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Article ; Online: Pou3f1 orchestrates a gene regulatory network controlling contralateral retinogeniculate projections.

Fries, Michel / Brown, Thomas W / Jolicoeur, Christine / Boulan, Benoit / Boudreau-Pinsonneault, Camille / Javed, Awais / Abram, Pénélope / Cayouette, Michel

Cell reports

2023 Volume 42, Issue 8, Page(s) 112985

Abstract: The balance of contralateral and ipsilateral retinogeniculate projections is critical for binocular vision, but the transcriptional programs regulating this process remain ill defined. Here we show that the Pou class homeobox protein POU3F1 is expressed ... ...

Abstract	The balance of contralateral and ipsilateral retinogeniculate projections is critical for binocular vision, but the transcriptional programs regulating this process remain ill defined. Here we show that the Pou class homeobox protein POU3F1 is expressed in nascent mouse contralateral retinal ganglion cells (cRGCs) but not ipsilateral RGCs (iRGCs). Upon Pou3f1 inactivation, the proportion of cRGCs is reduced in favor of iRGCs, leading to abnormal projection ratios at the optic chiasm. Conversely, misexpression of Pou3f1 in progenitors increases the production of cRGCs. Using CUT&RUN and RNA sequencing in gain- and loss-of-function assays, we demonstrate that POU3F1 regulates expression of several key members of the cRGC gene regulatory network. Finally, we report that POU3F1 is sufficient to induce RGC-like cell production, even in late-stage retinal progenitors of Atoh7 knockout mice. This work uncovers POU3F1 as a regulator of the cRGC transcriptional program, opening possibilities for optic nerve regenerative therapies.
Language	English
Publishing date	2023-08-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2023.112985
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Article ; Online: Corrigendum to Semaphorin 4C and 4G are ligands of Plexin-B2 required in cerebellar development [Mol. Cell. Neurosci., 2011 Feb;46(2):419-31].

Maier, Viola / Jolicoeur, Christine / Rayburn, Helen / Takegahara, Noriko / Kumanogoh, Atsushi / Kikutani, Hitoshi / Tessier-Lavigne, Marc / Wurst, Wolfgang / Friedel, Roland H

Molecular and cellular neurosciences

2023 Volume 125, Page(s) 103837

Language	English
Publishing date	2023-03-05
Publishing country	United States
Document type	Published Erratum
ZDB-ID	1046640-x
ISSN	1095-9327 ; 1044-7431
ISSN (online)	1095-9327
ISSN	1044-7431
DOI	10.1016/j.mcn.2023.103837
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Article ; Online: A Casz1-NuRD complex regulates temporal identity transitions in neural progenitors.

Mattar, Pierre / Jolicoeur, Christine / Dang, Thanh / Shah, Sujay / Clark, Brian S / Cayouette, Michel

Scientific reports

2021 Volume 11, Issue 1, Page(s) 3858

Abstract: Neural progenitor cells undergo identity transitions during development to ensure the generation different types of neurons and glia in the correct sequence and proportions. A number of temporal identity factors that control these transitions in ... ...

Abstract	Neural progenitor cells undergo identity transitions during development to ensure the generation different types of neurons and glia in the correct sequence and proportions. A number of temporal identity factors that control these transitions in progenitor competence have been identified, but the molecular mechanisms underlying their function remain unclear. Here, we asked how Casz1, the mammalian orthologue of Drosophila castor, regulates competence during retinal development. We show that Casz1 is required to control the transition between neurogenesis and gliogenesis. Using BioID proteomics, we reveal that Casz1 interacts with the nucleosome remodeling and deacetylase (NuRD) complex in retinal cells. Finally, we show that both the NuRD and the polycomb repressor complexes are required for Casz1 to promote the rod fate and suppress gliogenesis. As additional temporal identity factors have been found to interact with the NuRD complex in other contexts, we propose that these factors might act through this common biochemical process to regulate neurogenesis.
MeSH term(s)	Animals ; DNA-Binding Proteins/metabolism ; Ependymoglial Cells ; Mi-2 Nucleosome Remodeling and Deacetylase Complex/metabolism ; Mice ; Mice, Knockout ; Neural Stem Cells/physiology ; Neurogenesis ; Polycomb-Group Proteins/metabolism ; Retina/cytology ; Retina/embryology ; Transcription Factors/metabolism
Chemical Substances	CASZ1 protein, mouse ; DNA-Binding Proteins ; Polycomb-Group Proteins ; Transcription Factors ; Mi-2 Nucleosome Remodeling and Deacetylase Complex (EC 3.5.1.98)
Language	English
Publishing date	2021-02-16
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-83395-7
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Article ; Online: Numb regulates Tau levels and prevents neurodegeneration in tauopathy mouse models.

Lacomme, Marine / Hales, Sarah C / Brown, Thomas W / Stevanovic, Katarina / Jolicoeur, Christine / Cai, Jenny / Bois, Therence / Desrosiers, Melissa / Dalkara, Deniz / Cayouette, Michel

Science advances

2022 Volume 8, Issue 42, Page(s) eabm4295

Abstract: Accumulation of the microtubule-associated protein Tau is linked to neuronal cell death in tauopathies, but how intraneuronal Tau levels are regulated in health and disease remains unclear. Here, we show that conditional inactivation of the trafficking ... ...

Abstract	Accumulation of the microtubule-associated protein Tau is linked to neuronal cell death in tauopathies, but how intraneuronal Tau levels are regulated in health and disease remains unclear. Here, we show that conditional inactivation of the trafficking adaptor protein Numb in retinal ganglion cells (RGCs) increases Tau levels and leads to axonal blebbing, which is followed by neuronal cell loss in aged mice. In the TauP301S mouse model of tauopathy, conditional inactivation of Numb in RGCs and spinal motoneurons accelerates neurodegeneration, and loss of Numb in motoneurons also leads to precocious hindlimb paralysis. Conversely, overexpression of the long isoform of Numb (Numb-72) decreases intracellular Tau levels and reduces axonal blebbing in TauP301S RGCs, leading to improved electrical activity in cultured neurons and improves performance in a visually guided behavior test in vivo. These results uncover Numb as a key regulator of intracellular Tau levels and identify Numb-72 as a potential therapeutic factor for tauopathies.
MeSH term(s)	Mice ; Animals ; Tauopathies/genetics ; Tauopathies/metabolism ; tau Proteins/genetics ; tau Proteins/metabolism ; Disease Models, Animal ; Retinal Ganglion Cells/metabolism ; Axons/metabolism ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Nerve Tissue Proteins/metabolism
Chemical Substances	tau Proteins ; Numb protein, mouse ; Membrane Proteins ; Nerve Tissue Proteins
Language	English
Publishing date	2022-10-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.abm4295
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Article: A Molecular Blueprint at the Apical Surface Establishes Planar Asymmetry in Cochlear Hair Cells

Tarchini, Basile / Jolicoeur, Christine / Cayouette, Michel

Developmental cell. 2013 Oct. 14, v. 27, no. 1

2013

Abstract: Sound perception relies on the planar polarization of the mechanosensory hair cell apex, which develops a V-shaped stereocilia bundle pointing toward an eccentric kinocilium. It remains unknown how intrinsically asymmetric bundles arise and are ... ...

Abstract	Sound perception relies on the planar polarization of the mechanosensory hair cell apex, which develops a V-shaped stereocilia bundle pointing toward an eccentric kinocilium. It remains unknown how intrinsically asymmetric bundles arise and are concomitantly oriented in the tissue. We report here that mInsc, LGN, and Gαi proteins, which classically regulate mitotic spindle orientation, are polarized in a lateral microvilli-free region, or “bare zone,” at the apical hair cell surface. By creating and extending the bare zone, these proteins trigger a relocalization of the eccentric kinocilium midway toward the cell center. aPKC is restrained medially by mInsc/LGN/Gαi, resulting in compartmentalization of the apical surface that imparts the V-shaped distribution of stereocilia and brings the asymmetric bundle in register with the relocalized kinocilium. Gαi is additionally required for lateral orientation of cochlear hair cells, providing a possible mechanism to couple the emergence of asymmetric stereocilia bundles with planar cell polarity.
Keywords	cell polarity ; mitotic spindle apparatus ; proteins
Language	English
Dates of publication	2013-1014
Size	p. 88-102.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	2054967-2
ISSN	1878-1551 ; 1534-5807
ISSN (online)	1878-1551
ISSN	1534-5807
DOI	10.1016/j.devcel.2013.09.011
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Article ; Online: Leading-edge forensic DNA analyses and the necessity of including crime scene investigators, police officers and technicians in a DNA elimination database.

Lapointe, Martine / Rogic, Anita / Bourgoin, Sarah / Jolicoeur, Christine / Séguin, Diane

Forensic science international. Genetics

2015 Volume 19, Page(s) 50–55

Abstract: In recent years, sophisticated technology has significantly increased the sensitivity and analytical power of genetic analyses so that very little starting material may now produce viable genetic profiles. This sensitivity however, has also increased the ...

Abstract	In recent years, sophisticated technology has significantly increased the sensitivity and analytical power of genetic analyses so that very little starting material may now produce viable genetic profiles. This sensitivity however, has also increased the risk of detecting unknown genetic profiles assumed to be that of the perpetrator, yet originate from extraneous sources such as from crime scene workers. These contaminants may mislead investigations, keeping criminal cases active and unresolved for long spans of time. Voluntary submission of DNA samples from crime scene workers is fairly low, therefore we have created a promotional method for our staff elimination database that has resulted in a significant increase in voluntary samples since 2011. Our database enforces privacy safeguards and allows for optional anonymity to all staff members. We also offer information sessions at various police precincts to advise crime scene workers of the importance and success of our staff elimination database. This study, a pioneer in its field, has obtained 327 voluntary submissions from crime scene workers to date, of which 46 individual profiles (14%) have been matched to 58 criminal cases. By implementing our methods and respect for individual privacy, forensic laboratories everywhere may see similar growth and success in explaining unidentified genetic profiles in stagnate criminal cases.
MeSH term(s)	Crime ; DNA/genetics ; Databases, Genetic ; Forensic Genetics ; Humans ; Male ; Police
Chemical Substances	DNA (9007-49-2)
Language	English
Publishing date	2015-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2493339-9
ISSN	1878-0326 ; 1872-4973
ISSN (online)	1878-0326
ISSN	1872-4973
DOI	10.1016/j.fsigen.2015.06.002
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Article ; Online: A molecular blueprint at the apical surface establishes planar asymmetry in cochlear hair cells.

Tarchini, Basile / Jolicoeur, Christine / Cayouette, Michel

Developmental cell

2013 Volume 27, Issue 1, Page(s) 88–102

Abstract	Sound perception relies on the planar polarization of the mechanosensory hair cell apex, which develops a V-shaped stereocilia bundle pointing toward an eccentric kinocilium. It remains unknown how intrinsically asymmetric bundles arise and are concomitantly oriented in the tissue. We report here that mInsc, LGN, and Gαi proteins, which classically regulate mitotic spindle orientation, are polarized in a lateral microvilli-free region, or "bare zone," at the apical hair cell surface. By creating and extending the bare zone, these proteins trigger a relocalization of the eccentric kinocilium midway toward the cell center. aPKC is restrained medially by mInsc/LGN/Gαi, resulting in compartmentalization of the apical surface that imparts the V-shaped distribution of stereocilia and brings the asymmetric bundle in register with the relocalized kinocilium. Gαi is additionally required for lateral orientation of cochlear hair cells, providing a possible mechanism to couple the emergence of asymmetric stereocilia bundles with planar cell polarity.
MeSH term(s)	Animals ; Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Cell Membrane/metabolism ; Cell Polarity ; GTP-Binding Protein alpha Subunits, Gi-Go/genetics ; GTP-Binding Protein alpha Subunits, Gi-Go/metabolism ; Hair Cells, Auditory/cytology ; Hair Cells, Auditory/metabolism ; Hair Cells, Auditory/ultrastructure ; Mice ; Microvilli/metabolism ; Microvilli/ultrastructure ; Protein Kinase C/genetics ; Protein Kinase C/metabolism
Chemical Substances	Carrier Proteins ; Cell Cycle Proteins ; LGN protein, mouse ; inscuteable protein, mouse ; PKC-3 protein (EC 2.7.11.13) ; Protein Kinase C (EC 2.7.11.13) ; GTP-Binding Protein alpha Subunits, Gi-Go (EC 3.6.5.1)
Language	English
Publishing date	2013-10-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2054967-2
ISSN	1878-1551 ; 1534-5807
ISSN (online)	1878-1551
ISSN	1534-5807
DOI	10.1016/j.devcel.2013.09.011
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Zs.A 5742: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Boc Acts via Numb as a Shh-Dependent Endocytic Platform for Ptch1 Internalization and Shh-Mediated Axon Guidance.

Ferent, Julien / Giguère, Fanny / Jolicoeur, Christine / Morin, Steves / Michaud, Jean-Francois / Makihara, Shirin / Yam, Patricia T / Cayouette, Michel / Charron, Frederic

Neuron

2019 Volume 102, Issue 6, Page(s) 1157–1171.e5

Abstract: During development, Shh attracts commissural axons toward the floor plate through a non-canonical, transcription-independent signaling pathway that requires the receptor Boc. Here, we find that Shh induces Boc internalization into early endosomes and ... ...

Abstract	During development, Shh attracts commissural axons toward the floor plate through a non-canonical, transcription-independent signaling pathway that requires the receptor Boc. Here, we find that Shh induces Boc internalization into early endosomes and that endocytosis is required for Shh-mediated growth-cone turning. Numb, an endocytic adaptor, binds to Boc and is required for Boc internalization, Shh-mediated growth-cone turning in vitro, and commissural axon guidance in vivo. Similar to Boc, Ptch1 is also internalized by Shh in a Numb-dependent manner; however, the binding of Shh to Ptch1 alone is not sufficient to induce Ptch1 internalization nor growth-cone turning. Therefore, the binding of Shh to Boc is required for Ptch1 internalization and growth-cone turning. Our data support a model where Boc endocytosis via Numb is required for Ptch1 internalization and Shh signaling in axon guidance. Thus, Boc acts as a Shh-dependent endocytic platform gating Ptch1 internalization and Shh signaling.
MeSH term(s)	Animals ; Axon Guidance/genetics ; Endocytosis/genetics ; Gene Knockdown Techniques ; Growth Cones/metabolism ; Hedgehog Proteins/metabolism ; Immunoglobulin G/metabolism ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mice ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Neurons/metabolism ; Patched-1 Receptor/metabolism ; Receptors, Cell Surface/metabolism
Chemical Substances	Boc protein, mouse ; Hedgehog Proteins ; Immunoglobulin G ; Membrane Proteins ; Nerve Tissue Proteins ; Numb protein, mouse ; Patched-1 Receptor ; Ptch1 protein, mouse ; Receptors, Cell Surface ; Shh protein, mouse
Language	English
Publishing date	2019-05-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Video-Audio Media
ZDB-ID	808167-0
ISSN	1097-4199 ; 0896-6273
ISSN (online)	1097-4199
ISSN	0896-6273
DOI	10.1016/j.neuron.2019.04.003
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Zs.A 2496: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: In vivo evidence for unbiased Ikaros retinal lineages using an Ikaros-Cre mouse line driving clonal recombination.

Tarchini, Basile / Jolicoeur, Christine / Cayouette, Michel

Developmental dynamics : an official publication of the American Association of Anatomists

2012 Volume 241, Issue 12, Page(s) 1973–1985

Abstract: Background: We showed previously that the transcription factor Ikaros is expressed in early but not late retinal progenitors cells (RPCs), and is necessary and sufficient for the production of early-born neurons. Preliminary evidence using retinal ... ...

Abstract	Background: We showed previously that the transcription factor Ikaros is expressed in early but not late retinal progenitors cells (RPCs), and is necessary and sufficient for the production of early-born neurons. Preliminary evidence using retinal explant cultures qualitatively suggested that Ikaros-positive RPCs might share a common lineage with Ikaros-negative RPCs. Results: To explore further this question in vivo in a quantitative manner, we generated BAC transgenic mouse lines expressing Cre recombinase under the regulatory elements of the Ikaros gene, and crossed them with Cre reporter lines. Different transgenic lines labeled a variable number of RPCs, resulting in either dense or sparse radial arrays of reporter-positive progenies. Analysis of over 800 isolated cell arrays, which are most likely clones, confirmed that Ikaros-expressing RPCs generate both early- and late-born cell types in the same lineage, and that the overall cell composition of the arrays closely resembles that of the population of the mature retina. Interestingly, another sparse line did not label arrays, but appeared to specifically reflect Ikaros postmitotic expression in amacrine and ganglion cells. Conclusions: These mouse lines confirm the unbiased potential of the Ikaros lineage in vivo and provide novel tools for clonal lineage tracing and single neuron tracking in the retina.
MeSH term(s)	Animals ; Ikaros Transcription Factor/biosynthesis ; Ikaros Transcription Factor/genetics ; Integrases/biosynthesis ; Integrases/genetics ; Mice ; Mice, Transgenic ; Response Elements/physiology ; Retina/cytology ; Retina/metabolism ; Species Specificity ; Stem Cells/cytology ; Stem Cells/metabolism
Chemical Substances	Zfpn1a1 protein, mouse ; Ikaros Transcription Factor (148971-36-2) ; Cre recombinase (EC 2.7.7.-) ; Integrases (EC 2.7.7.-)
Language	English
Publishing date	2012-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1102541-4
ISSN	1097-0177 ; 1058-8388
ISSN (online)	1097-0177
ISSN	1058-8388
DOI	10.1002/dvdy.23881
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Article ; Online: DNA transfer during laundering may yield complete genetic profiles.

Noël, Sarah / Lagacé, Karine / Rogic, Anita / Granger, Dominic / Bourgoin, Sarah / Jolicoeur, Christine / Séguin, Diane

Forensic science international. Genetics

2016 Volume 23, Page(s) 240–247

Abstract: In a number of child sexual abuse cases, the alleged perpetrator is a member of the nuclear family. In those cases, there is a possibility that the suspect's DNA was innocently deposited onto the child's clothing without acts of sexual assault ever ... ...

Abstract	In a number of child sexual abuse cases, the alleged perpetrator is a member of the nuclear family. In those cases, there is a possibility that the suspect's DNA was innocently deposited onto the child's clothing without acts of sexual assault ever occurring, for example via secondary transfer within the washing machine. To assess the quantity and quality of DNA that may be transferred among clothing during laundering, we conducted three series of experiments. First, we evaluated the level of spermatozoa that may be transferred by washing pristine pairs of underwear with bed sheets containing a varying number of ejaculates. Secondly, we explored whether current genetic methods may also detect the transfer of DNA from vaginal secretions during a machine wash. Finally, we analyzed the background levels of DNA on children's underwear collected from control families where sexual abuse never occurred. For both spermatozoa and vaginal secretions, we revealed that sufficient amounts of DNA may transfer onto laundered clothing to yield complete genetic profiles. Furthermore, DNA from relatives living within the same household was found in most cuttings taken from control children's underwear. Based on these findings, we present a framework for the handling and interpretation of intrafamilial sexual abuse cases. These suggestions should help determine whether DNA was deposited directly onto a fabric or merely transferred during a wash.
MeSH term(s)	Bedding and Linens ; Cervix Mucus/chemistry ; Child ; Child Abuse, Sexual/diagnosis ; Child, Preschool ; Clothing ; DNA/isolation & purification ; DNA Fingerprinting ; Diagnostic Errors ; Female ; Humans ; Incest ; Laundering ; Male ; Polymerase Chain Reaction ; Spermatozoa/chemistry
Chemical Substances	DNA (9007-49-2)
Language	English
Publishing date	2016
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2493339-9
ISSN	1878-0326 ; 1872-4973
ISSN (online)	1878-0326
ISSN	1872-4973
DOI	10.1016/j.fsigen.2016.05.004
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