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Article ; Online: The Effect of Mianserin on Lifespan of Caenorhabditis elegan is Abolished by Glucose.

Almotayri, Abdullah / Thomas, Jency / Munasinghe, Mihiri / Jois, Markandeya

Current aging science

2021 Volume 14, Issue 2, Page(s) 118–123

Abstract: Background: The antidepressant Mianserin has been shown to extend the lifespan of Caenorhabditis elegan (C. elegan), a well-established model organism used in ageing research. The extension of lifespan in C. elegan was shown to be dependent on increased ...

Abstract	Background: The antidepressant Mianserin has been shown to extend the lifespan of Caenorhabditis elegan (C. elegan), a well-established model organism used in ageing research. The extension of lifespan in C. elegan was shown to be dependent on increased expression of the scaffolding protein (ANK3/unc-44). In contrast, antidepressant use in humans is associated with an increased risk of death. The C. elegan elegan in the laboratory are fed Escherichia coli (E. coli), a diet high in protein and low in carbohydrate, whereas a typical human diet is high in carbohydrates. We hypothesized that dietary carbohydrates might mitigate the lifespan-extension effect of mianserin. Objective: To investigate the effect of glucose added to the diet of C. elegan on the lifespan-extension effect of mianserin. Methods: Wild-type Bristol N2 and ANK3/unc-44 inactivating mutants were cultured on agar plates containing nematode growth medium and fed E. coli. Treatment groups included (C) control, (M50) 50 μM mianserin, (G) 73 mM glucose, and (M50G) 50 μM mianserin and 73 mM glucose. Lifespan was determined by monitoring the worms until they died. Statistical analysis was performed using the Kaplan-Meier version of the log-rank test. Results: Mianserin treatment resulted in a 12% increase in lifespan (P<0.05) of wild-type Bristol N2 worms but reduced lifespan by 6% in ANK3/unc-44 mutants, consistent with previous research. The addition of glucose to the diet reduced the lifespan of both strains of worms and abolished the lifespan-extension by mianserin. Conclusion: The addition of glucose to the diet of C. elegan abolishes the lifespan-extension effects of mianserin.
MeSH term(s)	Animals ; Caenorhabditis elegans/drug effects ; Caenorhabditis elegans Proteins ; Glucose/pharmacology ; Longevity ; Mianserin/pharmacology
Chemical Substances	Caenorhabditis elegans Proteins ; Mianserin (250PJI13LM) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2021-01-11
Publishing country	United Arab Emirates
Document type	Journal Article
ISSN	1874-6128
ISSN (online)	1874-6128
DOI	10.2174/1874609813999210104203614
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Potential contributions of the methodology to the variability of glycaemic index of foods.

Flavel, Matthew / Jois, Markandeya / Kitchen, Barry

World journal of diabetes

2021 Volume 12, Issue 2, Page(s) 108–123

Abstract: Glycaemic index (GI) testing provides a useful point of comparison between carbohydrate sources. For this comparison to be meaningful, the methods used to determine GI values need to be rigorous and consistent between testing events. This requirement has ...

Abstract	Glycaemic index (GI) testing provides a useful point of comparison between carbohydrate sources. For this comparison to be meaningful, the methods used to determine GI values need to be rigorous and consistent between testing events. This requirement has led to increasing standardization of the GI methodology, with an international standard developed in joint consultation with FAO/WHO (ISO 26642:2010
Language	English
Publishing date	2021-02-15
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2583471-X
ISSN	1948-9358
ISSN	1948-9358
DOI	10.4239/wjd.v12.i2.108
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Article: Early Exposure is Necessary for the Lifespan Extension Effects of Cocoa in

Munasinghe, Mihiri / Almotayri, Abdullah / Thomas, Jency / Heydarian, Deniz / Jois, Markandeya

Nutrition and metabolic insights

2021 Volume 14, Page(s) 11786388211029443

Abstract: Background: We previously showed that cocoa, a rich source of polyphenols improved the age-associated health and extended the lifespan in : Aim: In this study, we aimed to find out the effects of timing of cocoa exposure on longevity improving ... ...

Abstract	Background: We previously showed that cocoa, a rich source of polyphenols improved the age-associated health and extended the lifespan in Aim: In this study, we aimed to find out the effects of timing of cocoa exposure on longevity improving effects and the mechanisms and pathways involved in lifespan extension in Methods: The standard Results: Cocoa exposure starting from L1 stage till the death and till adult day 1 significantly extended the lifespan of worms. However, cocoa supplementation at other larval stages as well as at adulthood could not extend the lifespan, instead the lifespan was significantly reduced. Cocoa could not extend the lifespan of Conclusion: Early-start supplementation is essential for cocoa-mediated lifespan extension which is dependent on insulin/IGF-1 signaling pathway and mitochondrial respiration.
Language	English
Publishing date	2021-07-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2594646-8
ISSN	1178-6388
ISSN	1178-6388
DOI	10.1177/11786388211029443
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Article: Increased Milk Yield and Reduced Enteric Methane Concentration on a Commercial Dairy Farm Associated with Dietary Inclusion of Sugarcane Extract (

Ahmed, Awais / Flavel, Matthew / Mitchell, Shane / Macnab, Gregor / Dunuarachchige, Manisha Dunuarachchi / Desai, Aniruddha / Jois, Markandeya

Animals : an open access journal from MDPI

2023 Volume 13, Issue 20

Abstract: 1) Background: The purpose of this study was to assess the influence of a natural sugarcane extract (Polygain™) on milk production, milk composition and methane emissions on a commercial dairy farm. (2) Methods: A three-week baseline was established for ...

Abstract	(1) Background: The purpose of this study was to assess the influence of a natural sugarcane extract (Polygain™) on milk production, milk composition and methane emissions on a commercial dairy farm. (2) Methods: A three-week baseline was established for lactating Holstein × Friesian animals. Following this baseline period, these animals were fed Polygain™ at 0.25% of their estimated dry matter intake for 3 weeks. Methane concentration in the feed bin was determined at each milking using the Gascard NG Infrared Sensor (Edinburgh Sensors LTD). (3) Results: During the intervention phase milk yield increased significantly from 26.43 kg to 28.54 kg per cow per day, whilst methane emissions and bulk tank somatic cell counts decreased significantly in the intervention phase. For methane concentration, an average of 246 ppm during the baseline periods reduced to an average of 161.09 ppm during the intervention phase. For the bulk tank somatic cell counts, the average was observed at 283,200 during the baseline and reduced to an average value of 151,100 during the intervention phase. (4) Conclusions: The natural sugarcane extract was shown to have the potential to mitigate enteric methane emissions while also increasing production and animal wellbeing outcomes in a commercial dairy setting.
Language	English
Publishing date	2023-10-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani13203300
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Article: Metabolic and behavioral effects of olanzapine and fluoxetine on the model organism

Almotayri, Abdullah / Thomas, Jency / Munasinghe, Mihiri / Weerasinghe, Maneka / Heydarian, Deniz / Jois, Markandeya

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society

2021 Volume 29, Issue 8, Page(s) 917–929

Abstract: The use of many psychotropic drugs (PDs) is associated with increased caloric intake, significant weight gain, and metabolic disorders. The ... ...

Abstract	The use of many psychotropic drugs (PDs) is associated with increased caloric intake, significant weight gain, and metabolic disorders. The nematode
Language	English
Publishing date	2021-07-16
Publishing country	Saudi Arabia
Document type	Journal Article
ZDB-ID	1378024-4
ISSN	1319-0164
ISSN	1319-0164
DOI	10.1016/j.jsps.2021.07.006
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Article: Using 17

Puvvada, Rahul Krishna / Tang, Clarice Y / Thomas, Jency / Kay, Mitch / Higgs, Peter / Jois, Markandeya / Madhan, Ramesh / Gupta, Sabrina

Journal of diabetes and metabolic disorders

2022 Volume 22, Issue 1, Page(s) 375–383

Abstract: Purpose: This study was conducted to explore doctors' perceptions and understanding of the self-medication practices of people living with type 2 diabetes.: Methods: A qualitative research design incorporating 20 semi-structured, face-to-face ... ...

Abstract	Purpose: This study was conducted to explore doctors' perceptions and understanding of the self-medication practices of people living with type 2 diabetes. Methods: A qualitative research design incorporating 20 semi-structured, face-to-face interviews were conducted with doctors treating people with type 2 diabetes in Mysuru, India, between July 2019 and January 2020. All the interviews were conducted in doctors' clinics, audio-recorded and thematically analyzed. Results: Three themes were identified from these interviews- i) Doctors' beliefs towards their patients' use of traditional medicine and environmental factors influencing prescription practices, ii) Doctors reported little faith in traditional medicines, iii) Limited strategies implemented by doctors to overcome barriers to self-medications. Doctors reported greater belief in western medications over traditional medications and expressed concern that their patients favored traditional medications over western. Multiple factors such as social media, accessibility of healthcare facilities and pill burden influenced adherence to western medications. Also, lack of knowledge about traditional medications and trust in western medications available under government schemes have influenced prescription practices among doctors. It appears that doctors implemented strategies such as educating patients on the detrimental effects of self-medication and insisting on patients to take only western medications to achieve desired blood glucose levels when managing self-medication practices among people with diabetes. Conclusion: These results suggest that doctors have limited strategies to implement to prevent self-medication practices among people with diabetes. Increasing knowledge amongst doctors about JAS medication effectiveness and thereby garnering greater trust in generic medications. In addition, efforts should be made to identify the best ways to integrate traditional and western medicine into patient-centered care delivery. Supplementary information: The online version contains supplementary material available at 10.1007/s40200-022-01154-5.
Language	English
Publishing date	2022-11-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2680289-2
ISSN	2251-6581
ISSN	2251-6581
DOI	10.1007/s40200-022-01154-5
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Article ; Online: Determination of ewe behaviour around lambing time and prediction of parturition 7days prior to lambing by tri-axial accelerometer sensors in an extensive farming system

Sohi, Rajneet / Almasi, Fazel / Nguyen, Hien / Carroll, Alexandra / Trompf, Jason / Weerasinghe, Maneka / Bervan, Aidin / Godoy, Boris I. / Awais, Ahmed / Stear, Michael J. / Desai, Aniruddha / Jois, Markandeya

Animal Production Science. 2022, v. 62, no. 17 p.1729-1738

2022

Abstract: Context Lamb loss and dyctocia are two major challenges in extensive farming systems. While visual observation can be impractical due to the large sizes of paddocks, number of animals and high labour cost, wearable sensors can be used to monitor the ... ...

Abstract	Context Lamb loss and dyctocia are two major challenges in extensive farming systems. While visual observation can be impractical due to the large sizes of paddocks, number of animals and high labour cost, wearable sensors can be used to monitor the behaviour of ewes as there might be changes in their activities prior to lambing. This provides sufficient time for the farm manager to nurse those ewes that are at risk of dyctocia. Aim The objective of this study was to determine whether the behaviour of a pregnant ewe could predict the time of parturition. Methods Two separate trials were conducted: the first trial (T1), with 32 ewes, included human/video observations, and the second trial (T2), with 165 ewes, conducted with no humans present, to emulate real extensive farming settings. The ewes were fitted with tri-axial accelerometer sensors by means of halters. Three-dimensional movement data were collected for a period of at least 7 and 14days in T1 and T2 respectively. The sensor units were retrieved, and their data downloaded using ActiGraph software. Ewe behaviour was determined through support vector machine learning (SVM) algorithm, including licking, grazing, rumination, walking, and idling. The behaviours of ewes predicted by analysis of sensor data were compared with behaviours determined using visual observation (video recordings), with time synchronisation to validate the results. Deep learning and neural-network algorithms were used to predict lambing time. Key results The concordance percentages between visual observation and sensor data were 90±11, 81±15, 95±10, 96±6, and 93±8%±s.d. for grazing, licking, rumination, idling, and walking respectively. The deep-learning model predicted the time of lambing with 90% confidence via a quantile regression method, which can be interpereted as 90% prediction intervals, and shows that the time of lambing can be predicted with reasonable confidence approximately 240h before the actual lambing events. Conclusion It was possible to predict the time of parturition up to 10days before lambing. Implications The behaviour of ewes around lambing time has a direct effect on the survival of the lambs and therefore plays an important part in animal management. This knowledge could improve the productivity of sheep and considerably decrease lamb mortality rates.
Keywords	accelerometers ; actigraphy ; animal husbandry ; animal production ; computer software ; ewes ; farms ; humans ; models ; mortality ; parturition ; prediction ; regression analysis ; risk ; rumination ; support vector machines ; wages and remuneration ; accelerometer sensors ; extensive farming ; lamb survival ; lambing time ; machine learning ; quantile regression ; sheep behaviour
Language	English
Size	p. 1729-1738.
Publishing place	CSIRO Publishing
Document type	Article ; Online
ZDB-ID	2472524-9
ISSN	1836-5787 ; 1836-0939
ISSN (online)	1836-5787
ISSN	1836-0939
DOI	10.1071/AN21460
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Effects of herbs and spices on blood pressure: a systematic literature review of randomised controlled trials.

Driscoll, Kate S / Appathurai, Amanda / Jois, Markandeya / Radcliffe, Jessica E

Journal of hypertension

2018 Volume 37, Issue 4, Page(s) 671–679

Abstract: Hypertension is a major risk factor for cardiovascular disease, affecting 1 billion people worldwide. Literature suggests some herbs and spices have cardiovascular benefits, such as decreasing blood pressure; yet evidence is inconsistent. This article ... ...

Abstract	: Hypertension is a major risk factor for cardiovascular disease, affecting 1 billion people worldwide. Literature suggests some herbs and spices have cardiovascular benefits, such as decreasing blood pressure; yet evidence is inconsistent. This article reviewed randomized controlled trials investigating effects of herbs and spices on blood pressure in normotensive, pre-hypertensive and hypertensive participants. Ovid Medline, Embase, Biological abstracts, CINAHL and Cochrane Collaboration were systematically searched. After inclusion and exclusion criteria were applied, nine articles were included for analysis. Overall, three of the nine studies reported statistically significant results, including one of the two studies on hypertensive participants and two of the six studies on pre-hypertensive participants. The remaining study was conducted on normotensive participants and reported no change in blood pressure. There is evidence to suggest certain herbs and spices can reduce blood pressure in a hypertensive and pre-hypertensive population and may not induce hypotension in a normotensive population.
MeSH term(s)	Blood Pressure/drug effects ; Humans ; Hypertension/drug therapy ; Phytotherapy ; Plant Preparations/therapeutic use ; Randomized Controlled Trials as Topic ; Risk Factors ; Spices
Chemical Substances	Plant Preparations
Language	English
Publishing date	2018-11-13
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Systematic Review
ZDB-ID	605532-1
ISSN	1473-5598 ; 0263-6352 ; 0952-1178
ISSN (online)	1473-5598
ISSN	0263-6352 ; 0952-1178
DOI	10.1097/HJH.0000000000001952
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Zs.A 1885: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 614: Show issues

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Article ; Online: Quinoa Seed Lowers Serum Triglycerides in Overweight and Obese Subjects: A Dose-Response Randomized Controlled Clinical Trial.

Navarro-Perez, Diana / Radcliffe, Jessica / Tierney, Audrey / Jois, Markandeya

Current developments in nutrition

2017 Volume 1, Issue 9, Page(s) e001321

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2017-08-24
Publishing country	United States
Document type	Journal Article
ISSN	2475-2991
ISSN (online)	2475-2991
DOI	10.3945/cdn.117.001321
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Article ; Online: Factors affecting self-medication practices among people living with type 2 diabetes in India- A systematic review.

Puvvada, Rahul Krishna / Gupta, Sabrina / Tang, Clarice Y / N Althubyani, Anwar / Jois, Markandeya / Higgs, Peter / Ramesh, M / Thomas, Jency

Metabolism open

2020 Volume 9, Page(s) 100073

Abstract: Self-medication practices of type 2 diabetes in India include the use of both traditional and western medications. It is important to understand the factors influencing self-medication. A total of 3257 studies were screened and nine studies (six ... ...

Abstract	Self-medication practices of type 2 diabetes in India include the use of both traditional and western medications. It is important to understand the factors influencing self-medication. A total of 3257 studies were screened and nine studies (six quantitative and three qualitative) were included. The Hawker tool and Joanna Briggs Institute Critical Appraisal tool were used to assess the quality of studies. The findings of the quantitative studies were descriptively analysed while thematic analysis was performed to identify key themes from the qualitative studies. The analysis indicated that participants had greater trust in traditional medications regardless of their socioeconomic and/or educational backgrounds as these were often recommended by friends and family members. Low cost, ease of availability and perceived lower side effects of traditional medications were some of the factors contributing to greater trust. It is suggested that ongoing management of type 2 diabetes requires stringent policies and regulations in the dispensing of traditional and western medications. Continual education to inform people on the use of self-medications and its possible adverse effects is also required.
Language	English
Publishing date	2020-12-08
Publishing country	England
Document type	Journal Article
ISSN	2589-9368
ISSN (online)	2589-9368
DOI	10.1016/j.metop.2020.100073
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