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  1. Article ; Online: Hanging under the ledge: synergistic consequences of UVA and UVB radiation on scyphozoan polyp reproduction and health.

    Johnson, Lauren E / Treible, Laura M

    PeerJ

    2023  Volume 11, Page(s) e14749

    Abstract: Overexposure to ultraviolet radiation (UVR) emitted by the sun can damage and kill living cells in animals, plants, and microorganisms. In aquatic environments, UVR can penetrate nearly 47 m into the water column, severely impacting many marine organisms. ...

    Abstract Overexposure to ultraviolet radiation (UVR) emitted by the sun can damage and kill living cells in animals, plants, and microorganisms. In aquatic environments, UVR can penetrate nearly 47 m into the water column, severely impacting many marine organisms. Jellyfish are often considered resilient to environmental stressors, potentially explaining their success in environmentally disturbed areas, but the extent of their resilience to UVR is not well known. Here, we tested resiliency to UVR by exposing benthic polyps of the moon jellyfish,
    MeSH term(s) Animals ; Ultraviolet Rays ; Aquatic Organisms ; Reproduction
    Language English
    Publishing date 2023-02-02
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 2703241-3
    ISSN 2167-8359 ; 2167-8359
    ISSN (online) 2167-8359
    ISSN 2167-8359
    DOI 10.7717/peerj.14749
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  2. Article ; Online: Pilot Study of Feeding Tube Education Using a Graphic-Based Course.

    Johnson, Lauren / Maatman, Theresa

    WMJ : official publication of the State Medical Society of Wisconsin

    2022  Volume 121, Issue 1, Page(s) 64–67

    Abstract: Background: Residents receive little formal education about feeding tubes; however, patients experience fewer complications if a formal feeding tube curriculum is implemented.: Objective: The aim of this study was to evaluate a graphics-based course ... ...

    Abstract Background: Residents receive little formal education about feeding tubes; however, patients experience fewer complications if a formal feeding tube curriculum is implemented.
    Objective: The aim of this study was to evaluate a graphics-based course for internal medicine residents.
    Methods: Internal medicine residents participated in a new course on feeding tube placement and management. Surveys administered before and after the course assessed resident comfort level with the material.
    Results: Based on a 10-point Likert scale, mean improvement in comfort level for 4 scenarios was 1.69, 2.13, 2.44, and 3.07 points (
    Conclusion: The new course significantly improved resident comfort level regarding feeding tube placement and management. The use of graphics played a role in increasing residents' understanding.
    MeSH term(s) Clinical Competence ; Curriculum ; Humans ; Internship and Residency ; Pilot Projects ; Surveys and Questionnaires
    Language English
    Publishing date 2022-04-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 441051-8
    ISSN 2379-3961 ; 0043-6542 ; 1098-1861
    ISSN (online) 2379-3961
    ISSN 0043-6542 ; 1098-1861
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  3. Article ; Online: CMS Finalizes Rules for Distribution of 1000 New Medicare-Funded Residency Positions and Changes to Rural Training Track Programs.

    Schleiter Hitchell, Kristin / Johnson, Lauren

    Journal of graduate medical education

    2022  Volume 14, Issue 2, Page(s) 245–249

    MeSH term(s) Aged ; Centers for Medicare and Medicaid Services, U.S. ; Education, Medical, Graduate ; Family Practice/education ; Humans ; Internship and Residency ; Medicare ; United States
    Language English
    Publishing date 2022-04-14
    Publishing country United States
    Document type News
    ZDB-ID 2578612-X
    ISSN 1949-8357 ; 1949-8357
    ISSN (online) 1949-8357
    ISSN 1949-8357
    DOI 10.4300/JGME-D-22-00193.1
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  4. Article ; Online: Developmental toxicity of remdesivir, an anti-COVID-19 drug, is implicated by in vitro assays using morphogenetic embryoid bodies of mouse and human pluripotent stem cells.

    Kirkwood-Johnson, Lauren / Marikawa, Yusuke

    Birth defects research

    2022  Volume 115, Issue 2, Page(s) 224–239

    Abstract: Background: Remdesivir is an antiviral drug approved for the treatment of COVID-19, whose developmental toxicity remains unclear. More information about the safety of remdesivir is urgently needed for people of childbearing potential, who are affected ... ...

    Abstract Background: Remdesivir is an antiviral drug approved for the treatment of COVID-19, whose developmental toxicity remains unclear. More information about the safety of remdesivir is urgently needed for people of childbearing potential, who are affected by the ongoing pandemic. Morphogenetic embryoid bodies (MEBs) are three-dimensional (3D) aggregates of pluripotent stem cells that recapitulate embryonic body patterning in vitro, and have been used as effective embryo models to detect the developmental toxicity of chemical exposures specifically and sensitively.
    Methods: MEBs were generated from mouse P19C5 and human H9 pluripotent stem cells, and used to examine the effects of remdesivir. The morphological effects were assessed by analyzing the morphometric parameters of MEBs after exposure to varying concentrations of remdesivir. The molecular impact of remdesivir was evaluated by measuring the transcript levels of developmental regulator genes.
    Results: The mouse MEB morphogenesis was impaired by remdesivir at 1-8 μM. Remdesivir affected MEBs in a manner dependent on metabolic conversion, and its potency was higher than GS-441524 and GS-621763, presumptive anti-COVID-19 drugs that act similarly to remdesivir. The expressions of developmental regulator genes, particularly those involved in axial and somite patterning, were dysregulated by remdesivir. The early stage of MEB development was more vulnerable to remdesivir exposure than the later stage. The morphogenesis and gene expression profiles of human MEBs were also impaired by remdesivir at 1-8 μM.
    Conclusions: Remdesivir impaired mouse and human MEBs at concentrations that are comparable to the therapeutic plasma levels in humans, urging further investigation into the potential impact of remdesivir on developing embryos.
    MeSH term(s) Humans ; Embryoid Bodies/metabolism ; COVID-19/metabolism ; COVID-19 Drug Treatment ; Morphogenesis ; Pluripotent Stem Cells
    Chemical Substances GS-621763 (83BU3492RP) ; remdesivir (3QKI37EEHE)
    Language English
    Publishing date 2022-11-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2104792-3
    ISSN 2472-1727
    ISSN (online) 2472-1727
    DOI 10.1002/bdr2.2111
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  5. Article ; Online: Federal Bills Raise Cap on Medicare-Funded Residency Positions and Modify Graduate Medical Education Policies.

    Schleiter, Kristin / Johnson, Lauren

    Journal of graduate medical education

    2021  Volume 13, Issue 4, Page(s) 602–606

    MeSH term(s) Aged ; Education, Medical, Graduate ; Humans ; Internship and Residency ; Medicare ; Policy ; Training Support ; United States
    Language English
    Publishing date 2021-08-13
    Publishing country United States
    Document type News
    ZDB-ID 2578612-X
    ISSN 1949-8357 ; 1949-8357
    ISSN (online) 1949-8357
    ISSN 1949-8357
    DOI 10.4300/JGME-D-21-00642.1
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  6. Article ; Online: Maximizing Reflexive HCV RNA Testing of HCV Antibody-Reactive Samples Within United States Public Health Laboratories.

    Johnson, Lauren N / Gaynor, Anne M / Wroblewski, Kelly / Buss, Sarah N

    The Journal of infectious diseases

    2023  

    Abstract: Hepatitis C virus (HCV) infection can cause significant morbidity and mortality if left untreated and diagnosis is the first step in any treatment regimen. In the United States, a two-step algorithm is recommended for detection of current HCV infection. ... ...

    Abstract Hepatitis C virus (HCV) infection can cause significant morbidity and mortality if left untreated and diagnosis is the first step in any treatment regimen. In the United States, a two-step algorithm is recommended for detection of current HCV infection. The algorithm consists of an HCV antibody screening test followed by a supplemental test for HCV RNA if the HCV antibody test is reactive. To assess HCV testing practices and identify associated challenges, the Association of Public Health Laboratories (APHL) conducted a survey on HCV diagnostics practices of US public health laboratories. Additionally, APHL and the Centers for Disease Control and Prevention's (CDC) Division of Viral Hepatitis (DVH) convened a two-day meeting of HCV subject matter experts (SMEs) to identify opportunities for improvement in diagnosis of current HCV infection. Automatic reflexive HCV RNA testing of HCV antibody-reactive specimens was identified as a high priority target area by HCV SMEs and as a gap in laboratory practice by the APHL survey, which found that only 54% of respondent laboratories always automatically reflexed or referred an Ab-reactive specimen to an HCV RNA test. To facilitate accurate diagnosis and ensure that patients are not lost to follow up, laboratories and public health programs should work to ensure that the entire HCV testing algorithm (i.e., antibody and nucleic acid testing) can be completed with a sample(s) collected during a single patient visit.
    Language English
    Publishing date 2023-09-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiad191
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  7. Article: Methamphetamine spasm in the large caliber arteries-the severity is likely underestimated.

    Bikk, Andras / Chaudhari, Jeffery / Navaran, Prashanth / Johnson, Lauren / Pandit, Viraj

    Journal of vascular surgery cases and innovative techniques

    2023  Volume 10, Issue 1, Page(s) 101376

    Abstract: This report describes two cases of rarely reported, severe large arterial vascular spasms seen on computed tomography images after methamphetamine abuse. Although the effects of methamphetamine on the central nervous system and smaller arteries are ... ...

    Abstract This report describes two cases of rarely reported, severe large arterial vascular spasms seen on computed tomography images after methamphetamine abuse. Although the effects of methamphetamine on the central nervous system and smaller arteries are relatively well known, its effects on large caliber arteries are rarely discussed. We present two cases of severe large arterial multisegmented vasospasm, captured on contrast-enhanced computed tomography, several hours after methamphetamine abuse. One of the patients was discharged without apparent tissue loss or organ failure. The other developed severe heart failure, liver failure, and toe gangrene. The publication of the de-identified images has been approved by the VA Central California Health Care System's Research and Development Committee and Privacy Officer. Vascular surgeons and, perhaps, acute care physicians, who are usually aware of small arterial vasospastic conditions, should also be aware of this methamphetamine-induced large arterial finding, which can be quite dramatic in appearance on imaging.
    Language English
    Publishing date 2023-11-22
    Publishing country United States
    Document type Case Reports
    ISSN 2468-4287
    ISSN 2468-4287
    DOI 10.1016/j.jvscit.2023.101376
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  8. Article ; Online: 'Men at risk': sex work, tourism, and STI/HIV risk in Jamaica.

    Johnson, Lauren C

    Culture, health & sexuality

    2016  Volume 18, Issue 9, Page(s) 1025–1038

    Abstract: Female sex tourism has become an accepted income generator for many underemployed men in Jamaica who seek to reap economic benefits from relationships with visiting tourist women. This issue provides contexts to explore the numerous ways in which health ... ...

    Abstract Female sex tourism has become an accepted income generator for many underemployed men in Jamaica who seek to reap economic benefits from relationships with visiting tourist women. This issue provides contexts to explore the numerous ways in which health intersects with issues of masculinity, sexuality and marginality. Based on ethnographic fieldwork in a popular Jamaican resort town, this paper examines the health implications of female sex tourism for the local population and tourist visitors. Data from this project indicate the need for improved sexually transmitted infection education and HIV outreach work towards men who are involved in transactional sex with tourist women. Due to prevalent perceptions of masculinity and gendered notions of sexuality, men who engage in sex tourism constitute a population that rarely receives the attention of local and national health authorities. Data from this qualitative study suggest that engaging this particular vulnerable population could potentially decrease the risk of STI and HIV infection in the country's most popular resort areas. Research of this kind is urgently needed to better understand the risk factors and challenges for Caribbean populations, as well as to inform future prevention efforts in the region.
    MeSH term(s) HIV Infections/prevention & control ; Humans ; Jamaica ; Male ; Masculinity ; Qualitative Research ; Risk Factors ; Sex Work ; Sexual Behavior ; Sexually Transmitted Diseases/prevention & control
    Language English
    Publishing date 2016
    Publishing country England
    Document type Journal Article
    ZDB-ID 2023577-X
    ISSN 1464-5351 ; 1369-1058
    ISSN (online) 1464-5351
    ISSN 1369-1058
    DOI 10.1080/13691058.2016.1155750
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  9. Article: The effects of acute exercise on episodic memory function among young university students: moderation considerations by biological sex.

    Johnson, Lauren / Loprinzi, Paul D

    Health promotion perspectives

    2019  Volume 9, Issue 2, Page(s) 99–104

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2019-05-25
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2691688-5
    ISSN 2228-6497
    ISSN 2228-6497
    DOI 10.15171/hpp.2019.14
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  10. Article ; Online: Distractions in Forensic Evaluations.

    Brodsky, Stanley L / Johnson, Lauren N

    The journal of the American Academy of Psychiatry and the Law

    2019  Volume 47, Issue 3, Page(s) 360–364

    Abstract: Although test manuals and professional guidelines universally specify that forensic assessments should take place in quiet, private, and distraction-free environments, such absences of distractions are rare in jail and prison settings. In this article, ... ...

    Abstract Although test manuals and professional guidelines universally specify that forensic assessments should take place in quiet, private, and distraction-free environments, such absences of distractions are rare in jail and prison settings. In this article, four aspects of this problem are examined. First, compelling examples of noise and distractions are described to give a sense of the nature of the problem. Second, the portions of guidelines from the American Academy of Psychiatry and the Law and the American Psychological Association regarding distractions are presented, along with associated excerpts from test manuals and books. Third, related research findings about the effects of distractions are explored. Finally, overall perspectives of the problem are presented, with special attention given to methods of reporting and managing distractions, examinee habituation, examiner distraction, and ways of conceptualizing evaluation tasks in high-distraction environments.
    MeSH term(s) Forensic Psychiatry ; Forensic Psychology ; Guidelines as Topic ; Humans ; Interview, Psychological ; Noise/adverse effects ; Prisons ; Psychological Tests
    Language English
    Publishing date 2019-05-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1381489-8
    ISSN 1943-3662 ; 0091-634X ; 1093-6793
    ISSN (online) 1943-3662
    ISSN 0091-634X ; 1093-6793
    DOI 10.29158/JAAPL.003842-19
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