LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 82

Search options

  1. Article ; Online: Carbon Capture and Conversion.

    Jones, William D

    Journal of the American Chemical Society

    2020  Volume 142, Issue 11, Page(s) 4955–4957

    Language English
    Publishing date 2020-03-06
    Publishing country United States
    Document type Editorial ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.0c02356
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Cell signaling pathways controlling an axis organizing center in the zebrafish.

    Jones, William D / Mullins, Mary C

    Current topics in developmental biology

    2022  Volume 150, Page(s) 149–209

    Abstract: Body axis formation in vertebrate development entails the remarkable feat of patterning a myriad of specialized cell types and organ progenitors from a field of unpatterned, multipotent cells. This feat is achieved largely by secreted cell-cell signaling ...

    Abstract Body axis formation in vertebrate development entails the remarkable feat of patterning a myriad of specialized cell types and organ progenitors from a field of unpatterned, multipotent cells. This feat is achieved largely by secreted cell-cell signaling molecules, enabling cells at different positions within the embryo to adopt distinct fates. During patterning of the vertebrate embryonic axes, a multitude of cell fates is induced by a surprisingly small set of signaling pathways: Wnt, Nodal, Bone Morphogenetic Protein (BMP), and Fibroblast Growth Factor (FGF) signaling. These signals function as morphogens, specifying multiple cell fates in a concentration-dependent mechanism, and must therefore be distributed non-uniformly throughout the embryo. A primary signaling center that sets up spatial asymmetries in these signaling pathways to break the symmetry of the vertebrate embryo is known as the dorsal organizer. Discovered nearly a century ago by Hilde Mangold and Hans Spemann in the newt, the organizer has the remarkable ability to induce a secondary body axis when grafted ectopically into a host embryo. Here, we review the cell-cell signaling pathways that control the establishment of the dorsal organizer and its inductive functions in the zebrafish Danio rerio, a vertebrate model highly amenable to genetic manipulation. The organizer's remarkable inductive abilities continue to provide a fascinating source of scientific inquiry in the field of developmental biology.
    MeSH term(s) Animals ; Body Patterning/genetics ; Bone Morphogenetic Proteins/metabolism ; Gene Expression Regulation, Developmental ; Signal Transduction ; Zebrafish ; Zebrafish Proteins/genetics ; Zebrafish Proteins/metabolism
    Chemical Substances Bone Morphogenetic Proteins ; Zebrafish Proteins
    Language English
    Publishing date 2022-04-29
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ISSN 1557-8933 ; 0070-2153
    ISSN (online) 1557-8933
    ISSN 0070-2153
    DOI 10.1016/bs.ctdb.2022.03.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: ortho

    Ateşin, Tülay A / Jones, William D / Atesin, Abdurrahman C

    Inorganic chemistry

    2023  Volume 62, Issue 48, Page(s) 19698–19705

    Abstract: A recent study of the oxidative addition of zerovalent Ni to the C-CN bond of F-substituted benzonitriles showed significantly increased stabilization of the C-CN oxidative addition products ... ...

    Abstract A recent study of the oxidative addition of zerovalent Ni to the C-CN bond of F-substituted benzonitriles showed significantly increased stabilization of the C-CN oxidative addition products with
    Language English
    Publishing date 2023-11-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.3c03065
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Influencing Discharge Efficiency: Addressing Interdisciplinary Communication, Transportation, and COVID-19 as Barriers.

    Jones, William D / Rodts, Mary F / Merz, Julie

    Professional case management

    2022  Volume 27, Issue 4, Page(s) 169–180

    Abstract: Purpose: At one tertiary, academic medical center, two general medicine units averaged 94% and 97% occupancy causing strain on patient throughput. This project was implemented at these two comparable general medicine units, totaling 64 beds. On each of ... ...

    Abstract Purpose: At one tertiary, academic medical center, two general medicine units averaged 94% and 97% occupancy causing strain on patient throughput. This project was implemented at these two comparable general medicine units, totaling 64 beds. On each of these units, Pareto analyses on causal factors related to discharge order to exit time (DOTE) were performed. DOTE was defined as the period in minutes from when a provider orders a discharge to when the patient actually exits a room. Prime DOTE reduction opportunities were elicited that highlighted the need to address coordination of hospital discharge transportation; that is, arriving family members averaged 120 and 129 min for the two units, and medicars and ambulances averaged 122 and 156 min, which fell above the established 90-min overall strategic DOTE goal. Coordinating efficient discharges decreases the likelihood of hospital bottlenecking and improves patient satisfaction.
    Case management setting: The health care team is composed of physician and provider services, nursing, and case management, as well as the patient and family. Team-focused interventions aimed at reducing DOTE included leveraging interdisciplinary communication technology and messaging for efficiency and accuracy within the health care team and proactive scheduling of hospital discharge transportation arrival. Process objectives measured included percentage of the health care team educated and utilization of the discharge suite. Outcome objectives measured included median DOTE times, patient satisfaction, and emergency department boarding volume and times. Significantly, admissions for coronavirus disease-2019 (COVID-19) cases were also rapidly increasing early on during program implementation resulting in one of the two general medicine units to be designated for COVID-19 overflow.
    Research methodology: Using Lean methodology, the project design was formed based on the Institute for Healthcare Improvement's work on improving hospital-wide patient flow and the Agency for Healthcare Research and Quality's (AHRQ) IDEAL patient discharge framework to better achieve the well-known, triple aim. In response to COVID-19 demands, the Plan-Do-Study-Act process was warranted to be able to manage acute changes, using iterative processing.
    Results and implications: This program evaluation study assessed whether a communication training program that taught an interdisciplinary team of case managers, nurses, physicians, and related staff how to reduce DOTE was useful. The program had a material impact on the DOTE metric knowing that the hospital's ultimate strategic goal is to reduce DOTE to 90 min or less. A reduction in discharge time was documented when using weekly data from the hospital's discharge dashboard powered by the Maestro database. More specifically, nurses fully trained in the interdisciplinary communications program aimed to reduce DOTE had significantly lower DOTE outcomes on their discharges compared with untrained staff (i.e., average untrained = 127 min, average trained = 93 min). In addition, the fully trained nurses had 14% more of their discharges fall at or below the 90-min goal compared with untrained staff (i.e., untrained = 40%, trained = 54%). Supplemental research also suggested that the content of the communication training program was very relevant (e.g., empowering families to pick up the patients and using scheduling vs. will-call transportation strategies with patients lowered the DOTE metric). Corollary analyses showed that readmissions were also lowered, and patient satisfaction ratings increased. In addition, the interdisciplinary communications training program can benefit from being updated to include content on how COVID-19 issues adversely impact discharge times since significant relationships between various COVID-19 measures and higher discharge exit times were documented.
    MeSH term(s) COVID-19 ; Humans ; Interdisciplinary Communication ; Patient Care Team ; Patient Discharge ; Patient Satisfaction
    Language English
    Publishing date 2022-05-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2277201-7
    ISSN 1932-8095 ; 1539-0675 ; 1932-8087 ; 1529-7764
    ISSN (online) 1932-8095 ; 1539-0675
    ISSN 1932-8087 ; 1529-7764
    DOI 10.1097/NCM.0000000000000549
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article: Iridium(I)- and Rhodium(I)-Olefin Complexes Containing an α-Diimine Supporting Ligand.

    Kovach, James / Golisz, Suzanne R / Brennessel, William W / Jones, William D

    Organometallics

    2022  Volume 41, Issue 22, Page(s) 3167–3174

    Abstract: Iridium(I) complexes of the type IrX(olefin)(α-diimine) (α-diimine = 1,4-bis(2,6-xylyl)-2,3-dimethyl-1,4-diaza-1,3-butadiene; X = Cl, I, Me, ... ...

    Abstract Iridium(I) complexes of the type IrX(olefin)(α-diimine) (α-diimine = 1,4-bis(2,6-xylyl)-2,3-dimethyl-1,4-diaza-1,3-butadiene; X = Cl, I, Me, O
    Language English
    Publishing date 2022-04-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2006302-7
    ISSN 1520-6041 ; 0276-7333
    ISSN (online) 1520-6041
    ISSN 0276-7333
    DOI 10.1021/acs.organomet.2c00036
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: Photolysis of Tp'Rh(CNneopentyl)(PhNCNneopentyl) in the presence of ketones and esters: kinetic and thermodynamic selectivity for activation of different aliphatic C-H bonds.

    Parsons, Astrid M / Jones, William D

    Dalton transactions (Cambridge, England : 2003)

    2019  Volume 48, Issue 29, Page(s) 10945–10952

    Abstract: The active fragment [Tp'Rh(CNneopentyl)], generated from the precursor Tp'Rh(CNneopentyl)(PhN[double bond, length as m-dash]CNneopentyl), underwent oxidative addition of substituted ketones and esters resulting in Tp'Rh(CNneopentyl)(R)(H) complexes (Tp' = ...

    Abstract The active fragment [Tp'Rh(CNneopentyl)], generated from the precursor Tp'Rh(CNneopentyl)(PhN[double bond, length as m-dash]CNneopentyl), underwent oxidative addition of substituted ketones and esters resulting in Tp'Rh(CNneopentyl)(R)(H) complexes (Tp' = tris-(3,5-dimethylpyrazolyl)borate). These C-H activated complexes underwent reductive elimination at varying temperatures (24-70 °C) in C6D6 or C6D12. Using previously established kinetic techniques, the relative Rh-C bond strengths were calculated. Analysis of the relative Rh-C bond strengths vs. C-H bond strengths shows a linear correlation with slope RM-C/C-H = 1.22 (12). In general, α-substituents increase the relative Rh-C bond strengths compared to the C-H bond that is broken.
    Language English
    Publishing date 2019-02-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/c9dt01802f
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article: Mechanistic studies of transition metal-mediated C-C bond activation.

    Jones, William D

    Topics in current chemistry

    2014  Volume 346, Page(s) 1–31

    Abstract: Organometallic compounds have been found to be of use in cleaving C-C bonds, as strong metal-carbon bonds can be formed to replace the bond that is broken. Studies of the mechanism of C-C cleavage can provide insight into how these bonds can be cleaved, ... ...

    Abstract Organometallic compounds have been found to be of use in cleaving C-C bonds, as strong metal-carbon bonds can be formed to replace the bond that is broken. Studies of the mechanism of C-C cleavage can provide insight into how these bonds can be cleaved, and can give valuable information that can be used to develop new strategies for breaking C-C bonds and using the products in catalysis. In this chapter, we will examine a number of systems where mechanistic information has been obtained in C-C cleavage.
    Language English
    Publishing date 2014
    Publishing country Germany
    Document type Journal Article
    ISSN 0340-1022
    ISSN 0340-1022
    DOI 10.1007/128_2013_491
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Dehydrogenation of 1-Phenylethanol Catalyzed by Nickel(II)diphosphine Complexes.

    Geetha, Reshma / Kumar, Meenu / Kulkarni, Naveen V / Jones, William D

    Acta chimica Slovenica

    2021  Volume 68, Issue 4, Page(s) 955–960

    Abstract: Catalytic efficacy of the nickel(II)-diphosphine systems in the dehydrogenation of 1-phenylethanol to acetophenone under acceptorless conditions was investigated. Steric and electronic factors of the phosphine ligands were found to play an important role ...

    Abstract Catalytic efficacy of the nickel(II)-diphosphine systems in the dehydrogenation of 1-phenylethanol to acetophenone under acceptorless conditions was investigated. Steric and electronic factors of the phosphine ligands were found to play an important role in the catalysis, while the nature of the base used and the reaction conditions, viz. time, temperature, and stoichiometry, have also shown major influence. Based on the preliminary analysis, a homogeneous pathway, perhaps involving nickel hydride species, was proposed. Due to the gradual disintegration of the catalytic species, deterioration of catalytic activity was observed resulting into low to moderate conversions. Among the series of catalysts examined, the highest conversion of 52% was exhibited by the catalyst C4, dichloro(1,2-bis(diphenylphosphino)ethane)nickel(II) (5 mol%), when loaded with 50 mol% of sodium ethoxide in toluene at 120 °C.
    Language English
    Publishing date 2021-12-15
    Publishing country Slovenia
    Document type Journal Article
    ZDB-ID 2029709-9
    ISSN 1580-3155 ; 1318-0207
    ISSN (online) 1580-3155
    ISSN 1318-0207
    DOI 10.17344/acsi.2021.6920
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Reduced GS Domain Serine/Threonine Requirements of Fibrodysplasia Ossificans Progressiva Mutant Type I BMP Receptor ACVR1 in the Zebrafish.

    Allen, Robyn S / Jones, William D / Hale, Maya / Warder, Bailey N / Shore, Eileen M / Mullins, Mary C

    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

    2023  Volume 38, Issue 9, Page(s) 1364–1385

    Abstract: Fibrodysplasia ossificans progressiva (FOP) is a rare human genetic condition characterized by altered skeletal development and extraskeletal bone formation. All cases of FOP are caused by mutations in the type I bone morphogenetic protein (BMP) receptor ...

    Abstract Fibrodysplasia ossificans progressiva (FOP) is a rare human genetic condition characterized by altered skeletal development and extraskeletal bone formation. All cases of FOP are caused by mutations in the type I bone morphogenetic protein (BMP) receptor gene ACVR1 that result in overactivation of the BMP signaling pathway. Activation of the wild-type ACVR1 kinase requires assembly of a tetrameric type I and II BMP receptor complex followed by phosphorylation of the ACVR1 GS domain by type II BMP receptors. Previous studies showed that the FOP-mutant ACVR1-R206H required type II BMP receptors and presumptive glycine/serine-rich (GS) domain phosphorylation for overactive signaling. Structural modeling of the ACVR1-R206H mutant kinase domain supports the idea that FOP mutations alter the conformation of the GS domain, but it is unclear how this leads to overactive signaling. Here we show, using a developing zebrafish embryo BMP signaling assay, that the FOP-mutant receptors ACVR1-R206H and -G328R have reduced requirements for GS domain phosphorylatable sites to signal compared to wild-type ACVR1. Further, ligand-independent and ligand-dependent signaling through the FOP-mutant ACVR1 receptors have distinct GS domain phosphorylatable site requirements. ACVR1-G328R showed increased GS domain serine/threonine requirements for ligand-independent signaling compared to ACVR1-R206H, whereas it exhibited reduced serine/threonine requirements for ligand-dependent signaling. Remarkably, while ACVR1-R206H does not require the type I BMP receptor partner, Bmpr1, to signal, a ligand-dependent GS domain mutant of ACVR1-R206H could signal independently of Bmpr1 only when Bmp7 ligand was overexpressed. Of note, unlike human ACVR1-R206H, the zebrafish paralog Acvr1l-R203H does not show increased signaling activity. However, in domain-swapping studies, the human kinase domain, but not the human GS domain, was sufficient to confer overactive signaling to the Acvr1l-R203H receptor. Together these results reflect the importance of GS domain activation and kinase domain functions in regulating ACVR1 signaling and identify mechanisms of reduced regulatory constraints conferred by FOP mutations. © 2023 American Society for Bone and Mineral Research (ASBMR).
    MeSH term(s) Animals ; Humans ; Activin Receptors, Type I/genetics ; Activin Receptors, Type I/metabolism ; Bone Morphogenetic Protein Receptors/genetics ; Bone Morphogenetic Protein Receptors/metabolism ; Ligands ; Mutation/genetics ; Myositis Ossificans/genetics ; Myositis Ossificans/metabolism ; Signal Transduction/genetics ; Zebrafish/metabolism
    Chemical Substances Activin Receptors, Type I (EC 2.7.11.30) ; ACVR1 protein, human (EC 2.7.11.30) ; Bone Morphogenetic Protein Receptors (EC 2.7.11.30) ; Ligands ; acvr1l protein, zebrafish (EC 2.7.11.30)
    Language English
    Publishing date 2023-07-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 632783-7
    ISSN 1523-4681 ; 0884-0431
    ISSN (online) 1523-4681
    ISSN 0884-0431
    DOI 10.1002/jbmr.4869
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: A model of neocortical area patterning in the lissencephalic mouse may hold for larger gyrencephalic brains.

    Jones, William D / Guadiana, Sarah M / Grove, Elizabeth A

    The Journal of comparative neurology

    2019  Volume 527, Issue 9, Page(s) 1461–1477

    Abstract: In the mouse, two telencephalic signaling centers orchestrate embryonic patterning of the cerebral cortex. From the rostral patterning center in the telencephalon, the Fibroblast Growth Factor, FGF8, disperses as a morphogen to establish the rostral to ... ...

    Abstract In the mouse, two telencephalic signaling centers orchestrate embryonic patterning of the cerebral cortex. From the rostral patterning center in the telencephalon, the Fibroblast Growth Factor, FGF8, disperses as a morphogen to establish the rostral to caudal axis of the neocortical area map. FGF8 coordinates with Wnt3a from the cortical hem to regulate graded expression of transcription factors that position neocortical areas, and control hippocampal development. Whether similar signaling centers pattern the much larger cortices of carnivore and primate species, however, is unclear. The limited dispersion range of FGF8 and Wnt3a is inconsistent with patterning larger cortical primordia. Yet the implication that different mechanisms organize cortex in different mammals flies in the face of the tenet that developmental patterning mechanisms are conserved across vertebrate species. In the present study, both signaling centers were identified in the ferret telencephalon, as were expression gradients of the patterning transcription factor genes regulated by FGF8 and Wnt3a. Notably, at the stage corresponding to the peak period of FGF8 signaling in the mouse neocortical primordium (NP), the NP was the same size in ferret and mouse, which would allow morphogen patterning of the ferret NP. Subsequently, the size of ferret neocortex shot past that of the mouse. Images from online databases further suggest that NP growth in humans, too, is slowed in early cortical development. We propose that if early growth in larger brains is held back, mechanisms that pattern the neocortical area map in the mouse could be conserved across mammalian species.
    MeSH term(s) Animals ; Female ; Ferrets/embryology ; Fibroblast Growth Factor 8/biosynthesis ; Fibroblast Growth Factor 8/genetics ; Fibroblast Growth Factor 8/physiology ; Gene Expression Regulation, Developmental ; Gestational Age ; Humans ; In Situ Hybridization ; Lissencephaly/embryology ; Lissencephaly/pathology ; Male ; Mice ; Models, Animal ; Models, Neurological ; Neocortex/embryology ; Neocortex/pathology ; Organ Size ; Organogenesis ; Signal Transduction/physiology ; Somites/ultrastructure ; Species Specificity ; Transcription Factors/biosynthesis ; Transcription Factors/genetics ; Wnt3A Protein/biosynthesis ; Wnt3A Protein/genetics ; Wnt3A Protein/physiology
    Chemical Substances Fgf8 protein, mouse ; Transcription Factors ; Wnt3A Protein ; Fibroblast Growth Factor 8 (148997-75-5)
    Language English
    Publishing date 2019-02-06
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 3086-7
    ISSN 1096-9861 ; 0021-9967 ; 0092-7317
    ISSN (online) 1096-9861
    ISSN 0021-9967 ; 0092-7317
    DOI 10.1002/cne.24643
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top