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  1. AU="John F. Whitesides"
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  4. AU="Joseph R. Francica"
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  1. Article ; Online: Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations

    Wilton B. Williams / Jinsong Zhang / Chuancang Jiang / Nathan I. Nicely / Daniela Fera / Kan Luo / M. Anthony Moody / Hua-Xin Liao / S. Munir Alam / Thomas B. Kepler / Akshaya Ramesh / Kevin Wiehe / James A. Holland / Todd Bradley / Nathan Vandergrift / Kevin O. Saunders / Robert Parks / Andrew Foulger / Shi-Mao Xia /
    Mattia Bonsignori / David C. Montefiori / Mark Louder / Amanda Eaton / Sampa Santra / Richard Scearce / Laura Sutherland / Amanda Newman / Hilary Bouton-Verville / Cindy Bowman / Howard Bomze / Feng Gao / Dawn J. Marshall / John F. Whitesides / Xiaoyan Nie / Garnett Kelsoe / Steven G. Reed / Christopher B. Fox / Kim Clary / Marguerite Koutsoukos / David Franco / John R. Mascola / Stephen C. Harrison / Barton F. Haynes / Laurent Verkoczy

    Nature Communications, Vol 8, Iss 1, Pp 1-

    2017  Volume 20

    Abstract: An efficient HIV-1 vaccine will likely depend on eliciting broadly neutralizing antibodies (bnAb). Here the authors analyze the B cell repertoire in macaques and knock-in mice in response to sequential immunization with Env variants that induce a bnAb ... ...

    Abstract An efficient HIV-1 vaccine will likely depend on eliciting broadly neutralizing antibodies (bnAb). Here the authors analyze the B cell repertoire in macaques and knock-in mice in response to sequential immunization with Env variants that induce a bnAb targeting the CD4-binding site of Env in a HIV-1 infected individual.
    Keywords Science ; Q
    Language English
    Publishing date 2017-11-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Polyclonal B cell differentiation and loss of gastrointestinal tract germinal centers in the earliest stages of HIV-1 infection.

    Marc C Levesque / M Anthony Moody / Kwan-Ki Hwang / Dawn J Marshall / John F Whitesides / Joshua D Amos / Thaddeus C Gurley / Sallie Allgood / Benjamin B Haynes / Nathan A Vandergrift / Steven Plonk / Daniel C Parker / Myron S Cohen / Georgia D Tomaras / Paul A Goepfert / George M Shaw / Jörn E Schmitz / Joseph J Eron / Nicholas J Shaheen /
    Charles B Hicks / Hua-Xin Liao / Martin Markowitz / Garnett Kelsoe / David M Margolis / Barton F Haynes

    PLoS Medicine, Vol 6, Iss 7, p e

    2009  Volume 1000107

    Abstract: The antibody response to HIV-1 does not appear in the plasma until approximately 2-5 weeks after transmission, and neutralizing antibodies to autologous HIV-1 generally do not become detectable until 12 weeks or more after transmission. Moreover, levels ... ...

    Abstract The antibody response to HIV-1 does not appear in the plasma until approximately 2-5 weeks after transmission, and neutralizing antibodies to autologous HIV-1 generally do not become detectable until 12 weeks or more after transmission. Moreover, levels of HIV-1-specific antibodies decline on antiretroviral treatment. The mechanisms of this delay in the appearance of anti-HIV-1 antibodies and of their subsequent rapid decline are not known. While the effect of HIV-1 on depletion of gut CD4(+) T cells in acute HIV-1 infection is well described, we studied blood and tissue B cells soon after infection to determine the effect of early HIV-1 on these cells.In human participants, we analyzed B cells in blood as early as 17 days after HIV-1 infection, and in terminal ileum inductive and effector microenvironments beginning at 47 days after infection. We found that HIV-1 infection rapidly induced polyclonal activation and terminal differentiation of B cells in blood and in gut-associated lymphoid tissue (GALT) B cells. The specificities of antibodies produced by GALT memory B cells in acute HIV-1 infection (AHI) included not only HIV-1-specific antibodies, but also influenza-specific and autoreactive antibodies, indicating very early onset of HIV-1-induced polyclonal B cell activation. Follicular damage or germinal center loss in terminal ileum Peyer's patches was seen with 88% of follicles exhibiting B or T cell apoptosis and follicular lysis.Early induction of polyclonal B cell differentiation, coupled with follicular damage and germinal center loss soon after HIV-1 infection, may explain both the high rate of decline in HIV-1-induced antibody responses and the delay in plasma antibody responses to HIV-1. Please see later in the article for Editors' Summary.
    Keywords Medicine ; R
    Subject code 570
    Language English
    Publishing date 2009-07-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: H3N2 influenza infection elicits more cross-reactive and less clonally expanded anti-hemagglutinin antibodies than influenza vaccination.

    M Anthony Moody / Ruijun Zhang / Emmanuel B Walter / Christopher W Woods / Geoffrey S Ginsburg / Micah T McClain / Thomas N Denny / Xi Chen / Supriya Munshaw / Dawn J Marshall / John F Whitesides / Mark S Drinker / Joshua D Amos / Thaddeus C Gurley / Joshua A Eudailey / Andrew Foulger / Katherine R DeRosa / Robert Parks / R Ryan Meyerhoff /
    Jae-Sung Yu / Daniel M Kozink / Brice E Barefoot / Elizabeth A Ramsburg / Surender Khurana / Hana Golding / Nathan A Vandergrift / S Munir Alam / Georgia D Tomaras / Thomas B Kepler / Garnett Kelsoe / Hua-Xin Liao / Barton F Haynes

    PLoS ONE, Vol 6, Iss 10, p e

    2011  Volume 25797

    Abstract: During the recent H1N1 influenza pandemic, excess morbidity and mortality was seen in young but not older adults suggesting that prior infection with influenza strains may have protected older subjects. In contrast, a history of recent seasonal trivalent ...

    Abstract During the recent H1N1 influenza pandemic, excess morbidity and mortality was seen in young but not older adults suggesting that prior infection with influenza strains may have protected older subjects. In contrast, a history of recent seasonal trivalent vaccine in younger adults was not associated with protection.To study hemagglutinin (HA) antibody responses in influenza immunization and infection, we have studied the day 7 plasma cell repertoires of subjects immunized with seasonal trivalent inactivated influenza vaccine (TIV) and compared them to the plasma cell repertoires of subjects experimentally infected (EI) with influenza H3N2 A/Wisconsin/67/2005. The majority of circulating plasma cells after TIV produced influenza-specific antibodies, while most plasma cells after EI produced antibodies that did not react with influenza HA. While anti-HA antibodies from TIV subjects were primarily reactive with single or few HA strains, anti-HA antibodies from EI subjects were isolated that reacted with multiple HA strains. Plasma cell-derived anti-HA antibodies from TIV subjects showed more evidence of clonal expansion compared with antibodies from EI subjects. From an H3N2-infected subject, we isolated a 4-member clonal lineage of broadly cross-reactive antibodies that bound to multiple HA subtypes and neutralized both H1N1 and H3N2 viruses. This broad reactivity was not detected in post-infection plasma suggesting this broadly reactive clonal lineage was not immunodominant in this subject.The presence of broadly reactive subdominant antibody responses in some EI subjects suggests that improved vaccine designs that make broadly reactive antibody responses immunodominant could protect against novel influenza strains.
    Keywords Medicine ; R ; Science ; Q
    Subject code 570
    Language English
    Publishing date 2011-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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