Article ; Online: Radiofrequency septal reduction in symptomatic hypertrophic obstructive cardiomyopathy.
2016 Volume 13, Issue 9, Page(s) 1885–1890
Abstract: Background: Alcohol septal ablation remains the only approved nonsurgical therapeutic alternative for patients with drug-resistant hypertrophic obstructive cardiomyopathy (HOCM). Radiofrequency (RF) ablation offers another option for treating HOCM.: ... ...
Abstract | Background: Alcohol septal ablation remains the only approved nonsurgical therapeutic alternative for patients with drug-resistant hypertrophic obstructive cardiomyopathy (HOCM). Radiofrequency (RF) ablation offers another option for treating HOCM. Objective: The purpose of this study was to determine whether irrigated RF ablation can reduce symptomatic outflow tract obstruction in adults with HOCM. Methods: Patients with symptomatic HOCM and an outflow gradient of >50 mm Hg despite medication were offered RF ablation. In 11 patients, the hypertrophied interventricular septum was localized on a 3-dimensional mapping system and ablated via a transmitral or retrograde aortic approach. Results: Ten of 11(91%) patients had a significant and persistent reduction in resting and provocable left ventricular outflow tract gradients. Mean resting gradients at 12 months postprocedure were reduced by 85% (66.7 mm Hg at baseline to 10.0 mm Hg at 12 months); mean provocable gradients were reduced by 85% from baseline (136.2 mm Hg at baseline to 20.0 mm Hg at 12 months). Functional New York Heart Association heart classification improved from class 3.0 ± 0.0 in all patients to class mean of 1.8 ± 0.8. Conclusion: RF septal ablation for the treatment of HOCM is a safe therapeutic option that allows for significant reduction in left ventricular outflow tract gradients, improvement in symptoms, and increase in efficacy rates comparable to reported rates for alcohol septal ablation. |
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Language | English |
Publishing date | 2016-09 |
Publishing country | United States |
Document type | Journal Article |
ZDB-ID | 2229357-7 |
ISSN | 1556-3871 ; 1547-5271 |
ISSN (online) | 1556-3871 |
ISSN | 1547-5271 |
DOI | 10.1016/j.hrthm.2016.04.018 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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