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Article ; Online: Pediatric thoracic mass lesions

Gunes Orman / Prakash Masand / John Hicks / Thierry A.G.M. Huisman / R. Paul Guillerman

European Journal of Radiology Open, Vol 7, Iss , Pp 100240- (2020)

Beyond the common

2020

Abstract: Thoracic mass lesions can be categorized as originating in one of the three major compartments: a) chest wall and pleura, b) lung parenchyma and airways, c) mediastinum. While some of these, such as lymphoma, are common in both children and adults, ... ...

Abstract	Thoracic mass lesions can be categorized as originating in one of the three major compartments: a) chest wall and pleura, b) lung parenchyma and airways, c) mediastinum. While some of these, such as lymphoma, are common in both children and adults, others are rare and unique to childhood. The goal of this review is to familiarize radiologists with unusual but distinctive mass lesions of the pediatric thorax.
Keywords	Pediatric ; Chest ; Thorax ; Mass lesion ; Neoplasm ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Pedestrians and E-Scooters

Owain James / J I Swiderski / John Hicks / Denis Teoman / Ralph Buehler

Sustainability, Vol 11, Iss 20, p

An Initial Look at E-Scooter Parking and Perceptions by Riders and Non-Riders

2019 Volume 5591

Abstract: Since 2018, pedestrians in many U.S. cities have been sharing sidewalk space with dockless shared e-scooters. The introduction of e-scooters has received pushback from pedestrians. Complaints reported in the media include e-scooters blocking walkways and ...

Abstract	Since 2018, pedestrians in many U.S. cities have been sharing sidewalk space with dockless shared e-scooters. The introduction of e-scooters has received pushback from pedestrians. Complaints reported in the media include e-scooters blocking walkways and sidewalks when parked illegally as well as safety concerns from pedestrians who do not feel safe around moving e-scooters. However, little is known beyond a few initial studies on e-scooter parking and anecdotes about pedestrian perceptions of e-scooter safety. Our case study from Rosslyn, Virginia, helps shed light on these two issues. First, we conducted a survey of 181 e-scooter riders and non-riders asking about their perceived safety around riders of e-scooters and experiences of sidewalks blocked by e-scooters. We found highly divergent responses about safety and sidewalk blocking perceptions from riders and non-riders. Second, we conducted an observational study of 606 parked e-scooters along three mixed-use corridors in Rosslyn to investigate the relationship between the built environment and e-scooter parking. We found that 16% of 606 observed e-scooters were not parked properly and 6% (36 e-scooters) were blocking pedestrian right-of-way. Moreover, our survey showed that e-scooter trips in Rosslyn replaced trips otherwise taken by Uber, Lyft, or a taxi (39%), foot (33%), bicycle (12%), bus (7%), or car (7%).
Keywords	e-scooters ; pedestrians ; parking ; blocked sidewalk ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	380
Language	English
Publishing date	2019-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Primitive Myxoid Mesenchymal Tumor of Infancy Involving Chest Wall in an Infant: A Case Report and Clinicopathologic Correlation.

Foster, Jennifer H / Vasudevan, Sanjeev A / John Hicks, M / Schady, Deborah / Chintagumpala, Murali

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society

2016 Volume 19, Issue 3, Page(s) 244–248

Abstract: Primitive myxoid mesenchymal tumor of infancy (PMMTI) is a rare mesenchymal tumor of early childhood characterized by aggressive local infiltration of surrounding structures, rare metastases, and poor response to chemotherapy. Surgery alone appears to be ...

Abstract	Primitive myxoid mesenchymal tumor of infancy (PMMTI) is a rare mesenchymal tumor of early childhood characterized by aggressive local infiltration of surrounding structures, rare metastases, and poor response to chemotherapy. Surgery alone appears to be the most effective treatment given the lack of predilection for metastasis and poor response to traditional chemotherapy. Below we report a patient with PMMTI successfully managed with surgery and observation and summarize the existing literature on histopathologic features and treatment of this lesion.
MeSH term(s)	Female ; Humans ; Infant ; Sarcoma/pathology ; Sarcoma/surgery ; Soft Tissue Neoplasms/pathology ; Soft Tissue Neoplasms/surgery ; Thoracic Wall/pathology ; Thoracic Wall/surgery
Language	English
Publishing date	2016-05
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1463498-3
ISSN	1615-5742 ; 1093-5266
ISSN (online)	1615-5742
ISSN	1093-5266
DOI	10.2350/15-05-1644-CR.1
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Article ; Online: Image-Based Environmental Monitoring Sensor Application Using an Embedded Wireless Sensor Network

Jeongyeup Paek / John Hicks / Sharon Coe / Ramesh Govindan

Sensors, Vol 14, Iss 9, Pp 15981-

2014 Volume 16002

Abstract: This article discusses the experiences from the development and deployment of two image-based environmental monitoring sensor applications using an embedded wireless sensor network. Our system uses low-power image sensors and the Tenet general purpose ... ...

Abstract	This article discusses the experiences from the development and deployment of two image-based environmental monitoring sensor applications using an embedded wireless sensor network. Our system uses low-power image sensors and the Tenet general purpose sensing system for tiered embedded wireless sensor networks. It leverages Tenet’s built-in support for reliable delivery of high rate sensing data, scalability and its flexible scripting language, which enables mote-side image compression and the ease of deployment. Our first deployment of a pitfall trap monitoring application at the James San Jacinto Mountain Reserve provided us with insights and lessons learned into the deployment of and compression schemes for these embedded wireless imaging systems. Our three month-long deployment of a bird nest monitoring application resulted in over 100,000 images collected from a 19-camera node network deployed over an area of 0.05 square miles, despite highly variable environmental conditions. Our biologists found the on-line, near-real-time access to images to be useful for obtaining data on answering their biological questions.
Keywords	wireless sensor networks ; image sensors ; sensor applications ; tenet ; rcrt,cyclops ; environmental monitoring ; Technology (General) ; T1-995 ; Technology ; T ; Analytical chemistry ; QD71-142 ; Chemistry ; QD1-999 ; Science ; Q
Language	English
Publishing date	2014-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Assessing the impact of vulnerability on perceptions of social cohesion in the context of community resilience to disaster in the Blue Mountains

Redshaw, Sarah / John Hicks / Marion McCutcheon / Oliver Burmeister / Valerie Ingham

Australian journal of rural health. 2018 Feb., v. 26, no. 1

2018

Abstract: OBJECTIVE: To assess the impact of network communications, community participation and elements of vulnerability on the perception of social cohesiveness in the Blue Mountains local government area (Blue Mountains LGA). DESIGN: A questionnaire was ... ...

Abstract	OBJECTIVE: To assess the impact of network communications, community participation and elements of vulnerability on the perception of social cohesiveness in the Blue Mountains local government area (Blue Mountains LGA). DESIGN: A questionnaire was administered to residents of the Blue Mountains LGA. Econometric analysis of the resulting data was undertaken. SETTING: Blue Mountains LGA, Australia. PARTICIPANTS: One thousand one hundred and three residents of the Blue Mountains LGA responded to the questionnaire. MAIN OUTCOME MEASURE(S): The responses enabled the construction of variables measuring individual perceptions of community cohesiveness, their network communications and community participation. Demographic data and data on the vulnerabilities of individuals were also collected. RESULTS: The data were used in an econometric model which identified that network communications and community participation impacted positively on perceptions of social cohesiveness while vulnerability factors had a negative impact. CONCLUSIONS: Remedial action to build community cohesiveness and network communications can be expected to have a positive impact on social cohesiveness. In developing strategies to build community cohesiveness and network communication, particular care needs to be taken to ensure the inclusion of those members of society who are regarded as the most vulnerable.
Keywords	cohesion ; community service ; econometric models ; local government ; questionnaires ; rural health ; social cohesion ; society ; Australia
Language	English
Dates of publication	2018-02
Size	p. 14-19.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	2069573-1
ISSN	1440-1584 ; 1038-5282
ISSN (online)	1440-1584
ISSN	1038-5282
DOI	10.1111/ajr.12377
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The Role of FAS Receptor Methylation in Osteosarcoma Metastasis

Jiayi M. Sun / Wing-Yuk Chow / Gufeng Xu / M. John Hicks / Manjula Nakka / Jianhe Shen / Patrick Kwok Shing Ng / Aaron M. Taylor / Alexander Yu / Jason E. Farrar / Donald A. Barkauskas / Richard Gorlick / Jaime M. Guidry Auvil / Daniela Gerhard / Paul Meltzer / Rudy Guerra / Tsz-Kwong Man / Ching C. Lau / on behalf of the TARGET Osteosarcoma Consortium

International Journal of Molecular Sciences, Vol 24, Iss 12155, p

2023 Volume 12155

Abstract: Osteosarcoma is the most frequent primary malignant bone tumor with an annual incidence of about 400 cases in the United States. Osteosarcoma primarily metastasizes to the lungs, where FAS ligand (FASL) is constitutively expressed. The interaction of ... ...

Abstract	Osteosarcoma is the most frequent primary malignant bone tumor with an annual incidence of about 400 cases in the United States. Osteosarcoma primarily metastasizes to the lungs, where FAS ligand (FASL) is constitutively expressed. The interaction of FASL and its cell surface receptor, FAS, triggers apoptosis in normal cells; however, this function is altered in cancer cells. DNA methylation has previously been explored as a mechanism for altering FAS expression, but no variability was identified in the CpG island (CGI) overlapping the promoter. Analysis of an expanded region, including CGI shores and shelves, revealed high variability in the methylation of certain CpG sites that correlated significantly with FAS mRNA expression in a negative manner. Bisulfite sequencing revealed additional CpG sites, which were highly methylated in the metastatic LM7 cell line but unmethylated in its parental non-metastatic SaOS-2 cell line. Treatment with the demethylating agent, 5-azacytidine, resulted in a loss of methylation in CpG sites located within the FAS promoter and restored FAS protein expression in LM7 cells, resulting in reduced migration. Orthotopic implantation of 5-azacytidine treated LM7 cells into severe combined immunodeficient mice led to decreased lung metastases. These results suggest that DNA methylation of CGI shore sites may regulate FAS expression and constitute a potential target for osteosarcoma therapy, utilizing demethylating agents currently approved for the treatment of other cancers.
Keywords	osteosarcoma ; FAS receptor ; DNA methylation ; 5-azacytidine ; prognosis ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	570
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Nephron Progenitor But Not Stromal Progenitor Cells Give Rise to Wilms Tumors in Mouse Models with β-Catenin Activation or Wt1 Ablation and Igf2 Upregulation

Le Huang / Sharada Mokkapati / Qianghua Hu / E. Cristy Ruteshouser / M. John Hicks / Vicki Huff

Neoplasia : An International Journal for Oncology Research, Vol 18, Iss 2, Pp 71-

2016 Volume 81

Abstract: Wilms tumor, a common childhood tumor of the kidney, is thought to arise from undifferentiated renal mesenchyme. Variable tumor histology and the identification of tumor subsets displaying different gene expression profiles suggest that tumors may arise ... ...

Abstract	Wilms tumor, a common childhood tumor of the kidney, is thought to arise from undifferentiated renal mesenchyme. Variable tumor histology and the identification of tumor subsets displaying different gene expression profiles suggest that tumors may arise at different stages of mesenchyme differentiation and that this ontogenic variability impacts tumor pathology, biology, and clinical outcome. To test the tumorigenic potential of different cell types in the developing kidney, we used kidney progenitor-specific Cre recombinase alleles to introduce Wt1 and Ctnnb1 mutations, two alterations observed in Wilms tumor, into embryonic mouse kidney, with and without biallelic Igf2 expression, another alteration that is observed in a majority of tumors. Use of a Cre allele that targets nephron progenitors to introduce a Ctnnb1 mutation that stabilizes β-catenin resulted in the development of tumors with a predominant epithelial histology and a gene expression profile in which genes characteristic of early renal mesenchyme were not expressed. Nephron progenitors with Wt1 ablation and Igf2 biallelic expression were also tumorigenic but displayed a more triphasic histology and expressed early metanephric mesenchyme genes. In contrast, the targeting of these genetic alterations to stromal progenitors did not result in tumors. These data demonstrate that committed nephron progenitors can give rise to Wilms tumors and that committed stromal progenitors are less tumorigenic, suggesting that human Wilms tumors that display a predominantly stromal histology arise from mesenchyme before commitment to a stromal lineage.
Keywords	Medicine ; R ; Internal medicine ; RC31-1245 ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282
Subject code	616
Publishing date	2016-02-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: MYCN-driven fatty acid uptake is a metabolic vulnerability in neuroblastoma

Nature Communications, Vol 13, Iss 1, Pp 1-

2022 Volume 17

Abstract: Half of high-risk neuroblastoma patients have MYCN amplification. Here, the authors show that MYCN induces fatty acid uptake and synthesis to support neuroblastoma and inhibition of a fatty acid transporter impairs tumor progression in preclinical models. ...

Abstract	Half of high-risk neuroblastoma patients have MYCN amplification. Here, the authors show that MYCN induces fatty acid uptake and synthesis to support neuroblastoma and inhibition of a fatty acid transporter impairs tumor progression in preclinical models.
Keywords	Science ; Q
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Succession Planning in Australian Farming

John Hicks / Richard Sappey / Parikshit Basu / Deirdre Keogh / Rakesh Gupta

Australasian Accounting, Business and Finance Journal, Vol 6, Iss 4, Pp 94-

2012 Volume 110

Abstract: The theme of this paper is that succession planning in Australian farming is under-developed.It may be linked to economic and social change which suggests that farmers need to adapt togenerational change but this is being resisted or ignored. The ... ...

Abstract	The theme of this paper is that succession planning in Australian farming is under-developed.It may be linked to economic and social change which suggests that farmers need to adapt togenerational change but this is being resisted or ignored. The implications of this are the slowdecline of family farming, a poor transfer of skills and knowledge to subsequent generationsof farmers in some parts of the agricultural sector and the potential for an extension of thefinancial services industry to develop a more effective raft of succession planning measuresto mitigate the effects of a traditional approach to succession in agriculture.
Keywords	Succession planning ; farming ; Australia ; food security ; Business ; HF5001-6182 ; Commerce ; HF1-6182 ; Social Sciences ; H ; DOAJ:Business and Management ; DOAJ:Business and Economics
Language	English
Publishing date	2012-11-01T00:00:00Z
Publisher	University of Wollongong
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: CHAF1A Blocks Neuronal Differentiation and Promotes Neuroblastoma Oncogenesis via Metabolic Reprogramming

Advanced Science, Vol 8, Iss 19, Pp n/a-n/a (2021)

2021

Abstract: Abstract Neuroblastoma (NB) arises from oncogenic disruption of neural crest (NC) differentiation. Treatment with retinoic acid (RA) to induce differentiation has improved survival in some NB patients, but not all patients respond, and most NBs ... ...

Abstract	Abstract Neuroblastoma (NB) arises from oncogenic disruption of neural crest (NC) differentiation. Treatment with retinoic acid (RA) to induce differentiation has improved survival in some NB patients, but not all patients respond, and most NBs eventually develop resistance to RA. Loss of the chromatin modifier chromatin assembly factor 1 subunit p150 (CHAF1A) promotes NB cell differentiation; however, the mechanism by which CHAF1A drives NB oncogenesis has remained unexplored. This study shows that CHAF1A gain‐of‐function supports cell malignancy, blocks neuronal differentiation in three models (zebrafish NC, human NC, and human NB), and promotes NB oncogenesis. Mechanistically, CHAF1A upregulates polyamine metabolism, which blocks neuronal differentiation and promotes cell cycle progression. Targeting polyamine synthesis promotes NB differentiation and enhances the anti‐tumor activity of RA. The authors' results provide insight into the mechanisms that drive NB oncogenesis and suggest a rapidly translatable therapeutic approach (DFMO plus RA) to enhance the clinical efficacy of differentiation therapy in NB patients.
Keywords	CHAF1A ; metabolism ; neural crest differentiation ; neuroblastoma ; Science ; Q
Subject code	571
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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