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  1. Book: Bio-glasses

    Jones, Julian R.

    an introduction

    2012  

    Author's details ed. by Julian R. Jones
    Keywords Glass ; Biocompatible Materials ; Tissue Scaffolds ; Regeneration ; Drug Delivery Systems ; Glas ; Glaszustand ; Sol-Gel-Verfahren ; Tissue Engineering ; Zahnmedizin ; Chirurgie ; Strahlentherapie
    Subject Bestrahlung ; Radiotherapie ; Strahlenbehandlung ; Radioonkologie ; Surgery ; Odontologie ; Zahn-, Mund- und Kieferheilkunde ; Zahn-Mund-Kieferheilkunde ; Zahnheilkunde ; Restitution ; Tissue-Engineering ; Gewebezucht ; Sol-Gel-Prozess ; Sol-Gel-Übergang ; Sol-Gel-Prozeß ; Glasartiger Zustand ; Anorganisches Glas ; Glaskunst ; Silicatglas ; Silikatglas ; Glasgefäß
    Language English
    Size XVIII, 235 S. : Ill., graph. Darst.
    Publisher Wiley
    Publishing place Chichester u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT017317980
    ISBN 978-0-470-71161-3 ; 0-470-71161-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2012 A 3011 order for loan Magazin

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  2. Book: New materials and technologies for healthcare

    Hench, Larry L. / Jones, Julian R. / Fenn, Michael B.

    2012  

    Author's details ed. Larry Hench ; Julian R. Jones ; Michael B. Fenn
    Language English
    Size VIII, 511 S. : Ill., graph. Darst.
    Publisher Imperial College Press
    Publishing place London
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT016304082
    ISBN 978-1-84816-558-8 ; 1-84816-558-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2012 A 484 order for loan Magazin

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  3. Article ; Online: The effect of serum proteins on apatite growth for 45S5 Bioglass and common sol-gel derived glass in SBF

    Lin Sen / Jones Julian R.

    Biomedical Glasses, Vol 4, Iss 1, Pp 13-

    2018  Volume 20

    Abstract: The inhibitive effects of serum proteins on apatite growth was compared between melt-derived 45S5 Bioglass® and sol-gel derived bioactive glass of the 70S30C (70 mol% SiO2, 30 mol% CaO). By using techniques of XRD, TEM and Raman spectroscopy, the ... ...

    Abstract The inhibitive effects of serum proteins on apatite growth was compared between melt-derived 45S5 Bioglass® and sol-gel derived bioactive glass of the 70S30C (70 mol% SiO2, 30 mol% CaO). By using techniques of XRD, TEM and Raman spectroscopy, the transformation of amorphous calcium phosphate to crystalline apatite, and the resulting size and aspect ratio of the crystals, in simulated body fluid (SBF), was seen to decrease in the presence of serum. XRD showed more rapid HA formation on Bioglass particles, compared to that forming on 70S30C particles, however TEM showed similar size and frequency of the needle-like crystals. Phosphate reduction in SBF was similar for Bioglass and 70S30C. Calcium carbonate formation was more likely on the phosphate-free sol-gel glass than on Bioglass.
    Keywords Clay industries. Ceramics. Glass ; TP785-869 ; Medicine ; R
    Language English
    Publishing date 2018-02-01T00:00:00Z
    Publisher Sciendo
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  4. Article ; Online: Reprint of: Review of bioactive glass: From Hench to hybrids.

    Jones, Julian R

    Acta biomaterialia

    2015  Volume 23 Suppl, Page(s) S53–82

    Abstract: Bioactive glasses are reported to be able to stimulate more bone regeneration than other bioactive ceramics but they lag behind other bioactive ceramics in terms of commercial success. Bioactive glass has not yet reached its potential but research ... ...

    Abstract Bioactive glasses are reported to be able to stimulate more bone regeneration than other bioactive ceramics but they lag behind other bioactive ceramics in terms of commercial success. Bioactive glass has not yet reached its potential but research activity is growing. This paper reviews the current state of the art, starting with current products and moving onto recent developments. Larry Hench's 45S5 Bioglass® was the first artificial material that was found to form a chemical bond with bone, launching the field of bioactive ceramics. In vivo studies have shown that bioactive glasses bond with bone more rapidly than other bioceramics, and in vitro studies indicate that their osteogenic properties are due to their dissolution products stimulating osteoprogenitor cells at the genetic level. However, calcium phosphates such as tricalcium phosphate and synthetic hydroxyapatite are more widely used in the clinic. Some of the reasons are commercial, but others are due to the scientific limitations of the original Bioglass 45S5. An example is that it is difficult to produce porous bioactive glass templates (scaffolds) for bone regeneration from Bioglass 45S5 because it crystallizes during sintering. Recently, this has been overcome by understanding how the glass composition can be tailored to prevent crystallization. The sintering problems can also be avoided by synthesizing sol-gel glass, where the silica network is assembled at room temperature. Process developments in foaming, solid freeform fabrication and nanofibre spinning have now allowed the production of porous bioactive glass scaffolds from both melt- and sol-gel-derived glasses. An ideal scaffold for bone regeneration would share load with bone. Bioceramics cannot do this when the bone defect is subjected to cyclic loads, as they are brittle. To overcome this, bioactive glass polymer hybrids are being synthesized that have the potential to be tough, with congruent degradation of the bioactive inorganic and the polymer components. Key to this is creating nanoscale interpenetrating networks, the organic and inorganic components of which have covalent coupling between them, which involves careful control of the chemistry of the sol-gel process. Bioactive nanoparticles can also now be synthesized and their fate tracked as they are internalized in cells. This paper reviews the main developments in the field of bioactive glass and its variants, covering the importance of control of hierarchical structure, synthesis, processing and cellular response in the quest for new regenerative synthetic bone grafts. The paper takes the reader from Hench's Bioglass 45S5 to new hybrid materials that have tailorable mechanical properties and degradation rates.
    Language English
    Publishing date 2015-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2173841-5
    ISSN 1878-7568 ; 1742-7061
    ISSN (online) 1878-7568
    ISSN 1742-7061
    DOI 10.1016/j.actbio.2015.07.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: 3D printed hybrid scaffolds do not induce adverse inflammation in mice and direct human BM-MSC chondrogenesis

    Ferreira, Silvia A / Tallia, Francesca / Heyraud, Agathe / Walker, Simone A / Salzlechner, Christoph / Jones, Julian R / Rankin, Sara M

    Biomaterials and biosystems

    2024  Volume 13, Page(s) 100087

    Abstract: Biomaterials that can improve the healing of articular cartilage lesions are needed. To address this unmet need, we developed novel 3D printed silica/poly(tetrahydrofuran)/poly(ε-caprolactone) ( ... ...

    Abstract Biomaterials that can improve the healing of articular cartilage lesions are needed. To address this unmet need, we developed novel 3D printed silica/poly(tetrahydrofuran)/poly(ε-caprolactone) (SiO
    Language English
    Publishing date 2024-01-08
    Publishing country England
    Document type Journal Article
    ISSN 2666-5344
    ISSN (online) 2666-5344
    DOI 10.1016/j.bbiosy.2024.100087
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Nanocomposite Hydrogels with Polymer Grafted Silica Nanoparticles, Using Glucose Oxidase.

    Mohammed, Ali A / Li, Siwei / Sang, Tian / Jones, Julian R / Pinna, Alessandra

    Gels (Basel, Switzerland)

    2023  Volume 9, Issue 6

    Abstract: Nanocomposite hydrogels offer remarkable potential for applications in bone tissue engineering. They are synthesized through the chemical or physical crosslinking of polymers and nanomaterials, allowing for the enhancement of their behaviour by modifying ...

    Abstract Nanocomposite hydrogels offer remarkable potential for applications in bone tissue engineering. They are synthesized through the chemical or physical crosslinking of polymers and nanomaterials, allowing for the enhancement of their behaviour by modifying the properties and compositions of the nanomaterials involved. However, their mechanical properties require further enhancement to meet the demands of bone tissue engineering. Here, we present an approach to improve the mechanical properties of nanocomposite hydrogels by incorporating polymer grafted silica nanoparticles into a double network inspired hydrogel (gSNP Gels). The gSNP Gels were synthesised via a graft polymerization process using a redox initiator. gSNP Gels were formed by grafting 2-acrylamido-2-methylpropanesulfonic acid (AMPS) as the first network gel followed by a sequential second network acrylamide (AAm) onto amine functionalized silica nanoparticles (ASNPs). We utilized glucose oxidase (GOx) to create an oxygen-free atmosphere during polymerization, resulting in higher polymer conversion compared to argon degassing. The gSNP Gels showed excellent compressive strengths of 13.9 ± 5.5 MPa, a strain of 69.6 ± 6.4%, and a water content of 63.4% ± 1.8. The synthesis technique demonstrates a promising approach to enhance the mechanical properties of hydrogels, which can have significant implications for bone tissue engineering and other soft tissue applications.
    Language English
    Publishing date 2023-06-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2813982-3
    ISSN 2310-2861 ; 2310-2861
    ISSN (online) 2310-2861
    ISSN 2310-2861
    DOI 10.3390/gels9060486
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The effect of Si species released from bioactive glasses on cell behaviour: A quantitative review.

    Turner, Joel / Nandakumar, Arkhash / Anilbhai, Nikhit / Boccaccini, Aldo R / Jones, Julian R / Jell, Gavin

    Acta biomaterialia

    2023  Volume 170, Page(s) 39–52

    Abstract: Despite over 50 years of silicate bioactive glass (SBG) research, commercial success, and 6000+ published articles, there remains a lack of understanding of how soluble silicate (Si) species released from SBGs influences cellular responses. Using a ... ...

    Abstract Despite over 50 years of silicate bioactive glass (SBG) research, commercial success, and 6000+ published articles, there remains a lack of understanding of how soluble silicate (Si) species released from SBGs influences cellular responses. Using a systematic approach, this article quantitatively compares the in vitro responses of cells to SBG dissolution products reported in the literature and determines if there is a Si concentration ([Si]) dependent effect on cell behaviour. Cell behavioural responses to SBGs [Si] in dissolution products included metabolic activity (reported in 52 % of articles), cell number (24 %), protein production (22 %), gene expression (22 %) and biomineralization (24 %). There was a difference in the [Si] reported to cause increased (desirable) cellular responses (median = 30.2 ppm) compared to the [Si] reported to cause decreased (undesirable) cellular responses (median = 52.0 ppm) (P ≤ 0.001). The frequency of undesirable outcomes increased with increasing [Si], with ∼3 times more negative outcomes reported above 52 ppm. We also investigated the effect of [Si] on specific cellular outcomes (e.g., metabolic activity, angiogenesis, osteogenesis), if cell type/species influenced these responses and the impact of other ions (Ca, P, Na) within the SBG dissolution media on cell behaviour. This review has, for the first time, quantitatively compared the cellular responses to SBGs from the literature, providing a quantitative overview of SBG in vitro practices and presents evidence of a range of [Si] where desirable cellular responses may be more likely (30-52 ppm). This review also demonstrates the need for greater standardisation of in vitro methodological approaches and recommends some minimum reporting standards. STATEMENT OF SIGNIFICANCE: This systematic review investigates the relationship between the concentration of Si released from Si-bioactive glasses (SBG) and in vitro cellular responses. Si releasing materials continue to be of considerable scientific, commercial, and medical interest (with 1500+ articles published in the last 3 years) but there is considerable variation in the reported biologically effective Si concentrations and on the importance of Si on cell behaviour. Despite the variation in methodological approaches, this article demonstrated statistical commonalities in the Si concentrations that cause desirable and undesirable cellular behaviours, suggesting a window where positive cellular outcomes are more likely. This review also provides a quantitative analysis of in vitro practices within the bioactive glass field and highlights the need for greater standardisation.
    Language English
    Publishing date 2023-09-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2173841-5
    ISSN 1878-7568 ; 1742-7061
    ISSN (online) 1878-7568
    ISSN 1742-7061
    DOI 10.1016/j.actbio.2023.09.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Bioactive glass-based organic/inorganic hybrids: an analysis of the current trends in polymer design and selection.

    Gritsch, Lukas / Bossard, Cédric / Jallot, Edouard / Jones, Julian R / Lao, Jonathan

    Journal of materials chemistry. B

    2023  Volume 11, Issue 3, Page(s) 519–545

    Abstract: Bioactive glass-based organic/inorganic hybrids are a family of materials holding great promise in the biomedical field. Developed from bioactive glasses following recent advances in sol-gel and polymer chemistry, they can overcome many limitations of ... ...

    Abstract Bioactive glass-based organic/inorganic hybrids are a family of materials holding great promise in the biomedical field. Developed from bioactive glasses following recent advances in sol-gel and polymer chemistry, they can overcome many limitations of traditional composites typically used in bone repair and orthopedics. Thanks to their unique molecular structure, hybrids are often characterized by synergistic properties that go beyond a mere combination of their two components; it is possible to synthesize materials with a wide variety of mechanical and biological properties. The polymeric component, in particular, can be tailored to prepare tough, load-bearing materials, or rubber-like elastomers. It can also be a key factor in the determination of a wide range of interesting biological properties. In addition, polymers can also be used within hybrids as carriers for therapeutic ions (although this is normally the role of silica). This review offers a brief look into the history of hybrids, from the discovery of bioactive glasses to the latest developments, with a particular emphasis on polymer design and chemistry. First the benefits and limitations of hybrids will be discussed and compared with those of alternative approaches (for instance, nanocomposites). Then, key advances in the field will be presented focusing on the polymeric component: its chemistry, its physicochemical and biological advantages, its drawbacks, and selected applications. Comprehensive tables summarizing all the polymers used to date to fabricate sol-gel hybrids for biomedical applications are also provided, to offer a handbook of all the available candidates for hybrid synthesis. In addition to the current trends, open challenges and possible avenues of future development are proposed.
    MeSH term(s) Polymers ; Glass/chemistry ; Silicon Dioxide/chemistry ; Elastomers
    Chemical Substances Polymers ; Silicon Dioxide (7631-86-9) ; Elastomers
    Language English
    Publishing date 2023-01-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2702241-9
    ISSN 2050-7518 ; 2050-750X
    ISSN (online) 2050-7518
    ISSN 2050-750X
    DOI 10.1039/d2tb02089k
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Ovine Mesenchymal Stem Cell Chondrogenesis on a Novel 3D-Printed Hybrid Scaffold In Vitro.

    De Mori, Arianna / Heyraud, Agathe / Tallia, Francesca / Blunn, Gordon / Jones, Julian R / Roncada, Tosca / Cobb, Justin / Al-Jabri, Talal

    Bioengineering (Basel, Switzerland)

    2024  Volume 11, Issue 2

    Abstract: This study evaluated the use of silica/poly(tetrahydrofuran)/poly(ε-caprolactone) ( ... ...

    Abstract This study evaluated the use of silica/poly(tetrahydrofuran)/poly(ε-caprolactone) (SiO
    Language English
    Publishing date 2024-01-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2746191-9
    ISSN 2306-5354
    ISSN 2306-5354
    DOI 10.3390/bioengineering11020112
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Effect of Polymer Molecular Mass and Structure on the Mechanical Properties of Polymer-Glass Hybrids.

    Lee, Yu Lin / Lester, Daniel W / Jones, Julian R / Georgiou, Theoni K

    ACS omega

    2021  Volume 7, Issue 1, Page(s) 786–792

    Abstract: Organic-inorganic hybrid materials are a promising class of materials for tissue engineering and other biomedical applications. In this systematic study, the effect of the polymer molecular mass (MM) with a linear architecture on hybrid mechanical ... ...

    Abstract Organic-inorganic hybrid materials are a promising class of materials for tissue engineering and other biomedical applications. In this systematic study, the effect of the polymer molecular mass (MM) with a linear architecture on hybrid mechanical properties is reported. Well-defined linear poly(methyl methacrylate-
    Language English
    Publishing date 2021-12-22
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.1c05424
    Database MEDical Literature Analysis and Retrieval System OnLINE

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