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  1. Article ; Online: Disease-modifying therapies for multiple sclerosis.

    De Angelis, Floriana / John, Nevin A / Brownlee, Wallace J

    BMJ (Clinical research ed.)

    2018  Volume 363, Page(s) k4674

    MeSH term(s) Antibodies, Monoclonal, Humanized/adverse effects ; Antibodies, Monoclonal, Humanized/therapeutic use ; Cost-Benefit Analysis ; Humans ; Immunosuppressive Agents/adverse effects ; Immunosuppressive Agents/therapeutic use ; Multiple Sclerosis/drug therapy ; Practice Guidelines as Topic
    Chemical Substances Antibodies, Monoclonal, Humanized ; Immunosuppressive Agents
    Language English
    Publishing date 2018-11-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.k4674
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.10: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Screening for urinary tract colonisation prior to corticosteroid administration in acute multiple sclerosis relapses: Validation of an updated algorithm.

    O'Herlihy, Fergus / John, Nevin A / Li, Vivien / Porter, Bernadette / Lyons, Lucy / Rakusa, Martin / Curtis, Carmel / Panicker, Jalesh N / Chataway, Jeremy

    Journal of the neurological sciences

    2019  Volume 407, Page(s) 116456

    Abstract: Introduction: To evaluate an updated algorithm in the detection of urinary tract infection (UTI) prior to high-dose corticosteroid treatment in acute relapses in multiple sclerosis (MS). This updated algorithm aimed to decrease the unnecessary use of ... ...

    Abstract Introduction: To evaluate an updated algorithm in the detection of urinary tract infection (UTI) prior to high-dose corticosteroid treatment in acute relapses in multiple sclerosis (MS). This updated algorithm aimed to decrease the unnecessary use of antibiotics, whilst maintaining accuracy and safety.
    Methods: Prospective cohort study of 471 consecutive patients with MS relapses in a hospital-based outpatient acute relapse clinic. 172 patients met exclusion criteria, leaving 299 patients for analysis. Patients underwent urine dipstick and were treated for UTI if 2 or more of: nitrites, leukocyte esterase and cloudy urine were positive. Patients with confirmed acute MS relapse were treated with high dose intravenous or oral methylprednisolone.
    Results: Significant bacteriuria (>10
    Conclusion: With an improved specificity, this updated algorithm addresses previous issues concerning the unnecessary prescription of antibiotics, whilst improving accuracy and maintaining safety.
    MeSH term(s) Adrenal Cortex Hormones/therapeutic use ; Adult ; Algorithms ; Bacteriuria/diagnosis ; Female ; Humans ; Male ; Mass Screening ; Middle Aged ; Multiple Sclerosis/drug therapy ; Prospective Studies ; Recurrence ; Sensitivity and Specificity ; Urinary Tract Infections/diagnosis
    Chemical Substances Adrenal Cortex Hormones
    Language English
    Publishing date 2019-09-16
    Publishing country Netherlands
    Document type Journal Article ; Validation Study
    ZDB-ID 80160-4
    ISSN 1878-5883 ; 0022-510X ; 0374-8642
    ISSN (online) 1878-5883
    ISSN 0022-510X ; 0374-8642
    DOI 10.1016/j.jns.2019.116456
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 308: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Longitudinal Metabolite Changes in Progressive Multiple Sclerosis: A Study of 3 Potential Neuroprotective Treatments.

    John, Nevin A / Solanky, Bhavana S / De Angelis, Floriana / Parker, Richard A / Weir, Christopher J / Stutters, Jonathan / Carrasco, Ferran Prados / Schneider, Torben / Doshi, Anisha / Calvi, Alberto / Williams, Thomas / Plantone, Domenico / Monteverdi, Anita / MacManus, David / Marshall, Ian / Barkhof, Frederik / Gandini Wheeler-Kingshott, Claudia A M / Chataway, Jeremy

    Journal of magnetic resonance imaging : JMRI

    2023  Volume 59, Issue 6, Page(s) 2192–2201

    Abstract: Background: 1: Purpose: To assess the effect on neurometabolites from three candidate drugs after 96-weeks as seen by : Study-type: Longitudinal.: Population: 108 participants with SPMS randomized to receive neuroprotective drugs amiloride [ ... ...

    Abstract Background: 1
    Purpose: To assess the effect on neurometabolites from three candidate drugs after 96-weeks as seen by
    Study-type: Longitudinal.
    Population: 108 participants with SPMS randomized to receive neuroprotective drugs amiloride [mean age 55.4 (SD 7.4), 61% female], fluoxetine [55.6 (6.6), 71%], riluzole [54.6 (6.3), 68%], or placebo [54.8 (7.9), 67%].
    Field strength/sequence: 3-Tesla. Chemical-shift-imaging 2D-point-resolved-spectroscopy (PRESS), 3DT1.
    Assessment: Brain metabolites in normal appearing white matter (NAWM) and gray matter (GM), brain volume, lesion load, nine-hole peg test (9HPT), and paced auditory serial addition test were measured at baseline and at 96-weeks.
    Statistical tests: Paired t-test was used to analyze metabolite changes in the placebo arm over 96-weeks. Metabolite differences between treatment arms and placebo; and associations between baseline metabolites and upper limb function/information processing speed at 96-weeks assessed using multiple linear regression models. P-value<0.05 was considered statistically significant.
    Results: In the placebo arm, tCho increased in GM (mean difference = -0.32 IU) but decreased in NAWM (mean difference = 0.13 IU). Compared to placebo, in the fluoxetine arm, mIns/tCr was lower (β = -0.21); in the riluzole arm, GM Glx (β = -0.25) and Glx/tCr (β = -0.29) were reduced. Baseline tNAA(β = 0.22) and tNAA/tCr (β = 0.23) in NAWM were associated with 9HPT scores at 96-weeks.
    Data conclusion: 1
    Level of evidence: 1 TECHNICAL EFFICACY: Stage 4.
    MeSH term(s) Humans ; Female ; Male ; Middle Aged ; Neuroprotective Agents ; Longitudinal Studies ; Multiple Sclerosis, Chronic Progressive/diagnostic imaging ; Multiple Sclerosis, Chronic Progressive/drug therapy ; Multiple Sclerosis, Chronic Progressive/metabolism ; Riluzole ; Adult ; Fluoxetine ; Brain/diagnostic imaging ; Brain/metabolism ; Inositol/metabolism ; Creatine/metabolism ; Aspartic Acid/analogs & derivatives ; Aspartic Acid/metabolism ; Choline/metabolism ; Magnetic Resonance Spectroscopy ; Proton Magnetic Resonance Spectroscopy ; Glutamine/metabolism ; Glutamic Acid/metabolism ; Magnetic Resonance Imaging/methods ; Gray Matter/diagnostic imaging ; Gray Matter/metabolism
    Chemical Substances Neuroprotective Agents ; Riluzole (7LJ087RS6F) ; Fluoxetine (01K63SUP8D) ; Inositol (4L6452S749) ; Creatine (MU72812GK0) ; Aspartic Acid (30KYC7MIAI) ; Choline (N91BDP6H0X) ; N-acetylaspartate (997-55-7) ; Glutamine (0RH81L854J) ; Glutamic Acid (3KX376GY7L)
    Language English
    Publishing date 2023-10-03
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1146614-5
    ISSN 1522-2586 ; 1053-1807
    ISSN (online) 1522-2586
    ISSN 1053-1807
    DOI 10.1002/jmri.29017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 236: Show issues

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