Article ; Online: Altered Synapse Stability in the Early Stages of Tauopathy
Cell Reports, Vol 18, Iss 13, Pp 3063-
2017 Volume 3068
Abstract: Synapse loss is a key feature of dementia, but it is unclear whether synaptic dysfunction precedes degenerative phases of the disease. Here, we show that even before any decrease in synapse density, there is abnormal turnover of cortical axonal boutons ... ...
| Abstract | Synapse loss is a key feature of dementia, but it is unclear whether synaptic dysfunction precedes degenerative phases of the disease. Here, we show that even before any decrease in synapse density, there is abnormal turnover of cortical axonal boutons and dendritic spines in a mouse model of tauopathy-associated dementia. Strikingly, tauopathy drives a mismatch in synapse turnover; postsynaptic spines turn over more rapidly, whereas presynaptic boutons are stabilized. This imbalance between pre- and post-synaptic stability coincides with reduced synaptically driven neuronal activity in pre-degenerative stages of the disease. |
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| Keywords | dementia ; cortex ; 2-photon microscopy ; axon ; bouton ; dendritic spine ; neurodegeneration ; Biology (General) ; QH301-705.5 |
| Language | English |
| Publishing date | 2017-03-01T00:00:00Z |
| Publisher | Elsevier |
| Document type | Article ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
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