Artikel ; Online: Synthesis of Elaborate Benzofuran-2-carboxamide Derivatives through a Combination of 8-Aminoquinoline Directed C-H Arylation and Transamidation Chemistry.
Molecules (Basel, Switzerland)
2020 Band 25, Heft 2
Abstract: Herein, we present a short and highly modular synthetic route that involves 8-aminoquinoline directed C-H arylation and transamidation chemistry, and which enables access to a wide range of elaborate benzofuran-2-carboxamides. For the directed C-H ... ...
| Abstract | Herein, we present a short and highly modular synthetic route that involves 8-aminoquinoline directed C-H arylation and transamidation chemistry, and which enables access to a wide range of elaborate benzofuran-2-carboxamides. For the directed C-H arylation reactions, Pd catalysis was used to install a wide range of aryl and heteroaryl substituents at the C3 position of the benzofuran scaffold in high efficiency. Directing group cleavage and further diversification of the C3-arylated benzofuran products were then achieved in a single synthetic operation through the utilization of a one-pot, two-step transamidation procedure, which proceeded via the intermediate |
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| Mesh-Begriff(e) | Amides/chemistry ; Aminoquinolines/chemistry ; Benzene Derivatives/chemistry ; Benzofurans/chemistry ; Catalysis ; Molecular Structure |
| Chemische Substanzen | Amides ; Aminoquinolines ; Benzene Derivatives ; Benzofurans ; benzofuran (LK6946W774) ; 8-aminoquinoline (U34EAV21TG) |
| Sprache | Englisch |
| Erscheinungsdatum | 2020-01-15 |
| Erscheinungsland | Switzerland |
| Dokumenttyp | Journal Article |
| ZDB-ID | 1413402-0 |
| ISSN | 1420-3049 ; 1431-5165 ; 1420-3049 |
| ISSN (online) | 1420-3049 |
| ISSN | 1431-5165 ; 1420-3049 |
| DOI | 10.3390/molecules25020361 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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