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  1. Article: Non-Invasive Analysis of Human Liver Metabolism by Magnetic Resonance Spectroscopy.

    Jones, John G

    Metabolites

    2021  Volume 11, Issue 11

    Abstract: The liver is a key node of whole-body nutrient and fuel metabolism and is also the principal site for detoxification of xenobiotic compounds. As such, hepatic metabolite concentrations and/or turnover rates inform on the status of both hepatic and ... ...

    Abstract The liver is a key node of whole-body nutrient and fuel metabolism and is also the principal site for detoxification of xenobiotic compounds. As such, hepatic metabolite concentrations and/or turnover rates inform on the status of both hepatic and systemic metabolic diseases as well as the disposition of medications. As a tool to better understand liver metabolism in these settings, in vivo magnetic resonance spectroscopy (MRS) offers a non-invasive means of monitoring hepatic metabolic activity in real time both by direct observation of concentrations and dynamics of specific metabolites as well as by observation of their enrichment by stable isotope tracers. This review summarizes the applications and advances in human liver metabolic studies by in vivo MRS over the past 35 years and discusses future directions and opportunities that will be opened by the development of ultra-high field MR systems and by hyperpolarized stable isotope tracers.
    Language English
    Publishing date 2021-10-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo11110751
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: De novo lipogenesis in non-alcoholic fatty liver disease: Quantification with stable isotope tracers.

    Belew, Getachew Debas / Jones, John G

    European journal of clinical investigation

    2022  Volume 52, Issue 3, Page(s) e13733

    Abstract: Background: Non-alcoholic fatty liver disease (NAFLD) is characterized as an abnormal accumulation of triglyceride in hepatocytes. Hepatic de novo lipogenesis may play an important role in the accumulation of lipids in the liver during NAFLD. Due to the ...

    Abstract Background: Non-alcoholic fatty liver disease (NAFLD) is characterized as an abnormal accumulation of triglyceride in hepatocytes. Hepatic de novo lipogenesis may play an important role in the accumulation of lipids in the liver during NAFLD. Due to the importance of lipid biosynthetic fluxes in NAFLD and T2D, tracer methodologies have been developed for their study and quantification. Here, we address novel approaches to measure and quantify DNL using stable isotope tracers. Deuterated water is a widely used tracer for quantifying DNL rates in both animal models and humans. Enrichment of lipid hydrogens from
    Conclusions: Despite the clear association between elevated DNL activity and increased hepatic triglyceride levels, implementation of non-destructive and novel methods to quantify DNL and its contribution to NAFLD are also of huge interest.
    MeSH term(s) Animals ; Humans ; Lipogenesis ; Non-alcoholic Fatty Liver Disease/diagnostic imaging ; Non-alcoholic Fatty Liver Disease/metabolism ; Radioactive Tracers ; Radioisotopes
    Chemical Substances Radioactive Tracers ; Radioisotopes
    Language English
    Publishing date 2022-01-04
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 186196-7
    ISSN 1365-2362 ; 0014-2972 ; 0960-135X
    ISSN (online) 1365-2362
    ISSN 0014-2972 ; 0960-135X
    DOI 10.1111/eci.13733
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 677: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Article ; Online: Hepatic glucose and lipid metabolism.

    Jones, John G

    Diabetologia

    2016  Volume 59, Issue 6, Page(s) 1098–1103

    Abstract: The liver has a central role in the regulation of systemic glucose and lipid fluxes during feeding and fasting and also relies on these substrates for its own energy needs. These parallel requirements are met by coordinated control of carbohydrate and ... ...

    Abstract The liver has a central role in the regulation of systemic glucose and lipid fluxes during feeding and fasting and also relies on these substrates for its own energy needs. These parallel requirements are met by coordinated control of carbohydrate and lipid fluxes into and out of the Krebs cycle, which is highly tuned to nutrient availability and heavily regulated by insulin and glucagon. During progression of type 2 diabetes, hepatic carbohydrate and lipid biosynthesis fluxes become elevated, thus contributing to hyperglycaemia and hypertriacylglycerolaemia. Over this interval there are also significant fluctuations in hepatic energy state. To date, it is not known to what extent abnormal glucose and lipid fluxes are causally linked to altered energy states. Recent evidence that the glucose-lowering effects of metformin appear to be mediated by attenuation of hepatic energy generation places an additional spotlight on the interdependence of hepatic biosynthetic and oxidative fluxes. The transition from fasting to feeding results in a significant re-direction of hepatic glucose and lipid fluxes and may also incur a temporary hepatic energy deficit. At present, it is not known to what extent these variables are additionally modified by type 2 diabetes and/or non-alcoholic fatty liver disease. Thus, there is a compelling need to measure fluxes through oxidative, gluconeogenic and lipogenic pathways and determine their relationship with hepatic energy state in both fasting and fed conditions. New magnetic resonance-based technologies allow these variables to be non-invasively studied in animal models and humans. This review summarises a presentation given at the symposium entitled 'The liver in focus' at the 2015 annual meeting of the EASD. It is accompanied by two other reviews on topics from this symposium (by Kenneth Cusi, DOI: 10.1007/s00125-016-3952-1 , and by Hannele Yki-Järvinen, DOI: 10.1007/s00125-016-3944-1 ) and a commentary by the Session Chair, Michael Roden (DOI: 10.1007/s00125-016-3911-x ).
    MeSH term(s) Citric Acid Cycle/physiology ; Glucose/metabolism ; Humans ; Lipid Metabolism/physiology ; Liver/metabolism ; Magnetic Resonance Spectroscopy
    Chemical Substances Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2016-06
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1694-9
    ISSN 1432-0428 ; 0012-186X
    ISSN (online) 1432-0428
    ISSN 0012-186X
    DOI 10.1007/s00125-016-3940-5
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 279: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Article ; Online: The Gut Microbiome Responds Progressively to Fat and/or Sugar-Rich Diets and Is Differentially Modified by Dietary Fat and Sugar.

    Pessoa, João / Belew, Getachew D / Barroso, Cristina / Egas, Conceição / Jones, John G

    Nutrients

    2023  Volume 15, Issue 9

    Abstract: Describing diet-related effects on the gut microbiome is essential for understanding its interactions with fat and/or sugar-rich diets to promote obesity-related metabolic diseases. Here, we sequenced the V3-V4 hypervariable region of the bacterial 16S ... ...

    Abstract Describing diet-related effects on the gut microbiome is essential for understanding its interactions with fat and/or sugar-rich diets to promote obesity-related metabolic diseases. Here, we sequenced the V3-V4 hypervariable region of the bacterial 16S rRNA gene to study the composition and dynamics of the gut microbiome of adult mice fed diets rich in fat and/or sugar, at 9 and 18 weeks of diet. Under high-fat, high-sugar diet, the abundances of
    MeSH term(s) Animals ; Mice ; Sugars ; Dietary Fats ; Gastrointestinal Microbiome ; RNA, Ribosomal, 16S/genetics ; Diet, High-Fat/adverse effects ; Clostridiales ; Clostridiaceae ; Lactobacillales
    Chemical Substances Sugars ; Dietary Fats ; RNA, Ribosomal, 16S
    Language English
    Publishing date 2023-04-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15092097
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Peptidomics Unveils Distinct Acetylation Patterns of Histone and Annexin A1 in Differentiated Thyroid Cancer.

    Coelho, Margarida / Capela, João / Mendes, Vera M / Pacheco, João / Fernandes, Margarida Sá / Amendoeira, Isabel / Jones, John G / Raposo, Luís / Manadas, Bruno

    International journal of molecular sciences

    2023  Volume 25, Issue 1

    Abstract: Thyroid cancer is a common malignancy of the endocrine system. Nodules are routinely evaluated for malignancy risk by fine needle aspiration biopsy (FNAB), and in cases such as follicular lesions, differential diagnosis between benign and malignant ... ...

    Abstract Thyroid cancer is a common malignancy of the endocrine system. Nodules are routinely evaluated for malignancy risk by fine needle aspiration biopsy (FNAB), and in cases such as follicular lesions, differential diagnosis between benign and malignant nodules is highly uncertain. Therefore, the discovery of new biomarkers for this disease could be helpful in improving diagnostic accuracy. Thyroid nodule biopsies were subjected to a precipitation step with both the insoluble and supernatant fractions subjected to proteome and peptidome profiling. Proteomic analysis identified annexin A1 as a potential biomarker of thyroid cancer malignancy, with its levels increased in malignant samples. Also upregulated were the acetylated peptides of annexin A1, revealed by the peptidome analysis of the supernatant fraction. In addition, supernatant peptidomic analysis revealed a number of acetylated histone peptides that were significantly elevated in the malignant group, suggesting higher gene transcription activity in malignant tissue. Two of these peptides were found to be robust malignancy predictors, with an area under the receiver operating a characteristic curve (ROC AUC) above 0.95. Thus, this combination of proteomics and peptidomics analyses improved the detection of malignant lesions and also provided new evidence linking thyroid cancer development to heightened transcription activity. This study demonstrates the importance of peptidomic profiling in complementing traditional proteomics approaches.
    MeSH term(s) Humans ; Annexin A1 ; Histones ; Acetylation ; Proteomics ; Thyroid Neoplasms ; Adenocarcinoma ; Biopsy, Fine-Needle ; Psychomotor Agitation ; Peptides
    Chemical Substances Annexin A1 ; Histones ; Peptides
    Language English
    Publishing date 2023-12-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25010376
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  6. Article ; Online: Proteomics Reveals mRNA Regulation and the Action of Annexins in Thyroid Cancer.

    Coelho, Margarida / Capela, João / Anjo, Sandra I / Pacheco, João / Fernandes, Margarida Sá / Amendoeira, Isabel / Jones, John G / Raposo, Luís / Manadas, Bruno

    International journal of molecular sciences

    2023  Volume 24, Issue 19

    Abstract: Differentiated thyroid cancer is the most common malignancy of the endocrine system. Although most thyroid nodules are benign, given the high incidence of thyroid nodules in the population, it is important to understand the differences between benign and ...

    Abstract Differentiated thyroid cancer is the most common malignancy of the endocrine system. Although most thyroid nodules are benign, given the high incidence of thyroid nodules in the population, it is important to understand the differences between benign and malignant thyroid cancer and the molecular alterations associated with malignancy to improve detection and signal potential diagnostic, prognostic, and therapeutic targets. Proteomics analysis of benign and malignant human thyroid tissue largely revealed changes indicating modifications in RNA regulation, a common cancer characteristic. In addition, changes in the immune system and cell membrane/endocytic processes were also suggested to be involved. Annexin A1 was considered a potential malignancy biomarker and, similarly to other annexins, it was found to increase in the malignant group. Furthermore, a bioinformatics approach points to the transcription factor Sp1 as being potentially involved in most of the alterations seen in the malignant thyroid nodules.
    MeSH term(s) Humans ; Thyroid Nodule/diagnosis ; Annexins/genetics ; RNA, Messenger/genetics ; Proteomics ; Thyroid Neoplasms/pathology
    Chemical Substances Annexins ; RNA, Messenger
    Language English
    Publishing date 2023-09-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241914542
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  7. Article ; Online: Metabolic incorporation of H

    Coelho, Margarida / Barosa, Cristina / Tavares, Ludgero / Jones, John G

    NMR in biomedicine

    2020  Volume 33, Issue 11, Page(s) e4395

    Abstract: Water enriched with oxygen-18 ( ... ...

    Abstract Water enriched with oxygen-18 (H
    MeSH term(s) Carbon-13 Magnetic Resonance Spectroscopy ; Erythrocytes/metabolism ; Glucose/metabolism ; Glucose-6-Phosphate/metabolism ; Humans ; Oxygen/metabolism ; Oxygen Isotopes/metabolism ; Water/metabolism
    Chemical Substances Oxygen Isotopes ; Oxygen-18 ; Water (059QF0KO0R) ; Glucose-6-Phosphate (56-73-5) ; Glucose (IY9XDZ35W2) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2020-08-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1000976-0
    ISSN 1099-1492 ; 0952-3480
    ISSN (online) 1099-1492
    ISSN 0952-3480
    DOI 10.1002/nbm.4395
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2869: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Book: Agriculture and the environment

    Jones, John G. W.

    (Ellis Horwood series in environmental management, science and technology)

    1993  

    Author's details ed.: John Gareth Jones
    Series title Ellis Horwood series in environmental management, science and technology
    Keywords Landwirtschaft ; Umweltschutz ; Agrochemikalie ; Wasserverschmutzung ; Großbritannien ; Dränung ; Kosten-Nutzen-Analyse ; Europäische Gemeinschaften ; Flächenstilllegung ; Extensivierung ; Naturschutz
    Subject Ökologie ; Umweltvorsorge ; Drainage ; Bodenentwässerung ; Boden ; Bodenentwässrung ; Flächenstillegung ; Stilllegungsfläche ; Cost-benefit-Analyse ; Cost-benefit analysis ; Nutzen-Kosten-Analyse ; Kostennutzenanalyse ; Nutzenkostenanalyse ; Wasser ; Gewässerbelastung ; Wasserverunreinigung ; Gewässerverschmutzung ; Gewässerverunreinigung ; Gewässer ; Wasserbelastung ; Agrarchemikalie ; Agrarwirtschaft ; Agrarsektor ; Landwirtschaftlicher Sektor
    Size VI, 200 S. : Ill., graph. Darst., Kt.
    Publisher Horwood
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT004547485
    ISBN 0-13-065863-4 ; 978-0-13-065863-0
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    938/1590 available for loan (reading room) Freihandmagazin (U1)

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  9. Article: Effects of Meal Fructose/Glucose Composition on Postprandial Glucose Appearance and Hepatic Glycogen Synthesis in Healthy Subjects.

    Barosa, Cristina / Ribeiro, Rogério T / Andrade, Rita / Raposo, João F / Jones, John G

    Journal of clinical medicine

    2021  Volume 10, Issue 4

    Abstract: Dietary fructose overshadows glucose in promoting metabolic complications. Intestinal fructose metabolism (IFM) protects against these effects in rodents, by favoring gluconeogenesis, but the extent of IFM in humans is not known. We therefore aimed to ... ...

    Abstract Dietary fructose overshadows glucose in promoting metabolic complications. Intestinal fructose metabolism (IFM) protects against these effects in rodents, by favoring gluconeogenesis, but the extent of IFM in humans is not known. We therefore aimed to infer the extent of IFM by comparing the contribution of dietary fructose to systemic glucose and hepatic glycogen appearance postprandially. Twelve fasting healthy subjects ingested two protein meals in random order, one supplemented with 50 g 5/95 fructose/glucose (LF) and the other with 50 g 55/45 fructose/glucose (HF). Sources of postprandial plasma glucose appearance and hepatic glycogen synthesis were determined with deuterated water. Plasma glucose excursions, as well as pre- and post-meal insulin, c-peptide, and triglyceride levels were nearly identical for both meals. The total gluconeogenic contribution to plasma glucose appearance was significantly higher for HF versus LF (65 ± 2% vs. 34 ± 3%,
    Language English
    Publishing date 2021-02-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm10040596
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  10. Article ; Online: Positional and compositional analysis of saturated, monounsaturated, and polyunsaturated fatty acids in human adipose tissue triglyceride by

    Torres, Alejandra N / Tavares, Ludgero / Pereira, Maria J / Eriksson, Jan W / Jones, John G

    NMR in biomedicine

    2021  Volume 36, Issue 4, Page(s) e4632

    Abstract: The synthesis and turnover of triglyceride in adipose tissue involves enzymes with preferences for specific fatty acid classes and/or regioselectivity regarding the fatty acid position within the glycerol moiety. The focus of the current study was to ... ...

    Abstract The synthesis and turnover of triglyceride in adipose tissue involves enzymes with preferences for specific fatty acid classes and/or regioselectivity regarding the fatty acid position within the glycerol moiety. The focus of the current study was to characterize both the composition of fatty acids and their positional distribution in triglycerides of biopsied human subcutaneous adipose tissue, from subjects with wide ranges of body mass index (BMI) and insulin sensitivity, using
    MeSH term(s) Humans ; Adipose Tissue/chemistry ; Fatty Acids/analysis ; Fatty Acids, Unsaturated ; Glycerol/analysis ; Insulin Resistance ; Magnetic Resonance Spectroscopy ; Triglycerides/analysis ; Carbon Isotopes
    Chemical Substances Fatty Acids ; Fatty Acids, Unsaturated ; Glycerol (PDC6A3C0OX) ; Triglycerides ; Carbon Isotopes
    Language English
    Publishing date 2021-10-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1000976-0
    ISSN 1099-1492 ; 0952-3480
    ISSN (online) 1099-1492
    ISSN 0952-3480
    DOI 10.1002/nbm.4632
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