Article ; Online: A kinase-independent role for CDK8 in BCR-ABL1+ leukemia
Nature Communications, Vol 10, Iss 1, Pp 1-
2019 Volume 15
Abstract: Cyclin-dependent kinases are deregulated in blood cancers. Here, the authors show that CDK8, independent of its kinase activity, regulates mTOR signalling for the maintenance of BCR-ABL1+ leukemia, and that the dual inhibition of CDK8 and mTOR signalling ...
| Abstract | Cyclin-dependent kinases are deregulated in blood cancers. Here, the authors show that CDK8, independent of its kinase activity, regulates mTOR signalling for the maintenance of BCR-ABL1+ leukemia, and that the dual inhibition of CDK8 and mTOR signalling induces apoptosis in these cells. |
|---|---|
| Keywords | Science ; Q |
| Language | English |
| Publishing date | 2019-10-01T00:00:00Z |
| Publisher | Nature Publishing Group |
| Document type | Article ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
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