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  1. AU="John T Lear"
  2. AU="Rachidi, Saleh"
  3. AU="Baptista Serna, L" AU="Baptista Serna, L"
  4. AU=Fiandaca Massimo S
  5. AU="Belli, Sara"
  6. AU="Capogiri, Monica"
  7. AU="Al-Hattab, Eyad"
  8. AU="Hou, Tsung-Wei"
  9. AU="Meng, Ying Shirley"
  10. AU="Emanuele Rezoagli"
  11. AU="Verhagen, M A M T"
  12. AU="Haden, Kathleen"
  13. AU="Lee, Ju Yup"
  14. AU="Camilla Caimi"
  15. AU="Huynh, Nancy"
  16. AU="Sun, Weilin"
  17. AU="Whalon, Mark E."
  18. AU=Grishunin Kirill
  19. AU="Quaranta, Gianluigi"
  20. AU="Jitaroon, Kawinyarat"
  21. AU="Anderson, Eric C"
  22. AU="Thiyagarajan, Kamalraj"
  23. AU="Simnica, Donjetë"

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  1. Artikel ; Online: Photodynamic Therapy and Non-Melanoma Skin Cancer

    Liezel L. Griffin / John T. Lear

    Cancers, Vol 8, Iss 10, p

    2016  Band 98

    Abstract: Non-melanoma skin cancer (NMSC) is the most common malignancy among the Caucasian population. Photodynamic therapy (PDT) is gaining popularity for the treatment of basal cell carcinoma (BCC), Bowen’s disease (BD) and actinic keratosis (AK). A topical or ... ...

    Abstract Non-melanoma skin cancer (NMSC) is the most common malignancy among the Caucasian population. Photodynamic therapy (PDT) is gaining popularity for the treatment of basal cell carcinoma (BCC), Bowen’s disease (BD) and actinic keratosis (AK). A topical or systemic exogenous photosensitiser, results in selective uptake by malignant cells. Protoporphyrin IX (PpIX) is produced then activated by the introduction of a light source. Daylight-mediated MAL (methyl aminolaevulinate) PDT for AKs has the advantage of decreased pain and better patient tolerance. PDT is an effective treatment for superficial BCC, BD and both individual and field treatment of AKs. Excellent cosmesis can be achieved with high patient satisfaction. Variable results have been reported for nodular BCC, with improved outcomes following pretreatment and repeated PDT cycles. The more aggressive basisquamous, morphoeic infiltrating subtypes of BCC and invasive squamous cell carcinoma (SCC) are not suitable for PDT. Prevention of “field cancerization” in organ transplant recipients on long-term immunosuppression and patients with Gorlin syndrome (naevoid basal cell carcinoma syndrome) is a promising development. The optimisation of PDT techniques with improved photosensitiser delivery to target tissues, new generation photosensitisers and novel light sources may expand the future role of PDT in NMSC management.
    Schlagwörter photodynamic therapy ; non-melanoma skin cancer ; basal cell carcinoma ; actinic keratosis ; field cancerization ; organ transplant recipients ; Gorlin syndrome ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282 ; Internal medicine ; RC31-1245 ; Medicine ; R
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2016-10-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Use of Photodynamic Therapy for Treatment of Actinic Keratoses in Organ Transplant Recipients

    Christina Wlodek / Faisal R. Ali / John T. Lear

    BioMed Research International, Vol

    2013  Band 2013

    Abstract: Solid organ transplant recipients are predisposed to actinic keratoses (AK) and nonmelanoma skin cancers, owing to the lifelong immunosuppression required. Today, increasing numbers of organ transplants are being performed and organ transplant recipients ...

    Abstract Solid organ transplant recipients are predisposed to actinic keratoses (AK) and nonmelanoma skin cancers, owing to the lifelong immunosuppression required. Today, increasing numbers of organ transplants are being performed and organ transplant recipients (OTRs) are surviving much longer. Photodynamic therapy (PDT) is proving a highly effective treatment modality for AK amongst this susceptible group of patients. Following an overview of the pathogenesis of AK amongst OTRs, the authors review current safety and efficacy data and how this relates to the role of PDT for the treatment of AK in OTRs.
    Schlagwörter Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2013-01-01T00:00:00Z
    Verlag Hindawi Limited
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Comparison of ALitretinoin with PUVA as the first-line treatment in patients with severe chronic HAnd eczema (ALPHA)

    Catherine Smith / Miriam Wittmann / Fiona Cowdell / Sarah Brown / Catherine Reynolds / Catherine Fernandez / Sandy Tubeuf / Jane Nixon / Rachael Gilberts / Mark Goodfield / Isabelle L Smith / John T Lear / Lesley Sunderland / Cathy Green / Philip Hampton / Amy Barker / Armando Vargas-Palacios

    BMJ Open, Vol 12, Iss

    study protocol for a randomised controlled trial

    2022  Band 2

    Schlagwörter Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2022-02-01T00:00:00Z
    Verlag BMJ Publishing Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Melanoma in Organ Transplant Recipients

    Faisal R. Ali / John T. Lear

    Journal of Skin Cancer, Vol

    Incidence, Outcomes and Management Considerations

    2012  Band 2012

    Schlagwörter Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Oncology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Sprache Englisch
    Erscheinungsdatum 2012-01-01T00:00:00Z
    Verlag Hindawi Publishing Corporation
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Focus on Basal Cell Carcinoma

    John T. Lear / Vishal Madan / Venura Samarasinghe

    Journal of Skin Cancer, Vol

    2011  Band 2011

    Schlagwörter Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Oncology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Sprache Englisch
    Erscheinungsdatum 2011-01-01T00:00:00Z
    Verlag Hindawi Publishing Corporation
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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