LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 66

Search options

  1. Book ; Online ; E-Book: Principles and practice of clinical research

    Gallin, John I. / Ognibene, Frederick P. / Johnson, Laura L.

    2018  

    Title variant Clinical research
    Author's details edited by John I. Galli, Frederick P. Ognibene, Laura Lee Johnson
    Keywords Research / methods ; Research |x methods / methods ; Medicine/Research ; Medicine/Research/Methodology
    Language English
    Size 1 Online-Ressource (xvii, 806 Seiten)
    Edition Fourth edition
    Publisher Academic Press
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019509995
    ISBN 9780128499047 ; 9780128499054 ; 0128499044 ; 0128499052
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Mechanisms of lineage specification in Caenorhabditis elegans.

    Liu, Jun / Murray, John Isaac

    Genetics

    2023  Volume 225, Issue 4

    Abstract: The studies of cell fate and lineage specification are fundamental to our understanding of the development of multicellular organisms. Caenorhabditis elegans has been one of the premiere systems for studying cell fate specification mechanisms at single ... ...

    Abstract The studies of cell fate and lineage specification are fundamental to our understanding of the development of multicellular organisms. Caenorhabditis elegans has been one of the premiere systems for studying cell fate specification mechanisms at single cell resolution, due to its transparent nature, the invariant cell lineage, and fixed number of somatic cells. We discuss the general themes and regulatory mechanisms that have emerged from these studies, with a focus on somatic lineages and cell fates. We next review the key factors and pathways that regulate the specification of discrete cells and lineages during embryogenesis and postembryonic development; we focus on transcription factors and include numerous lineage diagrams that depict the expression of key factors that specify embryonic founder cells and postembryonic blast cells, and the diverse somatic cell fates they generate. We end by discussing some future perspectives in cell and lineage specification.
    MeSH term(s) Animals ; Caenorhabditis elegans ; Caenorhabditis elegans Proteins/metabolism ; Cell Differentiation/physiology ; Cell Lineage/physiology ; Transcription Factors/metabolism
    Chemical Substances Caenorhabditis elegans Proteins ; Transcription Factors
    Language English
    Publishing date 2023-11-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2167-2
    ISSN 1943-2631 ; 0016-6731
    ISSN (online) 1943-2631
    ISSN 0016-6731
    DOI 10.1093/genetics/iyad174
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 767: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: A spatiotemporally resolved atlas of mRNA decay in the

    Peng, Felicia / Nordgren, C Erik / Murray, John Isaac

    bioRxiv : the preprint server for biology

    2024  

    Abstract: During embryonic development, cells undergo dynamic changes in gene expression that are required for appropriate cell fate specification. Although both transcription and mRNA degradation contribute to gene expression dynamics, patterns of mRNA decay are ... ...

    Abstract During embryonic development, cells undergo dynamic changes in gene expression that are required for appropriate cell fate specification. Although both transcription and mRNA degradation contribute to gene expression dynamics, patterns of mRNA decay are less well-understood. Here we directly measured spatiotemporally resolved mRNA decay rates transcriptome-wide throughout
    Language English
    Publishing date 2024-01-16
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.01.15.575757
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Book: Principles and practice of clinical research

    Gallin, John I. / Ognibene, Frederick P.

    2012  

    Title variant Clinical research
    Author's details ed. by John I. Gallin ; Frederick P. Ognibene
    Keywords Research / methods ; Medicine/Research ; Medicine/Research/Methodology
    Subject code 610.72
    Language English
    Size XV, 780 S. : Ill., graph. Darst.
    Edition 3. ed.
    Publisher Elesevier Acad. Press
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    Note Includes bibliographical references and index. - Previous ed.: London: Academic, 2002. - Formerly CIP
    HBZ-ID HT017319809
    ISBN 978-0-12-382167-6 ; 0-12-382167-3
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2012 A 3016 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Transcript accumulation rates in the early

    Sivaramakrishnan, Priya / Watkins, Cameron / Murray, John Isaac

    Science advances

    2023  Volume 9, Issue 34, Page(s) eadi1270

    Abstract: Dynamic transcriptional changes are widespread in rapidly dividing developing embryos when cell fate decisions are made quickly. ... ...

    Abstract Dynamic transcriptional changes are widespread in rapidly dividing developing embryos when cell fate decisions are made quickly. The
    MeSH term(s) Animals ; Caenorhabditis elegans/genetics ; Embryo, Mammalian ; Cell Differentiation ; Genomics ; Kinetics ; RNA, Messenger/genetics
    Chemical Substances RNA, Messenger
    Language English
    Publishing date 2023-08-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.adi1270
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Performance Analysis of Machine Learning Algorithms for Energy Demand–Supply Prediction in Smart Grids

    Eric Cebekhulu / Adeiza James Onumanyi / Sherrin John Isaac

    Sustainability, Vol 14, Iss 2546, p

    2022  Volume 2546

    Abstract: The use of machine learning (ML) algorithms for power demand and supply prediction is becoming increasingly popular in smart grid systems. Due to the fact that there exist many simple ML algorithms/models in the literature, the question arises as to ... ...

    Abstract The use of machine learning (ML) algorithms for power demand and supply prediction is becoming increasingly popular in smart grid systems. Due to the fact that there exist many simple ML algorithms/models in the literature, the question arises as to whether there is any significant advantage(s) among these different ML algorithms, particularly as it pertains to power demand/supply prediction use cases. Toward answering this question, we examined six well-known ML algorithms for power prediction in smart grid systems, including the artificial neural network, Gaussian regression (GR), k-nearest neighbor, linear regression, random forest, and support vector machine (SVM). First, fairness was ensured by undertaking a thorough hyperparameter tuning exercise of the models under consideration. As a second step, power demand and supply statistics from the Eskom database were selected for day-ahead forecasting purposes. These datasets were based on system hourly demand as well as renewable generation sources. Hence, when their hyperparameters were properly tuned, the results obtained within the boundaries of the datasets utilized showed that there was little/no significant difference in the quantitative and qualitative performance of the different ML algorithms. As compared to photovoltaic (PV) power generation, we observed that these algorithms performed poorly in predicting wind power output. This could be related to the unpredictable wind-generated power obtained within the time range of the datasets employed. Furthermore, while the SVM algorithm achieved the slightly quickest empirical processing time, statistical tests revealed that there was no significant difference in the timing performance of the various algorithms, except for the GR algorithm. As a result, our preliminary findings suggest that using a variety of existing ML algorithms for power demand/supply prediction may not always yield statistically significant comparative prediction results, particularly for sources with regular patterns, such as solar PV ...
    Keywords Eskom ; forecasting ; hyperparameter ; machine learning ; tuning ; wind ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Subject code 006
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: Systems biology of embryonic development: Prospects for a complete understanding of the Caenorhabditis elegans embryo.

    Murray, John Isaac

    Wiley interdisciplinary reviews. Developmental biology

    2018  Volume 7, Issue 3, Page(s) e314

    Abstract: The convergence of developmental biology and modern genomics tools brings the potential for a comprehensive understanding of developmental systems. This is especially true for the Caenorhabditis elegans embryo because its small size, invariant ... ...

    Abstract The convergence of developmental biology and modern genomics tools brings the potential for a comprehensive understanding of developmental systems. This is especially true for the Caenorhabditis elegans embryo because its small size, invariant developmental lineage, and powerful genetic and genomic tools provide the prospect of a cellular resolution understanding of messenger RNA (mRNA) expression and regulation across the organism. We describe here how a systems biology framework might allow large-scale determination of the embryonic regulatory relationships encoded in the C. elegans genome. This framework consists of two broad steps: (a) defining the "parts list"-all genes expressed in all cells at each time during development and (b) iterative steps of computational modeling and refinement of these models by experimental perturbation. Substantial progress has been made towards defining the parts list through imaging methods such as large-scale green fluorescent protein (GFP) reporter analysis. Imaging results are now being augmented by high-resolution transcriptome methods such as single-cell RNA sequencing, and it is likely the complete expression patterns of all genes across the embryo will be known within the next few years. In contrast, the modeling and perturbation experiments performed so far have focused largely on individual cell types or genes, and improved methods will be needed to expand them to the full genome and organism. This emerging comprehensive map of embryonic expression and regulatory function will provide a powerful resource for developmental biologists, and would also allow scientists to ask questions not accessible without a comprehensive picture. This article is categorized under: Invertebrate Organogenesis > Worms Technologies > Analysis of the Transcriptome Gene Expression and Transcriptional Hierarchies > Gene Networks and Genomics.
    MeSH term(s) Animals ; Caenorhabditis elegans/embryology ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/metabolism ; Cell Lineage ; Gene Expression Regulation, Developmental ; Proteome/genetics ; Proteome/metabolism ; Systems Biology/methods ; Transcriptome
    Chemical Substances Proteome
    Language English
    Publishing date 2018-01-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ISSN 1759-7692
    ISSN (online) 1759-7692
    DOI 10.1002/wdev.314
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article ; Online: Silencing the alternative

    Priya Sivaramakrishnan / John Isaac Murray

    eLife, Vol

    2019  Volume 8

    Abstract: The transcription factor ztf-11 promotes neuronal differentiation by repressing other cell fates in the nematode worm C. elegans. ...

    Abstract The transcription factor ztf-11 promotes neuronal differentiation by repressing other cell fates in the nematode worm C. elegans.
    Keywords ZTF-11 ; Myt1 ; neurogenesis ; MuvB complex ; transcriptional repression ; neuronal differentiation ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2019-08-01T00:00:00Z
    Publisher eLife Sciences Publications Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article ; Online: Personalised care packages for people with rheumatoid arthritis

    Heidi Lempp / Arthur Pratt / Adam Young / Mwidimi Ndosi / Elena Nikiphorou / Mrinalini Dey / John Isaac / Amanda Busby

    RMD Open, Vol 10, Iss

    a mixed-methods study

    2024  Volume 1

    Abstract: Objectives Disease management in rheumatoid arthritis (RA) requires holistic assessment. We aimed to design personalised care packages suitable for people with RA.Methods This study was conducted using a mixed-methods approach and exploratory sequential ... ...

    Abstract Objectives Disease management in rheumatoid arthritis (RA) requires holistic assessment. We aimed to design personalised care packages suitable for people with RA.Methods This study was conducted using a mixed-methods approach and exploratory sequential design. Consensus workshops were held, involving people with RA and healthcare professionals (HCPs) treating them. Subsequently, an online survey sought views on future care packages for people with RA at relevant disease progression/stages, based on (1) results from previous quantitative data analyses (eg, socioeconomic/clinical factors), and (2) themes identified during workshops.Results Two conceptual care pathways were identified: (1) around the time of RA diagnosis, an early opportunity to influence the disease course; (2) for individuals with established RA, emphasising the importance of ‘the right MDT member at the right time’.Three care packages were suggested: (1) early care package (around RA diagnosis): introduction to MDT; (2) continuity of care package (established RA): primary/secondary providers; and (3) personalised holistic care package: integral to packages 1 and 2, implemented alongside allied health professionals.The survey received 41 responses; 82.9% agreed that people with RA need a consistent ‘early care package’ at diagnosis. 85.4% approved of additional care packages tailored to individuals’ clinical, psychological and social needs when moving to different stages of their long-term disease. Fleiss’ Kappa calculations demonstrated fair level of agreement among respondents.Conclusion Two care pathways, with three tailored care packages, were identified, with potential to improve management of people with RA. Future research will help to determine if such care packages can impact clinical (including patient-reported) outcomes.
    Keywords Medicine ; R
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Book: Principles and practice of clinical research

    Gallin, John I. / Ognibene, Frederick P.

    2007  

    Title variant Clinical research
    Author's details John I. Gallin ; Frederick P. Ognibene
    Keywords Research / methods ; Research |x methods / methods ; Medicine/Research ; Medicine/Research/Methodology
    Subject code 610.72
    Language English
    Size XVI, 430 S. : graph. Darst., 28cm
    Edition 2. ed.
    Publisher Elesevier Academic Press
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    Note Includes bibliographical references and index. - Previous ed.: London: Academic, 2002. - Formerly CIP
    HBZ-ID HT015213119
    ISBN 0-12-369440-X ; 978-0-12-369440-9
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2007 A 4128 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top