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  1. AU="Jones, Corey"
  2. AU="Van Ry, Alex"
  3. AU="Winniecia Dkhar"
  4. AU="Echeverria Correa, Luis E"
  5. AU="Nash, Robert J."
  6. AU="Anastasia Xourafa"
  7. AU="Koch, Flávia"
  8. AU="Stroo, Esther"
  9. AU="Bauer, B."
  10. AU="Heidorn, Marc William"
  11. AU="Doan, Ryan N"
  12. AU=Kovo Michal
  13. AU="Gaglani, Shiv"
  14. AU="Prathap G"
  15. AU="Luana Bessa"

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  1. Artikel: Recent updates and future perspectives in aziridine synthesis and reactivity.

    Dequina, Hillary J / Jones, Corey L / Schomaker, Jennifer M

    Chem

    2023  Band 9, Heft 7, Seite(n) 1658–1701

    Abstract: In this review, selected recent advances in the preparation and reactivity of aziridines using modern synthetic approaches are highlighted, while comparing these new strategies with more classical approaches. This critical analysis is designed to help ... ...

    Abstract In this review, selected recent advances in the preparation and reactivity of aziridines using modern synthetic approaches are highlighted, while comparing these new strategies with more classical approaches. This critical analysis is designed to help identify current gaps in the field and is showcasing new and exciting opportunities to move the chemistry of aziridines forward in the future.
    Sprache Englisch
    Erscheinungsdatum 2023-05-11
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2869032-1
    ISSN 2451-9294 ; 2451-9294 ; 2451-9308
    ISSN (online) 2451-9294
    ISSN 2451-9294 ; 2451-9308
    DOI 10.1016/j.chempr.2023.04.010
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Design, Synthesis, and Biological Evaluation of Potent 20S Proteasome Activators for the Potential Treatment of α-Synucleinopathies.

    Staerz, Sophia D / Jones, Corey L / Tepe, Jetze J

    Journal of medicinal chemistry

    2022  Band 65, Heft 9, Seite(n) 6631–6642

    Abstract: While neurodegenerative diseases affect millions of patients worldwide, there are insufficient available therapeutics to halt or slow down the progression of these diseases. A key pathological feature of several neurodegenerative diseases is the ... ...

    Abstract While neurodegenerative diseases affect millions of patients worldwide, there are insufficient available therapeutics to halt or slow down the progression of these diseases. A key pathological feature of several neurodegenerative diseases is the oligomerization and aggregation of specific intrinsically disordered proteins (IDPs) creating neuronal deposits, such as Lewy bodies in Parkinson's disease. Clearance of these pathogenic, aggregation-prone IDPs is mediated by the 20S isoform of the human proteasome. Thus, enhancing the 20S proteasome-mediated proteolysis could be a very useful therapeutic pathway to prevent neurotoxicity. Here, we report the successful development of sub-microM 20S proteasome activators based on a phenothiazine scaffold. This class of compounds prevented the accumulation of pathologically relevant IDPs, such as the pathogenic A53T mutated α-synuclein,
    Mesh-Begriff(e) Animals ; Humans ; Intrinsically Disordered Proteins/metabolism ; Mammals/metabolism ; Neurodegenerative Diseases ; Parkinson Disease/drug therapy ; Parkinson Disease/metabolism ; Proteasome Endopeptidase Complex/metabolism ; Proteolysis ; Synucleinopathies ; alpha-Synuclein/metabolism
    Chemische Substanzen Intrinsically Disordered Proteins ; alpha-Synuclein ; Proteasome Endopeptidase Complex (EC 3.4.25.1)
    Sprache Englisch
    Erscheinungsdatum 2022-04-27
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.1c02158
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Proteasome Activation to Combat Proteotoxicity.

    Jones, Corey L / Tepe, Jetze J

    Molecules (Basel, Switzerland)

    2019  Band 24, Heft 15

    Abstract: Loss of proteome fidelity leads to the accumulation of non-native protein aggregates and oxidatively damaged species: hallmarks of an aged cell. These misfolded and aggregated species are often found, and suggested to be the culpable party, in numerous ... ...

    Abstract Loss of proteome fidelity leads to the accumulation of non-native protein aggregates and oxidatively damaged species: hallmarks of an aged cell. These misfolded and aggregated species are often found, and suggested to be the culpable party, in numerous neurodegenerative diseases including Huntington's, Parkinson's, Amyotrophic Lateral Sclerosis (ALS), and Alzheimer's Diseases (AD). Many strategies for therapeutic intervention in proteotoxic pathologies have been put forth; one of the most promising is bolstering the efficacy of the proteasome to restore normal proteostasis. This strategy is ideal as monomeric precursors and oxidatively damaged proteins, so called "intrinsically disordered proteins" (IDPs), are targeted by the proteasome. This review will provide an overview of disorders in proteins, both intrinsic and acquired, with a focus on susceptibility to proteasomal degradation. We will then examine the proteasome with emphasis on newly published structural data and summarize current known small molecule proteasome activators.
    Mesh-Begriff(e) Animals ; Humans ; Intrinsically Disordered Proteins/chemistry ; Intrinsically Disordered Proteins/genetics ; Intrinsically Disordered Proteins/metabolism ; Oxidation-Reduction ; Oxidative Stress ; Proteasome Endopeptidase Complex/metabolism ; Protein Aggregates ; Protein Aggregation, Pathological ; Proteostasis ; Structure-Activity Relationship
    Chemische Substanzen Intrinsically Disordered Proteins ; Protein Aggregates ; Proteasome Endopeptidase Complex (EC 3.4.25.1)
    Sprache Englisch
    Erscheinungsdatum 2019-08-05
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules24152841
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Periprosthetic Joint Infection Risk After Primary Total Knee Arthroplasty: Are All Preoperative Corticosteroid Injections the Same?

    Muffly, Brian T / Ayeni, Ayomide M / Jones, Corey A / Heo, Kevin Y / Guild, George N / Premkumar, Ajay

    The Journal of arthroplasty

    2023  Band 39, Heft 5, Seite(n) 1312–1316.e7

    Abstract: Background: Previous evidence has demonstrated an increased risk of periprosthetic joint infection (PJI) following primary total knee arthroplasty (TKA) in patients receiving corticosteroid injection (CSI) within 3 months of surgery. The study aimed to ... ...

    Abstract Background: Previous evidence has demonstrated an increased risk of periprosthetic joint infection (PJI) following primary total knee arthroplasty (TKA) in patients receiving corticosteroid injection (CSI) within 3 months of surgery. The study aimed to determine if PJI risk after TKA varied among different corticosteroid agents.
    Methods: A total of 85,073 patients undergoing primary TKA from 2009 to 2019 were identified from a large national database. Of these, 1,092 (1.3%) received an ipsilateral, intra-articular CSI within 90 days of TKA. These patients were compared to those not receiving CSI using multivariate logistic regressions following 1:4 propensity score matching, with PJI development as the primary outcome.
    Results: Patients given an injection of any corticosteroid within 90 days of TKA had significantly higher PJI rates compared to controls (1.6 versus 0.41%; P < .001). This finding was driven by patients receiving methylprednisolone acetate (n = 543) or betamethasone (n = 153), with prevalence rates of 1.7 and 2.6%, respectively (P = .003 and P = .01, respectively). No significant increase in the rate of PJI was observed for patients receiving triamcinolone (1.2%; P = .08; n = 342) or dexamethasone (0.0%; P = 1; n = 54) within 90 days preceding TKA. PJI risk for all agents, administered more than 90 days preoperatively normalized to control levels (0.51 versus 0.34%).
    Conclusions: These results suggest that PJI risk varies with CSI type. In this large database study, only patients given methylprednisolone acetate or betamethasone injections within 90 days of surgery had significantly higher PJI rates compared to controls.
    Mesh-Begriff(e) Humans ; Arthroplasty, Replacement, Knee/adverse effects ; Prosthesis-Related Infections/epidemiology ; Prosthesis-Related Infections/etiology ; Prosthesis-Related Infections/surgery ; Methylprednisolone Acetate ; Arthritis, Infectious/etiology ; Adrenal Cortex Hormones/adverse effects ; Betamethasone ; Retrospective Studies
    Chemische Substanzen Methylprednisolone Acetate (43502P7F0P) ; Adrenal Cortex Hormones ; Betamethasone (9842X06Q6M)
    Sprache Englisch
    Erscheinungsdatum 2023-11-02
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 632770-9
    ISSN 1532-8406 ; 0883-5403
    ISSN (online) 1532-8406
    ISSN 0883-5403
    DOI 10.1016/j.arth.2023.10.053
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Incidence and Risk Factors of Heterotopic Ossification in the Knee After Reamed Tibial Nailing.

    Jones, Corey A / Seilern Und Aspang, Jesse / Holmes, Jeffrey S / Zamanzadeh, Ryan S / Phen, Huai M / Baker, J 'Lynn L / Hernandez-Irizarry, Roberto C / Moore, Thomas J

    Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews

    2024  Band 8, Heft 2

    Abstract: Introduction: Heterotopic ossification (HO) in the knee after tibial intramedullary nailing (IMN) has yet to be thoroughly investigated. Our aim was to assess frequency and associated factors for HO in the knee after tibial IMN.: Methods: This is a ... ...

    Abstract Introduction: Heterotopic ossification (HO) in the knee after tibial intramedullary nailing (IMN) has yet to be thoroughly investigated. Our aim was to assess frequency and associated factors for HO in the knee after tibial IMN.
    Methods: This is a retrospective review at a single level 1 urban trauma center of 213 patients who underwent reamed tibial IMN. Plain radiographs were reviewed postoperatively and on final follow-up (≥6 weeks). Chart review was performed for surgical approach (suprapatellar versus infrapatellar), demographics, injury characteristics, and clinical follow-up. The primary outcome was frequency of HO.
    Results: HO on final follow-up (mean: 41.43 weeks) was recorded in 15% cases. Postsurgical retroinfrapatellar reaming debris (odds ratio [OR], 4.73), Injury Severity Score (OR, 1.05), intensive care unit admission (OR, 2.89), chest injury (OR, 3.4), and ipsilateral retrograde femoral IMN (OR, 5.08) showed a notable association with HO development. No association was observed in HO formation between surgical approach, knee pain, or range-of-motion deficits.
    Discussion: Radiographic evidence of HO in the knee after reamed tibial IMN is not uncommon and is associated with retained reaming debris, Injury Severity Score, chest injury, intensive care unit admission, and ipsilateral retrograde femoral nailing. No differences were noted in HO formation between approaches. HO was not associated with knee pain or range-of-motion deficits.
    Mesh-Begriff(e) Humans ; Fracture Fixation, Intramedullary/adverse effects ; Incidence ; Tibial Fractures/surgery ; Tibial Fractures/etiology ; Risk Factors ; Pain/etiology ; Ossification, Heterotopic/diagnostic imaging ; Ossification, Heterotopic/epidemiology ; Ossification, Heterotopic/etiology ; Thoracic Injuries/etiology
    Sprache Englisch
    Erscheinungsdatum 2024-02-05
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2898328-2
    ISSN 2474-7661 ; 1067-151X
    ISSN (online) 2474-7661
    ISSN 1067-151X
    DOI e23.00258
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Quantification of Kuramoto Coupling Between Intrinsic Brain Networks Applied to fMRI Data in Major Depressive Disorder.

    Bauer, Lena G / Hirsch, Fabian / Jones, Corey / Hollander, Matthew / Grohs, Philipp / Anand, Amit / Plant, Claudia / Wohlschläger, Afra

    Frontiers in computational neuroscience

    2022  Band 16, Seite(n) 729556

    Abstract: Organized patterns of system-wide neural activity adapt fluently within the brain to adjust behavioral performance to environmental demands. In major depressive disorder (MD), markedly different co-activation patterns across the brain emerge from a ... ...

    Abstract Organized patterns of system-wide neural activity adapt fluently within the brain to adjust behavioral performance to environmental demands. In major depressive disorder (MD), markedly different co-activation patterns across the brain emerge from a rather similar structural substrate. Despite the application of advanced methods to describe the functional architecture, e.g., between intrinsic brain networks (IBNs), the underlying mechanisms mediating these differences remain elusive. Here we propose a novel complementary approach for quantifying the functional relations between IBNs based on the Kuramoto model. We directly estimate the Kuramoto coupling parameters (
    Sprache Englisch
    Erscheinungsdatum 2022-03-03
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2452964-3
    ISSN 1662-5188
    ISSN 1662-5188
    DOI 10.3389/fncom.2022.729556
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Acylated and alkylated benzo(crown-ethers) form ion-dependent ion channels in biological membranes.

    Carrasquel-Ursulaez, Willy / Dehghany, Mahzad / Jones, Corey L / Idikuda, Vinaykumar / Lu, Brian / Schomaker, Jennifer M / Chanda, Baron

    Biophysical journal

    2022  Band 121, Heft 6, Seite(n) 1105–1114

    Abstract: Synthetic ion channels based on benzo(crown-ether) compounds have been previously reported to function as ion-selective channels in planar lipid bilayers, with hydrogen bonding networks implicated in the formation of self-aggregated complexes. Herein, we ...

    Abstract Synthetic ion channels based on benzo(crown-ether) compounds have been previously reported to function as ion-selective channels in planar lipid bilayers, with hydrogen bonding networks implicated in the formation of self-aggregated complexes. Herein, we report the synthesis and characterization of two new families of benzo(crown-ether) compounds, termed monoacylated and monoalkylated benzo(crown-ethers) (MABCE), both of which lack hydrogen bond donors. Depending on the length of alkyl chain substituent and the size of macrocycle, MABCE compounds inhibit bacterial growth and transport ions across biological membranes. Single-channel recordings show that the activity is higher in the presence of K
    Mesh-Begriff(e) Cations ; Crown Ethers/chemistry ; Hydrogen Bonding ; Ion Channels/chemistry ; Lipid Bilayers/chemistry
    Chemische Substanzen Cations ; Crown Ethers ; Ion Channels ; Lipid Bilayers
    Sprache Englisch
    Erscheinungsdatum 2022-02-02
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 218078-9
    ISSN 1542-0086 ; 0006-3495
    ISSN (online) 1542-0086
    ISSN 0006-3495
    DOI 10.1016/j.bpj.2022.01.026
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Transport losses in market weight pigs: II. U.S. incidence and economic impact.

    Ritter, Matthew J / Yoder, Chad L / Jones, Corey L / Carr, Scott N / Calvo-Lorenzo, Michelle S

    Translational animal science

    2020  Band 4, Heft 2, Seite(n) txaa041

    Abstract: An industry survey representing approximately 310 million (M) market weight pigs was conducted with 20 U.S. slaughter facilities over the calendars years of 2012 to 2015 to determine the incidence, seasonal patterns, and estimated economic impact of dead ...

    Abstract An industry survey representing approximately 310 million (M) market weight pigs was conducted with 20 U.S. slaughter facilities over the calendars years of 2012 to 2015 to determine the incidence, seasonal patterns, and estimated economic impact of dead and non-ambulatory pigs. Each plant entered daily totals in a secure online database for the following variables: 1) pigs slaughtered, 2) dead on arrival (DOA; dead on the truck), 3) euthanized on arrival (EOA; non-ambulatory pig with an injury that required euthanasia), 4) dead in pen (DIP; died after unloading), and 5) non-ambulatory (pig unable to move or keep up with the rest of the group from unloading to stunning). Total dead pigs were calculated as DOA + EOA + DIP, and total losses were calculated as non-ambulatory + total dead. The economic impact was estimated based on the 4-yr weighted averages from USDA annual reports for market swine slaughtered (108,470,550 pigs), live market weight (126.9 kg), and live market price ($1.44/kg). The 4-yr weighted averages for total dead, non-ambulatory, and total losses were 0.26%, 0.63%, and 0.88%, respectively. Total dead consisted of 0.15% DOA, 0.05% EOA, and 0.05% DIP. The months with the highest rates of total dead were July (0.29%), August (0.32%), and September (0.30%), while the lowest incidence rates occurred in February (0.22%), March (0.22%), and April (0.22%). The months with the highest rates of non-ambulatory pigs were observed during the months of October (0.70%), November (0.71%), and December (0.70%), whereas the lowest rates of non-ambulatory pigs were observed during the months of April (0.57%), May (0.53%), and June (0.54%). The following assumptions were used in the economic analysis: 1) dead pigs received no value and 2) non-ambulatory pigs were discounted 30%. Based on these assumptions, the annual cost to the industry for dead and non-ambulatory pigs was estimated to be $52 M ($0.48 per pig marketed) and $37 M ($0.35 per pig marketed), respectively. Therefore, total losses represent approximately $89 M in economic losses or $0.83 per pig marketed. This is the first industry-wide survey on the incidence of transport losses in market weight pigs at U.S. slaughter facilities, and this information is important for establishing an industry baseline and benchmark for transport losses that can be used for measuring industry improvements.
    Sprache Englisch
    Erscheinungsdatum 2020-04-02
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 2573-2102
    ISSN (online) 2573-2102
    DOI 10.1093/tas/txaa041
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Re-evaluation of the mechanism of cytotoxicity of dialkylated lariat ether compounds.

    Carrasquel-Ursulaez, Willy / Reeves, Ryan D / Dehghany, Mahzad / Jones, Corey / Schomaker, Jennifer M / Chanda, Baron

    RSC advances

    2020  Band 10, Heft 66, Seite(n) 40391–40394

    Abstract: The cytotoxicity of dialkylated lariat ethers has been previously attributed to their ionophoric properties. Herein, we provide evidence that these effects are due to loss of membrane integrity rather than ion transport, a finding with important ... ...

    Abstract The cytotoxicity of dialkylated lariat ethers has been previously attributed to their ionophoric properties. Herein, we provide evidence that these effects are due to loss of membrane integrity rather than ion transport, a finding with important implications for the future design of synthetic ionophores.
    Sprache Englisch
    Erscheinungsdatum 2020-11-05
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d0ra08494h
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Yarning about pain: Evaluating communication training for health professionals at persistent pain services in Queensland, Australia.

    Bernardes, Christina M / Ekberg, Stuart / Birch, Stephen / Claus, Andrew / Bryant, Matthew / Meuter, Renata / Isua, Jermaine / Gray, Paul / Kluver, Joseph P / Malacova, Eva / Jones, Corey / Houkamau, Kushla / Taylor, Marayah / Lin, Ivan / Pratt, Gregory

    British journal of pain

    2023  Band 17, Heft 3, Seite(n) 306–319

    Abstract: Background: Providing cultural education to health professionals is essential in improving the quality of care and outcomes for Aboriginal and Torres Strait Islander patients. This study reports the evaluation of a novel training workshop used as an ... ...

    Abstract Background: Providing cultural education to health professionals is essential in improving the quality of care and outcomes for Aboriginal and Torres Strait Islander patients. This study reports the evaluation of a novel training workshop used as an intervention to improve communication with Aboriginal and Torres Strait Islander patients of persistent pain services.
    Methods: In this single-arm intervention study, health professionals undertook a one-day workshop, which included cultural capability and communication skills training based on a clinical yarning framework. The workshop was delivered across three adult persistent pain clinics in Queensland. At the end of the training, participants completed a retrospective pre/post evaluation questionnaire (5 points Likert scale
    Results: Fifty-seven health professionals were trained (
    Conclusion: This patient-centred communication training, delivered through a novel model that combines cultural capability and the clinical yarning framework applied to the pain management setting, was highly acceptable and significantly improved participants' perceived competence. This method is transferrable to other health system sectors seeking to train their clinical workforce with culturally sensitive communication skills.
    Sprache Englisch
    Erscheinungsdatum 2023-01-30
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2670872-3
    ISSN 2049-4645 ; 2049-4637
    ISSN (online) 2049-4645
    ISSN 2049-4637
    DOI 10.1177/20494637221149831
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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