Article ; Online: Insulin-mediated endothelin signaling is antiviral during West Nile virus infection.
2023 Volume 97, Issue 10, Page(s) e0111223
Abstract: Importance: Arboviruses, particularly those transmitted by mosquitoes, pose a significant threat to humans and are an increasing concern because of climate change, human activity, and expanding vector-competent populations. West Nile virus is of ... ...
| Abstract | Importance: Arboviruses, particularly those transmitted by mosquitoes, pose a significant threat to humans and are an increasing concern because of climate change, human activity, and expanding vector-competent populations. West Nile virus is of significant concern as the most frequent mosquito-borne disease transmitted annually within the continental United States. Here, we identify a previously uncharacterized signaling pathway that impacts West Nile virus infection, namely endothelin signaling. Additionally, we demonstrate that we can successfully translate results obtained from |
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| MeSH term(s) | Animals ; Humans ; Drosophila melanogaster/immunology ; Drosophila melanogaster/metabolism ; Drosophila melanogaster/virology ; Insulin/metabolism ; Signal Transduction ; West Nile Fever/immunology ; West Nile Fever/metabolism ; West Nile Fever/virology ; West Nile virus/immunology ; West Nile virus/physiology ; Endothelins/immunology ; Endothelins/metabolism |
| Chemical Substances | Insulin ; Endothelins |
| Language | English |
| Publishing date | 2023-10-05 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural |
| ZDB-ID | 80174-4 |
| ISSN | 1098-5514 ; 0022-538X |
| ISSN (online) | 1098-5514 |
| ISSN | 0022-538X |
| DOI | 10.1128/jvi.01112-23 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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