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  1. Article ; Online: Author Correction

    Jiyeon Lee / Julie M. Dimitry / Jong Hee Song / Minsoo Son / Patrick W. Sheehan / Melvin W. King / G. Travis Tabor / Young Ah Goo / Mitchell A. Lazar / Leonard Petrucelli / Erik S. Musiek

    Nature Communications, Vol 14, Iss 1, Pp 1-

    Microglial REV-ERBα regulates inflammation and lipid droplet formation to drive tauopathy in male mice

    2023  Volume 2

    Keywords Science ; Q
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Microglial REV-ERBα regulates inflammation and lipid droplet formation to drive tauopathy in male mice

    Jiyeon Lee / Julie M. Dimitry / Jong Hee Song / Minsoo Son / Patrick W. Sheehan / Melvin W. King / G. Travis Tabor / Young Ah Goo / Mitchell A. Lazar / Leonard Petrucelli / Erik S. Musiek

    Nature Communications, Vol 14, Iss 1, Pp 1-

    2023  Volume 17

    Abstract: Abstract Alzheimer’s disease, the most common age-related neurodegenerative disease, is characterized by tau aggregation and associated with disrupted circadian rhythms and dampened clock gene expression. REV-ERBα is a core circadian clock protein which ... ...

    Abstract Abstract Alzheimer’s disease, the most common age-related neurodegenerative disease, is characterized by tau aggregation and associated with disrupted circadian rhythms and dampened clock gene expression. REV-ERBα is a core circadian clock protein which also serves as a nuclear receptor and transcriptional repressor involved in lipid metabolism and macrophage function. Global REV-ERBα deletion has been shown to promote microglial activation and mitigate amyloid plaque formation. However, the cell-autonomous effects of microglial REV-ERBα in healthy brain and in tauopathy are unexplored. Here, we show that microglial REV-ERBα deletion enhances inflammatory signaling, disrupts lipid metabolism, and causes lipid droplet (LD) accumulation specifically in male microglia. These events impair microglial tau phagocytosis, which can be partially rescued by blockage of LD formation. In vivo, microglial REV-ERBα deletion exacerbates tau aggregation and neuroinflammation in two mouse tauopathy models, specifically in male mice. These data demonstrate the importance of microglial lipid droplets in tau accumulation and reveal REV-ERBα as a therapeutically accessible, sex-dependent regulator of microglial inflammatory signaling, lipid metabolism, and tauopathy.
    Keywords Science ; Q
    Subject code 572
    Language English
    Publishing date 2023-08-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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