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  1. Article ; Online: Response to a letter from Jesus Paula Carvalho and team regarding the Jones et al article on 'Complication rates and lymph node count between two different skin incisions at time of inguino-femoral lymph node dissection in vulvar cancer'.

    Jones, Sadie Esme Fleur / Howells, Robert / Sharma, Aarti

    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

    2020  Volume 30, Issue 8, Page(s) 1264

    MeSH term(s) Female ; Humans ; Lymph Node Excision ; Lymph Nodes/surgery ; Vulvar Neoplasms/surgery
    Language English
    Publishing date 2020-07-05
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1070385-8
    ISSN 1525-1438 ; 1048-891X
    ISSN (online) 1525-1438
    ISSN 1048-891X
    DOI 10.1136/ijgc-2020-001681
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Early Career Research and Publications Network: an International Gynecologic Cancer Society Initiative.

    Bhandoria, Geetu Prakash / Noll, Florencia / Hsu, Heng-Cheng / Jones, Sadie Esme Fleur / Farrell, Rhonda / Nair, Navya

    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

    2021  Volume 31, Issue 10, Page(s) 1398–1399

    MeSH term(s) Gynecology/education ; Humans ; Information Dissemination/methods ; Periodicals as Topic ; Societies, Medical
    Language English
    Publishing date 2021-09-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 1070385-8
    ISSN 1525-1438 ; 1048-891X
    ISSN (online) 1525-1438
    ISSN 1048-891X
    DOI 10.1136/ijgc-2021-002960
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Complication rates and lymph node count between two different skin incisions at time of inguino-femoral lymph node dissection in vulvar cancer.

    Jones, Sadie Esme Fleur / Lim, Kenneth / Davies, Jennifer / Howells, Robert / Jones, Rosalind / Sharma, Aarti

    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

    2020  Volume 30, Issue 8, Page(s) 1113–1117

    Abstract: Introduction: Inguino-femoral lymph node dissection plays a crucial role in the management of vulvar cancer. The procedure is associated with high complication rates, including infection, lymphocysts/lymphoedema and wound dehiscence. Several skin ... ...

    Abstract Introduction: Inguino-femoral lymph node dissection plays a crucial role in the management of vulvar cancer. The procedure is associated with high complication rates, including infection, lymphocysts/lymphoedema and wound dehiscence. Several skin incision techniques exist and practice among gynecology oncologists is variable. Little evidence exists to guide surgeons regarding the optimal surgical approach. This study aimed to determine the difference in 30-day complication rates, number of lymph nodes and length of stay between patients undergoing the modified oblique and classical 'lazy S' skin incision.
    Methods: A retrospective review between January 2014 and September 2018 was performed in the University Hospital of Wales, Cardiff. All cases of inguino-femoral lymph node dissection performed for vulvar cancer were included in the study without exclusion. Data collected included age, body mass index (BMI), incision type, suture material, length of hospital stay, complication rates, cancer stage, lymph node count, lymph node positivity rate and recurrence rates. Data were analyzed using SPSS software and clinical significance was set as p<0.05.
    Results: Thirty-five cases of classical 'lazy S' and 14 cases of modified oblique were included in the analysis. The mean patient age was 65 years (range 41-86) in the classical 'lazy S' group and 58 years (range 19-81) in the modified oblique group. The mean BMI was 28 kg/m
    Conclusion: The rate of overall and serious complications was lower after modified oblique skin incision compared with classical 'lazy S'. However, the absolute lymph node count and lymph node positivity rate were higher in the 'lazy S' group.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Drainage/adverse effects ; Female ; Femoral Artery ; Humans ; Inguinal Canal ; Length of Stay ; Lymph Node Excision/adverse effects ; Lymph Node Excision/methods ; Lymph Nodes/pathology ; Lymph Nodes/surgery ; Lymphatic Metastasis ; Middle Aged ; Neoplasm Staging ; Retrospective Studies ; Surgical Wound/complications ; Surgical Wound Dehiscence/etiology ; Vulvar Neoplasms/pathology ; Vulvar Neoplasms/surgery ; Wound Closure Techniques/adverse effects ; Young Adult
    Language English
    Publishing date 2020-05-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1070385-8
    ISSN 1525-1438 ; 1048-891X
    ISSN (online) 1525-1438
    ISSN 1048-891X
    DOI 10.1136/ijgc-2019-001014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: International Gynaecological Cancer Society (IGCS) 2020 Annual Global Meeting: Twitter activity analysis.

    Bhandoria, Geetu Prakash / Nair, Navya / Jones, Sadie Esme Fleur / Eriksson, Ane Gerda / Hsu, Heng-Cheng / Noll, Florencia / Ahmed, Wasim

    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

    2021  Volume 31, Issue 11, Page(s) 1453–1458

    Abstract: Objectives: Twitter is the most frequently used social media platform by healthcare practitioners, at medical conferences. This study aimed to analyze Twitter conversations during the virtual International Gynecological Cancer Society 2020 conference to ...

    Abstract Objectives: Twitter is the most frequently used social media platform by healthcare practitioners, at medical conferences. This study aimed to analyze Twitter conversations during the virtual International Gynecological Cancer Society 2020 conference to understand the interactions between Twitter users related to the conference.
    Methods: Tweets using the hashtag '#IGCS2020' were searched using the Twitter Search Application Programming Interface (API) during the period 10-13 September 2020. NodeXL Pro was used to retrieve data. The Clauset-Newman-Moore cluster algorithm clustered users into different groups or 'clusters' based on how users interacted.
    Results: There were 2009 registrants for the virtual IGCS 2020 conference. The total number of users within the network was 168, and there were 880 edges connecting users. Five types of edges were identified as follows: 'replies to' (n=18), 'mentions' (n=221), 'mentions in retweets' (n=375), retweets (n=198), and tweets (n=68). The most influential account was that of the IGCS account itself (@IGCSociety). The overall network shape resembled a community where distinct groups formed within the network. Our current analyses demonstrated that less than 10% of the total members interacted on Twitter.
    Conclusion: This study identified the most influential Twitter users within the '#IGCS2020' community. he results also confirmed the community network shape of the #IGCS2020 hashtag and found that the most frequent co-related words were 'ovarian' and 'cancer' (n=39).
    MeSH term(s) Congresses as Topic ; Gynecology/organization & administration ; Humans ; Medical Oncology/organization & administration ; Social Media/statistics & numerical data ; Societies, Medical
    Language English
    Publishing date 2021-09-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 1070385-8
    ISSN 1525-1438 ; 1048-891X
    ISSN (online) 1525-1438
    ISSN 1048-891X
    DOI 10.1136/ijgc-2021-002781
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Pressurized intraperitoneal aerosol chemotherapy (PIPAC): updated systematic review using the IDEAL framework.

    Baggaley, Alice E / Lafaurie, Guillaume B R C / Tate, Sophia J / Boshier, Piers R / Case, Amy / Prosser, Susan / Torkington, Jared / Jones, Sadie E F / Gwynne, Sarah H / Peters, Christopher J

    The British journal of surgery

    2022  Volume 110, Issue 1, Page(s) 10–18

    MeSH term(s) Humans ; Aerosols ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Peritoneal Neoplasms/drug therapy ; Peritoneum
    Chemical Substances Aerosols
    Language English
    Publishing date 2022-08-25
    Publishing country England
    Document type Journal Article ; Systematic Review
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1093/bjs/znac284
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Technique for inguino-femoral lymph node dissection in vulvar cancer: an international survey.

    Jones, Sadie Esme Fleur / Ramirez, Pedro T / Bhandoria, Geetu Prakash / Hsu, Heng-Cheng / Nair, Navya / Noll, Florencia / Hurt, Christopher N / Howells, Robert / Lim, Kenneth / Sharma, Aarti

    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

    2021  Volume 31, Issue 6, Page(s) 817–823

    Abstract: Background: Vulvar cancer is a rare disease and despite broad adoption of sentinel lymph node mapping to assess groin metastases, inguino-femoral lymph node dissection still plays a role in the management of this disease. Inguino-femoral lymph node ... ...

    Abstract Background: Vulvar cancer is a rare disease and despite broad adoption of sentinel lymph node mapping to assess groin metastases, inguino-femoral lymph node dissection still plays a role in the management of this disease. Inguino-femoral lymph node dissection is associated with high morbidity, and limited research exists to guide the best surgical approach.
    Objective: To determine international practice patterns in key aspects of the inguino-femoral lymph node dissection technique and provide data to guide future research.
    Methods: A survey addressing six key domains of practice patterns in performing inguino-femoral lymph node dissection was distributed internationally to gynecologic oncology surgeons between April and October 2020. The survey was distributed using the British Gynecological Cancer Society, the Society of Gynecologic Oncology, authors' direct links, the UK Audit and Research in Gynecology Oncology group, and Twitter.
    Results: A total of 259 responses were received from 18 countries. The majority (236/259, 91.1%) of respondents reported performing a modified oblique incision, routinely dissecting the superficial and deep inguino-femoral lymph nodes (137/185, 74.1%) with sparing of the saphenous vein (227/258, 88%). Most respondents did not routinely use compression dressings/underwear (169/252 (67.1%), used prophylactic antibiotics at the time of surgery only (167/257, 65%), and closed the skin with sutures (192 74.4%). Also, a drain is placed at the time of surgery by 243/259 (93.8%) surgeons, with most practitioners (144/243, 59.3%) waiting for drainage to be less than 30-50 mL in 24 hours before removal; most respondents (66.3%) routinely discharge patients with drain(s) in situ.
    Conclusion: Our study showed that most surgeons perform a modified oblique incision, dissect the superficial and deep inguino-femoral lymph nodes, and spare the saphenous vein when performing groin lymphadenectomy. This survey has demonstrated significant variability in inguino-femoral lymph node dissection in cases of vulvar cancer among gynecologic oncology surgeons internationally.
    MeSH term(s) Female ; Humans ; Sentinel Lymph Node Biopsy/methods ; Surveys and Questionnaires ; Vulvar Neoplasms/diagnosis ; Vulvar Neoplasms/pathology
    Language English
    Publishing date 2021-05-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 1070385-8
    ISSN 1525-1438 ; 1048-891X
    ISSN (online) 1525-1438
    ISSN 1048-891X
    DOI 10.1136/ijgc-2021-002452
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The IJGC Editorial Fellowship.

    Angeles, Martina Aida / Bhandoria, Geetu / Hsu, Heng-Cheng / Jones, Sadie Esme Fleur / Kacperczyk-Bartnik, Joanna / Nair, Navya / Noll, Florencia / Razumova, Zoia / Strojna, Aleksandra / Wan, Y Louise / van Ramshorst, Gabrielle H

    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

    2021  Volume 31, Issue 4, Page(s) 644–645

    MeSH term(s) Fellowships and Scholarships/standards ; Gynecology/education ; Humans ; Obstetrics/education
    Language English
    Publishing date 2021-01-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 1070385-8
    ISSN 1525-1438 ; 1048-891X
    ISSN (online) 1525-1438
    ISSN 1048-891X
    DOI 10.1136/ijgc-2020-002365
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  8. Article ; Online: Recurrence of vulval intraepithelial neoplasia following treatment with cidofovir or imiquimod: results from a multicentre, randomised, phase II trial (RT3VIN).

    Hurt, C N / Jones, Sef / Madden, T-A / Fiander, A / Nordin, A J / Naik, R / Powell, N / Carucci, M / Tristram, A

    BJOG : an international journal of obstetrics and gynaecology

    2018  Volume 125, Issue 9, Page(s) 1171–1177

    Abstract: Objective: To compare the recurrence rates after complete response to topical treatment with either cidofovir or imiquimod for vulval intraepithelial neoplasia (VIN) 3.: Design: A prospective, open, randomised multicentre trial.: Setting: 32 ... ...

    Abstract Objective: To compare the recurrence rates after complete response to topical treatment with either cidofovir or imiquimod for vulval intraepithelial neoplasia (VIN) 3.
    Design: A prospective, open, randomised multicentre trial.
    Setting: 32 general hospitals located in Wales and England.
    Population or sample: 180 patients were randomised consecutively between 21 October 2009 and 11 January 2013, 89 to cidofoovir (of whom 41 completely responded to treatment) and 91 to imiquimod (of whom 42 completely responded to treatment).
    Methods: After 24 weeks of treatment, complete responders were followed up at 6-monthly intervals for 24 months. At each visit, the Common Terminology Criteria for Adverse Events (CTCAE) v3.0 was assessed and any new lesions were biopsied for histology.
    Main outcome measures: Time to histologically confirmed disease recurrence (any grade of VIN).
    Results: The median length of follow up was 18.4 months. At 18 months, more participants were VIN-free in the cidofovir arm: 94% (95% CI 78.2-98.5) versus 71.6% (95% CI 52.0-84.3) [univariable hazard ratio (HR) 3.46, 95% CI 0.95-12.60, P = 0.059; multivariable HR 3.53, 95% CI 0.96-12.98, P = 0.057). The number of grade 2+ events was similar between treatment arms (imiquimod: 24/42 (57%) versus cidofovir: 27/41 (66%), χ2 = 0.665, P = 0.415), with no grade 4+.
    Conclusions: Long-term data indicates a trend towards response being maintained for longer following treatment with cidofovir than with imiquimod, with similar low rates of adverse events for each drug. Adverse event rates indicated acceptable safety of both drugs TWEETABLE ABSTRACT: Long-term follow up in the RT3VIN trial suggests cidofovir may maintain response for longer than imiquimod.
    MeSH term(s) Administration, Topical ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/adverse effects ; Carcinoma in Situ/drug therapy ; Carcinoma in Situ/epidemiology ; Carcinoma in Situ/pathology ; Cidofovir/administration & dosage ; Cidofovir/adverse effects ; Female ; Humans ; Imiquimod/administration & dosage ; Imiquimod/adverse effects ; Middle Aged ; Neoplasm Recurrence, Local/epidemiology ; Neoplasm Recurrence, Local/etiology ; Neoplasm Recurrence, Local/pathology ; Prospective Studies ; Treatment Outcome ; Vulvar Neoplasms/drug therapy ; Vulvar Neoplasms/epidemiology ; Vulvar Neoplasms/pathology
    Chemical Substances Antineoplastic Agents ; Cidofovir (JIL713Q00N) ; Imiquimod (P1QW714R7M)
    Language English
    Publishing date 2018-02-09
    Publishing country England
    Document type Clinical Trial, Phase II ; Journal Article ; Multicenter Study ; Randomized Controlled Trial
    ZDB-ID 2000931-8
    ISSN 1471-0528 ; 0306-5456 ; 1470-0328
    ISSN (online) 1471-0528
    ISSN 0306-5456 ; 1470-0328
    DOI 10.1111/1471-0528.15124
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Human Papillomavirus DNA Methylation Predicts Response to Treatment Using Cidofovir and Imiquimod in Vulval Intraepithelial Neoplasia 3.

    Jones, Sadie E F / Hibbitts, Samantha / Hurt, Christopher N / Bryant, Dean / Fiander, Alison N / Powell, Ned / Tristram, Amanda J

    Clinical cancer research : an official journal of the American Association for Cancer Research

    2017  Volume 23, Issue 18, Page(s) 5460–5468

    Abstract: Purpose: ...

    Abstract Purpose:
    MeSH term(s) Aminoquinolines/administration & dosage ; Aminoquinolines/adverse effects ; Aminoquinolines/therapeutic use ; Biomarkers ; Carcinoma in Situ/drug therapy ; Carcinoma in Situ/etiology ; Carcinoma in Situ/pathology ; Cidofovir ; Cytosine/administration & dosage ; Cytosine/adverse effects ; Cytosine/analogs & derivatives ; Cytosine/therapeutic use ; DNA Methylation ; DNA, Viral ; Drug Therapy, Combination ; Female ; Genes, Viral ; Humans ; Imiquimod ; Neoplasm Staging ; Organophosphonates/administration & dosage ; Organophosphonates/adverse effects ; Organophosphonates/therapeutic use ; Papillomaviridae/classification ; Papillomaviridae/genetics ; Papillomavirus Infections/complications ; Papillomavirus Infections/drug therapy ; Papillomavirus Infections/virology ; Promoter Regions, Genetic ; ROC Curve ; Treatment Outcome ; Vulvar Neoplasms/drug therapy ; Vulvar Neoplasms/etiology ; Vulvar Neoplasms/pathology
    Chemical Substances Aminoquinolines ; Biomarkers ; DNA, Viral ; Organophosphonates ; Cytosine (8J337D1HZY) ; Cidofovir (JIL713Q00N) ; Imiquimod (P1QW714R7M)
    Language English
    Publishing date 2017-06-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1225457-5
    ISSN 1557-3265 ; 1078-0432
    ISSN (online) 1557-3265
    ISSN 1078-0432
    DOI 10.1158/1078-0432.CCR-17-0040
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Are trainees working in obstetrics and gynecology confident and competent in the care of frail gynecological oncology patients?

    Owens, Gemma Louise / Sivalingam, Vanitha / Abdelrahman, Mohamed / Beirne, James P / Blake, Dominic / Collins, Anna / Davies, Rhianna / Dilley, James / Farquharson, Malcolm / Frimpong, Diana / Gomes, Nana / Hawco, Sarah / Ilenkovan, Narthana / Jones, Eleanor / Jones, Sadie Esme Fleur / Khan, Tabassum / Leung, Elaine / Otify, Mohamed / Parnell, Laura /
    Rimmer, Michael P / Ryan, Neil / Sanderson, Peter / Stocker, Linden / Wilkinson, Michael / Wong, Siewchee / Bharathan, Rasiah / Wan, Yee-Loi Louise

    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

    2020  Volume 30, Issue 12, Page(s) 1959–1965

    Abstract: Introduction: Older patients undergoing cancer surgery are at increased risk of post-operative complications, prolonged hospital stay, and mortality. Identification of frailty can help predict patients at high risk of peri-operative complications and ... ...

    Abstract Introduction: Older patients undergoing cancer surgery are at increased risk of post-operative complications, prolonged hospital stay, and mortality. Identification of frailty can help predict patients at high risk of peri-operative complications and allow a collaborative, multidisciplinary team approach to their care. A survey was conducted to assess the confidence and knowledge of trainees in obstetrics and gynecology regarding identification and management of peri-operative issues encountered in frail gynecological oncology patients.
    Methods: A web-based survey was distributed via the Audit and Research in Gynaecological Oncology (ARGO) collaborative and UK Audit and Research Collaborative in Obstetrics and Gynaecology (UKARCOG) . The survey on the management of frail peri-operative patients was disseminated to doctors-in-training (trainees) working in obstetrics and gynecology in the United Kingdom (UK) and Ireland. Specialty (ST1-7), subspecialty, and general practice trainees, non-training grade doctors, and foundation year doctors currently working in obstetrics and gynecology were eligible. Consultants were excluded. Study data were collected using REDCAP software hosted at the University of Manchester. Responses were collected over a 6-week period between January and February 2020.
    Results: Of the 666 trainees who participated, 67% (425/666) reported inadequate training in peri-operative management of frail patients. Validated frailty assessment tools were used by only 9% (59/638) of trainees and less than 1% (4/613) were able to correctly identify all the diagnostic features of frailty. Common misconceptions included the use of chronological age and gender in frailty assessments. The majority of trainees (76.5%, 448/586) correctly answered a series of questions relating to mental capacity; however, only 6% (36/606) were able to correctly identify all three diagnostic features of delirium. A total of 87% (495/571) of trainees supported closer collaboration with geriatricians and a multidisciplinary approach.
    Conclusions: Obstetrics and gynecology trainees reported inadequate training in the peri-operative care of frail gynecological oncology patients, and overwhelmingly favored input from geriatricians. Routine use of validated frailty assessment tools may aid diagnosis of frailty in the peri-operative setting. There is an unmet need for formal education in the management of frail surgical patients within the UK and Irish obstetrics and gynecology curriculum.
    MeSH term(s) Aged ; Aged, 80 and over ; Clinical Competence ; Education, Medical, Graduate ; Female ; Frail Elderly ; Genital Neoplasms, Female/therapy ; Geriatrics/education ; Gynecology/education ; Gynecology/standards ; Humans ; Internet ; Ireland ; Medical Oncology/education ; Obstetrics/education ; Obstetrics/standards ; Self Concept ; Students, Medical/psychology ; Surveys and Questionnaires ; United Kingdom
    Language English
    Publishing date 2020-10-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1070385-8
    ISSN 1525-1438 ; 1048-891X
    ISSN (online) 1525-1438
    ISSN 1048-891X
    DOI 10.1136/ijgc-2020-001834
    Database MEDical Literature Analysis and Retrieval System OnLINE

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