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  1. AU="John Alake"
  2. AU="McCarty, John M"
  3. AU="Rieger, Dirk"
  4. AU="Maria Camilla Cipriani"
  5. AU="Yu, Mo-Sang"
  6. AU="Arshad, Hassaan Bin"
  7. AU="Schwänke, Ulf"
  8. AU=Martin Rick
  9. AU="Narges ROUSTAEI"
  10. AU="Alsaady, Ammar"
  11. AU=Guo Zhinian
  12. AU=Dho Sascha E
  13. AU="Santiso-Quiñones, Gustavo"
  14. AU="Donovan, Lois E"
  15. AU="Xiong, Zhuo-Chao"
  16. AU="Mu, Dezhi"
  17. AU="Kaiser, Steffen"
  18. AU=Garlepp M J
  19. AU=Yang Zhenwei
  20. AU="Guillot, Loic"
  21. AU=Pocrnic Ivan
  22. AU="Rackova, Sylva"
  23. AU="Jordan Denizeau"
  24. AU="Alexandra J. Corbett"
  25. AU="Felderman, Howard E"
  26. AU="Chen, Fuxing"
  27. AU="Soekadar, Surjo R"
  28. AU="Pagotto, Sara"
  29. AU="Dominguez, Georgina Cutillas"
  30. AU=Barabutis Nektarios
  31. AU="Rumalla, Kavelin"
  32. AU=Meares Gordon P.
  33. AU="Gawron, Lori M"
  34. AU=Guettari Moez
  35. AU=Ma Xingcong
  36. AU="Greene, Kerrie" AU="Greene, Kerrie"
  37. AU="Adebayo, Abe"
  38. AU=Amoako Yaw Ampem
  39. AU="Khanna, Sakshum"

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  1. Artikel ; Online: Allanblackia floribunda Seed Extract Attenuates the Ethanol-Induced Gastric Ulcer in Rats via the Inhibition of TNF-α and INF-γ Levels and Modulation in the Expression of Ki67 Protein

    Francis Ackah Armah / Isaac Tabiri Henneh / John Alake / Wisdom Ahlidja / Benjamin Amoani / Eric Gyamerah Ofori / Baffour Asante-Kyei / Gbadamosi Ismail Temitayo / Christian Kweku Adokoh

    BioMed Research International, Vol

    2021  Band 2021

    Abstract: Allanblackia floribunda has been used to treat an upset stomach in African traditional medicine, but its efficacy and safety have not been scientifically studied. The present research is aimed at assessing the antiulcer property of the seed extract of ... ...

    Abstract Allanblackia floribunda has been used to treat an upset stomach in African traditional medicine, but its efficacy and safety have not been scientifically studied. The present research is aimed at assessing the antiulcer property of the seed extract of the plant to validate its traditional claim. Rats were pretreated with three doses of aqueous extract of A. floribunda (AFE) at 30, 100, and 300 mg/kg or omeprazole 10 mg/kg for 1 hr before the acute gastric ulcer was induced by oral administration of 5 mL/kg of 98% ethanol. The animals were sacrificed under anesthesia, and the stomach and blood were collected. The gross histology of the stomach, percentage protection conferred by the treatment, gastric pH, and serum TNF-α and INF-γ were assessed as well as the expression of Ki67 antigens. The antioxidant properties as well as the acute toxicity profile of the plant extract were also assessed. The results show that A. floribunda conferred significant protection on the rats against gastric ulceration with % protection of 46.15, 57.69, and 65.38 for AFE 30, 100, and 300 mg/kg, respectively, as well as 69.23% for omeprazole 10 mg/kg. The plant extract caused marked reductions in gastric pH, TNF-α, and INF-γ with statistical significance (p<0.001) for AFE 300 mg/kg and omeprazole 10 mg/kg. Also, the plant showed good antioxidant activity comparable to gallic acid. Furthermore, the plant extract modulated the expression of Ki67 antigens. All animals survived the 14-day delayed toxicity test with no significant differences in physical, hematological, and biochemical parameters between rats orally administered with supratherapeutic doses of AFE (5000 mg/kg) or normal saline. The study established that the gastroprotective effect of the seed extract of A. floribunda is attributable to its antisecretory, antioxidant, and anti-inflammatory properties. Additionally, the plant was found to promote ulcer healing via the modulation of the expression Ki67 and was safe at supratherapeutic doses.
    Schlagwörter Medicine ; R
    Thema/Rubrik (Code) 630
    Sprache Englisch
    Erscheinungsdatum 2021-01-01T00:00:00Z
    Verlag Hindawi Limited
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Antidepressant and Anxiolytic Effects and Subacute Toxicity of the Aerial Parts of Psychotria ankasensis J.B.Hall (Rubiaceae) in Murine Models

    Francis Ackah Armah / Isaac Tabiri Henneh / Isaac Kingsley Amponsah / Robert Peter Biney / Fynn Malcolm / John Alake / Wisdom Ahlidja / Mustapha Abubakar Ahmed / Christian Kweku Adokoh / Genevieve Etornam Adukpo / Desmond Omane Acheampong / Peter K. Gathumbi

    Evidence-Based Complementary and Alternative Medicine, Vol

    2021  Band 2021

    Abstract: Background. The present study aimed at validating the traditional use and toxicity profile of a methanolic extract of the aerial parts of Psychotria ankasensis in alleviating depression and anxiety disorders. Method. The antidepressant effect of ... ...

    Abstract Background. The present study aimed at validating the traditional use and toxicity profile of a methanolic extract of the aerial parts of Psychotria ankasensis in alleviating depression and anxiety disorders. Method. The antidepressant effect of methanolic extract of Psychotria ankasensis (PAE 30, 100, and 300 mg/kg, p.o.) was assessed in mice using the forced swim test (FST) and the tail suspension test (TST). The plant's anxiolytic potential was also evaluated in mice using the elevated plus-maze (EPM) and the open field tests (OFT). The subacute toxicity was assessed via oral administration of PAE at doses of 100, 300, and 1000 mg/kg in rats for 28 days. Results. PAE 100 and 300 mg/kg showed antidepressant-like properties by significantly (at least p<0.05) decreasing the frequency and duration of immobility in FST and TST. PAE (100 and 300 mg/kg) also showed a significant (at least p<0.05) anxiolytic effect in both EPM and OFT. In the EPM test, Emax for PAE and diazepam were 92.52 ± 40.11% and 85.95 ± 45.92%, respectively, whereas Emax was approximately 100% for both test drugs in the OFT. Subacute administration of PAE did not reveal any toxic effects with respect to organ weight index, haematological, serum biochemical, and histopathological parameters. Conclusions. Methanolic extract of P. ankasensis exhibited antidepressant-like and anxiolytic-like effects devoid of significant toxicity at the doses tested in murine models.
    Schlagwörter Other systems of medicine ; RZ201-999
    Thema/Rubrik (Code) 630
    Sprache Englisch
    Erscheinungsdatum 2021-01-01T00:00:00Z
    Verlag Hindawi Limited
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

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