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  1. Article ; Online: Phylogeny of Yellow Fever Virus, Uganda, 2016

    Holly R. Hughes / John Kayiwa / Eric C. Mossel / Julius Lutwama / J. Erin Staples / Amy J. Lambert

    Emerging Infectious Diseases, Vol 24, Iss 8, Pp 1598-

    2018  Volume 1599

    Abstract: In April 2016, a yellow fever outbreak was detected in Uganda. Removal of contaminating ribosomal RNA in a clinical sample improved the sensitivity of next-generation sequencing. Molecular analyses determined the Uganda yellow fever outbreak was distinct ...

    Abstract In April 2016, a yellow fever outbreak was detected in Uganda. Removal of contaminating ribosomal RNA in a clinical sample improved the sensitivity of next-generation sequencing. Molecular analyses determined the Uganda yellow fever outbreak was distinct from the concurrent yellow fever outbreak in Angola, improving our understanding of yellow fever epidemiology.
    Keywords Suggested citation for this article: Hughes HR ; Kayiwa J ; Mossel EC ; Lutwama J ; Staples JE ; Lambert AJ. Phylogeny of yellow fever virus ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
    Language English
    Publishing date 2018-08-01T00:00:00Z
    Publisher Centers for Disease Control and Prevention
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Main Routes of Entry and Genomic Diversity of SARS-CoV-2, Uganda

    Daniel Lule Bugembe / John Kayiwa / My V.T. Phan / Phiona Tushabe / Stephen Balinandi / Beatrice Dhaala / Jonas Lexow / Henry Mwebesa / Jane Aceng / Henry Kyobe / Deogratius Ssemwanga / Julius Lutwama / Pontiano Kaleebu / Matthew Cotten

    Emerging Infectious Diseases, Vol 26, Iss 10, Pp 2411-

    2020  Volume 2415

    Abstract: We established rapid local viral sequencing to document the genomic diversity of severe acute respiratory syndrome coronavirus 2 entering Uganda. Virus lineages closely followed the travel origins of infected persons. Our sequence data provide an ... ...

    Abstract We established rapid local viral sequencing to document the genomic diversity of severe acute respiratory syndrome coronavirus 2 entering Uganda. Virus lineages closely followed the travel origins of infected persons. Our sequence data provide an important baseline for tracking any further transmission of the virus throughout the country and region.
    Keywords COVID-19 ; 2019 novel coronavirus disease ; SARS-CoV-2 ; severe acute respiratory syndrome coronavirus 2 ; viruses ; respiratory infections ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216 ; covid19
    Language English
    Publishing date 2020-10-01T00:00:00Z
    Publisher Centers for Disease Control and Prevention
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  3. Article ; Online: Rapid Replacement of SARS-CoV-2 Variants by Delta and Subsequent Arrival of Omicron, Uganda, 2021

    Nicholas Bbosa / Deogratius Ssemwanga / Hamidah Namagembe / Ronald Kiiza / Jocelyn Kiconco / John Kayiwa / Tom Lutalo / Julius Lutwama / Alfred Ssekagiri / Isaac Ssewanyana / Susan Nabadda / Henry Kyobe-Bbosa / Jennifer Giandhari / Sureshnee Pillay / Upasana Ramphal / Yajna Ramphal / Yeshnee Naidoo / Derek Tshiabuila / Houriiyah Tegally /
    Emmanuel J. San / Eduan Wilkinson / Tulio de Oliveira / Pontiano Kaleebu

    Emerging Infectious Diseases, Vol 28, Iss 5, Pp 1021-

    2022  Volume 1025

    Abstract: Genomic surveillance in Uganda showed rapid replacement of severe acute respiratory syndrome coronavirus 2 over time by variants, dominated by Delta. However, detection of the more transmissible Omicron variant among travelers and increasing community ... ...

    Abstract Genomic surveillance in Uganda showed rapid replacement of severe acute respiratory syndrome coronavirus 2 over time by variants, dominated by Delta. However, detection of the more transmissible Omicron variant among travelers and increasing community transmission highlight the need for near–real-time genomic surveillance and adherence to infection control measures to prevent future pandemic waves.
    Keywords coronavirus disease ; COVID-19 ; severe acute respiratory coronavirus 2 ; SARS-CoV-2 ; coronaviruses ; viruses ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher Centers for Disease Control and Prevention
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Laboratory capacity assessments in 25 African countries at high risk of yellow fever, August-December 2018

    Barbara Wilmot Johnson / Maurice Demanou / Gamou Fall / Jean-Luc Betoulle / Celestina Obiekea / Alison Jane Basile / Cristina Domingo / Christin Goodman / Eric Mossel / Chantal Reusken / Erin Staples / Joana Filipa Machado de Morais / Zoraima Neto / Paula Paixão / Yves Eric Denon / Mariette Glitho / José Mahinou / Therese Kagone / Emmanuel Nakoune /
    Kadidja Gamougam / Elisabeth Pukuta Simbu / Steve Ahuka / Jean-Vivien Mombouli / Cynthia Goma-Nkoua / Edgard Valery Adjogoua / Adamu Tayachew / Berhane Beyene / Bakary Sanneh / Modou Lamin Jarju / Alphonse Mendy / Dodzi Kofi Amelor / Lawrence Ofosu-Appiah / David Opare / Lorreta Antwi / Rexford Adade / N'Faly Magassouba / Sabado Fernandes Gomes / Samson Limbaso / Joel Lutomiah / Burgess Gbelee Jr / John Dogba / Issa Cisse / Zakou Idde / Chikwe Ihekweazu / Nwando Mba / Ousmane Faye / Oumar Faye / Amadou Alpha Sall / Zikan Koroma / Manuela Alphonse Juma / James Ayei Maror / Mawahib Eldigail / Adel Hussein Elduma / Rehab Elageb / Kossi Badziklou / Koba Adjaho Komla / John Kayiwa / Julius Julian Lutwama / Lee Hampton / Mick Norman Mulders

    The Pan African Medical Journal, Vol 38, Iss

    2021  Volume 402

    Abstract: INTRODUCTION: accurate and timely laboratory diagnosis of yellow fever (YF) is critical to the Eliminate Yellow Fever Epidemics (EYE) strategy. Gavi, the Vaccine Alliance recognized the need to support and build capacity in the national and regional ... ...

    Abstract INTRODUCTION: accurate and timely laboratory diagnosis of yellow fever (YF) is critical to the Eliminate Yellow Fever Epidemics (EYE) strategy. Gavi, the Vaccine Alliance recognized the need to support and build capacity in the national and regional laboratories in the Global YF Laboratory Network (GYFLN) as part of this strategy. METHODS: to better understand current capacity, gaps and needs of the GYFLN laboratories in Africa, assessments were carried out in national and regional reference laboratories in the 25 African countries at high risk for YF outbreaks that were eligible for new financial support from Gavi. RESULTS: the assessments found that the GYFLN in Africa has high capacity but 21% of specimens were not tested due to lack of testing kits or reagents and approximately 50% of presumptive YF cases were not confirmed at the regional reference laboratory due to problems with shipping. CONCLUSION: the laboratory assessments helped to document the baseline capacities of these laboratories prior to Gavi funding to support strengthening YF laboratories.
    Keywords yellow fever ; laboratory ; diagnostics ; testing ; Medicine ; R
    Language English
    Publishing date 2021-04-01T00:00:00Z
    Publisher The Pan African Medical Journal
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  5. Article ; Online: Newly discovered ebola virus associated with hemorrhagic fever outbreak in Uganda.

    Jonathan S Towner / Tara K Sealy / Marina L Khristova / César G Albariño / Sean Conlan / Serena A Reeder / Phenix-Lan Quan / W Ian Lipkin / Robert Downing / Jordan W Tappero / Samuel Okware / Julius Lutwama / Barnabas Bakamutumaho / John Kayiwa / James A Comer / Pierre E Rollin / Thomas G Ksiazek / Stuart T Nichol

    PLoS Pathogens, Vol 4, Iss 11, p e

    2008  Volume 1000212

    Abstract: Over the past 30 years, Zaire and Sudan ebolaviruses have been responsible for large hemorrhagic fever (HF) outbreaks with case fatalities ranging from 53% to 90%, while a third species, Côte d'Ivoire ebolavirus, caused a single non-fatal HF case. In ... ...

    Abstract Over the past 30 years, Zaire and Sudan ebolaviruses have been responsible for large hemorrhagic fever (HF) outbreaks with case fatalities ranging from 53% to 90%, while a third species, Côte d'Ivoire ebolavirus, caused a single non-fatal HF case. In November 2007, HF cases were reported in Bundibugyo District, Western Uganda. Laboratory investigation of the initial 29 suspect-case blood specimens by classic methods (antigen capture, IgM and IgG ELISA) and a recently developed random-primed pyrosequencing approach quickly identified this to be an Ebola HF outbreak associated with a newly discovered ebolavirus species (Bundibugyo ebolavirus) distantly related to the Côte d'Ivoire ebolavirus found in western Africa. Due to the sequence divergence of this new virus relative to all previously recognized ebolaviruses, these findings have important implications for design of future diagnostic assays to monitor Ebola HF disease in humans and animals, and ongoing efforts to develop effective antivirals and vaccines.
    Keywords Immunologic diseases. Allergy ; RC581-607 ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2008-11-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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