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  1. Book: Neurobiology of disease

    Johnston, Michael V.

    2016  

    Author's details ed. by Michael V. Johnston
    Keywords Nervous System Diseases / physiopathology ; Nervous System Physiological Phenomena ; Neurobiology ; Neurosciences
    Language English
    Size XXXI, 1398 S. : Ill., graph. Darst.
    Edition 2. ed.
    Publisher Oxford Univ. Press
    Publishing place Oxford ; New York
    Publishing country Great Britain
    Document type Book
    Note Preceded by Neurobiology of disease / edited by Sid Gilman. 2007. - Includes bibliographical references and index
    HBZ-ID HT019134932
    ISBN 978-0-19-993783-7 ; 0-19-993783-4 ; 9780199937844 ; 0199937842
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2017 A 1217 available for loan (reading room) Lesesaal EG

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  2. Book: Aicardi's diseases of the nervous system in childhood

    Arzimanoglou, Alexis / O'Hare, Anne / Johnston, Michael V.

    2018  

    Author's details edited by Alexis Arzimanoglou, Anne O'Hare, Michael Johnston, Robert A. Ouvrier
    Keywords Pediatric neurology
    Language English
    Size xxviii, 1496 Seiten, Illustrationen, 25 cm
    Edition Fourth edition
    Publisher Mac Keith Press
    Publishing place London
    Publishing country Great Britain
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT019710326
    ISBN 978-1-909962-80-4 ; 1-909962-80-5
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2018 A 1263 available for loan (reading room) Lesesaal EG

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  3. Book: Principles of drug therapy in neurology

    Johnston, Michael V.

    (Contemporary neurology series ; 72)

    2008  

    Author's details ed. by Michael V. Johnston
    Series title Contemporary neurology series ; 72
    Collection
    Keywords Brain Diseases / drug therapy ; Mental Disorders / drug therapy ; Nervous System Diseases / drug therapy ; Neurologic Manifestations
    Language English
    Size XXIII, 558 S. : Ill., graph. Darst.
    Edition 2. ed.
    Publisher Oxford Univ. Press
    Publishing place Oxford u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT015542763
    ISBN 978-0-19-514683-7 ; 0-19-514683-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2008 A 2851 order for loan Magazin

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  4. Article ; Online: Update for surgeons on novel induction treatments for acute severe inflammatory bowel disease associated colitis.

    Levar, Timothy / Johnston, Michael / Ding, Nik S / Behrenbruch, Corina

    ANZ journal of surgery

    2024  

    Abstract: Background: The landscape of biologic agents for the treatment of inflammatory bowel disease (IBD) associated colitis is rapidly evolving, requiring surgeons to be up-to-date as part of multi-disciplinary, evidence-based care. An update on novel ... ...

    Abstract Background: The landscape of biologic agents for the treatment of inflammatory bowel disease (IBD) associated colitis is rapidly evolving, requiring surgeons to be up-to-date as part of multi-disciplinary, evidence-based care. An update on novel therapies used to induce remission in IBD-associated colitis is presented.
    Methods: A systematic search through Ovid MEDLINE and CENTRAL using a combination of MeSH terms and Boolean operators was conducted.
    Results: One thousand and twenty articles from which 38 articles were selected for inclusion in this review. Novel agents were trialled as 4th or 5th line treatment following conventional treatment failure. Rates of serious adverse effects were low. Janus kinase (JAK) inhibitors (upadacitinib and tofacitinib) were efficacious in inducing remission in ulcerative colitis, and IL-23p19 inhibitors (mirikizumab, guselkumab, and risankizumab) in Crohn's colitis. Evidence was limited for other drug classes.
    Conclusion: JAK-inhibitors and IL-23p19 inhibitors were found to be the most effective agents for inducting remission following failure of standard of care treatment. A significant proportion of patients did not respond, highlighting the inherent challenge in optimizing treatment for moderate to severe IBD-associated colitis. More robust study designs and comparator trials are required.
    Language English
    Publishing date 2024-03-07
    Publishing country Australia
    Document type Journal Article ; Review
    ZDB-ID 2050749-5
    ISSN 1445-2197 ; 1445-1433 ; 0004-8682
    ISSN (online) 1445-2197
    ISSN 1445-1433 ; 0004-8682
    DOI 10.1111/ans.18924
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 180: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Delayed diagnosis of congenital anorectal malformation.

    Ho, Elise / Noori, Jawed / Behrenbruch, Corina / Johnston, Michael

    ANZ journal of surgery

    2023  Volume 93, Issue 12, Page(s) 3023–3024

    MeSH term(s) Humans ; Anorectal Malformations/diagnosis ; Delayed Diagnosis ; Rectum/diagnostic imaging ; Rectum/surgery ; Abnormalities, Multiple ; Anal Canal/abnormalities
    Language English
    Publishing date 2023-09-19
    Publishing country Australia
    Document type Case Reports
    ZDB-ID 2050749-5
    ISSN 1445-2197 ; 1445-1433 ; 0004-8682
    ISSN (online) 1445-2197
    ISSN 1445-1433 ; 0004-8682
    DOI 10.1111/ans.18691
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 180: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Book: Basic biology for the thoracic surgeon

    Johnston, Michael R.

    (Chest surgery clinics of North America ; 5,1)

    1995  

    Author's details Michael R. Johnston, guest ed
    Series title Chest surgery clinics of North America ; 5,1
    Collection
    Keywords Thoracic Surgery ; Molecular Biology ; Thoraxchirurgie
    Subject Brustkorbchirurgie ; Brustkorb ; Herz-Thorax-Chirurgie
    Language English
    Size VIII, 176 S. : Ill., graph. Darst.
    Publisher Saunders
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT006569984
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 1358 -5,1- verfügbar in Königswinter Königswinter

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  7. Article: Cognitive Development One Year After Infantile Critical Pertussis.

    Johnston, Michael V

    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

    2018  Volume 19, Issue 2, Page(s) 161–162

    MeSH term(s) Cognition ; Humans ; Whooping Cough
    Language English
    Publishing date 2018-02-01
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2052349-X
    ISSN 1947-3893 ; 1529-7535
    ISSN (online) 1947-3893
    ISSN 1529-7535
    DOI 10.1097/PCC.0000000000001394
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5600: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 472: Show issues

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  8. Article: Molecular signatures of aggressive pediatric liver cancer.

    Johnston, Michael E / Timchenko, Nikolai

    Archives of stem cell and therapy

    2021  Volume 2, Issue 1, Page(s) 1–4

    Abstract: Liver masses account for 5 to 6% of pediatric cancer, which includes hepatoblastoma (HBL) along with rare cases of hepatocellular carcinoma (HCC). The most dangerous form of pediatric liver cancer is aggressive HBL, which can be characterized by chemo- ... ...

    Abstract Liver masses account for 5 to 6% of pediatric cancer, which includes hepatoblastoma (HBL) along with rare cases of hepatocellular carcinoma (HCC). The most dangerous form of pediatric liver cancer is aggressive HBL, which can be characterized by chemo-resistance and multiple nodules or metastases at diagnosis, all correlating with worse clinical prognosis. Despite intensive studies and a significant improvement in overall outcomes, very little is known about the key molecular pathways which determine the aggressiveness of pediatric liver cancer. Although genetic mutations have been reported in aggressive HBL, they represent a low level (1.9% per case) and are found mainly in two genes CTNNB1 and NRF2. Over the past 5 years, our liver biology and tumor group at Cincinnati Children's Hospital Medical Center has investigated molecular signatures of aggressive HBL by examination of fresh tissue specimens, which were studied immediately after surgery to preserve the integrity of key biochemical pathways. Summarization of these high quality HBL samples discovered several critical pathways that are specific for aggressive pediatric liver cancer. These pathways include three characteristics: Conversion of tumor suppressor proteins (TSPs) by posttranslational modifications into oncogenesActivation of specific chromosomal regions, i.e., Aggressive Liver Cancer Domains (ALCDs) within many oncogenes, resulting in increased expression of oncogenesPotential epigenetic mechanisms that open chromatin structure of oncogenes via ALCDs. This commentary summarizes our key findings and discusses development of potential ALCD-based therapeutic approaches.
    Language English
    Publishing date 2021-03-05
    Publishing country United States
    Document type Journal Article
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Protocols to Dissolve Amorphous Urate Crystals in Urine.

    Behan, Kristina Jackson / Johnston, Michael A

    Laboratory medicine

    2021  Volume 53, Issue 3, Page(s) e63–e68

    Abstract: Objective: Amorphous urate crystals can obscure significant findings during a routine urinalysis. There is no standardized protocol to minimize their effect.: Materials and methods: We tested 210 urine specimens. Three specimens had high red blood ... ...

    Abstract Objective: Amorphous urate crystals can obscure significant findings during a routine urinalysis. There is no standardized protocol to minimize their effect.
    Materials and methods: We tested 210 urine specimens. Three specimens had high red blood cell (RBC) or white blood cell (WBC) counts. Fifty-six specimens formed amorphous urates. Sediment from these specimens was treated with 50 mM sodium hydroxide (NaOH) at a 1:2 and/or 1:4 dilution. We warmed 22 specimens with crystals at various temperatures.
    Results: Amorphous urate crystals formed in concentrated urine with an acidic pH. Adding 50 mM NaOH dissolved amorphous urates, revealing the presence of underlying bacteria and yeast, but WBC and RBC counts were grossly decreased. Prewarming unspun specimens to 60°C for 90 seconds dissolved most amorphous urates.
    Conclusion: The protocol to eliminate amorphous urate crystals is to prewarm the specimen before testing. Adding 50 mM NaOH to sediment dissolves amorphous urates to enhance the visibility of bacteria and yeast but has a deleterious effect on WBC and RBC.
    MeSH term(s) Humans ; Leukocyte Count ; Saccharomyces cerevisiae ; Sodium Hydroxide ; Uric Acid ; Urinalysis/methods
    Chemical Substances Uric Acid (268B43MJ25) ; Sodium Hydroxide (55X04QC32I)
    Language English
    Publishing date 2021-10-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 391758-7
    ISSN 1943-7730 ; 0007-5027
    ISSN (online) 1943-7730
    ISSN 0007-5027
    DOI 10.1093/labmed/lmab088
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 1013: Show issues Location:
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  10. Article ; Online: 15-year survivorship of a unique dual-modular femoral stem in primary hip arthroplasty.

    Scott, David F / Eppich, Kade / Mehić, Edin / Gray, Celeste / Smith, Crystal Lederhos / Johnston, Michael

    BMC musculoskeletal disorders

    2024  Volume 25, Issue 1, Page(s) 312

    Abstract: Background: Hip offset, version, and length are interdependent femoral variables which determine stability and leg length. Balancing these competing variables remains a core challenge in hip arthroplasty. The potential benefits of modular femoral stems ... ...

    Abstract Background: Hip offset, version, and length are interdependent femoral variables which determine stability and leg length. Balancing these competing variables remains a core challenge in hip arthroplasty. The potential benefits of modular femoral stems have been overshadowed by higher rates of failure. The objective of this study was to assess the survivorship of a unique dual-modular femoral stem at an average 15-year follow-up period.
    Methods: The records of all patients with osteoarthritis who underwent primary total hip arthroplasty with this device between 2004-2009 were reviewed. There were no exclusions for BMI or other factors. We examined the data with Kaplan-Meier survival analysis. The primary endpoint for survival was mechanical failure of the modular neck-body junction.
    Results: The survivorship of this device in 172 subjects was 100% with none experiencing mechanical failure of the modular junction at an average of 15 years. 60 patients died of causes unrelated to their THA and 9 patients were lost to follow-up. There were three early (≤ 12 months) dislocations (1.7%), and seven total dislocations (4.1%). 16 patients underwent reoperations during the follow-up period, none for any complication of the modular junction. Radiographic results showed well-fixed femoral stems in all cases. There were no leg length discrepancies of greater than 10 mm, and 85% were within 5 mm.
    Conclusion: There were no mechanical failures of the modular junction in any of the subjects over the average 15-year period, demonstrating that this dual-modular design is not associated with increased failure rates. We achieved a 1.7% early dislocation rate and a 4.1% total dislocation rate without any clinically significant leg length discrepancies.
    MeSH term(s) Humans ; Arthroplasty, Replacement, Hip/instrumentation ; Arthroplasty, Replacement, Hip/adverse effects ; Arthroplasty, Replacement, Hip/methods ; Female ; Male ; Hip Prosthesis ; Middle Aged ; Aged ; Prosthesis Design ; Prosthesis Failure ; Adult ; Follow-Up Studies ; Osteoarthritis, Hip/surgery ; Retrospective Studies ; Aged, 80 and over ; Kaplan-Meier Estimate ; Reoperation/statistics & numerical data ; Femur/surgery ; Femur/diagnostic imaging ; Time Factors
    Language English
    Publishing date 2024-04-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041355-5
    ISSN 1471-2474 ; 1471-2474
    ISSN (online) 1471-2474
    ISSN 1471-2474
    DOI 10.1186/s12891-024-07422-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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