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  1. AU="John R. Kouvaris"
  2. AU="Tripathy, Ashutosh"
  3. AU="Sharpley, Ann L"
  4. AU="Kragt, Lea"
  5. AU="Cui, Yanyan"
  6. AU="Morton, Jennifer P"

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  1. Article ; Online: Bone Density as a Marker of Response to Radiotherapy in Bone Metastatic Lesions

    Vassilis Kouloulias / Zoi Liakouli / Anna Zygogianni / Kyriaki Mystakidou / John R. Kouvaris

    International Journal of Molecular Sciences, Vol 17, Iss 9, p

    A Review of the Published Data

    2016  Volume 1391

    Abstract: Metastases to the bone are presenting in a great percentage of patients with cancer, causing a variety of symptoms, affecting the quality of life and survival of patients. A multidisciplinary approach from different health providers is required for ... ...

    Abstract Metastases to the bone are presenting in a great percentage of patients with cancer, causing a variety of symptoms, affecting the quality of life and survival of patients. A multidisciplinary approach from different health providers is required for treatment, including radiation oncologists, medical oncologists and surgeons. The role of radiotherapy in the management of bone metastases has long been established through multiple randomized trials. The estimation of response to the therapy is subjective and is based on the palliation of the symptoms that the patients report. However, a quantification of the tumor burden and response to the treatment with the use of an objective method to measure those parameters is a clinical expectation in oncology. The change in bone density in affected areas (mainly lytic) after local radiotherapy, representing the cellular changes that have occurred, is a promising marker of response to treatment.
    Keywords bone metastasis ; radiotherapy ; bone density ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 616
    Language English
    Publishing date 2016-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Cytoprotective Efficacy of Amifostine Against Radiation- Induced Rectal Toxicity

    John R. Kouvaris / Vassilis E. Kouloulias

    Molecules, Vol 13, Iss 4, Pp 892-

    Objective and Subjective Grading Scales for Radiomucositis

    2008  Volume 903

    Abstract: Curative radiation therapy of pelvic malignancies, frequently results in doselimitingtoxicities such as serous, mucoid, or more rarely, bloody diarrhea. Several studieshave evaluated the cytoprotective effects of amifostine in preventing rectal ... ...

    Abstract Curative radiation therapy of pelvic malignancies, frequently results in doselimitingtoxicities such as serous, mucoid, or more rarely, bloody diarrhea. Several studieshave evaluated the cytoprotective effects of amifostine in preventing rectal mucositisassociated with radiation treatment. We searched Medline for published comparativestudies that evaluated the use of amifostine to reduce radiation-induced toxicity associatedwith pelvic irradiation. In ten studies there was an evidence-based cytoprotection (P less than 0.05)by amifostine. Although results are variable, current evidence suggests that amifostine mayhave a radioprotective effect in the rectal mucosa, particularly when administeredintrarectally. Significant improvements were seen in both symptomatic and objective(rectosigmoidoscopy) end points. There is a need to conduct well-designed clinical trialswith sufficient numbers of participants to confirm these findings together with a costbenefitstudy. Objective measurements using rectosigmoidoscopy are superior tosubjective measures such as WHO or RTOG/EORTC toxicity grading scales.
    Keywords Cytoprotection ; radiotherapy ; rectum ; mucositis ; toxicity ; amifostine ; Organic chemistry ; QD241-441
    Language English
    Publishing date 2008-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  3. Article ; Online: Prognostic Value of MRS Metabolites in Postoperative Irradiated High Grade Gliomas

    Maria Tolia / Dimitrios Verganelakis / Nikolaos Tsoukalas / George Kyrgias / Matilda Papathanasiou / Eftichia Mosa / Ioannis Kokakis / John R. Kouvaris / George Pissakas / Kyriaki Pistevou-Gombaki / Nikolaos Kelekis / Vasileios Kouloulias

    BioMed Research International, Vol

    2015  Volume 2015

    Abstract: Purpose. We studied the prognostic significance of Magnetic Resonance Spectroscopy (MRS) in operated high grade gliomas. Materials and Methods. Twelve patients were treated with radiotherapy and Temozolomide. The MRS data were taken four weeks after ... ...

    Abstract Purpose. We studied the prognostic significance of Magnetic Resonance Spectroscopy (MRS) in operated high grade gliomas. Materials and Methods. Twelve patients were treated with radiotherapy and Temozolomide. The MRS data were taken four weeks after operation (before radiotherapy) and every six months after the completion of RT. The N-acetyl aspartate, choline, creatine, and myo-inositol parameters were quantified, analyzed, and correlated to recurrence-free survival (RFS). Results. The median RFS was 26.06 months. RFS was significantly worse in elderly patients (P=0.001) along with the higher choline/creatine ratios at either baseline (P= 0.003) or six months post Radiotherapy (P=0.042). Median RFS was 23 months in high choline/creatine levels ≥2 at 6 months after radiotherapy and 11 months for those with <2 choline/creatine levels. There was a significant correlation of maximum difference of choline/creatine ratio with RFS (rho = 0.64, P=0.045). Conclusion. Age and choline/creatine ratio are strong independent prognostic factors in high grade gliomas.
    Keywords Medicine ; R
    Language English
    Publishing date 2015-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Prognostic Significance of Serum Inflammatory Response Markers in Newly Diagnosed Non-Small Cell Lung Cancer before Chemoirradiation

    Maria Tolia / Nikolaos Tsoukalas / George Kyrgias / Eftychia Mosa / Apostolos Maras / Ioannis Kokakis / Zoi Liakouli / John R. Kouvaris / Konstantinos Liaskonis / Nikolaos Charalampakis / Kyriaki Pistevou-Gombaki / Nikolaos Kelekis / Vassilis Kouloulias

    BioMed Research International, Vol

    2015  Volume 2015

    Abstract: Purpose. To identify whether the serum’s baseline C-reactive protein (CRP) and albumin (Alb) levels related to clinicopathological parameters and overall survival (OS) in non-small cell lung cancer (NSCLC). Methods. In total, 100 consecutive patients ( ... ...

    Abstract Purpose. To identify whether the serum’s baseline C-reactive protein (CRP) and albumin (Alb) levels related to clinicopathological parameters and overall survival (OS) in non-small cell lung cancer (NSCLC). Methods. In total, 100 consecutive patients (mean age = 68.38 ± 10.85 years) that underwent chemoradiotherapy were studied. Measurements of CRP and Alb were performed before any treatment. Results. Serum CRP levels were significantly associated with histological grade (P<0.001), TNM stage (P<0.001), PS (P=0.009), and Alb (P<0.001). Additionally CRP and Alb levels were found significantly associated with overall survival in univariate analysis (log-rank test, P<0.001 and P=0.002, resp.) and CRP remained significant after controlling for age, alcohol, performance status, and TNM stage, whereas albumin showed a borderline effect on the hazard rate (P=0.052). Conclusions. CRP and Alb are both promising biomarkers in identification of NSCLC patients with poor prognosis and form a possible target for intensifying their therapies.
    Keywords Medicine ; R
    Language English
    Publishing date 2015-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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