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  1. Article ; Online: Controlling Adsorption of Diblock Copolymer Nanoparticles onto an Aldehyde-Functionalized Hydrophilic Polymer Brush via pH Modulation.

    Astier, Samuel / Johnson, Edwin C / Norvilaite, Oleta / Varlas, Spyridon / Brotherton, Emma E / Sanderson, George / Leggett, Graham J / Armes, Steven P

    Langmuir : the ACS journal of surfaces and colloids

    2024  

    Abstract: Sterically stabilized diblock copolymer nanoparticles with a well-defined spherical morphology and tunable diameter were prepared by RAFT aqueous emulsion polymerization of benzyl methacrylate at 70 °C. The steric stabilizer precursor used for these ... ...

    Abstract Sterically stabilized diblock copolymer nanoparticles with a well-defined spherical morphology and tunable diameter were prepared by RAFT aqueous emulsion polymerization of benzyl methacrylate at 70 °C. The steric stabilizer precursor used for these syntheses contained pendent
    Language English
    Publishing date 2024-02-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.3c03392
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Adsorption of Aldehyde-Functional Diblock Copolymer Spheres onto Surface-Grafted Polymer Brushes via Dynamic Covalent Chemistry Enables Friction Modification.

    Johnson, Edwin C / Varlas, Spyridon / Norvilaite, Oleta / Neal, Thomas J / Brotherton, Emma E / Sanderson, George / Leggett, Graham J / Armes, Steven P

    Chemistry of materials : a publication of the American Chemical Society

    2023  Volume 35, Issue 15, Page(s) 6109–6122

    Abstract: Dynamic covalent chemistry has been exploited to prepare numerous examples of adaptable polymeric materials that exhibit unique properties. Herein, the chemical adsorption of aldehyde-functional diblock copolymer spherical nanoparticles onto amine- ... ...

    Abstract Dynamic covalent chemistry has been exploited to prepare numerous examples of adaptable polymeric materials that exhibit unique properties. Herein, the chemical adsorption of aldehyde-functional diblock copolymer spherical nanoparticles onto amine-functionalized surface-grafted polymer brushes via dynamic Schiff base chemistry is demonstrated. Initially, a series of
    Language English
    Publishing date 2023-07-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1500399-1
    ISSN 1520-5002 ; 0897-4756
    ISSN (online) 1520-5002
    ISSN 0897-4756
    DOI 10.1021/acs.chemmater.3c01227
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Comparing polymer-surfactant complexes to polyelectrolytes.

    Gresham, Isaac J / Johnson, Edwin C / Robertson, Hayden / Willott, Joshua D / Webber, Grant B / Wanless, Erica J / Nelson, Andrew R J / Prescott, Stuart W

    Journal of colloid and interface science

    2023  Volume 655, Page(s) 262–272

    Abstract: Hypothesis: Understanding the complex interactions between polymers and surfactants is required to optimise commercially relevant systems such as paint, toothpaste and detergent. Neutral polymers complex with surfactants, forming 'pearl necklace' ... ...

    Abstract Hypothesis: Understanding the complex interactions between polymers and surfactants is required to optimise commercially relevant systems such as paint, toothpaste and detergent. Neutral polymers complex with surfactants, forming 'pearl necklace' structures that are often conceptualised as pseudo-polyelectrolytes. Here we pose two questions to test the limits of this analogy: Firstly, in the presence of salt, do these polymer-surfactant systems behave like polyelectrolytes? Secondly, do polymer-surfactant complexes resist geometric confinement like polyelectrolytes?
    Experiments: We test the limits of the pseudo-polyelectrolyte analogy through studying a poly(N-isopropylacrylamide) (PNIPAM) brush in the presence of sodium dodecylsulfate (SDS). Brushes are ideal for interrogating pseudo-polyelectrolytes, as neutral and polyelectrolyte brushes exhibit distinct and well understood behaviours. Spectroscopic ellipsometry, quartz crystal microbalance with dissipation monitoring (QCM-D), and neutron reflectometry (NR) were used to monitor the behaviour and structure of the PNIPAM-SDS system as a function of NaCl concentration. The ability of the PNIPAM-SDS complex to resist geometric confinement was probed with NR.
    Findings: At a fixed SDS concentration below the zero-salt CMC, increasing NaCl concentration <100 mM promoted brush swelling due to an increase in osmotic pressure, not dissimilar to a weak polyelectrolyte. At these salt concentrations, the swelling of the brush could be described by a single parameter: the effective CMC. However, at high NaCl concentrations (e.g., 500 mM) no brush collapse was observed at all (non-zero) concentrations of SDS studied, contrary to what is seen for many polyelectrolytes. Study of the polymer-surfactant system under confinement revealed that the physical volume of surfactant dominates the structure of the strongly confined system, which further differentiates it from the polyelectrolyte case.
    Language English
    Publishing date 2023-10-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241597-5
    ISSN 1095-7103 ; 0021-9797
    ISSN (online) 1095-7103
    ISSN 0021-9797
    DOI 10.1016/j.jcis.2023.10.101
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Hydrophilic Aldehyde-Functional Polymer Brushes: Synthesis, Characterization, and Potential Bioapplications.

    Brotherton, Emma E / Johnson, Edwin C / Smallridge, Mark J / Hammond, Deborah B / Leggett, Graham J / Armes, Steven P

    Macromolecules

    2023  Volume 56, Issue 5, Page(s) 2070–2080

    Abstract: Surface-initiated activators regenerated by electron transfer atom transfer radical polymerization (ARGET ATRP) is used to polymerize ... ...

    Abstract Surface-initiated activators regenerated by electron transfer atom transfer radical polymerization (ARGET ATRP) is used to polymerize a
    Language English
    Publishing date 2023-02-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3436-8
    ISSN 0024-9297
    ISSN 0024-9297
    DOI 10.1021/acs.macromol.2c02471
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Histidine-Functionalized Diblock Copolymer Nanoparticles Exhibit Enhanced Adsorption onto Planar Stainless Steel.

    Brotherton, Emma E / Josland, Daniel / György, Csilla / Johnson, Edwin C / Chan, Derek H H / Smallridge, Mark J / Armes, Steven P

    Macromolecular rapid communications

    2023  Volume 44, Issue 16, Page(s) e2200903

    Abstract: RAFT aqueous emulsion polymerization of isopropylideneglycerol monomethacrylate (IPGMA) is used to prepare a series of ... ...

    Abstract RAFT aqueous emulsion polymerization of isopropylideneglycerol monomethacrylate (IPGMA) is used to prepare a series of PGEO5MA
    MeSH term(s) Histidine/chemistry ; Stainless Steel ; Adsorption ; Polymers/chemistry ; Nanoparticles/chemistry
    Chemical Substances Histidine (4QD397987E) ; Stainless Steel (12597-68-1) ; Polymers
    Language English
    Publishing date 2023-01-09
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1475027-2
    ISSN 1521-3927 ; 1022-1336
    ISSN (online) 1521-3927
    ISSN 1022-1336
    DOI 10.1002/marc.202200903
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Mucoadhesive pickering nanoemulsions via dynamic covalent chemistry

    Hunter, Saul J. / Abu Elella, Mahmoud H. / Johnson, Edwin C. / Taramova, Laura / Brotherton, Emma E. / Armes, Steven P. / Khutoryanskiy, Vitaliy V. / Smallridge, Mark J.

    Journal of Colloid And Interface Science. 2023 Dec., v. 651 p.334-345

    2023  

    Abstract: Hypothesis. Submicron oil droplets stabilized using aldehyde-functionalized nanoparticles should adhere to the primary amine groups present at the surface of sheep nasal mucosal tissue via Schiff base chemistry. Experiments. Well-defined sterically- ... ...

    Abstract Hypothesis. Submicron oil droplets stabilized using aldehyde-functionalized nanoparticles should adhere to the primary amine groups present at the surface of sheep nasal mucosal tissue via Schiff base chemistry. Experiments. Well-defined sterically-stabilized diblock copolymer nanoparticles of 20 nm diameter were prepared in the form of concentrated aqueous dispersions via reversible addition-fragmentation chain transfer (RAFT) aqueous emulsion polymerization of 2,2,2-trifluoroethyl methacrylate (TFEMA) using a water-soluble methacrylic precursor bearing cis-diol groups. Some of these hydroxyl-functional nanoparticles were then selectively oxidized using an aqueous solution of sodium periodate to form a second batch of nanoparticles bearing pendent aldehyde groups within the steric stabilizer chains. Subjecting either hydroxyl- or aldehyde-functional nanoparticles to high-shear homogenization with a model oil (squalane) produced oil-in-water Pickering macroemulsions of 20–30 µm diameter. High-pressure microfluidization of such macroemulsions led to formation of the corresponding Pickering nanoemulsions with a mean droplet diameter of around 200 nm. Quartz crystal microbalance (QCM) experiments were used to examine adsorption of both nanoparticles and oil droplets onto a model planar substrate bearing primary amine groups, while a fluorescence microscopy-based mucoadhesion assay was developed to assess adsorption of the oil droplets onto sheep nasal mucosal tissue. Findings. Squalane droplets coated with aldehyde-functional nanoparticles adhered significantly more strongly to sheep nasal mucosal tissue than those coated with the corresponding hydroxyl-functional nanoparticles. This difference was attributed to the formation of surface imine bonds via Schiff base chemistry and was also observed for the two types of nanoparticles alone in QCM studies. Preliminary biocompatibility studies using planaria indicated only mild toxicity for these new mucoadhesive Pickering nanoemulsions, suggesting potential applications for the localized delivery of hydrophobic drugs.
    Keywords adsorption ; aldehydes ; aqueous solutions ; bioadhesives ; biocompatibility ; composite polymers ; droplets ; emulsions ; fluorescence microscopy ; homogenization ; hydrophobicity ; imines ; mucoadhesion ; nanoparticles ; nose ; oils ; polymerization ; quartz crystal microbalance ; schiff bases ; sheep ; sodium ; stabilizers ; toxicity ; water solubility ; Nanoemulsions ; Pickering emulsions ; Block copolymers ; Sterically-stabilized nanoparticles ; Schiff base chemistry ; Aldehyde-functional
    Language English
    Dates of publication 2023-12
    Size p. 334-345.
    Publishing place Elsevier Inc.
    Document type Article ; Online
    ZDB-ID 241597-5
    ISSN 1095-7103 ; 0021-9797
    ISSN (online) 1095-7103
    ISSN 0021-9797
    DOI 10.1016/j.jcis.2023.07.162
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

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  7. Article ; Online: N-acetylaspartylglutamate is not demonstrated to be a selective mGlu₃receptor agonist.

    Johnson, Edwin C

    Journal of neurochemistry

    2011  Volume 119, Issue 5, Page(s) 896–898

    MeSH term(s) Animals ; Central Nervous System/metabolism ; Central Nervous System/physiology ; Dipeptides/metabolism ; Humans ; Neurotransmitter Agents/metabolism ; Receptors, Metabotropic Glutamate/agonists ; Receptors, Metabotropic Glutamate/metabolism
    Chemical Substances Dipeptides ; Neurotransmitter Agents ; Receptors, Metabotropic Glutamate ; metabotropic glutamate receptor 3 ; isospaglumic acid (1W8M12WXYL)
    Language English
    Publishing date 2011-12
    Publishing country England
    Document type Editorial
    ZDB-ID 80158-6
    ISSN 1471-4159 ; 0022-3042 ; 1474-1644
    ISSN (online) 1471-4159
    ISSN 0022-3042 ; 1474-1644
    DOI 10.1111/j.1471-4159.2011.07480.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui II Zs.170: Show issues Location:
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  8. Article ; Online: Effect of surfactants on the thermoresponse of PNIPAM investigated in the brush geometry.

    Gresham, Isaac J / Willott, Joshua D / Johnson, Edwin C / Li, Peixun / Webber, Grant B / Wanless, Erica J / Nelson, Andrew R J / Prescott, Stuart W

    Journal of colloid and interface science

    2022  Volume 631, Issue Pt A, Page(s) 260–271

    Abstract: Hypothesis: Anionic surfactants have been reported to interact with poly(N-isopropyl acrylamide) (PNIPAM), suppressing its thermoresponse. Scattering and NMR studies of the anionic sodium dodecylsulfate (SDS) system propose that the PNIPAM-surfactant ... ...

    Abstract Hypothesis: Anionic surfactants have been reported to interact with poly(N-isopropyl acrylamide) (PNIPAM), suppressing its thermoresponse. Scattering and NMR studies of the anionic sodium dodecylsulfate (SDS) system propose that the PNIPAM-surfactant interaction is purely hydrophobic. However, prior phenomenological investigations of a range of surfactant identities (anionic, cationic, nonionic) show that only anionic surfactants affect the thermoresponse and conformation of PNIPAM, implying that the hydrophilic head-group also contributes. Crucially, the phenomenological experiments do not measure the affinity of the tested surfactants to the polymer, only their effect on its behaviour.
    Experiments: We study the adsorption of six surfactants within a planar PNIPAM brush system, elucidating the polymer conformation, thermoresponse, and surfactant adsorption kinetics using ellipsometry, neutron reflectometry (NR), optical reflectometry and the quartz crystal microbalance technique. NR is used to measure the distribution of surfactants within the brush.
    Findings: We find that only anionic surfactants modify the structure and thermoresponse of PNIPAM, with the greater affinity of anionic surfactants for PNIPAM (relative to cationic and nonionic surfactants) being the primary reason for this behaviour. These results show that the surfactant head-group has a more critical role in mediating PNIPAM-surfactant interaction than previously reported. Taking inspiration from prior molecular dynamics work on the PEO-surfactant system, we propose an interaction mechanism for PNIPAM and SDS that reconciles evidence for hydrophobic interaction with the observed head-group-dependent affinity.
    MeSH term(s) Surface-Active Agents ; Acrylic Resins ; Sodium Dodecyl Sulfate ; Pulmonary Surfactants ; Excipients ; Polymers
    Chemical Substances Surface-Active Agents ; poly-N-isopropylacrylamide (25189-55-3) ; Acrylic Resins ; Sodium Dodecyl Sulfate (368GB5141J) ; Pulmonary Surfactants ; Excipients ; Polymers
    Language English
    Publishing date 2022-10-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241597-5
    ISSN 1095-7103 ; 0021-9797
    ISSN (online) 1095-7103
    ISSN 0021-9797
    DOI 10.1016/j.jcis.2022.10.071
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Poly(

    Humphreys, Ben A / Johnson, Edwin C / Wanless, Erica J / Webber, Grant B

    Langmuir : the ACS journal of surfaces and colloids

    2019  Volume 35, Issue 33, Page(s) 10818–10830

    Abstract: The stability of poly( ...

    Abstract The stability of poly(
    Language English
    Publishing date 2019-08-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.9b00695
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Interplay of Composition, pH, and Temperature on the Conformation of Multi-stimulus-responsive Copolymer Brushes: Comparison of Experiment and Theory.

    Johnson, Edwin C / Willott, Joshua D / de Vos, Wiebe M / Wanless, Erica J / Webber, Grant B

    Langmuir : the ACS journal of surfaces and colloids

    2020  Volume 36, Issue 21, Page(s) 5765–5777

    Abstract: Poly(2-(2-methoxyethoxy)ethyl methacrylate) ( ... ...

    Abstract Poly(2-(2-methoxyethoxy)ethyl methacrylate) (PMEO
    Language English
    Publishing date 2020-05-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.0c00424
    Database MEDical Literature Analysis and Retrieval System OnLINE

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