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Article ; Online: Laboratory Aspects of Minimal / Measurable Residual Disease Testing in B-Lymphoblastic Leukemia.

Choi, John Kim / Mead, Paul E

2023 Volume 43, Issue 1, Page(s) 115–125

Abstract: Minimal residual disease detection provides critical prognostic predictor of treatment outcome and is the standard of care for B lymphoblastic leukemia. Flow cytometry-based minimal residual disease detection is the most common test modality and has high ...

Abstract	Minimal residual disease detection provides critical prognostic predictor of treatment outcome and is the standard of care for B lymphoblastic leukemia. Flow cytometry-based minimal residual disease detection is the most common test modality and has high sensitivity (0.01%) and a rapid turnaround time (24 hours). This article details the leukemia associated immunophenotype analysis approach for flow cytometry-based minimal residual disease detection used at St. Jude Children's Research Hospital and importance of using guide gates and back-gating.
MeSH term(s)	Child ; Humans ; Neoplasm, Residual/diagnosis ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/diagnosis ; Treatment Outcome ; Prognosis ; Flow Cytometry
Language	English
Publishing date	2023-02-09
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	604580-7
ISSN	1557-9832 ; 0272-2712
ISSN (online)	1557-9832
ISSN	0272-2712
DOI	10.1016/j.cll.2022.09.022
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Article ; Online: Laboratory Aspects of Minimal / Measurable Residual Disease Testing in B-Lymphoblastic Leukemia.

Choi, John Kim / Mead, Paul E

Clinics in laboratory medicine

2021 Volume 41, Issue 3, Page(s) 485–495

Abstract	Minimal residual disease detection provides critical prognostic predictor of treatment outcome and is the standard of care for B lymphoblastic leukemia. Flow cytometry-based minimal residual disease detection is the most common test modality and has high sensitivity (0.01%) and a rapid turnaround time (24 hours). This article details the leukemia associated immunophenotype analysis approach for flow cytometry-based minimal residual disease detection used at St. Jude Children's Research Hospital and importance of using guide gates and back-gating.
MeSH term(s)	Child ; Flow Cytometry ; Humans ; Immunophenotyping ; Laboratories ; Neoplasm, Residual ; Precursor Cell Lymphoblastic Leukemia-Lymphoma
Language	English
Publishing date	2021-07-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	604580-7
ISSN	1557-9832 ; 0272-2712
ISSN (online)	1557-9832
ISSN	0272-2712
DOI	10.1016/j.cll.2021.03.013
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Progressive multifocal leukoencephalopathy selectively affecting Broca's and Wernicke's areas in an immunocompetent patient

Renaid B. Kim, BS / David N. Irani, MD / John Kim, MD

Radiology Case Reports, Vol 18, Iss 3, Pp 1334-

A case report

2023 Volume 1336

Abstract: Progressive multifocal leukoencephalopathy (PML) is a rare, often fatal, demyelinating disease of the central nervous system. The disease almost exclusively presents in immunosuppressed patients, such as those with acquired immunodeficiency syndrome, a ... ...

Abstract	Progressive multifocal leukoencephalopathy (PML) is a rare, often fatal, demyelinating disease of the central nervous system. The disease almost exclusively presents in immunosuppressed patients, such as those with acquired immunodeficiency syndrome, a hematopoietic malignancy, or a transplanted organ; it is extremely rare in patients without immunosuppression. We present a case of a 74-year-old female with radiographic and histopathological findings consistent with PML that possibly arose in the setting of Sjögren's-related vasculitis but no immunosuppression.
Keywords	Progressive multifocal leukoencephalopathy ; JC polyomavirus ; Encephalopathy ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Chemical and Topological Control of Surfaces Using Functional Parylene Coatings

Tahereh Mohammadi Hafshejani / Xiaoyang Zhong / John Kim / Bahar Dadfar / Joerg Lahann

Organic Materials, Vol 5, Iss 02, Pp 98-

2023 Volume 111

Abstract: Abstract Chemical vapor deposition (CVD) polymerization is a prevalent technique for fabricating conformal, defect-free, and systematically adjustable organic thin films. CVD is particularly beneficial for barrier coatings due to its ability to eliminate ...

Abstract	Abstract Chemical vapor deposition (CVD) polymerization is a prevalent technique for fabricating conformal, defect-free, and systematically adjustable organic thin films. CVD is particularly beneficial for barrier coatings due to its ability to eliminate solvent-related environmental, health, and safety risk factors and provide a wide spectrum of post-polymerization modification strategies. This review discusses poly-p-xylylene and its functional derivatives. CVD polymerization of [2.2]paracyclophane precursors has undergone a recent renaissance due to advancements in chemical and morphological surface manipulation. This review summarizes emerging trends based on the following outline: Table of content: 1 Introduction 2 CVD Polymerization as a Sustainable Coating Technology 3 CVD Instrumentation 4 Poly-p-xylylene Coatings: Background of Polymerization Process and Functionalized Films 5 Main Applications of Poly-p-xylylenes 6 Area-Selective CVD Polymerization 7 Fabrication and Applications of Topological Structures 8 Conclusions and Outlook
Keywords	cvd polymerization ; biointerfaces ; area-selective deposition ; multifunctional interfaces ; surface engineering ; Chemistry ; QD1-999
Subject code	620
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	Georg Thieme Verlag
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Patient-specific, re-engineered cardiomyocyte model confirms the circumstance-dependent arrhythmia risk associated with the African-specific common SCN5A polymorphism p.S1103Y: Implications for the increased sudden deaths observed in black individuals during the COVID-19 pandemic.

Hamrick, Samantha K / John Kim, C S / Tester, David J / Giudicessi, John R / Ackerman, Michael J

Heart rhythm

2021 Volume 19, Issue 5, Page(s) 822–827

Abstract: Background: During the early stages of the coronavirus disease 2019 (COVID-19) pandemic, a marked increase in sudden cardiac death (SCD) was observed. The p.S1103Y-SCN5A common variant, which is present in ∼8% of individuals of African descent, may be a ...

Abstract	Background: During the early stages of the coronavirus disease 2019 (COVID-19) pandemic, a marked increase in sudden cardiac death (SCD) was observed. The p.S1103Y-SCN5A common variant, which is present in ∼8% of individuals of African descent, may be a circumstance-dependent, SCD-predisposing, proarrhythmic polymorphism in the setting of hypoxia-induced acidosis or QT-prolonging drug use. Objective: The purpose of this study was to ascertain the effects of acidosis and hydroxychloroquine (HCQ) on the action potential duration (APD) in a patient-specific induced pluripotent stem cell-derived cardiomyocyte (iPSC-CM) model of p.S1103Y-SCN5A. Methods: iPSC-CMs were generated from a 14-year-old p.S1103Y-SCN5A-positive African American male. The patient's variant-corrected iPSC-CMs (isogenic control [IC]) were generated using CRISPR/Cas9 technology. FluoVolt voltage-sensitive dye was used to assess APD Results: Under baseline conditions (pH 7.4), there was no difference in APD Conclusion: Although the African-specific p.S1103Y-SCN5A common variant had no effect on APD
MeSH term(s)	Adolescent ; Arrhythmias, Cardiac/genetics ; Blacks/genetics ; COVID-19 ; Cells, Cultured ; Death, Sudden, Cardiac/epidemiology ; Death, Sudden, Cardiac/etiology ; Humans ; Induced Pluripotent Stem Cells/cytology ; Male ; Myocytes, Cardiac/cytology ; NAV1.5 Voltage-Gated Sodium Channel/genetics ; Pandemics
Chemical Substances	NAV1.5 Voltage-Gated Sodium Channel ; SCN5A protein, human
Language	English
Publishing date	2021-12-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	2229357-7
ISSN	1556-3871 ; 1547-5271
ISSN (online)	1556-3871
ISSN	1547-5271
DOI	10.1016/j.hrthm.2021.12.029
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Article ; Online: Immunogenicity and safety of mixed COVID-19 vaccine regimens in patients with immune-mediated inflammatory diseases

Carol A Hitchon / Charles N Bernstein / Ruth Ann Marrie / John Kim / Sheila F O’Brien / Christine Mesa / Catherine Card

BMJ Open, Vol 13, Iss

a single-centre prospective cohort study

2023 Volume 5

Abstract: Objective Among persons with immune-mediated inflammatory diseases (IMIDs) who received SARS-CoV-2 vaccines, we compared postvaccine antibody responses and IMID disease activity/states.Design Single-centre prospective cohort study.Setting Specialty ... ...

Abstract	Objective Among persons with immune-mediated inflammatory diseases (IMIDs) who received SARS-CoV-2 vaccines, we compared postvaccine antibody responses and IMID disease activity/states.Design Single-centre prospective cohort study.Setting Specialty ambulatory clinics in central Canada.Participants People with inflammatory arthritis (n=78; 77% rheumatoid arthritis), systemic autoimmune rheumatic diseases (n=84; 57% lupus), inflammatory bowel disease (n=93; 43% Crohn’s) and multiple sclerosis (n=72; 71% relapsing-remitting) (female 79.4%, white 84.7%, mean (SD) age 56.0 (14.3) years) received COVID-19 vaccinations between March 2021 and September 2022.Primary outcome Postvaccination anti-spike, anti-receptor binding domain (anti-RBD) and anti-nucleocapsid (anti-NC) IgG antibodies tested by multiplex immunoassays compared across vaccine regimens and with responses in 370 age-matched and sex-matched vaccinated controls.Secondary outcomes COVID-19 infection and self-reported IMID disease activity/state.Results Most (216/327, 66.1%) received homologous messenger RNA (mRNA) (BNT162b2 or mRNA1273) vaccines, 2.4% received homologous ChAdOx1 and 30.6% received heterologous vaccines (23.9% ChAdOx1/mRNA, 6.4% heterologous mRNA) for their first two vaccines (V1, V2). Seroconversion rates were 52.0% (91/175) for post-V1 anti-spike and 58.9% (103/175) for anti-RBD; 91.5% (214/234) for post-V2 anti-spike and 90.2% (211/234) for anti-RBD; and were lower than controls (post-V2 anti-spike 98.1% (360/370), p<0.0001). Antibody titres decreased 3 months after V2 but increased 1 month after the third vaccine (V3) and 1 month after the fourth vaccine (V4) (BAU/mL median (IQR), anti-spike 1835 (2448) 1 month post-V2, 629.1 (883.4) 3 months post-V2, 4757.5 (7033.1) 1 month post-V3 and 4356.0 (9393.4) 1 month post-V4; anti-RBD 1686.8 (2199.44) 1 month post-V2, 555.8 (809.3) 3 months post-V2, 4280.3 (6380.6) 1 month post-V3 and 4792.2 (11 673.78) 1 month post-V4). If primed with a vector vaccine, an mRNA vaccine increased antibody ...
Keywords	Medicine ; R
Subject code	610
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Subtle imaging signs of sigmoid sinus thrombosis in otitis media (“otitic hydrocephalus”)

Alejandra M. Maiz, MD / Emily Chang, MD / Tatiana K. Deveney, MD / John Kim, MD / Jonathan D. Trobe, MD

Radiology Case Reports, Vol 18, Iss 9, Pp 3188-

2023 Volume 3191

Abstract: A 3-year-old boy developed otitis media, mastoiditis, papilledema, sixth nerve palsy, and increased intracranial pressure. The initial diagnosis was idiopathic intracranial hypertension, but doubt about that diagnosis at such a young age led to imaging ... ...

Abstract	A 3-year-old boy developed otitis media, mastoiditis, papilledema, sixth nerve palsy, and increased intracranial pressure. The initial diagnosis was idiopathic intracranial hypertension, but doubt about that diagnosis at such a young age led to imaging reevaluation. When the abnormalities from multiple pulse sequences were aggregated with this clinical input, the correct diagnosis of otitic hydrocephalus emerged, allowing prompt implementation of appropriate treatment to avoid the risk of venous stroke.
Keywords	Otitic hydrocephalus ; Papilledema ; Mastoiditis ; Dural venous sinus thrombosis ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Mixed-phenotype acute leukemia, T/megakaryoblastic.

Klairmont, Matthew M / Choi, John Kim

Blood

2018 Volume 132, Issue 22, Page(s) 2418

MeSH term(s)	Antigens, CD/analysis ; Bone Marrow/pathology ; Female ; Humans ; Infant, Newborn ; Leukemia, Megakaryoblastic, Acute/complications ; Leukemia, Megakaryoblastic, Acute/genetics ; Leukemia, Megakaryoblastic, Acute/pathology ; Leukemia, Megakaryoblastic, Acute/therapy ; Lymphocytes/pathology ; Male ; Megakaryocyte Progenitor Cells/pathology ; Phenotype ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/complications ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/therapy ; Stem Cell Transplantation ; T-Lymphocytes/pathology
Chemical Substances	Antigens, CD
Language	English
Publishing date	2018-11-29
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood-2018-09-871194
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Article ; Online: Development of a Patient-Specific p.D85N-Potassium Voltage-Gated Channel Subfamily E Member 1-Induced Pluripotent Stem Cell-Derived Cardiomyocyte Model for Drug-Induced Long QT Syndrome.

Kim, Maengjo / Ye, Dan / John Kim, C S / Zhou, Wei / Tester, David J / Giudicessi, John R / Ackerman, Michael J

Circulation. Genomic and precision medicine

2021 Volume 14, Issue 3, Page(s) e003234

Abstract: Background: Prior epidemiological studies demonstrated that the p.D85N-Potassium voltage-gated channel subfamily E member 1 (KCNE1) common variant reduces repolarization reserve and predisposes to drug-induced QT prolongation/torsades de pointes. We ... ...

Abstract	Background: Prior epidemiological studies demonstrated that the p.D85N-Potassium voltage-gated channel subfamily E member 1 (KCNE1) common variant reduces repolarization reserve and predisposes to drug-induced QT prolongation/torsades de pointes. We sought to develop a cellular model for drug-induced long QT syndrome using a patient-specific induced pluripotent stem cell-derived cardiomyocyte (iPSC-CM). Methods: p.D85N-KCNE1 iPSCs were generated from a 23-year-old female with an exaggerated heart rate-corrected QT interval response to metoclopramide (ΔQTc of 160 ms). Clustered regularly interspaced short palindromic repeats-associated 9 technology was used to generate gene-corrected isogenic iPSCs. Field potential duration and action potential duration (APD) were measured from iPSC-CMs. Results: At baseline, p.D85N-KCNE1 iPSC-CMs displayed significantly longer field potential duration (281±15 ms, n=13 versus 223±8.6 ms, n=14, Conclusions: This iPSC-CM study provides further evidence that the p.D85N-KCNE1 common variant in combination with environmental factors such as QT prolonging drugs and female sex is proarrhythmic.
MeSH term(s)	Adult ; Amino Acid Substitution ; Female ; Gastroesophageal Reflux/genetics ; Gastroesophageal Reflux/metabolism ; Gastroesophageal Reflux/therapy ; Humans ; Induced Pluripotent Stem Cells/metabolism ; Long QT Syndrome/chemically induced ; Long QT Syndrome/genetics ; Long QT Syndrome/metabolism ; Metoclopramide/administration & dosage ; Metoclopramide/adverse effects ; Mutation, Missense ; Myocytes, Cardiac/metabolism ; Potassium Channels, Voltage-Gated/genetics ; Potassium Channels, Voltage-Gated/metabolism
Chemical Substances	KCNE1 protein, human ; Potassium Channels, Voltage-Gated ; Metoclopramide (L4YEB44I46)
Language	English
Publishing date	2021-05-18
Publishing country	United States
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2574-8300
ISSN (online)	2574-8300
DOI	10.1161/CIRCGEN.120.003234
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: MRAS

Higgins, Erin M / Bos, J Martijn / Dotzler, Steven M / John Kim, C S / Ackerman, Michael J

Circulation. Genomic and precision medicine

2019 Volume 12, Issue 11, Page(s) e002648

Abstract: Background: MRAS: Methods: iPSCs were derived from a patient with a p.Gly23Val-MRAS variant to assess the effect of : Results: Compared with controls, both patient and disease modeled iPSC-CMs were significantly larger and demonstrated changes in ... ...

Abstract	Background: MRAS Methods: iPSCs were derived from a patient with a p.Gly23Val-MRAS variant to assess the effect of Results: Compared with controls, both patient and disease modeled iPSC-CMs were significantly larger and demonstrated changes in gene expression and intracellular pathway signaling characteristic of cardiac hypertrophy. Additionally, patient and disease modeled iPSC-CMs displayed impaired Ca Conclusions: p.Gly23Val-MRAS is both necessary and sufficient to elicit a cardiac hypertrophy phenotype in iPSC-CMs that includes increased cell size, changes in cardiac gene expression, and abnormal calcium handling-providing further evidence to establish the monogenetic pathogenicity of p.Gly23Val-MRAS in NS with cardiac hypertrophy.
MeSH term(s)	Base Sequence ; Cardiomegaly/genetics ; Cardiomegaly/metabolism ; Cells, Cultured ; Female ; Genetic Predisposition to Disease ; Humans ; Induced Pluripotent Stem Cells/metabolism ; Mutation ; Myocytes, Cardiac/metabolism ; Noonan Syndrome/genetics ; Phenotype ; ras Proteins/genetics ; ras Proteins/metabolism
Chemical Substances	MRAS protein, human ; ras Proteins (EC 3.6.5.2)
Language	English
Publishing date	2019-10-22
Publishing country	United States
Document type	Case Reports ; Journal Article ; Research Support, N.I.H., Extramural
ISSN	2574-8300
ISSN (online)	2574-8300
DOI	10.1161/CIRCGEN.119.002648
Database	MEDical Literature Analysis and Retrieval System OnLINE

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