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  1. Article ; Online: Helicobacter pylori diagnosis and treatment in Africa: The First Lagos Consensus Statement of the African Helicobacter and Microbiota Study Group (AHMSG).

    Smith, Stella I / Schulz, Christian / Ugiagbe, Rose / Ndip, Roland / Dieye, Yakhya / Leja, Marcis / Onyekwere, Charles / Ndububa, Dennis / Ajayi, Abraham / Jolaiya, Tolulope Funbi / Jaka, Hyasinta / Setshedi, Mashiko / Gunturu, Revathi / Otegbayo, Jesse Abiodun / Lahbabi-Amrani, Naima / Arigbabu, Anthony Oluwole / Kayamba, Violet / Nashidengo, Pueya Abdulrashid

    Digestive diseases (Basel, Switzerland)

    2024  

    Abstract: Background: Helicobacter pylori (H. pylori) infection is the most prevalent type of bacterial infection. Current guidelines from different regions of the world neglect specific African conditions and requirements. The African Helicobacter and Microbiota ...

    Abstract Background: Helicobacter pylori (H. pylori) infection is the most prevalent type of bacterial infection. Current guidelines from different regions of the world neglect specific African conditions and requirements. The African Helicobacter and Microbiota Study Group (AHMSG), founded in 2022, aims to create an Africa-specific consensus report reflecting Africa-specific issues.
    Summary: Eighteen experts from nine African countries and two European delegates supported by nine African collaborators from eight other countries prepared statements on the most important African issues in four working groups: (1) epidemiology, (2) diagnosis, (3) indications and prevention, and (4) treatment. Limited resources, restricted access to medical systems, and underdeveloped diagnostic facilities differ from those of other regions. The results of the individual working groups were presented for the final consensus voting, which included all board members.
    Key messages: There is need for further studies on H. pylori prevalence in Africa, with diagnosis hinged on specific African situation. Treatment of H. pylori in the African setting should be based on accessibility and reimbursement, while indication and prevention should be defined in specific African countries.
    Language English
    Publishing date 2024-03-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 632798-9
    ISSN 1421-9875 ; 0257-2753
    ISSN (online) 1421-9875
    ISSN 0257-2753
    DOI 10.1159/000537878
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Duodenal ulcer promoting gene (DupA), plasticity region genes and sigma factors in H. pyloristrains from Nigeria.

    Jolaiya, Tolulope Funbi / Fowora, Muinah Adenike / Onyekwere, Charles / Ugiagbe, Rose / Agbo, Ifeanyi Ifeoma / Lesi, Olufunmilayo / Ndububa, Dennis Amojuayi / Adekanle, Olusegun / Njom, Henry Akum / Idowu, Ayodeji / Adeleye, Isaac Adeyemi / Bamidele, Moses / Ngoka, Favor Ndidiamaka / Palamides, Pia Fiona / Smith, Stella Ifeanyi

    Journal of infection in developing countries

    2020  Volume 14, Issue 2, Page(s) 162–168

    Abstract: Introduction: Helicobacter pylori is a principal cause of gastric cancer. The aim of this study was to determine the prevalence and contribution of duodenal ulcer promoting gene A (dupA), the plasticity region genes and sigma factors in relation to ... ...

    Abstract Introduction: Helicobacter pylori is a principal cause of gastric cancer. The aim of this study was to determine the prevalence and contribution of duodenal ulcer promoting gene A (dupA), the plasticity region genes and sigma factors in relation to their pathological expression of H. pylori infections in the Nigerian population.
    Methodology: Polymerase Chain Reaction was used to analyze a total of forty-nine H. pylori strains isolated from patients attending various endoscopic units in tertiary hospitals in Nigeria for complete dupA (G27 variant), jhp0917, jhp0918, other plasticity region genes jhp 914/917, jhp0914, jhp0940 and sigma factors.
    Results: PCR results indicated that the prevalence of complete dupA (G27 variants), jhp0917, jhp0918 and other plasticity region genes jhp0914, jhp0914/0917 and jhp0940 in the H. pylori strains were 4%, 53%, 88%, 73%, 12% and 0% respectively. The prevalence values of the sigma factors were 96%, 92%, 80% for rpoN,  fliA and rpoD respectively. However, the endoscopic findings showed that erosion, normal mucosal, ulcer, hyperaemic stomach, mucosal atrophy and oedematous stomach in the patients where the H. pylori strains were isolated were 40.8%, 32.7%, 10.2%, 8.2%, 2.0% and 6.1% respectively. There was significant association between jhp0917, jhp914/917 and G27 variant and the endoscopic findings, while other plasticity genes showed no association with the endoscopic findings.
    Conclusion: These results suggest that the presence of jhp0917, jhp0914/917 and G27 variant could be used as marker to predict the pathological effect of severity in Nigeria patients with H. pylori infection.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biopsy ; Child ; Duodenal Ulcer/epidemiology ; Female ; Genes, Bacterial ; Helicobacter Infections/epidemiology ; Helicobacter pylori/genetics ; Helicobacter pylori/isolation & purification ; Humans ; Male ; Middle Aged ; Nigeria ; Polymerase Chain Reaction ; Sigma Factor/genetics ; Virulence Factors/genetics ; Young Adult
    Chemical Substances DupA protein, Helicobacter pylori ; Sigma Factor ; Virulence Factors
    Language English
    Publishing date 2020-02-29
    Publishing country Italy
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2394024-4
    ISSN 1972-2680 ; 2036-6590
    ISSN (online) 1972-2680
    ISSN 2036-6590
    DOI 10.3855/jidc.11746
    Database MEDical Literature Analysis and Retrieval System OnLINE

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