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  1. Book: Huntington's disease

    Bates, Gillian / Tabrizi, Sarah / Jones, Lesley

    (Oxford monographs on medical genetics ; 64)

    2014  

    Author's details ed. by Gillian Bates ; Sarah Tabrizi , Lesley Jones
    Series title Oxford monographs on medical genetics ; 64
    Collection
    Keywords Huntington Disease
    Language English
    Size IX, 502 S. : Ill., graph. Darst.
    Edition 4. ed.
    Publisher Oxford Univ. Press
    Publishing place Oxford u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT018285009
    ISBN 978-0-19-992914-6 ; 0-19-992914-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2014 A 2241 available for loan (reading room) Lesesaal EG

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  2. Book ; Conference proceedings: Ancient concepts of the Hippocratic

    Dean-Jones, Lesley / Rosen, Ralph Mark

    papers presented at the XIIIth International Hippocrates Colloquium, Austin, Texas, August 2008

    (Studies in ancient medicine ; 46)

    2016  

    Event/congress International Hippocrates Colloquium (13., 2008, AustinTex.)
    Author's details ed. by Lesley Dean-Jones and Ralph M. Rosen
    Series title Studies in ancient medicine ; 46
    Collection
    Keywords Philosophy, Medical / history ; History, Ancient ; Greek World
    Language English ; French
    Size VII, 474 S.
    Publisher Brill
    Publishing place Leiden u.a.
    Publishing country Netherlands
    Document type Book ; Conference proceedings
    Note In English; two papers in French ; Includes bibliographical references and index
    HBZ-ID HT018811695
    ISBN 978-90-04-30701-8 ; 978-90-04-30740-7 ; 90-04-30701-X ; 90-04-30740-0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2015 A 3887 available for loan (reading room) Lesesaal EG

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  3. Article ; Online: Bicycling for Rehabilitation of Persons With Parkinson Disease: A Scoping Review.

    Palmieri, John L / Jones, Lesley / Schenkman, Margaret / Deutsch, Judith E

    Journal of neurologic physical therapy : JNPT

    2024  

    Abstract: Background and purpose: Exercise is beneficial for persons with Parkinson disease (PwPD). The overarching purpose of this scoping review was to provide guidance to clinicians and scientists regarding current evidence for bicycling exercise for PwPD. A ... ...

    Abstract Background and purpose: Exercise is beneficial for persons with Parkinson disease (PwPD). The overarching purpose of this scoping review was to provide guidance to clinicians and scientists regarding current evidence for bicycling exercise for PwPD. A scoping review was conducted to examine the heterogeneous literature on stationary bicycling for PwPD to reduce motor symptoms and body function structure impairments, improve activities and motor performance, and reduce disease severity.
    Methods: The Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guidelines were followed. PubMed, CINAHL, and PEDro were searched from inception to January 23, 2023. Articles reporting original data on relevant outcome measures were included. Search results were screened and articles were extracted. Data were analyzed quantitatively with percentages of significant and clinically meaningful findings and qualitatively to extract themes.
    Results: Bicycling was categorized using bicycle types (assisted, nonassisted) and training modes (speed, aerobic, force). A high percentage of the 34 studies showed statistical significance for reducing motor symptoms (83%), body function structure impairments (78%), disease severity (82%), and improving activities (gait 72%, balance 60%). Clinically meaningful findings were achieved in 71% of the studies for reduction in disease severity and in 50% for improving gait.
    Discussion and conclusions: The literature on bicycling for PwPD has evolved from speed to aerobic studies. The terminology describing types of bicycling was simplified. Of all the outcomes reported, reduction of disease severity achieved the highest frequency of clinical meaningful improvements. Bicycling was comparable with other forms of aerobic training for walking speed and endurance. Opportunities for translation to practice and research are presented.
    Video abstract available: for more insights from the authors (see the Video, Supplemental Digital Content 1 available at: http://links.lww.com/JNPT/A462).
    Language English
    Publishing date 2024-05-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2276921-3
    ISSN 1557-0584 ; 1557-0576 ; 1085-049X
    ISSN (online) 1557-0584
    ISSN 1557-0576 ; 1085-049X
    DOI 10.1097/NPT.0000000000000466
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6541: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Huntington's Disease Gene Hunters: An Expanding Tale.

    Rosser, Anne E / Jones, Lesley

    Movement disorders clinical practice

    2021  Volume 9, Issue 3, Page(s) 330–333

    Language English
    Publishing date 2021-12-16
    Publishing country United States
    Document type Journal Article
    ISSN 2330-1619
    ISSN (online) 2330-1619
    DOI 10.1002/mdc3.13375
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  5. Article ; Online: Expanding student nurse placement activity in Welsh care homes: An evaluation study.

    Williams, Sharon / Caley, Lynne / Kingdom-Mills, Sarah / Cassidy, Simon / Jones, Lesley

    International journal of nursing practice

    2024  , Page(s) e13242

    Abstract: Aim: Expanding and sustaining student nurse placements outside of the acute sector is a universal challenge. This paper aims to evaluate the Care Home Education Facilitator Role introduced in one area of Wales, United Kingdom, and to report on the ... ...

    Abstract Aim: Expanding and sustaining student nurse placements outside of the acute sector is a universal challenge. This paper aims to evaluate the Care Home Education Facilitator Role introduced in one area of Wales, United Kingdom, and to report on the outcomes achieved from this novel role.
    Methods: Semi-structured interviews were undertaken with key stakeholders including the Care Home Education Facilitator postholder leading the pilot, care home managers, higher education institutions' placement managers/coordinators, student nurses and national health service staff.
    Results: Five key areas were identified, which included timing of introducing the post and establishing a clear rationale and understanding of the intention of the role. The benefits, challenges and suggested improvements to the Care Home Education Facilitator initiative are provided.
    Conclusion: Introducing the role of the Care Home Education Facilitator to work closely with key stakeholders resulted in increased placements for student nurses, but investing time in developing relationships with these stakeholders was critical to the success of the role.
    Language English
    Publishing date 2024-02-08
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1381116-2
    ISSN 1440-172X ; 1322-7114
    ISSN (online) 1440-172X
    ISSN 1322-7114
    DOI 10.1111/ijn.13242
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4740: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Introducing the '3 Fs model of complexity' for people with dementia accessing a NHS mental health in-patient dementia assessment ward: An interpretive description study.

    Jones, Lesley / Cullum, Nicky / Watson, Ruth / Keady, John

    Dementia (London, England)

    2022  , Page(s) 14713012221136313

    Abstract: Background: In the United Kingdom, the use of the terms 'complex' and 'complexity' alongside dementia is reflected in a number of policy and practice documents. However, there is a lack of evidence that explores how complexity is perceived, constructed ... ...

    Abstract Background: In the United Kingdom, the use of the terms 'complex' and 'complexity' alongside dementia is reflected in a number of policy and practice documents. However, there is a lack of evidence that explores how complexity is perceived, constructed and experienced by people with dementia, family carers and practitioners working in the NHS dementia inpatient assessment wards [dementia assessment wards].
    Objective: To explore the meaning and concept of complexity in dementia from within the setting of a dementia assessment ward and develop a practice model.
    Methods: The study was conducted over three phases: 1) an online electronic survey of UK national dementia leaders; 2) individual interviews and a focus group with dementia practitioners in two dementia assessment wards; 3) case studies of four patients with dementia resident on a dementia assessment ward which included their identified family carer/consultee, the named clinician on the ward involved in that person's care and a care records review.
    Results: The findings highlighted that complexity is constructed through a number of interconnected and interrelated domains that vary in acuity. These findings have been developed into the '3 Fs Model of Complexity' and the 3'Fs' stand for Fixed, Flexible and Fluctuating. The Fixed domain consists of six components which are always present in complexity. The Flexible domain consists of 14 components and a person with dementia may experience any number of Flexible domain components at any one time. The Fluctuating domain highlights that all components have the ability to vary in their acuity.
    Conclusion: The '3 Fs Model of Complexity' may facilitate a more holistic view of a person with dementia than when 'symptoms' are viewed in isolation. Going forward, and subject to further refinement and testing, the '3 Fs Model of Complexity' could help guide the selection of tailored, personalised interventions for people with dementia, including formulation approaches.
    Language English
    Publishing date 2022-11-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2084045-7
    ISSN 1741-2684 ; 1471-3012
    ISSN (online) 1741-2684
    ISSN 1471-3012
    DOI 10.1177/14713012221136313
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Special Issue: DNA Repair and Somatic Repeat Expansion in Huntington's Disease.

    Jones, Lesley / Wheeler, Vanessa C / Pearson, Christopher E

    Journal of Huntington's disease

    2021  Volume 10, Issue 1, Page(s) 3–5

    MeSH term(s) Animals ; DNA Repair/genetics ; Humans ; Huntingtin Protein/genetics ; Huntington Disease/genetics ; Huntington Disease/therapy ; Trinucleotide Repeat Expansion/genetics
    Chemical Substances HTT protein, human ; Huntingtin Protein
    Language English
    Publishing date 2021-02-07
    Publishing country Netherlands
    Document type Introductory Journal Article
    ZDB-ID 2673033-9
    ISSN 1879-6400 ; 1879-6397
    ISSN (online) 1879-6400
    ISSN 1879-6397
    DOI 10.3233/JHD-219001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Author Response: Timing and Impact of Psychiatric, Cognitive, and Motor Abnormalities in Huntington Disease.

    Massey, Thomas H / McAllister, Branduff / Rosser, Anne E / Jones, Lesley

    Neurology

    2022  Volume 98, Issue 12, Page(s) 515

    MeSH term(s) Cognition ; Humans ; Huntington Disease/complications ; Huntington Disease/psychology ; Neuropsychological Tests
    Language English
    Publishing date 2022-03-21
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000200162
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui II Zs.153: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 18: Show issues
    Zs.MO 374: Show issues

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  9. Article: Identifying the Hippocratic.

    Dean-Jones, Lesley

    Studies in ancient medicine

    2016  Volume 46, Page(s) 1–14

    MeSH term(s) Greek World ; History, Ancient ; Manuscripts, Medical as Topic/history
    Language English
    Publishing date 2016
    Publishing country Netherlands
    Document type Historical Article ; Introductory Journal Article
    ISSN 0925-1421
    ISSN 0925-1421
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The central role of DNA damage and repair in CAG repeat diseases.

    Massey, Thomas H / Jones, Lesley

    Disease models & mechanisms

    2018  Volume 11, Issue 1

    Abstract: Diseases such as Huntington's disease and certain spinocerebellar ataxias are caused by the expansion of genomic cytosine-adenine-guanine (CAG) trinucleotide repeats beyond a specific threshold. These diseases are all characterised by neurological ... ...

    Abstract Diseases such as Huntington's disease and certain spinocerebellar ataxias are caused by the expansion of genomic cytosine-adenine-guanine (CAG) trinucleotide repeats beyond a specific threshold. These diseases are all characterised by neurological symptoms and central neurodegeneration, but our understanding of how expanded repeats drive neuronal loss is incomplete. Recent human genetic evidence implicates DNA repair pathways, especially mismatch repair, in modifying the onset and progression of CAG repeat diseases. Repair pathways might operate directly on repeat sequences by licensing or inhibiting repeat expansion in neurons. Alternatively, or in addition, because many of the genes containing pathogenic CAG repeats encode proteins that themselves have roles in the DNA damage response, it is possible that repeat expansions impair specific DNA repair pathways. DNA damage could then accrue in neurons, leading to further expansion at repeat loci, thus setting up a vicious cycle of pathology. In this review, we consider DNA damage and repair pathways in postmitotic neurons in the context of disease-causing CAG repeats. Investigating and understanding these pathways, which are clearly relevant in promoting and ameliorating disease in humans, is a research priority, as they are known to modify disease and therefore constitute prevalidated drug targets.
    MeSH term(s) Animals ; DNA Damage/genetics ; DNA Repair/genetics ; Genome ; Humans ; Models, Biological ; Trinucleotide Repeat Expansion/genetics
    Language English
    Publishing date 2018-01-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2451104-3
    ISSN 1754-8411 ; 1754-8403
    ISSN (online) 1754-8411
    ISSN 1754-8403
    DOI 10.1242/dmm.031930
    Database MEDical Literature Analysis and Retrieval System OnLINE

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