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  1. Article: How Were Wait Times for Priority Procedures in Canada Impacted during the First Six Months of the COVID-19 Pandemic?

    Reason, Ben / Pichora, Erin / Johnson, Tracy

    Healthcare quarterly (Toronto, Ont.)

    2022  Volume 24, Issue 4, Page(s) 11–15

    Abstract: In 2020, health systems across Canada responded to the COVID-19 pandemic by making rapid changes to reduce the risk of exposure for patients and staff and to allocate resources toward the treatment of COVID-19 patients. This included postponing surgical ... ...

    Abstract In 2020, health systems across Canada responded to the COVID-19 pandemic by making rapid changes to reduce the risk of exposure for patients and staff and to allocate resources toward the treatment of COVID-19 patients. This included postponing surgical and diagnostic procedures. Data collected by the Canadian Institute for Health Information show that these interventions resulted in longer wait times across all provinces in April-September 2020 for scheduled surgical procedures, such as hip and knee replacements and cataract surgeries. The impact on wait times for cancer surgeries and diagnostic imaging varied by type of procedure and jurisdiction, while the wait times for hip fracture repair and radiation therapy were not impacted. Subsequent waves of the COVID-19 pandemic added to the initial backlog of procedures, and it will take time to assess the long-term impact of surgical and diagnostic imaging delays on patient outcomes and wait times.
    MeSH term(s) COVID-19/epidemiology ; Canada/epidemiology ; Humans ; Pandemics/prevention & control ; SARS-CoV-2 ; Waiting Lists
    Language English
    Publishing date 2022-02-25
    Publishing country Canada
    Document type Journal Article
    ISSN 1710-2774
    ISSN 1710-2774
    DOI 10.12927/hcq.2022.26717
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Differential dopamine modulation of spinal reflex amplitudes is associated with the presence or absence of the autonomic nervous system.

    Johnson, Tracy L / Clemens, Stefan

    Neuroscience letters

    2020  Volume 742, Page(s) 135514

    Abstract: The spinal cord contains a highly collateralized network of descending dopamine (DA) fibers that stem from the dorso-posterior hypothalamic A11 region in the brain, however, the modulatory actions of DA have generally only been assessed in lumbar ... ...

    Abstract The spinal cord contains a highly collateralized network of descending dopamine (DA) fibers that stem from the dorso-posterior hypothalamic A11 region in the brain, however, the modulatory actions of DA have generally only been assessed in lumbar segments L2-L5. In contrast to these exclusively sensorimotor segments, spinal cords segments T1-L2 and, in mouse, L6-S2, additionally contain the intermediolateral (IML) nucleus, the origin of autonomic nervous system (ANS). Here, we tested if the different spinal circuits in sensorimotor and IML-containing segments react differently to the modulation of the monosynaptic reflex (MSR) by DA. Bath-application of DA (1 μM) led to a decrease of MSR amplitude in L3-L5 segments; however, in IML-containing segments (T10-L2, and S1/2) the MSR response was facilitated. We did not observe any difference in the response between thoracic (sympathetic) and lumbosacral (parasympathetic) segments. Application of the D2-receptor agonists bromocriptine or quinpirole mimicked the effects of DA, while blocking D2 receptor pathways with raclopride or application with the D1-receptor agonist SKF 38393 led to an increase of the MSR in L3-L5 segments and a decrease of the MSR in IML-containing segments. In contrast, in the presence of the gap-junction blockers, carbenoloxone and quinine, DA modulatory actions in IML-containing segments were similar to those of sensorimotor L3-L5 segments. We suggest that DA modulates MSR amplitudes in the spinal cord in a segment-specific manner, and that the differential outcome observed in ANS segments may be a result of gap junctions in the IML.
    MeSH term(s) Animals ; Autonomic Nervous System/drug effects ; Autonomic Nervous System/physiology ; Dopamine/pharmacology ; Dopamine D2 Receptor Antagonists/pharmacology ; Electric Stimulation/methods ; Female ; Male ; Mice ; Mice, Inbred C57BL ; Organ Culture Techniques ; Receptors, Dopamine D2/agonists ; Receptors, Dopamine D2/physiology ; Reflex/drug effects ; Reflex/physiology ; Spinal Cord/drug effects ; Spinal Cord/physiology
    Chemical Substances DRD2 protein, mouse ; Dopamine D2 Receptor Antagonists ; Receptors, Dopamine D2 ; Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2020-11-20
    Publishing country Ireland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 194929-9
    ISSN 1872-7972 ; 0304-3940
    ISSN (online) 1872-7972
    ISSN 0304-3940
    DOI 10.1016/j.neulet.2020.135514
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  3. Article ; Online: Complexity in Health: Can Design Help Support Interdisciplinary Solutions?

    Andrawes, Ledia / Johnson, Tracy / Coleman, Michael

    Global health, science and practice

    2021  Volume 9, Issue Suppl 2, Page(s) S217–S225

    Language English
    Publishing date 2021-11-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2710875-2
    ISSN 2169-575X ; 2169-575X
    ISSN (online) 2169-575X
    ISSN 2169-575X
    DOI 10.9745/GHSP-D-21-00222
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Design for Health: Human-Centered Design Looks to the Future.

    Johnson, Tracy / Das, Shilpa / Tyler, Nikki

    Global health, science and practice

    2021  Volume 9, Issue Suppl 2, Page(s) S190–S194

    Language English
    Publishing date 2021-11-29
    Publishing country United States
    Document type Editorial
    ZDB-ID 2710875-2
    ISSN 2169-575X ; 2169-575X
    ISSN (online) 2169-575X
    ISSN 2169-575X
    DOI 10.9745/GHSP-D-21-00608
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  5. Article ; Online: Leverage the power of ritual to improve community health worker efficacy and public health outcomes: Lessons from Bihar, India.

    Legare, Cristine / Burger, Oskar / Johnson, Tracy / Mor, Nachiket / Saldanha, Neela

    The Lancet regional health. Southeast Asia

    2022  Volume 1, Page(s) 100006

    Abstract: Biomedical health interventions now have global reach and interact in complex and often poorly understood ways with traditional medical rituals that precede biomedicine. People often experience biomedical practices and treatments as rituals because they ... ...

    Abstract Biomedical health interventions now have global reach and interact in complex and often poorly understood ways with traditional medical rituals that precede biomedicine. People often experience biomedical practices and treatments as rituals because they are very similar from an experiential perspective.
    Funding: Grants INV-008582 and INV-016014 to C.L. from The Bill & Melinda Gates Foundation funded this manuscript.
    Language English
    Publishing date 2022-05-05
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2772-3682
    ISSN (online) 2772-3682
    DOI 10.1016/j.lansea.2022.04.002
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  6. Article ; Online: The Exon Junction Complex: A Multitasking Guardian of the Transcriptome.

    Leung, Calvin S / Johnson, Tracy L

    Molecular cell

    2019  Volume 72, Issue 5, Page(s) 799–801

    Abstract: In a recent issue of Molecular Cell, Boehm et al. (2018), Blazquez et al. (2018), and Gonatopoulos-Pournatzis et al. (2018) uncover novel mechanisms by which the cell regulates splicing of cryptic splice sites and microexons. ...

    Abstract In a recent issue of Molecular Cell, Boehm et al. (2018), Blazquez et al. (2018), and Gonatopoulos-Pournatzis et al. (2018) uncover novel mechanisms by which the cell regulates splicing of cryptic splice sites and microexons.
    MeSH term(s) Cell Nucleus ; Exons ; RNA Splice Sites ; RNA Splicing ; Transcriptome
    Chemical Substances RNA Splice Sites
    Language English
    Publishing date 2019-01-09
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2018.11.030
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    Zs.A 5055: Show issues Location:
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  7. Article ; Online: Intron RNA sequences help yeast cells to survive starvation.

    Edwards, Samantha R / Johnson, Tracy L

    Nature

    2019  Volume 565, Issue 7741, Page(s) 578–579

    MeSH term(s) Base Sequence ; Introns ; RNA Splicing ; RNA, Fungal
    Chemical Substances RNA, Fungal
    Language English
    Publishing date 2019-01-25
    Publishing country England
    Document type News ; Comment
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-019-00088-y
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    Zs.A 26: Show issues Location:
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    Zs.MO 244: Show issues

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  8. Article: Coordination of Care Could Improve: Canadian Results from the Commonwealth Fund International Health Policy Survey of Primary Care Physicians.

    Sovran, Vanessa / Ytsma, Alison / Husak, Liudmila / Johnson, Tracy

    Healthcare quarterly (Toronto, Ont.)

    2020  Volume 23, Issue 2, Page(s) 6–8

    Abstract: Care coordination is a critical component of a strong primary care system. The Commonwealth Fund (CMWF) 2019 International Health Policy Survey of Primary Care Physicians polled physicians in 11 countries, allowing international and pan-Canadian ... ...

    Abstract Care coordination is a critical component of a strong primary care system. The Commonwealth Fund (CMWF) 2019 International Health Policy Survey of Primary Care Physicians polled physicians in 11 countries, allowing international and pan-Canadian comparisons of physicians' perspectives in this area. Canadian physicians indicated that there was room for improvement in coordinating care with those outside their practice, particularly specialists, home-based care providers and social services. Opportunities may arise in learning from higher-performing CMWF countries and in adopting new information technologies that are growing methods of facilitating communication across care settings.
    MeSH term(s) Canada ; Continuity of Patient Care ; Humans ; Physicians, Primary Care/statistics & numerical data ; Practice Patterns, Physicians' ; Primary Health Care/methods ; Primary Health Care/organization & administration ; Social Work ; Surveys and Questionnaires
    Language English
    Publishing date 2020-08-07
    Publishing country Canada
    Document type Journal Article
    ISSN 1710-2774
    ISSN 1710-2774
    DOI 10.12927/hcq.2020.26283
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  9. Article ; Online: Offering Better Standards of Dialysis Care for Immigrants: The Colorado Example.

    Cervantes, Lilia / Johnson, Tracy / Hill, Aubrey / Earnest, Mark

    Clinical journal of the American Society of Nephrology : CJASN

    2020  Volume 15, Issue 10, Page(s) 1516–1518

    MeSH term(s) Colorado ; Health Policy ; Health Services Accessibility/standards ; Humans ; Kidney Failure, Chronic/therapy ; Medicaid/legislation & jurisprudence ; Renal Dialysis ; Undocumented Immigrants ; United States
    Language English
    Publishing date 2020-05-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2226665-3
    ISSN 1555-905X ; 1555-9041
    ISSN (online) 1555-905X
    ISSN 1555-9041
    DOI 10.2215/CJN.01190120
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  10. Article ; Online: Mathematical modeling identifies potential gene structure determinants of co-transcriptional control of alternative pre-mRNA splicing.

    Davis-Turak, Jeremy / Johnson, Tracy L / Hoffmann, Alexander

    Nucleic acids research

    2019  Volume 47, Issue 3, Page(s) 1602–1603

    Language English
    Publishing date 2019-02-01
    Publishing country England
    Document type Journal Article ; Published Erratum
    ZDB-ID 186809-3
    ISSN 1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
    ISSN (online) 1362-4962 ; 1362-4954
    ISSN 0301-5610 ; 0305-1048
    DOI 10.1093/nar/gkz013
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