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Article ; Online: Using the Triangle of Human Ecology for understanding self-rated depression: A quantitative study based on the HUNT 3 cohort.

Nielsen, Anja F / Jørgensen, Stig H / Jones, Andrew P

2023 , Page(s) 14034948221122638

Abstract: Aims: To test the Triangle of Human Ecology by examining associations between unipolar depression and different measures of human biological factors, health behaviour, and the physical environment.: Methods: Data originate from the third wave of the ... ...

Abstract	Aims: To test the Triangle of Human Ecology by examining associations between unipolar depression and different measures of human biological factors, health behaviour, and the physical environment. Methods: Data originate from the third wave of the Nord-Trøndelag Health Study (2006-2008). The survey was based on a random sample of 50,000 Norwegians (response rate: 54%). Logistic regression was performed, using unipolar depression, measured with the Hospital Anxiety and Depression Scale score, as outcome variable and 38 explanatory variables. Results: Biological factors including older age and male gender were associated with higher odds of depression, as were behavioural factors including drinking behaviour and having a neurotic personality. Reduced odds were associated with units of alcohol consumed, extrovert personality and physical activity. Social networks were an environmental factor with reduced odds at both personal and neighbourhood levels, as was warmer outdoor temperatures. Conclusions: Using the Triangle of Human Ecology provides a holistic insight into how behaviour, biology and the environment influence mental health
Language	English
Publishing date	2023-09-25
Publishing country	Sweden
Document type	Journal Article
ZDB-ID	1475054-5
ISSN	1651-1905 ; 1403-4948
ISSN (online)	1651-1905
ISSN	1403-4948
DOI	10.1177/14034948221122638
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Article ; Online: Glucocorticoid prescribing in neurology.

Jones, Andrew P / Debono, Miguel / Walsh, Jennifer / Smith, Cheryl / Hunt, Leanne / McKevitt, Fiona M

Practical neurology

2024

Abstract: Glucocorticoids are commonly used for neurological disorders, but they can have significant adverse effects, including adrenal insufficiency, hyperglycaemia, osteoporosis and increased infection risk. Long-term use of corticosteroids requires the ... ...

Abstract	Glucocorticoids are commonly used for neurological disorders, but they can have significant adverse effects, including adrenal insufficiency, hyperglycaemia, osteoporosis and increased infection risk. Long-term use of corticosteroids requires the prescriber to plan risk mitigation, including monitoring and often coprescribing. This article highlights the potential risks of corticosteroid prescribing and draws together up-to-date guidance with multispecialty input to clarify ways of reducing those risks. We discuss home blood glucose monitoring and consider a steroid safety checklist to promote safer steroid prescribing.
Language	English
Publishing date	2024-03-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2170881-2
ISSN	1474-7766 ; 1474-7758
ISSN (online)	1474-7766
ISSN	1474-7758
DOI	10.1136/pn-2023-003855
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Article ; Online: Residential neighbourhood greenspace is associated with reduced risk of cardiovascular disease: A prospective cohort study.

Dalton, Alice M / Jones, Andrew P

PloS one

2020 Volume 15, Issue 1, Page(s) e0226524

Abstract: Background: Living in a greener neighbourhood may reduce the risk of developing incident cardiovascular disease, but evidence is limited by reliance on cross-sectional comparisons. We use data from a longitudinal study with a time-independent measure of ...

Abstract	Background: Living in a greener neighbourhood may reduce the risk of developing incident cardiovascular disease, but evidence is limited by reliance on cross-sectional comparisons. We use data from a longitudinal study with a time-independent measure of risk to explore the association between exposure to greenspace and cardiovascular disease. Methods: Data was from the European Prospective Investigation of Cancer Norfolk UK cohort, baseline 1993-1997 (n = 24,420). Neighbourhoods were defined as 800m radius zones around participants' home, according to their home postcode (zip code) in the year 2000. Greenspace exposure was identified using classified satellite imagery. Adjusted Cox proportional hazards regression examined associations between greenspace and incident cardiovascular disease. Mediation analysis assessed if physical activity mediated associations, whilst modification by rurality, socio-economic status and age was explored. Results: The mean age of participants was 59.2 years at baseline, 54.7% were female, and mean follow-up time was 14.5 years. Individuals living in the greenest neighbourhood quartile had a 7% lower relative hazard of developing cardiovascular disease than other neighbourhoods (HR 0.93; 95% CI 0.88, 0.97; p = 0.003) after adjusting for age, sex, BMI, prevalent diabetes and socio-economic status (SES). Physical activity did not mediate the relationship (greenest compared to the least green quartile HR 0.99; 95% CI 0.97, 1.01; p = 0.416). Models predicted incidence of cardiovascular disease in the least green neighbourhoods (19.4% greenspace on average) would fall by 4.8% (95% CI 1.6%, 8.2% p = 0.003) if they were as green as the average neighbourhood (59.0% greenspace). Occupation moderated the relationship, whereby exposure to greenspace was not associated with incident CVD for participants engaged in manual occupations. Conclusions: Greener home neighbourhoods may protect against risk of cardiovascular disease even after accounting for SES, whilst the mechanism does not appear to be strongly associated with physical activity. Putative causal mechanisms require investigation.
MeSH term(s)	Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/prevention & control ; Environment Design ; Exercise ; Female ; Humans ; Incidence ; Longitudinal Studies ; Male ; Middle Aged ; Prospective Studies ; Residence Characteristics ; Risk Reduction Behavior ; United Kingdom/epidemiology
Language	English
Publishing date	2020-01-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0226524
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Article ; Online: A 3-year review of MRI safety incidents within a UK independent sector provider of diagnostic services.

Hudson, Darren / Jones, Andrew P

BJR open

2019 Volume 1, Issue 1, Page(s) 20180006

Abstract: A review of MRI safety incidents conducted over a 3-year period for a large independent sector diagnostic imaging provider in the UK. The review took a systematic approach using reports logged on an internal incident reporting system that were then ... ...

Abstract	A review of MRI safety incidents conducted over a 3-year period for a large independent sector diagnostic imaging provider in the UK. The review took a systematic approach using reports logged on an internal incident reporting system that were then categorised and analysed for themes and trends. Notable cases and actions taken are also described from within the period. MRI safety-related events made up 7.5% of the total number of incident reports submitted and 15.5% of all MRI-related reports. The MR safety-related incidence report rate was 0.05% (1 per 1987 patients), which is relatively low considering the number of patients seen in our facilities each day. Internal MRI safety events indicated the main trends to be around referral of contraindicated devices (32% of reports) and failure in the screening process (21.5%-either due to unexpected implants or being unable to confirm safety). To improve practice and work to reduce incidents, advice and instructional materials were developed. The review suggests a potential approach to categorisation of MRI-related safety events which could allow comparisons to be made across organisations, helping to look for trends and guide learning. It also provides insight into the state of MRI safety within the organisation, a rationale for some of the interventions introduced to improve safety, and discussion around common issues arising in MRI safety.
Language	English
Publishing date	2019-04-30
Publishing country	England
Document type	Journal Article
ISSN	2513-9878
ISSN (online)	2513-9878
DOI	10.1259/bjro.20180006
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Article ; Online: Initial Clinical Laboratory Response to COVID-19: A Survey of Medical Laboratory Professionals.

Nuñez-Argote, Letycia / Baker, Dana P / Jones, Andrew P

Laboratory medicine

2021 Volume 52, Issue 4, Page(s) e115–e124

Abstract: Objective: To explore the experiences of medical laboratory professionals (MLPs) and their perceptions of the needs of clinical laboratories in response to COVID-19.: Methods: We surveyed laboratory professionals working in United States clinical ... ...

Abstract	Objective: To explore the experiences of medical laboratory professionals (MLPs) and their perceptions of the needs of clinical laboratories in response to COVID-19. Methods: We surveyed laboratory professionals working in United States clinical laboratories during the initial months of the pandemic. Results: Overall clinical laboratory testing and overtime work for laboratorians decreased during the first months of the pandemic. Laboratory professionals reported better or unchanged job satisfaction, feelings toward their work, and morale in their workplace, which were related to healthcare facility and laboratory leadership response. They reported receiving in-kind gifts, but no hazard pay, for their essential work. Important supply needs included reagents and personal protective equipment (PPE). Conclusion: The response by healthcare facilities and laboratory leadership can influence MLPs job satisfaction, feelings toward their work, and laboratory morale during a pandemic. Current COVID-19 laboratory testing management, in the absence of sufficient reagents and supplies, cannot fully address the needs of clinical laboratories.
Language	English
Publishing date	2021-05-03
Publishing country	England
Document type	Journal Article
ZDB-ID	391758-7
ISSN	1943-7730 ; 0007-5027
ISSN (online)	1943-7730
ISSN	0007-5027
DOI	10.1093/labmed/lmab021
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Article: Long-Term Assessment of Lurasidone in Schizophrenia: Post Hoc Analysis of a 12-Month, Double Blind, Active-Controlled Trial and 6-Month Open-Label Extension Study.

Patel, Preeya J / Weidenfeller, Christian / Jones, Andrew P / Nilsson, Jens / Hsu, Jay

Neurology and therapy

2020 Volume 10, Issue 1, Page(s) 121–147

Abstract: Introduction: A post hoc analysis of a double-blind (DB) active control trial and an open-label extension (OLE) study was conducted to evaluate the long-term effects of lurasidone in patients with schizophrenia.: Methods: In the DB trial, patients ... ...

Abstract	Introduction: A post hoc analysis of a double-blind (DB) active control trial and an open-label extension (OLE) study was conducted to evaluate the long-term effects of lurasidone in patients with schizophrenia. Methods: In the DB trial, patients were randomised to receive lurasidone or risperidone for 12 months. In OLE, all patients received lurasidone for an additional 6 months. Treatment-emergent adverse events (TEAEs) were evaluated. Efficacy assessments included relapse rate (DB trial only), and Positive and Negative Syndrome Scale, Clinical Global Impression-Severity scale, and Montgomery-Åsberg Depression Rating Scale. Results: In the DB trial, patients with schizophrenia were randomised to lurasidone (n = 399) and risperidone (n = 190), of whom 129 and 84 continued into OLE, respectively. During the DB trial, incidence of TEAEs was similar for lurasidone (84.1%) and risperidone (84.2%). Lurasidone was associated with minimal changes in metabolic variables and prolactin levels, whereas risperidone was associated with clinically significant increases in prolactin and fasting glucose levels. The proportion of patients with metabolic syndrome was significantly lower in patients treated with lurasidone versus risperidone at the end of the DB trial (25.5% vs 40.4%; p = 0.0177). During OLE, patients switching from risperidone to lurasidone experienced a reduction in weight and prolactin levels; those continuing treatment with lurasidone experienced minimal changes in metabolic variables and prolactin. At the end of OLE, the proportion of patients with metabolic syndrome was no longer significantly different between groups (23.5% vs 31.5%; p = not significant). Efficacy outcomes were generally similar between groups during the DB trial, and were maintained during OLE. Conclusion: Lurasidone was generally well tolerated and effective in clinically stable schizophrenia patients over the long term. Lurasidone was also generally well tolerated and maintained effectiveness over 6 months in patients switching from risperidone. Patients switching from risperidone experienced improvements in metabolic parameters and prolactin levels. These findings confirm lurasidone's long-term effectiveness and favourable metabolic profile in patients with schizophrenia. Trial registration: ClinicalTrials.gov identifier NCT00641745.
Language	English
Publishing date	2020-10-24
Publishing country	New Zealand
Document type	Journal Article
ISSN	2193-8253
ISSN	2193-8253
DOI	10.1007/s40120-020-00221-4
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Article ; Online: The relationship between international trade and non-nutritional health outcomes: A systematic review of quantitative studies.

Burns, Darren K / Jones, Andrew P / Suhrcke, Marc

Social science & medicine (1982)

2016 Volume 152, Page(s) 9–17

Abstract: Markets throughout the world have been reducing barriers to international trade and investment in recent years. The resulting increases in levels of international trade and investment have subsequently generated research interest into the potential ... ...

Abstract	Markets throughout the world have been reducing barriers to international trade and investment in recent years. The resulting increases in levels of international trade and investment have subsequently generated research interest into the potential population health impact. We present a systematic review of quantitative studies investigating the relationship between international trade, foreign direct investment and non-nutritional health outcomes. Articles were systematically collected from the SCOPUS, PubMed, EconLit and Web of Science databases. Due to the heterogeneous nature of the evidence considered, the 16 included articles were subdivided into individual level data analyses, selected country analyses and international panel analyses. Articles were then quality assessed using a tool developed as part of the project. Nine of the studies were assessed to be high quality, six as medium quality, and one as low quality. The evidence from the quantitative literature suggests that overall, there appears to be a beneficial association between international trade and population health. There was also evidence of the importance of foreign direct investment, yet a lack of research considering the direction of causality. Taken together, quantitative research into the relationship between trade and non-nutritional health indicates trade to be beneficial, yet this body of research is still in its infancy. Future quantitative studies based on this foundation will provide a stronger basis on which to inform relevant national and international institutions about the health consequences of trade policies.
MeSH term(s)	Commerce/economics ; Global Health ; Humans ; Internationality ; Investments
Language	English
Publishing date	2016-01-19
Publishing country	England
Document type	Journal Article ; Review ; Systematic Review
ZDB-ID	4766-1
ISSN	1873-5347 ; 0037-7856 ; 0277-9536
ISSN (online)	1873-5347
ISSN	0037-7856 ; 0277-9536
DOI	10.1016/j.socscimed.2016.01.021
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Article ; Online: Is foreign direct investment good for health in low and middle income countries? An instrumental variable approach.

Burns, Darren K / Jones, Andrew P / Goryakin, Yevgeniy / Suhrcke, Marc

Social science & medicine (1982)

2017 Volume 181, Page(s) 74–82

Abstract: There is a scarcity of quantitative research into the effect of FDI on population health in low and middle income countries (LMICs). This paper investigates the relationship using annual panel data from 85 LMICs between 1974 and 2012. When controlling ... ...

Abstract	There is a scarcity of quantitative research into the effect of FDI on population health in low and middle income countries (LMICs). This paper investigates the relationship using annual panel data from 85 LMICs between 1974 and 2012. When controlling for time trends, country fixed effects, correlation between repeated observations, relevant covariates, and endogeneity via a novel instrumental variable approach, we find FDI to have a beneficial effect on overall health, proxied by life expectancy. When investigating age-specific mortality rates, we find a stronger beneficial effect of FDI on adult mortality, yet no association with either infant or child mortality. Notably, FDI effects on health remain undetected in all models which do not control for endogeneity. Exploring the effect of sector-specific FDI on health in LMICs, we provide preliminary evidence of a weak inverse association between secondary (i.e. manufacturing) sector FDI and overall life expectancy. Our results thus suggest that FDI has provided an overall benefit to population health in LMICs, particularly in adults, yet investments into the secondary sector could be harmful to health.
Language	English
Publishing date	2017
Publishing country	England
Document type	Journal Article
ZDB-ID	4766-1
ISSN	1873-5347 ; 0037-7856 ; 0277-9536
ISSN (online)	1873-5347
ISSN	0037-7856 ; 0277-9536
DOI	10.1016/j.socscimed.2017.03.054
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Book ; Conference proceedings: Special issue: extracting information from spatial datasets

Jones, Andrew P

[All of the papers in this special issue were presented at the 2004 GISRUK annual conference held at the University of East Anglia]

(Computers, environment and urban systems ; 31.2007,1)

2007

Event/congress	GISRUK annual conference (2004, Norwich)
Author's details	guest ed.: Andrew P. Jones
Series title	Computers, environment and urban systems ; 31.2007,1
Language	English
Size	106 S., Ill., graph. Darst., Kt.
Publisher	Elsevier
Publishing place	Amsterdam u.a.
Document type	Book ; Conference proceedings
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: A framework for understanding school based physical environmental influences on childhood obesity.

Harrison, Flo / Jones, Andrew P

Health & place

2011 Volume 18, Issue 3, Page(s) 639–648

Abstract: Schools are inviting settings for the promotion of healthy behaviours in children, and a number of interventions have been trialled to improve diet or increase physical activity levels with the ultimate aim of reducing the prevalence of obesity. However, ...

Abstract	Schools are inviting settings for the promotion of healthy behaviours in children, and a number of interventions have been trialled to improve diet or increase physical activity levels with the ultimate aim of reducing the prevalence of obesity. However, these have seen mixed results and there is suggestion that consideration needs to be given to a broader definition of the school environment in order to encourage sustainable behaviour changes. This review considers evidence for associations between the physical school environment and diet, physical activity and adiposity. School environment covers the neighbourhood around the school as well as the school grounds, buildings and facilities. Reviewed evidence is used to construct a conceptual framework for understanding associations between the physical school environment and adiposity and related behaviours. The framework highlights how school environments may be modified to promote behaviour changes, and how they may limit or enhance the success of other school-based interventions. Consideration is also given to where future work may best be directed.
MeSH term(s)	Adolescent ; Child ; Environment Design ; Female ; Humans ; Male ; Obesity/etiology ; Obesity/prevention & control ; Residence Characteristics ; Risk Reduction Behavior ; Schools ; Social Environment ; United Kingdom
Language	English
Publishing date	2011-12-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1262540-1
ISSN	1873-2054 ; 1353-8292
ISSN (online)	1873-2054
ISSN	1353-8292
DOI	10.1016/j.healthplace.2011.12.009
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