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  1. Article: Technical opportunities and challenges in developing total-body PET scanners for mice and rats.

    Du, Junwei / Jones, Terry

    EJNMMI physics

    2023  Volume 10, Issue 1, Page(s) 2

    Abstract: Positron emission tomography (PET) is the most sensitive in vivo molecular imaging technique available. Small animal PET has been widely used in studying pharmaceutical biodistribution and disease progression over time by imaging a wide range of ... ...

    Abstract Positron emission tomography (PET) is the most sensitive in vivo molecular imaging technique available. Small animal PET has been widely used in studying pharmaceutical biodistribution and disease progression over time by imaging a wide range of biological processes. However, it remains true that almost all small animal PET studies using mouse or rat as preclinical models are either limited by the spatial resolution or the sensitivity (especially for dynamic studies), or both, reducing the quantitative accuracy and quantitative precision of the results. Total-body small animal PET scanners, which have axial lengths longer than the nose-to-anus length of the mouse/rat and can provide high sensitivity across the entire body of mouse/rat, can realize new opportunities for small animal PET. This article aims to discuss the technical opportunities and challenges in developing total-body small animal PET scanners for mice and rats.
    Language English
    Publishing date 2023-01-02
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2768912-8
    ISSN 2197-7364
    ISSN 2197-7364
    DOI 10.1186/s40658-022-00523-6
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  2. Article ; Online: Oseltamivir-Current Dosing Recommendations Reduce the Therapeutic Benefit in Patients With Mild to Moderate Renal Function and/or Large Body Mass: A Review of the Literature With Recommendations to Optimize Dosing, Including the Use of Therapeutic Drug Monitoring.

    Jones, Terry E

    Therapeutic drug monitoring

    2020  Volume 43, Issue 1, Page(s) 103–107

    Abstract: Purpose: Oseltamivir is indicated for the treatment and prophylaxis of influenza infections. Achieving therapeutic concentrations EARLY in the course of the infection impacts greatly on the magnitude of benefit. Oseltamivir is renally cleared and dose ... ...

    Abstract Purpose: Oseltamivir is indicated for the treatment and prophylaxis of influenza infections. Achieving therapeutic concentrations EARLY in the course of the infection impacts greatly on the magnitude of benefit. Oseltamivir is renally cleared and dose reductions are advised for patients with renal impairment. The purpose of this review was to determine whether these dose reductions facilitate the early attainment of therapeutic concentrations. The review also examined the effect of body mass on the same outcome.
    Method: Oseltamivir is administered as a prodrug and converted to the active carboxylate moiety in the liver. Published articles that included oseltamivir carboxylate (OC) pharmacokinetics in patients with renal impairment and those with large body mass were reviewed. Concentrations of OC achieved in the first 24 hours were compared with those from patients with normal renal function and body mass.
    Results: Studies that informed dosage regimens for patients with mild to moderately impaired renal function focused on attaining steady-state concentrations similar to those observed in patients with normal renal function. They overlooked the importance of achieving therapeutic concentrations EARLY in the course of the infection. As a result, many patients will not attain therapeutic concentrations until too late in the infection. This is also true for patients with a large body mass.
    Conclusions: Current dosing advice for oseltamivir in patients with mild to moderate renal impairment and those with a larger body mass are likely to reduce (or even negate) its efficacy. The first dose should be 75 mg for patients with normal body mass and proportionately larger when body mass is larger. Subsequent doses should be reduced in proportion to the degree of renal impairment. Timely therapeutic drug monitoring can provide invaluable dosing (and other) information to the clinician treating patients with influenza and could improve patient outcomes.
    MeSH term(s) Antiviral Agents/administration & dosage ; Antiviral Agents/therapeutic use ; Body Mass Index ; Drug Monitoring ; Humans ; Influenza, Human/drug therapy ; Kidney/physiology ; Kidney/physiopathology ; Oseltamivir/administration & dosage ; Oseltamivir/therapeutic use
    Chemical Substances Antiviral Agents ; Oseltamivir (20O93L6F9H)
    Language English
    Publishing date 2020-09-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 424443-6
    ISSN 1536-3694 ; 0163-4356
    ISSN (online) 1536-3694
    ISSN 0163-4356
    DOI 10.1097/FTD.0000000000000797
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  3. Article ; Online: A realist model for home visitation program evaluation.

    Roane, Jeniece S / Jones, Terry L

    Journal of pediatric nursing

    2022  Volume 64, Page(s) e6–e14

    Abstract: Increased attention on home visitation as a strategy to reduce child maltreatment and increased funding to support home visitation programs has led to their rapid and widespread adoption in the United States and internationally. The rapid adoption of ... ...

    Abstract Increased attention on home visitation as a strategy to reduce child maltreatment and increased funding to support home visitation programs has led to their rapid and widespread adoption in the United States and internationally. The rapid adoption of home visitation programs has occurred without an adequate understanding of the underlying mechanisms of influence on child maltreatment. Consequently, there is a lack of consistency in structures and processes across programs. The variability in structures and processes within and across programs has contributed to the inconsistent findings related to the effectiveness of home visitation as a strategy to constrain child maltreatment. Identifying the underlying mechanisms that are facilitating or constraining program success or failure is essential for informing policy and practice. We propose the use of realist theory to identify the underlying mechanisms of home visitation programs. While realist theory has been used broadly in the social sciences, its uptake in nursing has been slow. Despite its limited use in nursing, realism's primary function, seeking to identify the underlying mechanisms in complex social programs, makes it suitable for investigating many complex phenomena that are of interest to nurse scientists. Here we discuss the theoretical foundations for home visitation programs, the recent evidence for program effectiveness, significant home visitation program components, and we propose a realist model for home visitation program evaluation that may aid in identifying how, for whom, and under what conditions home visitation programs work when these programs are implemented to address child maltreatment.
    MeSH term(s) Child ; Child Abuse/prevention & control ; House Calls ; Humans ; Program Evaluation ; United States
    Language English
    Publishing date 2022-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632731-x
    ISSN 1532-8449 ; 0882-5963
    ISSN (online) 1532-8449
    ISSN 0882-5963
    DOI 10.1016/j.pedn.2022.01.012
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  4. Article ; Online: Factors facilitating or inhibiting the capacity for effective leadership among front-line nurse managers: A scoping review.

    Frangieh, Jihane / Jones, Terry

    Journal of nursing management

    2022  Volume 30, Issue 7, Page(s) 2653–2669

    Abstract: Aims: The purpose of this scoping review is to map and synthesize research studies addressing the factors that impact leadership behaviours of front-line nurse managers.: Background: Leadership is a fundamental component of the role of front-line ... ...

    Abstract Aims: The purpose of this scoping review is to map and synthesize research studies addressing the factors that impact leadership behaviours of front-line nurse managers.
    Background: Leadership is a fundamental component of the role of front-line nurse managers. Ineffective leadership is associated with costly outcomes; thus, organizations seek effective strategies to facilitate consistent demonstration of leadership behaviours.
    Evaluation: Using a scoping review methodology, findings from 26 empirical studies were mapped to identify barriers and facilitators of leadership among front-line nurse managers. Major categories included personal and environmental factors with subthemes of personal characteristics, competencies and social support.
    Key issues: Available evidence captures the influence of personal characteristics, education, competency and formal social support on leadership capacity. The role of informal social support was not captured.
    Conclusions: Multiple personal and environmental factors influence the capacity for leadership behaviours among front-line nurse managers. Strategies such as leadership development programmes, mentorship and peer support programmes, and work environments that support relational and structural support may increase leadership capacity for front-line nurse managers.
    Implications for nursing management: Senior nurse leaders can use the results of this review to guide implementation of evidence-based strategies to recruit and retain front-line nurse managers.
    Language English
    Publishing date 2022-09-29
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1162321-4
    ISSN 1365-2834 ; 0966-0429
    ISSN (online) 1365-2834
    ISSN 0966-0429
    DOI 10.1111/jonm.13776
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  5. Article ; Online: Problems with paper entitled The impact of tacrolimus exposure on extrarenal adverse effects in adult transplant recipients.

    Jones, Terry E

    British journal of clinical pharmacology

    2019  Volume 86, Issue 12, Page(s) 2536–2537

    MeSH term(s) Adult ; Graft Rejection ; Humans ; Immunosuppressive Agents/adverse effects ; Kidney Transplantation/adverse effects ; Tacrolimus/adverse effects ; Transplant Recipients
    Chemical Substances Immunosuppressive Agents ; Tacrolimus (WM0HAQ4WNM)
    Language English
    Publishing date 2019-12-17
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 188974-6
    ISSN 1365-2125 ; 0306-5251 ; 0264-3774
    ISSN (online) 1365-2125
    ISSN 0306-5251 ; 0264-3774
    DOI 10.1111/bcp.14106
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  6. Article: Safety and Pharmacokinetics of FMX103 (1.5% Minocycline Topical Foam) in Subjects with Moderate-to-Severe Papulopustular Rosacea under Maximum-use Treatment Conditions.

    Jones, Terry M / Stuart, Iain

    The Journal of clinical and aesthetic dermatology

    2021  Volume 14, Issue 3, Page(s) E53–E57

    Abstract: BACKGROUND: ...

    Abstract BACKGROUND:
    Language English
    Publishing date 2021-03-01
    Publishing country United States
    Document type Journal Article
    ISSN 1941-2789
    ISSN 1941-2789
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  7. Article ; Online: Nurse Cognition, Decision Support, and Barcode Medication Administration: A Conceptual Framework for Research, Practice, and Education.

    Sloss, Elizabeth Ann / Jones, Terry L

    Computers, informatics, nursing : CIN

    2021  Volume 39, Issue 12, Page(s) 851–857

    Abstract: This article synthesizes theoretical perspectives related to nurse cognition. We present a conceptual model that can be used by multiple stakeholders to study and contemplate how nurses use clinical decision support systems, and specifically, Barcode- ... ...

    Abstract This article synthesizes theoretical perspectives related to nurse cognition. We present a conceptual model that can be used by multiple stakeholders to study and contemplate how nurses use clinical decision support systems, and specifically, Barcode-Assisted Medication Administration, to make decisions during the delivery of care. Theoretical perspectives integrated into the model include dual process theory, the Cognitive Continuum Theory, human factors engineering, and the Recognition-Primed Decision model. The resulting framework illustrates the process of nurse cognition during Barcode-Assisted Medication Administration. Additionally, the model includes individual or human and environmental factors that may influence nurse cognition and decision making. It is important to consider the influence of individual, human, and environmental factors on the process of nurse cognition and decision making. Specifically, it is necessary to explore the impact of heuristics and biases on clinician decision making, particularly related to the development of alarm and alert fatigue. Aided by the proposed framework, stakeholders may begin to identify heuristics and cognitive biases that influence the decision of clinicians to accept or override a clinical decision support system alert and whether heuristics and biases are associated with inappropriate alert override.
    MeSH term(s) Cognition ; Decision Making ; Decision Support Systems, Clinical ; Heuristics ; Humans
    Language English
    Publishing date 2021-05-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2078463-6
    ISSN 1538-9774 ; 1538-2931
    ISSN (online) 1538-9774
    ISSN 1538-2931
    DOI 10.1097/CIN.0000000000000724
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  8. Article ; Online: Leadership Behaviors of Frontline Nurse Managers: A Mixed-Methods Research Study Identifying Essential Areas for Social Support.

    Frangieh, Jihane / Jones, Terry / Kinser, Patricia Anne / Baker, Kathy / Elswick, Ronald K / Thacker, Leroy R

    The Journal of nursing administration

    2024  Volume 54, Issue 2, Page(s) 102–110

    Abstract: Objective: This study examined how frontline nurse managers (FLNMs) perceive and experience formal and informal social support and how personal factors and social support relate to their transformational leadership (TL) behaviors.: Background: ... ...

    Abstract Objective: This study examined how frontline nurse managers (FLNMs) perceive and experience formal and informal social support and how personal factors and social support relate to their transformational leadership (TL) behaviors.
    Background: Ineffective leadership by FLNMs is associated with costly outcomes. Evidence suggests that leadership development is a function of personal and social factors; however, a better understanding of this process is needed.
    Methods: A convergent mixed-methods design was used. The quantitative strand included a cross-sectional survey in a sample of FLNMs. The qualitative strand used a semistructured interview and a descriptive qualitative approach with a subset of this sample.
    Results: Formal and informal social support is positively related to the TL behaviors of FLNMs as evidenced by the convergent data. The influence of family members in the work-related decisions of FLNMs has been underreported in the literature and is an area for consideration in supporting retention and desired leadership behaviors.
    Conclusion: The findings of this study imply a need for organizations to establish systems that endorse the growth of FLNMS, create opportunities for career advancement, and integrate members of the FLNMs' personal support systems into recognition initiatives.
    MeSH term(s) Humans ; Cross-Sectional Studies ; Leadership ; Nurse Administrators ; Social Support ; Acidosis, Lactic
    Language English
    Publishing date 2024-01-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 193141-6
    ISSN 1539-0721 ; 1539-073X ; 0002-0443
    ISSN (online) 1539-0721 ; 1539-073X
    ISSN 0002-0443
    DOI 10.1097/NNA.0000000000001389
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  9. Article ; Online: Factors Influencing Medication Administration Outcomes Among New Graduate Nurses Using Bar Code-Assisted Medication Administration.

    Sloss, Elizabeth A / Jones, Terry L / Baker, Kathy / Robins, Jo Lynne W / Thacker, Leroy R

    Computers, informatics, nursing : CIN

    2024  Volume 42, Issue 3, Page(s) 199–206

    Abstract: Paramount to patient safety is the ability for nurses to make clinical decisions free from human error. Yet, the dynamic clinical environment in which nurses work is characterized by uncertainty, urgency, and high consequence, necessitating that nurses ... ...

    Abstract Paramount to patient safety is the ability for nurses to make clinical decisions free from human error. Yet, the dynamic clinical environment in which nurses work is characterized by uncertainty, urgency, and high consequence, necessitating that nurses make quick and critical decisions. The aim of this study was to examine the influence of human and environmental factors on the decision to administer among new graduate nurses in response to alert generation during bar code-assisted medication administration. The design for this study was a descriptive, longitudinal, observational cohort design using EHR audit log and administrative data. The study was set at a large, urban medical center in the United States and included 132 new graduate nurses who worked on adult, inpatient units. Research variables included human and environmental factors. Data analysis included descriptive and inferential analyses. This study found that participants continued with administration of a medication in 90.75% of alert encounters. When considering the response to an alert, residency cohort, alert category, and previous exposure variables were associated with the decision to proceed with administration. It is important to continue to study factors that influence nurses' decision-making, particularly during the process of medication administration, to improve patient safety and outcomes.
    MeSH term(s) Adult ; Humans ; Education, Nursing, Graduate ; Data Analysis ; Hospitals ; Inpatients ; Patient Safety
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Observational Study ; Journal Article
    ZDB-ID 2078463-6
    ISSN 1538-9774 ; 1538-2931
    ISSN (online) 1538-9774
    ISSN 1538-2931
    DOI 10.1097/CIN.0000000000001083
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  10. Article ; Online: Describing Medication Administration and Alert Patterns Experienced by New Graduate Nurses During the First Year of Practice.

    Sloss, Elizabeth Ann / Jones, Terry L / Baker, Kathy / Robins, Jo Lynne W / Thacker, Leroy R

    Computers, informatics, nursing : CIN

    2024  Volume 42, Issue 2, Page(s) 94–103

    Abstract: The aim of this study was to describe medication administration and alert patterns among a cohort of new graduate nurses over the first year of practice. Medical errors related to clinical decision-making, including medication administration errors, may ... ...

    Abstract The aim of this study was to describe medication administration and alert patterns among a cohort of new graduate nurses over the first year of practice. Medical errors related to clinical decision-making, including medication administration errors, may occur more frequently among new graduate nurses. To better understand nursing workflow and documentation workload in today's clinical environment, it is important to understand patterns of medication administration and alert generation during barcode-assisted medication administration. Study objectives were addressed through a descriptive, longitudinal, observational cohort design using secondary data analysis. Set in a large, urban medical center in the United States, the study sample included 132 new graduate nurses who worked on adult, inpatient units and administered medication using barcode-assisted medication administration. Data were collected through electronic health record and administration sources. New graduate nurses in the sample experienced a total of 587 879 alert and medication administration encounters, administering 772 unique medications to 17 388 unique patients. Nurses experienced an average medication workload of 28.09 medications per shift, 3.98% of which were associated with alerts, over their first year of practice. In addition to high volume of medication administration, new graduate nurses administer many different types of medications and are exposed to numerous alerts while using barcode-assisted medication administration.
    MeSH term(s) Adult ; Humans ; Documentation ; Education, Nursing, Graduate ; Electronic Health Records ; Medication Errors/prevention & control ; Pharmaceutical Preparations ; Longitudinal Studies ; Cohort Studies
    Chemical Substances Pharmaceutical Preparations
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 2078463-6
    ISSN 1538-9774 ; 1538-2931
    ISSN (online) 1538-9774
    ISSN 1538-2931
    DOI 10.1097/CIN.0000000000001035
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