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Article: Evaluation of Clinical and Genetic Determinants of Treatment OutCome In EGFR Mutation Positive Advanced Lung Adenocarcinoma.

Jokic, Vera / Savic-Vujovic, Katarina / Spasic, Jelena / Bukumiric, Zoran / Marinkovic, Mladen / Radosavljevic, Davorin / Cavic, Milena

Dose-response : a publication of International Hormesis Society

2022 Volume 20, Issue 3, Page(s) 15593258221117354

Abstract: Background: The aim of this research was to evaluate clinical and low-cost genetic determinants of treatment outcome in : Material and methods: EGFR: Results: Patients were treated with EGFR-TKIs for a period of 1-39months (median 9), with a ... ...

Abstract	Background: The aim of this research was to evaluate clinical and low-cost genetic determinants of treatment outcome in Material and methods: EGFR Results: Patients were treated with EGFR-TKIs for a period of 1-39months (median 9), with a median PFS of 12.0 months (10.4-13.6, CI 95%), and a median OS of 19.0 months (15.1-22.7, CI 95%). The presence of pain was significantly correlated with the existence of bone ( Conclusions: EGFR
Language	English
Publishing date	2022-08-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2440820-7
ISSN	1559-3258
ISSN	1559-3258
DOI	10.1177/15593258221117354
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Article ; Online: An update on atrial fibrillation: focus on stroke risk reduction strategies.

Potpara, T / Jokic, V / Medic, B / Prostran, M / Lip, G

Minerva medica

2015 Volume 106, Issue 5, Page(s) 259–273

Abstract: Atrial fibrillation (AF) currently affects approximately 2% of the general adult population, and the number of patients suffering from AF constantly increases. Although the occurrence of AF rarely poses an immediate threat to patient's survival, the ... ...

Abstract	Atrial fibrillation (AF) currently affects approximately 2% of the general adult population, and the number of patients suffering from AF constantly increases. Although the occurrence of AF rarely poses an immediate threat to patient's survival, the arrhythmia is associated with significant cardiovascular morbidity and mortality mostly resulting from ischemic stroke or systemic thromboembolism, or heart failure. Overall, patients with AF have a 5-fold greater risk of stroke compared to individuals in sinus rhythm, but individual stroke risk depends on the presence of various stroke risk factors, and optimal stroke prevention is essential for AF patients. Several major advances in AF-related stroke prevention have been achieved recently, including the refinements in stroke and bleeding risk assessment with an essential shift in the recognition of AF patients who should be offered oral anticoagulant (OAC) therapy, the advent of non-vitamin K antagonist oral anticoagulants (NOACs) which are increasingly used in the "real-world" setting, as well as the development of non-pharmacological means of thromboprophylaxis in AF patients (e.g., left atrial appendage [LAA] occluding devices). In this review article, we summarize these recent developments in stroke risk reduction strategies and discuss the main principles of decision-making regarding OAC therapy in AF patients.
Language	English
Publishing date	2015-10
Publishing country	Italy
Document type	Journal Article
ZDB-ID	123586-2
ISSN	1827-1669 ; 0026-4806
ISSN (online)	1827-1669
ISSN	0026-4806
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Article ; Online: Hematological parameters in EGFR-mutated advanced NSCLC patients treated with TKIs: predicting survival and toxicity.

Jokic, Vera / Savic-Vujovic, Katarina / Spasic, Jelena / Stanic, Nemanja / Marinkovic, Mladen / Radosavljevic, Davorin / Cavic, Milena

Expert review of anticancer therapy

2021 Volume 21, Issue 6, Page(s) 673–679

Abstract: ... ...

Abstract	Background
MeSH term(s)	Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; ErbB Receptors/genetics ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Mutation ; Protein Kinase Inhibitors/adverse effects ; Retrospective Studies
Chemical Substances	Protein Kinase Inhibitors ; EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1)
Language	English
Publishing date	2021-03-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2112544-2
ISSN	1744-8328 ; 1473-7140
ISSN (online)	1744-8328
ISSN	1473-7140
DOI	10.1080/14737140.2021.1893694
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Article: Measurement uncertainty estimation of health risk from exposure to natural radionuclides in soil

Spasic Jokic, Vesna / Zupunski, Ljubica / Zupunski, Ivan

Measurement. 2013 Oct., v. 46, no. 8

2013

Abstract: Cancer mortality risk were estimated due to external exposure to ⁴⁰K in soil. Uncertainty estimation was performed for the risk considered as a measurand. It was presented uncertainty estimation using two methods. One method is based on the Guide to the ... ...

Abstract	Cancer mortality risk were estimated due to external exposure to ⁴⁰K in soil. Uncertainty estimation was performed for the risk considered as a measurand. It was presented uncertainty estimation using two methods. One method is based on the Guide to the Expression of Uncertainty in Measurement Framework (GUF) and other represents Monte Carlo method. For the Monte Carlo method, the mean of the obtained distribution that represents mortality cancer risk estimation, due to one year exposure to ⁴⁰K with mean activity concentration of 708Bq/kg in soil, is 12.9×10⁻⁶ with 90% confidential interval (k≈1.64) of (4.7–25.5)×10⁻⁶. According to GUF the mean value is estimated as 10.9×10⁻⁶, with 90% confidential interval of (0.9–20.8)×10⁻⁶. Uncertainty of assessed risk obtained by numerical simulation is slightly different with asymmetrical boundaries related to the mean value, comparing to the uncertainty estimated using GUF.
Keywords	Monte Carlo method ; mathematical models ; mortality ; radionuclides ; risk ; risk estimate ; soil ; uncertainty
Language	English
Dates of publication	2013-10
Size	p. 2376-2383.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	2000550-7
ISSN	0263-2241
ISSN	0263-2241
DOI	10.1016/j.measurement.2013.04.019
Database	NAL-Catalogue (AGRICOLA)

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Article: [Consequences of the Chernobyl disaster in the region of the Republic of Serbia].

Popović, Dragana / Spasić-Jokić, Vesna

Vojnosanitetski pregled

2006 Volume 63, Issue 5, Page(s) 481–487

MeSH term(s)	Cesium Radioisotopes/analysis ; Chernobyl Nuclear Accident ; Humans ; Radiation Dosage ; Radioactive Fallout ; Yugoslavia
Chemical Substances	Cesium Radioisotopes ; Radioactive Fallout
Language	Serbian
Publishing date	2006-05-15
Publishing country	Serbia
Document type	Journal Article
ZDB-ID	123795-0
ISSN	0042-8450
ISSN	0042-8450
DOI	10.2298/vsp0605481p
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Article: Hyperthermic intrathoracic chemotherapy (HITHOC) in ovarian carcinoma - a propos of a case.

Stojiljkovic, Dejan / Nikolic, Srdjan / Cvetkovic, Ana / Jokic, Vladimir / Spurnic, Igor / Jokic, Stevan / Goran, Merima / Kocic, Milan / Miletic, Nebojsa / Filipovic, Jovan / Stojiljkovic, Tanja / Lukac, Branislav

Journal of B.U.ON. : official journal of the Balkan Union of Oncology

2019 Volume 23, Issue 7, Page(s) 153–155

Abstract: A female patient aged 42, started chemotherapy for advanced ovarian carcinoma in June 2016. Considering intraoperative findings, cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) were performed, followed by adjuvant ... ...

Abstract	A female patient aged 42, started chemotherapy for advanced ovarian carcinoma in June 2016. Considering intraoperative findings, cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) were performed, followed by adjuvant chemotherapy. In March 2018, computed tomography (CT) examination showed disease progression in the form of pleural carcinomatosis with increased levels of tumor markers. In April 2018, total parietal pleurectomy, partial visceral pleurectomy, and then hyperthermic intrathoracic chemotherapy (HITHOC) with cisplatin were performed. The procedure was uneventful, as was the postoperative course. The patient was discharged on the 13th postoperative day with no major postoperative complications. Three months after surgery, CT showed no signs of disease relapse. Since this is a relatively new method of treating pleural carcinomatosis, real results are to be expected with larger series of patients and longer postoperative follow-up.
MeSH term(s)	Adult ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Chemotherapy, Cancer, Regional Perfusion/methods ; Combined Modality Therapy ; Female ; Humans ; Hyperthermia, Induced/methods ; Ovarian Neoplasms/pathology ; Ovarian Neoplasms/therapy ; Peritoneal Neoplasms/secondary ; Peritoneal Neoplasms/therapy ; Prognosis
Language	English
Publishing date	2019-02-02
Publishing country	Greece
Document type	Case Reports ; Journal Article
ZDB-ID	2040386-0
ISSN	2241-6293 ; 1107-0625
ISSN (online)	2241-6293
ISSN	1107-0625
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Article: Evaluation of diagnostic parameters from parotid and submandibular dynamic salivary glands scintigraphy and unstimulated sialometry in Sjögren's syndrome.

Dugonjić, Sanja / Stefanović, Dušan / Ethurović, Branka / Spasić-Jokić, Vesna / Ajdinović, Boris

Hellenic journal of nuclear medicine

2014 Volume 17, Issue 2, Page(s) 116–122

Abstract: Our aim was to validate eight scintigraphic salivary gland (SG) parameters, as diagnostic parameters in patients with Sjögren's syndrome (SS). We used the standardized stimulated dynamic salivary gland scintigraphy (DSGS) protocol and correlated this ... ...

Abstract	Our aim was to validate eight scintigraphic salivary gland (SG) parameters, as diagnostic parameters in patients with Sjögren's syndrome (SS). We used the standardized stimulated dynamic salivary gland scintigraphy (DSGS) protocol and correlated this with the unstimulated whole sialometry (UWS) functions. The DSGS and UWS tests meeting the European and the USA diagnostic classification criteria for SS were applied in twenty patients and in ten normal controls. The DSGS tests were performed 60min after the intravenous (i.v.) injection of 370MBq of technetium-99m-pertechnetate ((99m)TcO(-)4) and after per os stimulation with a 0.5g tablet of ascorbic acid administered 40min after the injection. Using time-activity curves, eight different parameters were calculated for each parotid gland (PG) and each submandibular salivary gland (SMG): a) time at maximum counts (Tmax), b) time at minimum counts (Tmin), c) maximum accumulation (MA), d) accumulation velocity (AV), e) maximum secretion (MS), f) maximum stimulated secretion (MSS), g) stimulated secretion velocity (SSV), and h) uptake ratio (UR). Values of UWS below 2.5mL/15min, were considered abnormal. All these parameters, as for the PG, showed significant abnormality in SS patients (P<0.001), especially of the secretion function. All SMG parameters also showed a significant abnormality (P<0.001), but especially of the accumulation function. There was a greater impairment of the above parameters in SMG than in PG in the SS patients. Sensitivity of the standardized DSGS was 100%, specificity 80%, negative prognostic value 100%, and positive prognostic value 91%. Sensitivity of UWS was 75%. In conclusion, this paper suggested that the best diagnostic parameters for the SS patients were those of: a) the maximum secretion, b) the maximum stimulated secretion for both the parotid and the submandibular glands, c) maximum accumulation and d) accumulation velocity of submandibular glands. The times at maximum and at minimum counts were non diagnostic.
MeSH term(s)	Adult ; Aged ; Early Diagnosis ; Female ; Humans ; Male ; Middle Aged ; Parotid Gland/diagnostic imaging ; Radionuclide Imaging ; Sensitivity and Specificity ; Sjogren's Syndrome/diagnostic imaging ; Submandibular Gland/diagnostic imaging ; Young Adult
Language	English
Publishing date	2014-05
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2186026-9
ISSN	1790-5427 ; 1108-1430
ISSN	1790-5427 ; 1108-1430
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Zs.A 6058: Show issues

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Article ; Online: Effective dose estimation and lifetime cancer mortality risk assessment from exposure to Chernobyl 137Cs on the territory of Belgrade City and the region of Vojvodina, Serbia.

Spasić-Jokić, Vesna / Zupunski, Ljubica / Janković, Ljiljana / Gordanić, Vojin

Environmental science and pollution research international

2011 Volume 18, Issue 5, Page(s) 708–715

Abstract: Purpose: The purpose of this paper is to determine the activity concentrations of radionuclide (137)Cs in soil samples on the territory of Belgrade and the province of Vojvodina. Also, the lifetime cancer mortality risk from external exposure during 1 ... ...

Abstract	Purpose: The purpose of this paper is to determine the activity concentrations of radionuclide (137)Cs in soil samples on the territory of Belgrade and the province of Vojvodina. Also, the lifetime cancer mortality risk from external exposure during 1 year is assessed, and the effective dose is estimated. Methods: Eighty eight soil samples were collected from 30 uncultivated locations in Belgrade, and 30 soil samples were collected from 10 locations in the province of Vojvodina. Activity concentrations were measured using an HPGe detector. Using dose conversion factors taken from "EPA Federal Guidance Report 12," annual effective doses from external sources were estimated. The lifetime cancer mortality risk was assessed using cancer risk coefficients taken from "EPA Federal Guidance Report 13." Results: Activity concentrations of (137)Cs for the territory of Belgrade are in the range of 2.07-89.1 Bq/kg with a mean value of 23.77 Bq/kg; the estimated annual effective doses are in the range of 0.41-17.5 nSv with a mean value of 4.67 nSv, and assessed lifetime cancer mortality risks, normalized on 100,000 inhabitants, are in the range 0.2-9.5 × 10(-5) with a mean value 2.5 × 10(-5). Activity concentrations of (137)Cs for the province of Vojvodina are in the range of 2.73-18.9 Bq/kg with a mean value of 8.57 Bq/kg; estimated annual effective doses are in the range of 0.54-3.71 nSv with a mean value of 1.68 nSv, and assessed lifetime cancer mortality risks, normalized on 100,000 inhabitants, are in the range of 0.3-2.0 × 10(-5) with a mean value 0.9 × 10(-5). Conclusion: Receiving doses are low from (137)Cs radionuclides occurring in soil, according to the linear no-threshold approach; the risk for cancer development exists but is very small.
MeSH term(s)	Cesium/toxicity ; Cesium Radioisotopes ; Chernobyl Nuclear Accident ; Environmental Exposure/analysis ; Humans ; Neoplasms/epidemiology ; Neoplasms/mortality ; Neoplasms, Radiation-Induced/mortality ; Radiation Dosage ; Radiation Monitoring ; Radioactive Fallout ; Risk Assessment ; Serbia/epidemiology ; Soil Pollutants, Radioactive/toxicity
Chemical Substances	Cesium Radioisotopes ; Radioactive Fallout ; Soil Pollutants, Radioactive ; Cesium (1KSV9V4Y4I)
Language	English
Publishing date	2011-04-05
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-011-0493-5
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Article ; Online: Non-Vitamin K Oral Anticoagulant Drugs for Stroke Prevention in Patients with Atrial Fibrillation and Chronic Kidney Disease.

Potpara, Tatjana S / Jokic, Vera / Dagres, Nikolaos / Larsen, Torben B / Lane, Deirdre A / Hindricks, Gerhard / Lip, Gregory Y H

Current medicinal chemistry

2016 Volume 23, Issue 19, Page(s) 2055–2069

Abstract: Atrial fibrillation (AF) and chronic kidney disease (CKD) are disorders with increasing prevalence. The presence of CKD increases the risk of incident AF and vice versa, and the presence of AF may accelerate CKD progression. Nearly a third of patients ... ...

Abstract	Atrial fibrillation (AF) and chronic kidney disease (CKD) are disorders with increasing prevalence. The presence of CKD increases the risk of incident AF and vice versa, and the presence of AF may accelerate CKD progression. Nearly a third of patients with established CKD also have AF, whilst half of AF patients may have some degree of renal dysfunction. Both AF and CKD are associated with increased cardiovascular morbidity and mortality, including significantly increased risk of stroke or systemic embolism. Oral anticoagulant therapy (OAC), either with vitamin K antagonists or with non-vitamin K oral anticoagulants (NOACs) is essential to optimise prevention of stroke and systemic embolism in AF patients with one or more stroke risk factors, and NOACs are more convenient and generally safer than vitamin K antagonists mostly due to consistently reduced risk of intracranial bleeding. The use of OAC must be balanced against the risk of OAC-related bleeding, which depends on the presence of bleeding risk factors. Renal failure is a well-established bleeding risk factor and renal function should be routinely assessed in all patients presenting with AF. Since the risk of bleeding increases in parallel with CKD severity, the clinical decision to use OAC in AF patients with severe CKD may be challenging. In this review article we summarize the OAC agents currently used in clinical practice and discuss the role of NOACs for stroke prevention in patients with AF and CKD.
MeSH term(s)	Administration, Oral ; Anticoagulants/therapeutic use ; Atrial Fibrillation/complications ; Atrial Fibrillation/pathology ; Clinical Trials as Topic ; Dabigatran/therapeutic use ; Embolism/complications ; Embolism/prevention & control ; Humans ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/pathology ; Stroke/complications ; Stroke/prevention & control ; Warfarin/therapeutic use
Chemical Substances	Anticoagulants ; Warfarin (5Q7ZVV76EI) ; Dabigatran (I0VM4M70GC)
Language	English
Publishing date	2016-01-22
Publishing country	United Arab Emirates
Document type	Journal Article ; Review
ZDB-ID	1319315-6
ISSN	1875-533X ; 0929-8673
ISSN (online)	1875-533X
ISSN	0929-8673
DOI	10.2174/0929867323666160210130109
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Article ; Online: Cardiac Arrhythmias in Patients with Chronic Kidney Disease: Implications of Renal Failure for Antiarrhythmic Drug Therapy.

Potpara, Tatjana S / Jokic, Vera / Dagres, Nikolaos / Marin, Francisco / Prostran, Milica S / Blomstrom-Lundqvist, Carina / Lip, Gregory Y H

Current medicinal chemistry

2016 Volume 23, Issue 19, Page(s) 2070–2083

Abstract: The kidney has numerous complex interactions with the heart, including shared risk factors (e.g., hypertension, dyslipidemia, etc.) and mutual amplification of morbidity and mortality. Both cardiovascular diseases and chronic kidney disease (CKD) may ... ...

Abstract	The kidney has numerous complex interactions with the heart, including shared risk factors (e.g., hypertension, dyslipidemia, etc.) and mutual amplification of morbidity and mortality. Both cardiovascular diseases and chronic kidney disease (CKD) may cause various alterations in cardiovascular system, metabolic homeostasis and autonomic nervous system that may facilitate the occurrence of cardiac arrhythmias. Also, pre-existent or incident cardiac arrhythmias such as atrial fibrillation (AF) may accelerate the progression of CKD. Patients with CKD may experience various cardiac rhythm disturbances including sudden cardiac death. Contemporary management of cardiac arrhythmias includes the use of antiarrhythmic drugs (AADs), catheter ablation and cardiac implantable electronic devices (CIEDs). Importantly, AADs are not used only as the principal treatment strategy, but also as an adjunct therapy in combination with CIEDs, to facilitate their effects or to minimize inappropriate device activation in selected patients. Along with their principal antiarrhythmic effect, AADs may also induce cardiac arrhythmias and the risk for such proarrhythmic effect(s) is particularly increased in patients with reduced left ventricular systolic function or in the setting of electrolyte imbalance. Moreover, CKD itself can induce profound alterations in the pharmacokinetics and pharmacodynamics of many drugs including AADs, thus facilitating the drug accumulation and increased exposure. Hence, the use of AADs in patients with CKD may be challenging. In this review article, we provide an overview of the characteristics of arrhythmogenesis in patients with CKD with special emphasis on the complexity of pharmacokinetics and risk for proarrhythmias when using AADs in patients with cardiac arrhythmias and CKD.
MeSH term(s)	Adrenergic beta-Antagonists/adverse effects ; Adrenergic beta-Antagonists/therapeutic use ; Anti-Arrhythmia Agents/adverse effects ; Anti-Arrhythmia Agents/therapeutic use ; Arrhythmias, Cardiac/complications ; Arrhythmias, Cardiac/drug therapy ; Atherosclerosis/complications ; Atherosclerosis/drug therapy ; Atrial Fibrillation/complications ; Atrial Fibrillation/drug therapy ; Death, Sudden, Cardiac/etiology ; Electrolytes/metabolism ; Glomerular Filtration Rate ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/metabolism ; Renal Insufficiency, Chronic/physiopathology
Chemical Substances	Adrenergic beta-Antagonists ; Anti-Arrhythmia Agents ; Electrolytes
Language	English
Publishing date	2016-03-04
Publishing country	United Arab Emirates
Document type	Journal Article ; Review
ZDB-ID	1319315-6
ISSN	1875-533X ; 0929-8673
ISSN (online)	1875-533X
ISSN	0929-8673
DOI	10.2174/0929867323666160309114246
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