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Article ; Online: Effectiveness of Transcranial Direct Current Stimulation as an Adjuvant to Aphasia Treatment Following Stroke: Evidence From Systematic Reviews and Meta-Analyses.

Raymer, Anastasia M / Johnson, Rachel K

American journal of speech-language pathology

2024 , Page(s) 1–13

Abstract: Purpose: Transcranial direct current stimulation (tDCS) is a neuromodulation tool to amplify neural excitability and enhance outcomes associated with speech-language therapy (SLT). Stimulation currents to the left and right hemispheres vary in applying ... ...

Abstract	Purpose: Transcranial direct current stimulation (tDCS) is a neuromodulation tool to amplify neural excitability and enhance outcomes associated with speech-language therapy (SLT). Stimulation currents to the left and right hemispheres vary in applying anodal (excitatory), cathodal (inhibitory), or bihemispheric signals. Several systematic reviews (SRs) and meta-analyses (MAs) have summarized the large literature examining tDCS for aphasia rehabilitation. The purpose of this project was to appraise the quality of SRs and MAs of tDCS for aphasia and examine the weight of the evidence for language outcomes in individuals with aphasia beyond SLT alone. Method: We searched four databases for SRs/MAs examining effects of tDCS for poststroke aphasia. We identified 16 reviews, with nine that incorporated MA to quantify results. Two reviewers reliably coded articles for methodological rigor using the AMSTAR 2 (A MeaSurement Tool to Assess Systematic Reviews, Version 2). We then summarized findings of the 16 reviews. Results: The AMSTAR 2 appraisal criteria suggest that critical weaknesses were noted among all reviews except those by Elsner et al. (2015, 2019). Reviews summarized three to 48 studies, as some included only randomized crossover trials and others included all trial designs. All SRs and one MA reported improvements following tDCS stimulation for general aphasia abilities and measures of repetition and speech fluency. Five recent MAs reported significant naming improvements following tDCS using all stimulation arrays. No tDCS effects were noted for comprehension measures. Conclusions: As the tDCS literature matured, the conclusions of MAs merged with earlier SRs reporting statistically positive benefits over SLT alone. Most consistent results are reported for naming measures, leaving some to question the clinical significance of tDCS effects for functional measures of aphasia recovery. Although the tDCS literature is expansive, important questions remain before the technique can be confidently recommended for clinical practice.
Language	English
Publishing date	2024-02-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	1154406-5
ISSN	1558-9110 ; 1058-0360
ISSN (online)	1558-9110
ISSN	1058-0360
DOI	10.1044/2024_AJSLP-23-00312
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 3716: Show issues

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Article ; Online: Reported Barriers to Augmentative and Alternative Communication Service Delivery and Learning Preferences Among Speech-Language Pathologists.

Gohsman, Meredith K / Johnson, Rachel K

American journal of speech-language pathology

2023 Volume 32, Issue 4, Page(s) 1595–1609

Abstract: Purpose: Speech-language pathologists (SLPs) report extensive barriers to delivering augmentative and alternative communication (AAC) services, including the knowledge and skills necessary for AAC service delivery. Although nearly all graduate programs ... ...

Abstract	Purpose: Speech-language pathologists (SLPs) report extensive barriers to delivering augmentative and alternative communication (AAC) services, including the knowledge and skills necessary for AAC service delivery. Although nearly all graduate programs report the inclusion of preservice training for SLPs to provide AAC services, existing research on SLPs' characteristics of AAC service provision does not reflect these changes. This study aimed to identify current AAC service delivery characteristics, barriers, and learning preferences reported by SLPs. Method: A survey invitation was distributed to SLPs with American Speech-Language-Hearing Association (ASHA) Certificate of Clinical Competence through social media and the ASHA Community discussion groups. Results: Participants were 530 SLPs who predominantly identified as general practice SLPs. Participants reported 1%-25% of their weekly patient caseload has AAC needs for communication or receives AAC intervention. SLPs reported feeling at least "knowledgeable" in more than half of the targeted competency areas. The reported primary barriers to AAC service provision are knowledge, caseload, and time. Preferences for topic, format, and frequency and duration for AAC-related continuing education were highly variable among SLPs. Conclusions: SLPs' barriers to AAC service delivery are consistent with research from the last 15 years, revealing a lack of systematic, organizational, and informational mechanisms to support SLPs as vital members of the AAC team. Those involved in post-service instruction and training must consider the training needs of SLPs with varying competence and their experience with AAC modalities, clinical practice backgrounds, and learning preferences. AAC-related training and continuing education must reflect SLP's daily practice, learning needs, and preferences. Supplemental material: https://doi.org/10.23641/asha.23503809.
MeSH term(s)	Humans ; Speech ; Pathologists ; Communication Disorders/diagnosis ; Communication Disorders/therapy ; Learning ; Communication ; Surveys and Questionnaires ; Speech-Language Pathology/education
Language	English
Publishing date	2023-06-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	1154406-5
ISSN	1558-9110 ; 1058-0360
ISSN (online)	1558-9110
ISSN	1058-0360
DOI	10.1044/2023_AJSLP-22-00036
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Article ; Online: Predictors for Augmentative and Alternative Communication Clinical Service Provision: Closing the Gap.

Johnson, Rachel K / Gohsman, Meredith K

American journal of speech-language pathology

2023 Volume 32, Issue 4, Page(s) 1532–1564

Abstract: Purpose: At the core of the clinical services provided by a speech-language pathologist (SLP) is upholding the human right to communicate. Augmentative and alternative communication (AAC) modalities support communication across environments by offering ... ...

Abstract	Purpose: At the core of the clinical services provided by a speech-language pathologist (SLP) is upholding the human right to communicate. Augmentative and alternative communication (AAC) modalities support communication across environments by offering temporary or permanent solutions. Barriers to AAC service provision include translation of knowledge into clinical practice, which remains problematic despite changes to AAC preservice training addressing the knowledge barrier. This study aims to understand the importance of factors impacting the provision of AAC clinical services. Method: From the survey data of SLPs ( Results: The factors impacting SLPs' knowledge and barriers to practice are related to clinical practicum experiences. Engagement in AAC-related continuing education (CE) is the primary contributor to the use of AAC service provision. Predictors for barriers to AAC clinical provision are associated with clinical practicum experiences, the average number of patients seen weekly, and geographic region. Preference for CE topics and frequency depend on the work setting. Conclusions: Hands-on clinical practicum experience addresses opportunity barriers in AAC service provision, contributing explicitly to the value of collaboration in AAC service delivery and highlights the importance of evidence-based professional development content. The findings from this study are reassuring in that clinicians are using AAC and suggest that high-quality professional development is an effective means to address the gap between knowledge generation and translation in the field. Supplemental material: https://doi.org/10.23641/asha.23202170.
MeSH term(s)	Humans ; Delivery of Health Care ; Communication Disorders/diagnosis ; Communication Disorders/therapy ; Communication ; Education, Special ; Language ; Speech-Language Pathology/education ; Communication Aids for Disabled
Language	English
Publishing date	2023-06-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	1154406-5
ISSN	1558-9110 ; 1058-0360
ISSN (online)	1558-9110
ISSN	1058-0360
DOI	10.1044/2023_AJSLP-22-00320
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Zs.A 3716: Show issues

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Article: A Permissive Amide

Chen, Xiaoyan / Johnson, Rachel M / Li, Bo

ACS catalysis

2023 Volume 13, Issue 3, Page(s) 1899–1905

Abstract: ... ...

Abstract	Amide
Language	English
Publishing date	2023-01-18
Publishing country	United States
Document type	Journal Article
ISSN	2155-5435
ISSN	2155-5435
DOI	10.1021/acscatal.2c05439
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Article ; Online: The Hybrid Antibiotic Thiomarinol A Overcomes Intrinsic Resistance in

Johnson, Rachel M / Li, Kelin / Chen, Xiaoyan / Morgan, Gina L / Aubé, Jeffrey / Li, Bo

ACS infectious diseases

2024 Volume 10, Issue 2, Page(s) 582–593

Abstract: An impermeable outer membrane and multidrug efflux pumps work in concert to provide Gram-negative bacteria with intrinsic resistance against many antibiotics. These resistance mechanisms reduce the intracellular concentrations of antibiotics and render ... ...

Abstract	An impermeable outer membrane and multidrug efflux pumps work in concert to provide Gram-negative bacteria with intrinsic resistance against many antibiotics. These resistance mechanisms reduce the intracellular concentrations of antibiotics and render them ineffective. The natural product thiomarinol A combines holothin, a dithiolopyrrolone antibiotic, with marinolic acid A, a close analogue of mupirocin. The hybridity of thiomarinol A converts the mupirocin scaffold from inhibiting Gram-positive bacteria to inhibiting both Gram-positive and -negative bacteria. We found that thiomarinol A accumulates significantly more than mupirocin within the Gram-negative bacterium
MeSH term(s)	Anti-Bacterial Agents/chemistry ; Mupirocin/pharmacology ; Mupirocin/chemistry ; Mupirocin/analogs & derivatives ; Escherichia coli ; Gram-Negative Bacteria
Chemical Substances	Anti-Bacterial Agents ; thiomarinol (146697-04-3) ; Mupirocin (D0GX863OA5)
Language	English
Publishing date	2024-01-16
Publishing country	United States
Document type	Journal Article
ISSN	2373-8227
ISSN (online)	2373-8227
DOI	10.1021/acsinfecdis.3c00504
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Impact of Asian and Black Donor and Recipient Ethnicity on the Outcomes After Deceased Donor Kidney Transplantation in the United Kingdom.

Hakeem, Abdul Rahman / Asthana, Sonal / Johnson, Rachel / Brown, Chloe / Ahmad, Niaz

Transplant international : official journal of the European Society for Organ Transplantation

2024 Volume 37, Page(s) 12605

Abstract: Patients of Asian and black ethnicity face disadvantage on the renal transplant waiting list in the UK, because of lack of human leucocyte antigen and blood group matched donors from an overwhelmingly white deceased donor pool. This study evaluates ... ...

Abstract	Patients of Asian and black ethnicity face disadvantage on the renal transplant waiting list in the UK, because of lack of human leucocyte antigen and blood group matched donors from an overwhelmingly white deceased donor pool. This study evaluates outcomes of renal allografts from Asian and black donors. The UK Transplant Registry was analysed for adult deceased donor kidney only transplants performed between 2001 and 2015. Asian and black ethnicity patients constituted 12.4% and 6.7% of all deceased donor recipients but only 1.6% and 1.2% of all deceased donors, respectively. Unadjusted survival analysis demonstrated significantly inferior long-term allograft outcomes associated with Asian and black donors, compared to white donors. On Cox-regression analysis, Asian donor and black recipient ethnicities were associated with poorer outcomes than white counterparts, and on ethnicity matching, compared with the white donor-white recipient baseline group and adjusting for other donor and recipient factors, 5-year graft outcomes were significantly poorer for black donor-black recipient, Asian donor-white recipient, and white donor-black recipient combinations in decreasing order of worse unadjusted 5-year graft survival. Increased deceased donation among ethnic minorities could benefit the recipient pool by increasing available organs. However, it may require a refined approach to enhance outcomes.
MeSH term(s)	Humans ; Kidney Transplantation ; United Kingdom ; Male ; Female ; Graft Survival ; Asian People ; Adult ; Middle Aged ; Tissue Donors/supply & distribution ; Black People/statistics & numerical data ; Registries ; White People/statistics & numerical data ; Treatment Outcome ; Aged ; Proportional Hazards Models ; Waiting Lists ; Transplant Recipients/statistics & numerical data
Language	English
Publishing date	2024-04-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	639435-8
ISSN	1432-2277 ; 0934-0874
ISSN (online)	1432-2277
ISSN	0934-0874
DOI	10.3389/ti.2024.12605
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Zs.A 2358: Show issues

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Article: Severe Heart Failure After Fetal Loss and COVID-19: A Diagnostically Challenging Case With Complicated Timing.

Lim, Roy / Johnson, Rachel R / Denney, Brian / Zalikha, Lina

Cureus

2023 Volume 15, Issue 3, Page(s) e36866

Abstract: Coronavirus disease 2019 (COVID-19), initially recognized to cause respiratory system complications, has been found to also affect the cardiovascular system leading to myocardial damage and subsequently causing heart failure. Peripartum cardiomyopathy, ... ...

Abstract	Coronavirus disease 2019 (COVID-19), initially recognized to cause respiratory system complications, has been found to also affect the cardiovascular system leading to myocardial damage and subsequently causing heart failure. Peripartum cardiomyopathy, though an uncommon condition, may also manifest as heart failure toward the end of pregnancy. This atypical case highlights the potential diagnostic overlap between COVID-19 heart failure and peripartum cardiomyopathy. At this point, there is no recommended algorithm used to distinguish one disease from another.
Language	English
Publishing date	2023-03-29
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.36866
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Considerations in the assessment and management of ADHD within the TGDNB population.

Kristensen, Zoe / Drinkwater, Caitlyn / Johnson, Rachel / Menkes, David B

The New Zealand medical journal

2023 Volume 136, Issue 1587, Page(s) 46–51

Abstract: Aims: In this article we consider current literature around Attention Deficit Hyperactivity Disorder (ADHD) in the transgender, gender diverse and non-binary (TGDNB) population.: Methods: Literature review.: Results: N/A conclusions: We outline ... ...

Abstract	Aims: In this article we consider current literature around Attention Deficit Hyperactivity Disorder (ADHD) in the transgender, gender diverse and non-binary (TGDNB) population. Methods: Literature review. Results: N/A conclusions: We outline specific considerations pertaining to the assessment and treatment of ADHD in this group and highlight evidential gaps and avenues for future research. We conclude that TGDNB individuals should be considered a "special population" with regards to ADHD and encourage mental health practitioners to consider specific TGDNB mental health needs beyond capacity assessments and gender-affirming care.
MeSH term(s)	Humans ; Attention Deficit Disorder with Hyperactivity/diagnosis ; Attention Deficit Disorder with Hyperactivity/epidemiology ; Attention Deficit Disorder with Hyperactivity/psychology ; Attention Deficit Disorder with Hyperactivity/therapy ; Mental Health ; New Zealand/epidemiology ; Transgender Persons/psychology ; Sexual and Gender Minorities/psychology
Language	English
Publishing date	2023-12-15
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	390590-1
ISSN	1175-8716 ; 0028-8446 ; 0110-7704
ISSN (online)	1175-8716
ISSN	0028-8446 ; 0110-7704
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Ua VI Zs.396: Show issues

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Article ; Online: Central venous catheter-associated deep vein thrombosis in critically ill pediatric patients: risk factors, prevention, and treatment.

Johnson, Rachel R / Faustino, E Vincent S

Current opinion in pediatrics

2022 Volume 34, Issue 3, Page(s) 273–278

Abstract: Purpose of review: Central venous catheter (CVC) placement and ICU admission are the two most important risk factors for pediatric deep vein thrombosis. The optimal prevention and treatment strategies for CVC-associated deep vein thrombosis (CADVT) are ... ...

Abstract	Purpose of review: Central venous catheter (CVC) placement and ICU admission are the two most important risk factors for pediatric deep vein thrombosis. The optimal prevention and treatment strategies for CVC-associated deep vein thrombosis (CADVT) are unclear, but recently, seminal studies have been published. This review aims to summarize the recent literature on CADVT in critically ill children. Recent findings: Recent publications focused on three themes: risk factors, prevention, and treatment of CADVT. Newly identified risk factors for CADVT relate to Virchow's triad of hemostasis, blood vessel injury, and hypercoagulability. New risk prediction models have moderately good accuracy in predicting CADVT. Though previous data on pharmacologic CADVT prophylaxis was equivocal, recent studies indicate that low-molecular-weight heparin may be effective in preventing CADVT, particularly in critically ill children. Finally, new studies suggest that direct oral anticoagulants and shorter treatment times are noninferior to traditional agents and treatment durations in the treatment of CADVT. Summary: Recent research suggests new ways to accurately identify children at high risk of CADVT, effectively prevent CADVT, and optimize CADVT treatment. Future research should focus on understanding the pathobiology of CADVT formation, prevention, and treatment in critically ill children.
MeSH term(s)	Central Venous Catheters/adverse effects ; Child ; Critical Illness/therapy ; Humans ; Risk Factors ; Venous Thrombosis/diagnosis ; Venous Thrombosis/etiology ; Venous Thrombosis/prevention & control
Language	English
Publishing date	2022-05-19
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1049374-8
ISSN	1531-698X ; 1040-8703
ISSN (online)	1531-698X
ISSN	1040-8703
DOI	10.1097/MOP.0000000000001128
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Zs.A 3049: Show issues

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Article ; Online: Reducing Intake of Sugar-Sweetened Beverages Is Vital to Improving Our Nation's Health.

Johnson, Rachel K

Circulation

2016 Volume 133, Issue 4, Page(s) 347–349

MeSH term(s)	Beverages/adverse effects ; Female ; Humans ; Intra-Abdominal Fat/metabolism ; Male ; Subcutaneous Fat/metabolism ; Sweetening Agents/adverse effects
Chemical Substances	Sweetening Agents
Language	English
Publishing date	2016-01-26
Publishing country	United States
Document type	Comment ; Editorial
ZDB-ID	80099-5
ISSN	1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
ISSN (online)	1524-4539
ISSN	0009-7322 ; 0069-4193 ; 0065-8499
DOI	10.1161/CIRCULATIONAHA.115.020453
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