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  1. Article: Meningioma uptake of

    Courtney, Michael / Johnston, Ciaran / Nasoodi, Afshin

    Acta radiologica open

    2021  Volume 10, Issue 2, Page(s) 2058460120981001

    Abstract: Prostate cancer is the most common malignancy in men with high incidence of recurrence following treatment. Biochemical recurrence, as indicated by rising PSA levels following successful treatment of the primary disease, is a frequent encounter in ... ...

    Abstract Prostate cancer is the most common malignancy in men with high incidence of recurrence following treatment. Biochemical recurrence, as indicated by rising PSA levels following successful treatment of the primary disease, is a frequent encounter in routine clinical practice.
    Language English
    Publishing date 2021-02-11
    Publishing country England
    Document type Case Reports
    ZDB-ID 2818429-4
    ISSN 2058-4601
    ISSN 2058-4601
    DOI 10.1177/2058460120981001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Spurious Uptake on 68Ga-Prostate-Specific Membrane Antigen PET/CT Due to Ankylosing Spondylitis; A Rare Pitfall in Imaging of Biochemical Recurrence of Prostate Cancer.

    Heaney, Roisin M / Johnston, Ciaran / Nasoodi, Afshin

    Clinical nuclear medicine

    2021  Volume 46, Issue 7, Page(s) e373–e375

    Abstract: Abstract: Bone is one of the most common sites of prostate cancer recurrence, and 68Ga-prostate-specific membrane antigen (PSMA) uptake by benign bone entities poses a diagnostic dilemma. We describe the case of a 60-year-old man with recurrence in a ... ...

    Abstract Abstract: Bone is one of the most common sites of prostate cancer recurrence, and 68Ga-prostate-specific membrane antigen (PSMA) uptake by benign bone entities poses a diagnostic dilemma. We describe the case of a 60-year-old man with recurrence in a small presacral node on 68Ga-PSMA PET/CT. Of note, the images also demonstrated bilateral asymmetrical sacroiliac joint uptake. A history of ankylosing spondylitis was subsequently elicited, confirming the radiographic suspicion of sacroiliitis, therefore confirming the nonmalignant nature of 68Ga-PSMA uptake related to sacroiliitis rather than osseous recurrence from prostate carcinoma. 68Ga-PSMA uptake may indicate angioneogenesis in sacroiliitis and consequently may be helpful in assessing disease activity and therapy response.
    MeSH term(s) Biological Transport ; Edetic Acid/analogs & derivatives ; Edetic Acid/metabolism ; Gallium Isotopes ; Gallium Radioisotopes ; Humans ; Male ; Middle Aged ; Oligopeptides/metabolism ; Positron Emission Tomography Computed Tomography ; Prostatic Neoplasms/complications ; Prostatic Neoplasms/diagnostic imaging ; Recurrence ; Spondylitis, Ankylosing/complications ; Spondylitis, Ankylosing/diagnostic imaging ; Spondylitis, Ankylosing/metabolism
    Chemical Substances Gallium Isotopes ; Gallium Radioisotopes ; Oligopeptides ; gallium 68 PSMA-11 ; Edetic Acid (9G34HU7RV0)
    Language English
    Publishing date 2021-03-30
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 197628-x
    ISSN 1536-0229 ; 0363-9762
    ISSN (online) 1536-0229
    ISSN 0363-9762
    DOI 10.1097/RLU.0000000000003616
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: COVID-19; beyond the obvious: how do we move forward?

    Nasoodi, Afshin / Johnston, Ciaran / Fraioli, Francesco

    European journal of nuclear medicine and molecular imaging

    2020  Volume 47, Issue 9, Page(s) 2070–2071

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Fluorodeoxyglucose F18 ; Humans ; Pandemics ; Pneumonia, Viral ; Positron Emission Tomography Computed Tomography ; SARS-CoV-2
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Keywords covid19
    Language English
    Publishing date 2020-06-11
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-020-04905-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: COVID-19 beyond the obvious: how do we move forward? The status surrounding chloroquine and other drugs as potential anti-infective agents for COVID-19

    Nasoodi, Afshin / Johnston, Ciaran / Fraioli, Francesco / Ramotar, Dindial

    European Journal of Nuclear Medicine and Molecular Imaging

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #620319
    Database COVID19

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  5. Article ; Online: COVID-19; beyond the obvious

    Nasoodi, Afshin / Johnston, Ciaran / Fraioli, Francesco

    European Journal of Nuclear Medicine and Molecular Imaging

    how do we move forward?

    2020  Volume 47, Issue 9, Page(s) 2070–2071

    Keywords Radiology Nuclear Medicine and imaging ; General Medicine ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-020-04905-9
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Intra-articular Melanoma Metastasis in the Ankle Joint.

    Murphy, Jennifer / Brennan, Ian / Johnston, Ciaran

    Clinical nuclear medicine

    2017  Volume 42, Issue 10, Page(s) 793–794

    Abstract: Intra-articular melanoma metastases are rare. We present a case of a 65-year-old woman with metastatic melanoma in the right ankle joint. F-FDG PET/CT was performed from the vertex to the toes, which demonstrated FDG-avid inguinal lymphadenopathy and an ... ...

    Abstract Intra-articular melanoma metastases are rare. We present a case of a 65-year-old woman with metastatic melanoma in the right ankle joint. F-FDG PET/CT was performed from the vertex to the toes, which demonstrated FDG-avid inguinal lymphadenopathy and an intensely FDG-avid soft tissue mass adjacent to the neck of the talus within the right ankle joint. The intra-articular mass was subsequently resected and histologically confirmed as metastatic melanoma. This case emphasizes the value of the contemporaneous CT in these studies for accurate anatomical localization in diagnostically challenging clinical scenarios.
    Language English
    Publishing date 2017-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 197628-x
    ISSN 1536-0229 ; 0363-9762
    ISSN (online) 1536-0229
    ISSN 0363-9762
    DOI 10.1097/RLU.0000000000001790
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Can the Efficacy of [

    O'Neill, Hazel / Malik, Vinod / Johnston, Ciaran / Reynolds, John V / O'Sullivan, Jacintha

    Pharmaceuticals (Basel, Switzerland)

    2019  Volume 12, Issue 1

    Abstract: Positron Emission Tomography (PET) is a functional imaging modality widely used in clinical oncology. Over the years the sensitivity and specificity of PET has improved with the advent of specific radiotracers, increased technical accuracy of PET ... ...

    Abstract Positron Emission Tomography (PET) is a functional imaging modality widely used in clinical oncology. Over the years the sensitivity and specificity of PET has improved with the advent of specific radiotracers, increased technical accuracy of PET scanners and incremental experience of Radiologists. However, significant limitations exist-most notably false positives and false negatives. Additionally, the accuracy of PET varies between cancer types and in some cancers, is no longer considered a standard imaging modality. This review considers the relative influence of macroscopic tumour features such as size and morphology on 2-Deoxy-2-[
    Language English
    Publishing date 2019-01-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph12010016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: High prevalence of abnormalities on chest radiography in rheumatoid arthritis.

    Goggins, Michael R / Conway, Richard / Durcan, Laura J / Johnston, Ciaran / Cunnane, Gaye

    Clinical rheumatology

    2019  Volume 38, Issue 12, Page(s) 3375–3380

    Abstract: Introduction: Chest radiography (CXR) is commonly performed in rheumatoid arthritis (RA), particularly for the diagnosis of pulmonary disease. However, other structures are visible on CXR, abnormalities of which may contribute to morbidity and early ... ...

    Abstract Introduction: Chest radiography (CXR) is commonly performed in rheumatoid arthritis (RA), particularly for the diagnosis of pulmonary disease. However, other structures are visible on CXR, abnormalities of which may contribute to morbidity and early mortality. This study was undertaken to evaluate the extent of CXR abnormalities in RA patients.
    Methods: Consecutive out-patients meeting the 2010 ACR/EULAR classification criteria for RA were included. The most recent CXR was assessed by two independent reviewers. Abnormalities identified were recorded and compared to the formal CXR report. Predictors of abnormalities on CXR were assessed using chi-squared tests. SPSS 18.0 was used for statistical analysis.
    Results: One hundred and ninety-eight patients were included. Mean age was 62 years (range 18-90). One hundred and nine (55.1%) were current or ex-smokers. One hundred and fifty-six (79%) patients were seropositive and 123 (62.1%) had joint erosions. A recent CXR was available in 163 (82%) cases. Abnormalities were identified in 129 (79.1%). Ninety-seven (60%) had bony abnormalities. Seventy-one (43.6%) had pulmonary abnormalities; old tuberculosis in 34 (20.9%), hyperinflation in 24 (14.7%), interstitial changes in 20 (13.3%), nodules in 4 (2.4%), consolidation in 2 (1.2%), and pneumothorax in 1 (0.6%). Cardiomegaly was identified in 37 (22.7%) and aortic calcification in 24 (14.7%). Age (p = 0.001), male gender (p = 0.01), and seropositivity (p = 0.04) were significantly associated with lung abnormalities. Cardiomegaly was associated with hypertension (p = 0.012) and ischaemic heart disease (p = 0.018).
    Conclusion: Abnormalities were identified in 79% of chest radiographs in RA patients. Sixty-six percent of these were not reported. Clinicians need to be aware of the need to check for abnormalities.Key Points• RA patients have a high prevalence of CXR abnormalities.• Many of these are of clinical significance.• Age, being male, and seropositivity were associated with lung abnormalities.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Arthritis, Rheumatoid/diagnostic imaging ; Arthritis, Rheumatoid/epidemiology ; Cross-Sectional Studies ; Female ; Humans ; Ireland/epidemiology ; Male ; Middle Aged ; Prevalence ; Radiography, Thoracic ; Spondylarthritis/diagnostic imaging ; Spondylarthritis/epidemiology ; Thoracic Vertebrae/diagnostic imaging ; Young Adult
    Language English
    Publishing date 2019-08-08
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 604755-5
    ISSN 1434-9949 ; 0770-3198
    ISSN (online) 1434-9949
    ISSN 0770-3198
    DOI 10.1007/s10067-019-04717-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: 18F-FDG-PET/CT is of limited value in primary staging of early stage cervical cancer.

    Driscoll, Dearbhail O / Halpenny, Darragh / Johnston, Ciaran / Sheehy, Niall / Keogan, Mary

    Abdominal imaging

    2015  Volume 40, Issue 1, Page(s) 127–133

    Abstract: Purpose: To assess the clinical benefit of 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (18F-FDG-PET/CT) in evaluating pelvic lymph nodes in patients with early stage cervical cancer (FIGO stage 1a–1b1), who have magnetic ... ...

    Abstract Purpose: To assess the clinical benefit of 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (18F-FDG-PET/CT) in evaluating pelvic lymph nodes in patients with early stage cervical cancer (FIGO stage 1a–1b1), who have magnetic resonance imaging (MRI)-defined lymph node negative disease, with histopathologic results as the reference standard.
    Materials and methods: We assessed one hundred and seventy nine sequential 18F-FDG-PET/CT scans in women with newly diagnosed cervical carcinoma between January 2009 and September 2011. 47 of these patients had early stage disease (FIGO stage 1a–1b1) with no suspicious lymph nodes on MRI. 18F-FDG-PET/CT images were analyzed and histopathological findings (pelvic lymph node resection) served as the reference standard.
    Results: The median age of patients was 48 (range 22–86) years. 66 % had squamous histotype. Median number of nodes dissected per patient was 21 (range 8–47), 2 of 47 patients had nodal metastases (4.25 %). All patients in this group had no suspicious lymph nodes on 18F-FDG-PET/CT. Overall patient based sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of 18F-FDG-PET/CT for detection of nodal disease were 0 %, 100 %, 0 %, 96 %, and 96 % respectively.
    Conclusion: Pathologic validation of 18F-FDG-PET/CT imaging demonstrates little value for 18F-FDG-PET/CT in patients with early stage (FIGO stage 1a–1b1) MRI-defined lymph node negative cervical carcinoma. Since the likelihood of metastatic nodal disease is very low in women with stage 1a–1b1 cervical cancer, we believe that 18F-FDG-PET/CT should not have a role in the routine pre-treatment evaluation of these women.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Cervix Uteri/diagnostic imaging ; Cervix Uteri/pathology ; Female ; Fluorodeoxyglucose F18 ; Humans ; Lymph Nodes/diagnostic imaging ; Lymph Nodes/pathology ; Lymphatic Metastasis ; Middle Aged ; Multimodal Imaging ; Neoplasm Staging ; Pelvis ; Positron-Emission Tomography ; Radiopharmaceuticals ; Reproducibility of Results ; Sensitivity and Specificity ; Tomography, X-Ray Computed ; Uterine Cervical Neoplasms/diagnosis ; Uterine Cervical Neoplasms/pathology ; Young Adult
    Chemical Substances Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2015-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1144553-1
    ISSN 1432-0509 ; 0942-8925
    ISSN (online) 1432-0509
    ISSN 0942-8925
    DOI 10.1007/s00261-014-0194-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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