S rRNA sequencing of gut microbiota indicated that maternal exposure modified fecal bacterial composition. In conclusion, the results showed that early-life exposure to a mixture of POPs reduced colorectal cancer initiation and promotion, possibly through modulation of the microbial and biochemical environment. Further studies should focus on the development of colorectal cancer after combined maternal and dietary exposures to environmentally relevant low-dose POP mixtures.
    Keywords amino acids ; animal models ; bacterial communities ; carcinogenesis ; colorectal neoplasms ; energy ; histopathology ; humans ; intestinal microorganisms ; intestines ; lactation ; light microscopy ; lipids ; maternal exposure ; metabolism ; metabolites ; metabolomics ; mice ; nuclear magnetic resonance spectroscopy ; persistent organic pollutants ; pregnancy ; ribosomal RNA ; sequence analysis
    Language English
    Dates of publication 2020-0312
    Publishing place Elsevier Ltd
    Document type Article
    Note Pre-press version
    ZDB-ID 120089-6
    ISSN 1879-1298 ; 0045-6535 ; 0366-7111
    ISSN (online) 1879-1298
    ISSN 0045-6535 ; 0366-7111
    DOI 10.1016/j.chemosphere.2020.126484
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2540: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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