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Artikel ; Online: NC1184: Molecular Mechanisms Regulating Skeletal Muscle Growth and Differentiation.

Johnson, Sally E

2022 Band 100, Heft 8

Mesh-Begriff(e)	Animals ; Cell Differentiation ; Muscle Development ; Muscle, Skeletal/physiology
Sprache	Englisch
Erscheinungsdatum	2022-07-23
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	390959-1
ISSN	1525-3163 ; 0021-8812
ISSN (online)	1525-3163
ISSN	0021-8812
DOI	10.1093/jas/skac229
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Effect of mycobacterial cell wall fractions on dairy cow health and fertility.

Johnson, Sally E

Journal of animal science

2021 Band 99, Heft 9

Mesh-Begriff(e)	Animals ; Cattle ; Cell Wall ; Dairying ; Female ; Fertility ; Lactation
Sprache	Englisch
Erscheinungsdatum	2021-09-01
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	390959-1
ISSN	1525-3163 ; 0021-8812
ISSN (online)	1525-3163
ISSN	0021-8812
DOI	10.1093/jas/skab227
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Intravenous Injection of Sodium Hyaluronate Diminishes Basal Inflammatory Gene Expression in Equine Skeletal Muscle.

Gregg, Savannah R / Barshick, Madison R / Johnson, Sally E

Animals : an open access journal from MDPI

2023 Band 13, Heft 19

Abstract: Following strenuous exercise, skeletal muscle experiences an acute inflammatory state that initiates the repair process. Systemic hyaluronic acid (HA) is injected to horses routinely as a joint anti-inflammatory. To gain insight into the effects of HA on ...

Abstract	Following strenuous exercise, skeletal muscle experiences an acute inflammatory state that initiates the repair process. Systemic hyaluronic acid (HA) is injected to horses routinely as a joint anti-inflammatory. To gain insight into the effects of HA on skeletal muscle, adult Thoroughbred geldings (n = 6) were injected with a commercial HA product weekly for 3 weeks prior to performing a submaximal exercise test. Gluteal muscle (GM) biopsies were obtained before and 1 h after exercise for gene expression analysis and HA localization. The results from RNA sequencing demonstrate differences in gene expression between non-injected controls (CON; n = 6) and HA horses. Prior to exercise, HA horses contained fewer (
Sprache	Englisch
Erscheinungsdatum	2023-09-27
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani13193030
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Emily Alyssa Halpern Keram, MD: The Not So Accidental Forensic Psychiatrist.

Johnson, Sally C

The journal of the American Academy of Psychiatry and the Law

2016 Band 44, Heft 1, Seite(n) 14–18

Mesh-Begriff(e)	Administrative Personnel ; Forensic Psychiatry ; History, 20th Century ; History, 21st Century ; Societies, Medical
Sprache	Englisch
Erscheinungsdatum	2016-03
Erscheinungsland	United States
Dokumenttyp	Biography ; Historical Article ; Journal Article ; Portraits
ZDB-ID	1381489-8
ISSN	1943-3662 ; 0091-634X ; 1093-6793
ISSN (online)	1943-3662
ISSN	0091-634X ; 1093-6793
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Evidence for primary care services at A&E.

Johnson, Sally J

BMJ (Clinical research ed.)

2015 Band 350, Seite(n) h3352

Mesh-Begriff(e)	Emergency Service, Hospital/organization & administration ; Hospital Design and Construction ; Humans ; Primary Health Care/organization & administration
Sprache	Englisch
Erscheinungsdatum	2015-06-24
Erscheinungsland	England
Dokumenttyp	Comment ; Letter
ZDB-ID	1362901-3
ISSN	1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
ISSN (online)	1756-1833
ISSN	0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
DOI	10.1136/bmj.h3352
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Molecular and biochemical regulation of skeletal muscle metabolism.

Zumbaugh, Morgan D / Johnson, Sally E / Shi, Tim H / Gerrard, David E

Journal of animal science

2022 Band 100, Heft 8

Abstract: Skeletal muscle hypertrophy is a culmination of catabolic and anabolic processes that are interwoven into major metabolic pathways, and as such modulation of skeletal muscle metabolism may have implications on animal growth efficiency. Muscle is composed ...

Abstract	Skeletal muscle hypertrophy is a culmination of catabolic and anabolic processes that are interwoven into major metabolic pathways, and as such modulation of skeletal muscle metabolism may have implications on animal growth efficiency. Muscle is composed of a heterogeneous population of muscle fibers that can be classified by metabolism (oxidative or glycolytic) and contractile speed (slow or fast). Although slow fibers (type I) rely heavily on oxidative metabolism, presumably to fuel long or continuous bouts of work, fast fibers (type IIa, IIx, and IIb) vary in their metabolic capability and can range from having a high oxidative capacity to a high glycolytic capacity. The plasticity of muscle permits continuous adaptations to changing intrinsic and extrinsic stimuli that can shift the classification of muscle fibers, which has implications on fiber size, nutrient utilization, and protein turnover rate. The purpose of this paper is to summarize the major metabolic pathways in skeletal muscle and the associated regulatory pathways.
Mesh-Begriff(e)	Adaptation, Physiological ; Animals ; Muscle Contraction/physiology ; Muscle Fibers, Skeletal/metabolism ; Muscle, Skeletal/metabolism ; Oxidation-Reduction
Sprache	Englisch
Erscheinungsdatum	2022-08-01
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	390959-1
ISSN	1525-3163 ; 0021-8812
ISSN (online)	1525-3163
ISSN	0021-8812
DOI	10.1093/jas/skac035
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Short Communication: Supplementation with calcium butyrate causes an increase in the percentage of oxidative fibers in equine gluteus medius muscle.

Busse, Nicolas I / Gonzalez, Madison L / Wagner, Ashley L / Johnson, Sally E

Journal of animal science

2022 Band 100, Heft 8

Abstract: Optimal athletic performance requires meeting the energetic demands of the muscle fibers, which are a function of myosin ATPase enzymatic activity. Skeletal muscle with a predominant oxidative metabolism underlies equine athletic success. Sodium butyrate, ...

Abstract	Optimal athletic performance requires meeting the energetic demands of the muscle fibers, which are a function of myosin ATPase enzymatic activity. Skeletal muscle with a predominant oxidative metabolism underlies equine athletic success. Sodium butyrate, a short-chain fatty acid, can affect muscle fiber composition in pigs. To determine if a similar scenario exists in horses, 12 adult Thoroughbred geldings (7.4 ± 0.6 yr of age; mean ± SEM) were fed 16 g of calcium butyrate (CB) or an equivalent amount of carrier (CON) daily for 30 d in a crossover design. Middle gluteal muscle biopsies were collected before and after the feeding trial for immunohistochemical determination of fiber type, and RNA and protein isolation. After 30 d, CB increased (P < 0.05) the percentage of type IIA fibers and tended (P = 0.13) to reduce the numbers of type IIX fibers in comparison to control (CON). No changes (P > 0.05) in type I, IIA, or IIX fiber size were observed in response to CB. No differences (P > 0.05) were noted in the abundance of succinate dehydrogenase (SDH) protein or activity between horses receiving CB or CON. Myogenin mRNA abundance was unaffected (P > 0.05) by 30 d of CB supplementation. The increase in type IIA fibers in the absence of altered mitochondrial SDH enzymatic activity suggests that CB affects myosin ATPase expression independent of altered metabolism.
Mesh-Begriff(e)	Animals ; Butyrates/metabolism ; Calcium/metabolism ; Dietary Supplements ; Horses ; Male ; Muscle Fibers, Skeletal/metabolism ; Muscle, Skeletal/metabolism ; Myosin Heavy Chains/genetics ; Myosin Heavy Chains/metabolism ; Myosins ; Oxidative Stress ; Swine
Chemische Substanzen	Butyrates ; Myosin Heavy Chains (EC 3.6.4.1) ; Myosins (EC 3.6.4.1) ; Calcium (SY7Q814VUP)
Sprache	Englisch
Erscheinungsdatum	2022-07-29
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	390959-1
ISSN	1525-3163 ; 0021-8812
ISSN (online)	1525-3163
ISSN	0021-8812
DOI	10.1093/jas/skac108
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Eculizumab in the treatment of Shiga toxin haemolytic uraemic syndrome.

Walsh, Patrick R / Johnson, Sally

Pediatric nephrology (Berlin, Germany)

2018 Band 34, Heft 9, Seite(n) 1485–1492

Abstract: Haemolytic uraemic syndrome (HUS) remains a leading cause of paediatric acute kidney injury (AKI). Haemolytic uraemic syndrome is characterised by the triad of microangiopathic haemolytic anaemia, thrombocytopenia and AKI. In ~ 90% of cases, HUS is a ... ...

Abstract	Haemolytic uraemic syndrome (HUS) remains a leading cause of paediatric acute kidney injury (AKI). Haemolytic uraemic syndrome is characterised by the triad of microangiopathic haemolytic anaemia, thrombocytopenia and AKI. In ~ 90% of cases, HUS is a consequence of infection with Shiga toxin-producing E. coli (STEC), most commonly serotype O157:H7. Acute mortality from STEC-HUS is now less than 5%; however, there is significant long-term renal morbidity in one third of survivors. Currently, no specific treatment exists for STEC-HUS. There is growing interest in the role of complement in the pathogenesis of STEC-HUS due to the discovery of inherited and acquired dysregulation of the alternative complement system in the closely related disorder, atypical HUS (aHUS). The treatment of aHUS has been revolutionised by the introduction of the anti-C5 monoclonal antibody, eculizumab. However, the role of complement and anti-complement therapy in STEC-HUS remains unclear. Herein, we review the current evidence of the role of complement in STEC-HUS focusing on the use of eculizumab in this disease.
Mesh-Begriff(e)	Antibodies, Monoclonal, Humanized/pharmacology ; Antibodies, Monoclonal, Humanized/therapeutic use ; Child ; Complement Inactivating Agents/pharmacology ; Complement Inactivating Agents/therapeutic use ; Complement Pathway, Alternative/drug effects ; Complement Pathway, Alternative/immunology ; Complement System Proteins/immunology ; Erythrocyte Transfusion ; Hemolytic-Uremic Syndrome/immunology ; Hemolytic-Uremic Syndrome/microbiology ; Hemolytic-Uremic Syndrome/therapy ; Humans ; Renal Dialysis ; Shiga Toxin/immunology ; Shiga-Toxigenic Escherichia coli/immunology ; Shiga-Toxigenic Escherichia coli/isolation & purification ; Treatment Outcome
Chemische Substanzen	Antibodies, Monoclonal, Humanized ; Complement Inactivating Agents ; Shiga Toxin (75757-64-1) ; Complement System Proteins (9007-36-7) ; eculizumab (A3ULP0F556)
Sprache	Englisch
Erscheinungsdatum	2018-07-30
Erscheinungsland	Germany
Dokumenttyp	Journal Article ; Review
ZDB-ID	631932-4
ISSN	1432-198X ; 0931-041X
ISSN (online)	1432-198X
ISSN	0931-041X
DOI	10.1007/s00467-018-4025-0
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: β-Hydroxy β-methylbutyrate supplementation to adult Thoroughbred geldings increases type IIA fiber content in the gluteus medius.

Busse, Nicolas I / Gonzalez, Madison L / Krason, Mackenzie L / Johnson, Sally E

Journal of animal science

2021 Band 99, Heft 10

Abstract: Consumption of β-hydroxy β-methylbutyrate (HMB) alters muscle composition and metabolism leading to strength and agility improvements in human athletes. To determine if HMB affects athletic performance and muscle function in horses, Thoroughbred geldings ...

Abstract	Consumption of β-hydroxy β-methylbutyrate (HMB) alters muscle composition and metabolism leading to strength and agility improvements in human athletes. To determine if HMB affects athletic performance and muscle function in horses, Thoroughbred geldings were fed a control (CON; n = 5) or HMB (n = 6) supplement for 6 wk prior to completing a standardized exercise test (SET). Gluteus medius (GM) muscle biopsies were obtained before the SET for fiber typing. Heart rate, biceps femoris (BF) and semitendinosus (ST) surface electromyograms (EMG), and fore and hind limbs metacarpophalangeal joint angles were captured at the gallop of the SET. Results demonstrate that HMB supplementation increased (P < 0.05) the percentage of type IIA and IIA/X muscle fibers in the GM with a corresponding decrease (P < 0.05) in type IIX fibers. The percentage of type I fibers was unaffected by diet. Supplementation with HMB did not result in any measurable effects on performance or biomechanical properties by comparison to CON. Supplementation with HMB resulted in an increase (P < 0.05) in ST median frequency at speeds of 10 m/s and greater. Increasing treadmill speed resulted in an increase (P < 0.05) in stride length and the maximal proximal forelimb fetlock angle, and a decrease (P < 0.05) in stance phase time of the gait cycle. Integrated EMG (iEMG) increased (P < 0.05) with increasing treadmill speeds for both the BF and ST with the BF exhibiting greater (P < 0.05) iEMG values than the ST. In summary, HMB increased the percentage of type IIA GM fibers, which did not translate into improved performance.
Mesh-Begriff(e)	Animals ; Dietary Supplements ; Horses ; Male ; Muscles ; Valerates
Chemische Substanzen	Valerates ; beta-hydroxyisovaleric acid (3F752311CD)
Sprache	Englisch
Erscheinungsdatum	2021-09-13
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	390959-1
ISSN	1525-3163 ; 0021-8812
ISSN (online)	1525-3163
ISSN	0021-8812
DOI	10.1093/jas/skab264
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: The initial delay to mitotic activity in primary cultures of equine satellite cells is reduced by combinations of growth factors.

Barshick, Madison R / Gonzalez, Madison L / Busse, Nicolas I / Helsel, Patricia J / Johnson, Sally E

Journal of animal science

2022 Band 100, Heft 8

Abstract: Satellite cell (SC) activation is defined as the time frame during which the stem cell becomes poised to reenter G1 of the cell cycle. The growth factors and events leading to full mitotic activation in equine SCs remain largely unknown. Insulin-like ... ...

Abstract	Satellite cell (SC) activation is defined as the time frame during which the stem cell becomes poised to reenter G1 of the cell cycle. The growth factors and events leading to full mitotic activation in equine SCs remain largely unknown. Insulin-like growth factor I (IGF-I), hepatocyte growth factor (HGF), and fibroblast growth factor 2 (FGF2) are sequentially transcribed during the muscle repair and recovery period following strenuous exercise in adult horses. Expression of IGF-I occurs within 24 h of the postexercise recovery period suggesting it may affect early SC actions. As a first step, gluteus medius muscle cryosections from adult horses (n = 9) were examined for the presence of central nuclei (CN), a marker of SC addition to the fiber. Results demonstrate few CN fibers prior to exercise with a 3-fold increase (P = 0.05) 24 h postexercise. Cultures of SC (n = 4 isolates) were treated with 100 ng/mL IGF-I for varying times prior to measurement of myogenic events. Results demonstrate that IGF-I does not affect the initial lag period, proliferation, or subsequent differentiation of equine SC in vitro (P > 0.05). However, media containing a combination of IGF-I and 10 ng/mL FGF2 and 25 ng/mL HGF hastens (P < 0.05) the time to S-phase entry in fresh isolates of SCs. Media supplementation with optimal concentrations of FGF2, HGF, or a combination of HGF and FGF2 suppresses (P < 0.05) the percentage of myogenin immunopositive SCs to levels below that found in control- or IGF-I-treated SCs. These results provide new insight into the combinatorial roles growth factors play during equine SC myogenesis.
Mesh-Begriff(e)	Animals ; Cells, Cultured ; Fibroblast Growth Factor 2/metabolism ; Fibroblast Growth Factor 2/pharmacology ; Horses ; Insulin-Like Growth Factor I/metabolism ; Muscle Development ; Muscle, Skeletal/metabolism ; Myoblasts ; Satellite Cells, Skeletal Muscle/metabolism
Chemische Substanzen	Fibroblast Growth Factor 2 (103107-01-3) ; Insulin-Like Growth Factor I (67763-96-6)
Sprache	Englisch
Erscheinungsdatum	2022-07-23
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	390959-1
ISSN	1525-3163 ; 0021-8812
ISSN (online)	1525-3163
ISSN	0021-8812
DOI	10.1093/jas/skac140
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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